Abstract:
:The spontaneously hypertensive rat model with reduced NO synthesis (SHRLN) shares features with aging and hypertension in humans, among other a severe aortic stiffening. The present in vivo study aimed to compare thoracic (TA) and abdominal (AA) aortic stiffness in the SHRLN (treated 5 weeks with L-NAME), SHR, and normotensive Wistar Kyoto (WKY). Dynamic properties of TA and AA were measured in the same rats, using echotracking recording of aortic diameter coupled with blood pressure (BP). Measurements were performed first at operating BP and then after BP reduction in hypertensive rats, thus in isobaric conditions. Histological staining and immunohistochemistry were used for structural analysis at both sites. At operating pressure, BP and pulse pressure (PP) were higher in SHRLN compared with SHR. Stiffness index was also increased and distensibility decreased in both TA and AA in SHRLN. At WKY-matched blood pressure, isobaric AA parameters remained specifically altered in SHRLN, whereas TA recovered to values identical to WKYs. Collagen, fibronectin, α5-selectin, and FAK were increased in SHRLN compared with SHR or WKY. Nevertheless, only the strong accumulations of fibronectin and collagen at the AA site in SHRLN were associated with intrinsic stiffening. In conclusion, we confirm that NO restriction associated with hypertension induces a severe pathological phenotype and shows that L-NAME induced stiffening is more pronounced in AA than in TA as a result of greater fibrosis.
journal_name
Int J Hypertensjournal_title
International journal of hypertensionauthors
Lindesay G,Bézie Y,Ragonnet C,Duchatelle V,Isabelle M,Villeneuve N,Vayssettes-Courchay Cdoi
10.1155/2019/8070198subject
Has Abstractpub_date
2019-03-19 00:00:00pages
8070198eissn
2090-0384issn
2090-0392journal_volume
2019pub_type
杂志文章abstract::Myocardial fibrosis is characterized by excessive deposition of myocardial interstitial collagen, abnormal distribution, and excessive proliferation of fibroblasts. According to the researches in recent years, myocardial fibrosis, as the pathological basis of various cardiovascular diseases, has been proven to be a co...
journal_title:International journal of hypertension
pub_type: 杂志文章,评审
doi:10.1155/2020/3014693
更新日期:2020-01-31 00:00:00
abstract::In 2005, the International Society of Nephrology (ISN) established the Global Outreach Program (GO) aimed at building a capacity for detecting and managing chronic kidney disease and its complications in low- and middle-income countries. Here we report data from the 2006-2007 screening program (1025 subjects from the ...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2012/951734
更新日期:2012-01-01 00:00:00
abstract::Objective. The purpose of this study was to investigate whether short sleepers (<6 hrs) who worked the non-day-shift were at greater likelihood of reporting hypertension and if these associations varied by individuals' ethnicity. Methods. Analysis was based on the 2010 National Health Interview Survey (NHIS). A total ...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2015/697275
更新日期:2015-01-01 00:00:00
abstract::The aim of this study was to establish whether an independent relationship exists between CD4 count and hypertension and if this relationship is modified or confounded by the body mass index (BMI). Methods. A secondary data analysis of a cross-sectional study on 200 HIV/AIDS patients at a referral hospital in Cameroon...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2018/1691474
更新日期:2018-01-22 00:00:00
abstract::Mitochondrial dysfunction is implicated in many cardiovascular diseases, including hypertension, and may be associated with an overactive renin-angiotensin system (RAS). Angiotensin (Ang) II, a potent vasoconstrictor hormone of the RAS, also impairs baroreflex and mitochondrial function. Most deleterious cardiovascula...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2013/136028
更新日期:2013-01-01 00:00:00
abstract::Alterations in the autonomic cardiovascular control have been implicated to play an important etiologic role in preeclampsia. The present study was designed to evaluate autonomic functions in preeclamptic pregnant women and compare the values with normotensive pregnant and healthy nonpregnant controls. Assessment of a...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2018/8163824
更新日期:2018-09-18 00:00:00
abstract:Background:Epoxide hydrolase 2 (EPHX2) gene coding for soluble epoxide hydrolase is a potential candidate in the pathogenesis of hypertension. Objectives:We aimed to assess the association of a missense mutation, R287Q, in EPHX2) gene coding for soluble epoxide hydrolase is a potential candidate in the pathogenesis of...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2020/2351547
更新日期:2020-02-28 00:00:00
abstract::Hypertension remains a public health burden despite advances in its management. Hence, the search for further risk stratification tools and prevention and new treatment approaches continues. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with hypertension. Interestingly, riboflavin, as a ...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2020/4267246
更新日期:2020-02-13 00:00:00
abstract::Essential hypertension has a high incidence worldwide, and patients with essential hypertension endure a lifetime of medication, leading to a heavy economic burden on the patient's family and causing serious impacts on the patient's quality of life. Much evidence has demonstrated that acupuncture as an adjunctive ther...
