Abstract:
:Endothelial dysfunction is one of the main characteristics of chronic hypertension and it is characterized by impaired nitric oxide (NO) bioactivity determined by increased levels of reactive oxygen species. Endothelial function is usually evaluated by measuring the vasodilation induced by the local NO production stimulated by external mechanical or pharmacological agent. These vascular reactivity tests may be carried out in different models of experimental hypertension such as NO-deficient rats, spontaneously hypertensive rats, salt-sensitive rats, and many others. Wire myograph and pressurized myograph are the principal methods used for vascular studies. Usually, increasing concentrations of the vasodilator acetylcholine are added in cumulative manner to perform endothelium-dependent concentration-response curves. Analysis of vascular mechanics is relevant to identify arterial stiffness. Both endothelial dysfunction and vascular stiffness have been shown to be associated with increased cardiovascular risk.
journal_name
Int J Hypertensjournal_title
International journal of hypertensionauthors
Neves MF,Kasal DA,Cunha AR,Medeiros Fdoi
10.1155/2012/187526subject
Has Abstractpub_date
2012-01-01 00:00:00pages
187526eissn
2090-0384issn
2090-0392journal_volume
2012pub_type
杂志文章abstract:Background:Given that hypertension in adulthood has its onset in childhood, it is not surprising that the prevalence of hypertension among adolescents has also increased in recent years. However, there are limited data on the prevalence of hypertension and also the new AAP guideline has not yet been applied to the Indo...
journal_title:International journal of hypertension
pub_type: 杂志文章
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journal_title:International journal of hypertension
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pub_type: 杂志文章
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journal_title:International journal of hypertension
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journal_title:International journal of hypertension
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journal_title:International journal of hypertension
pub_type: 杂志文章,评审
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2019/7929706
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journal_title:International journal of hypertension
pub_type: 杂志文章
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journal_title:International journal of hypertension
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:International journal of hypertension
pub_type: 杂志文章
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abstract::[This corrects the article DOI: 10.1155/2019/6709817.]. ...
journal_title:International journal of hypertension
pub_type: 已发布勘误
doi:10.1155/2019/2907675
更新日期:2019-10-13 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
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