Vascular dysfunction as target organ damage in animal models of hypertension.

Abstract:

:Endothelial dysfunction is one of the main characteristics of chronic hypertension and it is characterized by impaired nitric oxide (NO) bioactivity determined by increased levels of reactive oxygen species. Endothelial function is usually evaluated by measuring the vasodilation induced by the local NO production stimulated by external mechanical or pharmacological agent. These vascular reactivity tests may be carried out in different models of experimental hypertension such as NO-deficient rats, spontaneously hypertensive rats, salt-sensitive rats, and many others. Wire myograph and pressurized myograph are the principal methods used for vascular studies. Usually, increasing concentrations of the vasodilator acetylcholine are added in cumulative manner to perform endothelium-dependent concentration-response curves. Analysis of vascular mechanics is relevant to identify arterial stiffness. Both endothelial dysfunction and vascular stiffness have been shown to be associated with increased cardiovascular risk.

journal_name

Int J Hypertens

authors

Neves MF,Kasal DA,Cunha AR,Medeiros F

doi

10.1155/2012/187526

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

187526

eissn

2090-0384

issn

2090-0392

journal_volume

2012

pub_type

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