Abstract:
Introduction:Hypertension, particularly pulse pressure [PP] is a major risk factor for end-stage renal disease. However, the effect of individual components of hypertension namely PP, systolic [SBP] and diastolic blood pressure [DBP] on kidney function, in the general African population is unknown. Methods:Data were collected on 944 participants [aged 40-75 y], living in villages in the area around the city of Kumasi, Ghana, on demographics, medications, height, weight, BP and 24-hour creatinine clearance (CrCl). Results:The demographic and clinical characteristics were: age 55(11) [mean (SD)] years, females 62%, rural village-dwellers 52%, diabetes 1·5%, BMI 21(4) kg/m2, 24-hourCrCl as a measure of glomerular filtration rate (GFR) 84(23) ml/min/1.73 m2. 29% had BP >140/90 mmHg; SBP and DBP were 125/74(26/14) mmHg, PP was 51(17) mmHg. PP increased with age by 0.55(95% CI: 0.46,0.64) mmHg/year. PP was higher (53(17) v 49(15) mmHg; p < 0.001) in the semiurban participants. GFR decreased both with increasing PP [-0.19 (-0.27,-0.10 ml/min/1.73 m2/mmHg; p < 0.001] and SBP [-0.09 (-0.14,-0.03) ml/min/1.73 m2/mmHg; p < 0.001] but there was no significant relationship with DBP [-0.04 (-0.15,0.06)]. After adjusting for SBP, the relationship between GFR and PP became steeper [-0.31 (-0.50,-0.12) ml/min/1.73 m2/mmHg; p < 0.001]. Using multivariate regression analysis that included PP, age, gender, BMI, only increasing age [-0.75 (-0.88,-0.62)] and decreasing BMI [0.49 (0.16,0.81)] were associated with decreased kidney function. Conclusions:In this homogeneous West-African population, PP increased with age and had a steeper relationship with declining kidney function than SBP or DBP.
journal_name
Int J Hypertensjournal_title
International journal of hypertensionauthors
Banerjee D,Plange-Rhule J,Chitalia N,Kumi K,Micah FB,Cappuccio FP,Eastwood JBdoi
10.1155/2018/7864564subject
Has Abstractpub_date
2018-10-04 00:00:00pages
7864564eissn
2090-0384issn
2090-0392journal_volume
2018pub_type
杂志文章abstract::Organic nitrates are a group of very effective anti-ischemic drugs. They are used for the treatment of patients with stable angina, acute myocardial infarction, and chronic congestive heart failure. A major therapeutic limitation inherent to organic nitrates is the development of tolerance, which occurs during chronic...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2012/842632
更新日期:2012-01-01 00:00:00
abstract::Objectives. To determine the changes in blood pressure levels and antihypertensive medication use in the postrenal transplantation period compared to pretransplantation one. Methods. A comparative cross-sectional study was carried out on renal transplant recipients at the Kenyatta National Hospital, a national referra...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2016/8450596
更新日期:2016-01-01 00:00:00
abstract::Hypertension remains a public health burden despite advances in its management. Hence, the search for further risk stratification tools and prevention and new treatment approaches continues. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with hypertension. Interestingly, riboflavin, as a ...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2020/4267246
更新日期:2020-02-13 00:00:00
abstract::Objective. This study aimed to assess the prevalence and associated factors of hypertension in newly declared municipalities of Kathmandu, Nepal. Design, Settings, and Participants. This was a community-based cross-sectional study conducted in the municipalities of Kathmandu District, Nepal, between January and July 2...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2016/1656938
更新日期:2016-01-01 00:00:00
abstract::It has been previously documented that carotid intima-media thickness (cIMT) is a predictor of cardiovascular disease. The aim of this study was to identify clinical parameters associated with an increased cIMT treated hypertensive women. Female patients (n = 116) with essential hypertension, aged 40-65 years, were in...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2012/257501
更新日期:2012-01-01 00:00:00
abstract::Poor eating habits may represent cardiovascular risk factors since high intake of fat and saturated fatty acids contributes to dyslipidemia, obesity, diabetes mellitus, and hypertension. Thus, nutritional interventions are recognized as important strategies for primary prevention of hypertension and as adjuvants to ph...
