Abstract:
:Primary aldosteronism is a main cause of secondary hypertension which can be effectively treated. The screening test for primary aldosteronism is benefit for minimizing damage to the patient. In the previous retrospective study, we obtained the optimal cutoff value of aldosterone-to-renin ratio detected by chemiluminescence assay, a newly developing method, and prompted its high efficiency in primary aldosteronism screening in upright position. In this study, we want to evaluate its efficiency in practical work. We used this ratio to continuously screen 238 patients, and 58 patients were finally diagnosed with primary aldosteronism. We found it had 86.13% accuracy rate in the upright position compared with the final clinical diagnosis. False negative and positive rates were 13.79% and 13.89%. Diagnostic sensitivity and specificity were 86.21% and 86.11%, which are slightly different from results in our previous study. False negative rate can be improved by combining the aldosterone-to-renin ratio with aldosterone concentration. We also found impaired glucose tolerance may be a reason for high false positive rate. Besides, chemiluminescence assay may be interfered in aldosterone detection. Although it has some shortcomings, chemiluminescence assay-detected aldosterone-to-renin ratio is a highly effective index for screening primary aldosteronism in practice.
journal_name
Int J Hypertensjournal_title
International journal of hypertensionauthors
Lin W,Li Y,Chen D,Yao Z,Xu H,Chen Y,Xiao J,Feng P,Gan Wdoi
10.1155/2020/3934212subject
Has Abstractpub_date
2020-08-27 00:00:00pages
3934212eissn
2090-0384issn
2090-0392journal_volume
2020pub_type
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journal_title:International journal of hypertension
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journal_title:International journal of hypertension
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journal_title:International journal of hypertension
pub_type: 已发布勘误
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pub_type: 杂志文章,评审
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