Abstract:
:Myocardial fibrosis is characterized by excessive deposition of myocardial interstitial collagen, abnormal distribution, and excessive proliferation of fibroblasts. According to the researches in recent years, myocardial fibrosis, as the pathological basis of various cardiovascular diseases, has been proven to be a core determinant in ventricular remodeling. Pressure load is one of the causes of myocardial fibrosis. In experimental models of pressure-overload-induced myocardial fibrosis, significant increase in left ventricular parameters such as interventricular septal thickness and left ventricular posterior wall thickness and the decrease of ejection fraction are some of the manifestations of cardiac damage. These morphological and functional changes have a serious impact on the maintenance of physiological functions. Therefore, establishing a suitable myocardial fibrosis model is the basis of its pathogenesis research. This paper will discuss the methods of establishing myocardial fibrosis model and compare the advantages and disadvantages of the models in order to provide a strong basis for establishing a myocardial fibrosis model.
journal_name
Int J Hypertensjournal_title
International journal of hypertensionauthors
Ding Y,Wang Y,Jia Q,Wang X,Lu Y,Zhang A,Lv S,Zhang Jdoi
10.1155/2020/3014693subject
Has Abstractpub_date
2020-01-31 00:00:00pages
3014693eissn
2090-0384issn
2090-0392journal_volume
2020pub_type
杂志文章,评审abstract:Background:Hypertension is a major cardiovascular risk factor that is linked with fatal complications and is an overwhelming global challenge. Primary prevention is a key to control hypertension with identification of major risk factors. This study was aimed at assessing the prevalence and factors associated with hyper...
journal_title:International journal of hypertension
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abstract::The purpose of this cross-sectional study was to investigate the association of periodontitis and/or tooth loss with hypertension by excluding the common confounders. Eighty-one Tanzanian women who were aged 46-58 years, nonsmokers, nonalcoholic drinkers, and on no medication underwent clinical examination. Multiple-r...
journal_title:International journal of hypertension
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journal_title:International journal of hypertension
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journal_title:International journal of hypertension
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journal_title:International journal of hypertension
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abstract::In 2005, the International Society of Nephrology (ISN) established the Global Outreach Program (GO) aimed at building a capacity for detecting and managing chronic kidney disease and its complications in low- and middle-income countries. Here we report data from the 2006-2007 screening program (1025 subjects from the ...
journal_title:International journal of hypertension
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abstract::In 288 men and women from general population in a cross-sectional survey, all neuropsychological tests were negatively associated with age; memory and executive function were also positively related with education. The hypertensives (HT) were less efficient than the normotensives (NT) in the test of memory with interf...
journal_title:International journal of hypertension
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journal_title:International journal of hypertension
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journal_title:International journal of hypertension
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journal_title:International journal of hypertension
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abstract::The distribution of the T29C TGFβ1 gene polymorphism was analyzed in 198 hypertensives with left ventricular hypertrophy (LVH) and in 235 hypertensives without LVH. Circulating TGFβ1 levels, procollagen type III levels, microalbuminuria, and left ventricular geometry and function were evaluated in all the hypertensive...
journal_title:International journal of hypertension
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journal_title:International journal of hypertension
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journal_title:International journal of hypertension
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journal_title:International journal of hypertension
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journal_title:International journal of hypertension
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journal_title:International journal of hypertension
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journal_title:International journal of hypertension
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journal_title:International journal of hypertension
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