journal_title:International journal of hypertension
pub_type: 杂志文章,评审
doi:10.1155/2016/6791519
更新日期:2016-01-01 00:00:00
abstract::This study aimed to determine the prevalence of Self-Monitoring Blood Pressure amongst people with hypertension using a cross-sectional survey. Of the 955 who replied (53%), 293 (31%) reported that they self-monitored blood pressure. Nearly 60% (198/331) self-monitored at least monthly. Diabetic patients monitoring th...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2012/582068
更新日期:2012-01-01 00:00:00
abstract:Background:White-coat hypertension (HT), masked HT, HT with white-coat effect, and masked uncontrolled HT are well-recognized problems of over- and undertreatment of high blood pressure in real-life practice. However, little is known about the true prevalence in Thailand. Objectives:To examine the prevalence and chara...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2020/3261408
更新日期:2020-04-09 00:00:00
abstract::The distribution of the T29C TGFβ1 gene polymorphism was analyzed in 198 hypertensives with left ventricular hypertrophy (LVH) and in 235 hypertensives without LVH. Circulating TGFβ1 levels, procollagen type III levels, microalbuminuria, and left ventricular geometry and function were evaluated in all the hypertensive...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2010/647147
更新日期:2010-03-23 00:00:00
abstract:Background:Hypertension remains a cause of morbidity and mortality in the Ashanti Region of Ghana. It has been featured in the top ten causes of OPD attendance, admissions, and deaths since 2012. We investigated the sociodemographic characteristics and spatial distribution of inpatient hypertensives and factors associa...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2017/6537956
更新日期:2017-01-01 00:00:00
abstract::Hypertension frequently complicates chronic kidney disease (CKD), with studies showing clinical benefit from blood pressure lowering. Subgroups of patients with severe hypertension exist. We aimed to identify patients with the greatest mortality risk from uncontrolled hypertension to define the prevalence and phenotyp...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2013/597906
更新日期:2013-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2019/6709817.]. ...
journal_title:International journal of hypertension
pub_type: 已发布勘误
doi:10.1155/2019/2907675
更新日期:2019-10-13 00:00:00
abstract::Resistant hypertension (RHTN) is defined as blood pressure (BP) that remains uncontrolled in spite of intake of ≥3 antihypertensive medications, ideally prescribed at optimal doses and one of which is a diuretic. The incidence of primary aldosteronism (PA) in patients with RHTN is estimated in prospective studies to b...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2011/837817
更新日期:2011-01-20 00:00:00
abstract:Background:Angiopoietin-like protein 3 (ANGPTL3) plays a pivotal role in lipid metabolism and angiogenesis, and there is growing interest regarding the association between ANGPTL3 and coronary artery disease (CAD). This study aims to investigate whether ANGPTL3 levels can be used to predict the future occurrence of maj...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2020/2980954
更新日期:2020-03-27 00:00:00
abstract::The aim of this study was to establish whether an independent relationship exists between CD4 count and hypertension and if this relationship is modified or confounded by the body mass index (BMI). Methods. A secondary data analysis of a cross-sectional study on 200 HIV/AIDS patients at a referral hospital in Cameroon...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2018/1691474
更新日期:2018-01-22 00:00:00
abstract::In 2005, the International Society of Nephrology (ISN) established the Global Outreach Program (GO) aimed at building a capacity for detecting and managing chronic kidney disease and its complications in low- and middle-income countries. Here we report data from the 2006-2007 screening program (1025 subjects from the ...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2012/951734
更新日期:2012-01-01 00:00:00
abstract::Our aim was to investigate factors predicting blood pressure (BP) variability during diagnostic cerebral angiography and associations between BP variability and clinical outcomes in patients with acute and subacute ischemic stroke and intracranial artery stenosis. 114 patients with ischemic stroke and intracranial art...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2020/6214581
更新日期:2020-09-01 00:00:00
abstract:Background:Epoxide hydrolase 2 (EPHX2) gene coding for soluble epoxide hydrolase is a potential candidate in the pathogenesis of hypertension. Objectives:We aimed to assess the association of a missense mutation, R287Q, in EPHX2) gene coding for soluble epoxide hydrolase is a potential candidate in the pathogenesis of...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2020/2351547
更新日期:2020-02-28 00:00:00
abstract::The human renin gene has been widely known to be involved in essential hypertension (EH) pathogenesis. Genetic variant C-5434T of REN enhancer contributed to renin gene transcription and serum renin regulation. However, the mechanism associated with the transcription level changes remains unknown, and only a few repor...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2015/486961
更新日期:2015-01-01 00:00:00
abstract:Background:Hypertension imposes stresses on many organs like heart and kidney. However, studies that show the effect of hypertension on the lungs are limited. Objective:To assess pulmonary function status of hypertensive patients aged 30-64 years at Zewditu Memorial Hospital, 2017. Methods:Hospital based comparative ...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2018/5492680
更新日期:2018-11-12 00:00:00
abstract::Sodium transport through various nephron segments is quite important in regulating sodium reabsorption and blood pressure. Among several regulators of this process, insulin acts on almost all the nephron segments and is a strong enhancer of sodium reabsorption. Sodium-proton exchanger type 3 (NHE3) is a main regulator...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2011/391762
更新日期:2011-01-01 00:00:00
abstract::Myocardial fibrosis is characterized by excessive deposition of myocardial interstitial collagen, abnormal distribution, and excessive proliferation of fibroblasts. According to the researches in recent years, myocardial fibrosis, as the pathological basis of various cardiovascular diseases, has been proven to be a co...
journal_title:International journal of hypertension
pub_type: 杂志文章,评审
doi:10.1155/2020/3014693
更新日期:2020-01-31 00:00:00
abstract::Increasing blood pressure has a continuum of adverse risk for cardiovascular events. Traditionally this single measure was used to determine who to treat and how vigorously. However, estimating absolute risk rather than measurement of a single risk factor such as blood pressure is a superior method to identify who is ...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2011/595791
更新日期:2011-01-01 00:00:00
abstract::Aim. To evaluate whether body fat distribution, birth weight, and family history for diabetes (FHD) were associated with metabolic syndrome (MetS) in children and adolescents. Methods. A total of 439 Italian obese children and adolescents (5-18 years) were enrolled. Subjects were divided into 2 groups: prepubertal and...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2011/257168
更新日期:2011-02-22 00:00:00
abstract::We investigated the effects of resistance exercise under hypoxia on postexercise hemodynamics in eight healthy young males. The subjects belonged to a track & field club (sprinters, hurdlers, and long jumpers) and engage in regular physical training (1-2 h per day, 3-5 days per week). Each participant performed eight ...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2018/1456972
更新日期:2018-07-26 00:00:00
abstract::Angiotensin II increases blood pressure and stimulates thirst and sodium appetite in the brain. It also stimulates secretion of aldosterone from the adrenal zona glomerulosa and epinephrine from the adrenal medulla. The rat has 3 subtypes of angiotensin II receptors: AT1a, AT1b, and AT2. mRNAs for all three subtypes o...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2013/175428
更新日期:2013-01-01 00:00:00
abstract::Hypertension is known as the major risk factor for cardiovascular mortality and morbidity. Antihypertensive agents are directed to prevent many of the harmful effects of elevated blood pressure, yet medication nonadherence hinders the effectiveness of these therapies. Nowadays the use of mobile phone has vastly spread...
journal_title:International journal of hypertension
pub_type: 杂志文章,评审
doi:10.1155/2019/9021017
更新日期:2019-04-07 00:00:00
abstract::The purpose of this cross-sectional study was to investigate the association of periodontitis and/or tooth loss with hypertension by excluding the common confounders. Eighty-one Tanzanian women who were aged 46-58 years, nonsmokers, nonalcoholic drinkers, and on no medication underwent clinical examination. Multiple-r...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2011/695719
更新日期:2011-01-01 00:00:00
abstract::African Americans have the highest prevalence of hypertension in the world which may emanate from their predisposition to heightened endothelial inflammation. The purpose of this study was to determine the effects of a 6-month aerobic exercise training (AEXT) intervention on the inflammatory biomarkers interleukin-10 ...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2013/538017
更新日期:2013-01-01 00:00:00
abstract::Mouse models provide powerful tools for studying the mechanisms underlying the dysfunction of the autonomic reflex control of cardiovascular function and those involved in cardiovascular diseases. The established murine model of two-kidney, one-clip (2K1C) angiotensin II-dependent hypertension represents a useful tool...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2012/968123
更新日期:2012-01-01 00:00:00