journal_title:International journal of hypertension
pub_type: 杂志文章,评审
doi:10.1155/2019/8676490
更新日期:2019-03-07 00:00:00
abstract:Aim:The aim of present study was to determine the safety and efficacy of a new renal artery denervation system for treatment of hypertensive patients. Methods:Hypertensive patients with mean office systolic blood pressure ≥150mmHg and ≤180mmHg or an average of 24-hour ambulatory systolic blood pressure ≥145mmHg and ≤1...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2019/7929706
更新日期:2019-02-14 00:00:00
abstract::Endothelial dysfunction is one of the main characteristics of chronic hypertension and it is characterized by impaired nitric oxide (NO) bioactivity determined by increased levels of reactive oxygen species. Endothelial function is usually evaluated by measuring the vasodilation induced by the local NO production stim...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2012/187526
更新日期:2012-01-01 00:00:00
abstract::Aim. To evaluate whether body fat distribution, birth weight, and family history for diabetes (FHD) were associated with metabolic syndrome (MetS) in children and adolescents. Methods. A total of 439 Italian obese children and adolescents (5-18 years) were enrolled. Subjects were divided into 2 groups: prepubertal and...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2011/257168
更新日期:2011-02-22 00:00:00
abstract::African Americans have the highest prevalence of hypertension in the world which may emanate from their predisposition to heightened endothelial inflammation. The purpose of this study was to determine the effects of a 6-month aerobic exercise training (AEXT) intervention on the inflammatory biomarkers interleukin-10 ...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2013/538017
更新日期:2013-01-01 00:00:00
abstract::This study examined the relationships between SES and diabetes and hypertension for Korean adults using the Korean National Health and Nutritional Examination Survey. To handle the four dummy dependent variables: Diabetes and Hypertension, Diabetes alone, Hypertension alone, and Diabetes or Hypertension, four differen...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2010/410794
更新日期:2010-06-21 00:00:00
abstract::Hypertension is known as the major risk factor for cardiovascular mortality and morbidity. Antihypertensive agents are directed to prevent many of the harmful effects of elevated blood pressure, yet medication nonadherence hinders the effectiveness of these therapies. Nowadays the use of mobile phone has vastly spread...
journal_title:International journal of hypertension
pub_type: 杂志文章,评审
doi:10.1155/2019/9021017
更新日期:2019-04-07 00:00:00
abstract::Background. Effective antihypertensive treatment depends on patient compliance regarding prescribed medications. We assessed the impact of beliefs related towards antihypertensive medication on blood pressure control in a population-based sample treated for hypertension. Methods. We used data from the Characteristics ...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2019/9385397
更新日期:2019-07-28 00:00:00
abstract:Objective:There is poor adherence to antihypertensive therapies among women in India. To determine its socioeconomic barriers we performed a qualitative study on Indian rural women with hypertension. Methods:In-depth interviews with women having hypertension and presenting to outpatient department at a teaching hospit...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2019/5749648
更新日期:2019-01-23 00:00:00
abstract::Hypertension frequently complicates chronic kidney disease (CKD), with studies showing clinical benefit from blood pressure lowering. Subgroups of patients with severe hypertension exist. We aimed to identify patients with the greatest mortality risk from uncontrolled hypertension to define the prevalence and phenotyp...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2013/597906
更新日期:2013-01-01 00:00:00
abstract:Background:Hypertension remains a cause of morbidity and mortality in the Ashanti Region of Ghana. It has been featured in the top ten causes of OPD attendance, admissions, and deaths since 2012. We investigated the sociodemographic characteristics and spatial distribution of inpatient hypertensives and factors associa...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2017/6537956
更新日期:2017-01-01 00:00:00
abstract::The distribution of the T29C TGFβ1 gene polymorphism was analyzed in 198 hypertensives with left ventricular hypertrophy (LVH) and in 235 hypertensives without LVH. Circulating TGFβ1 levels, procollagen type III levels, microalbuminuria, and left ventricular geometry and function were evaluated in all the hypertensive...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2010/647147
更新日期:2010-03-23 00:00:00
abstract::[This corrects the article DOI: 10.1155/2019/6709817.]. ...
journal_title:International journal of hypertension
pub_type: 已发布勘误
doi:10.1155/2019/2907675
更新日期:2019-10-13 00:00:00
abstract::It has been previously documented that carotid intima-media thickness (cIMT) is a predictor of cardiovascular disease. The aim of this study was to identify clinical parameters associated with an increased cIMT treated hypertensive women. Female patients (n = 116) with essential hypertension, aged 40-65 years, were in...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2012/257501
更新日期:2012-01-01 00:00:00
abstract::We report on the first survey of hypertension in undergraduates in Sierra Leone. Levels of hypertension (12%) and obesity (4%) appear low compared to the general population but given the rapid increase of both and the expectation that many graduates will enter the formal employment sector and a sedentary lifestyle, th...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2017/8196362
更新日期:2017-01-01 00:00:00
abstract:Background:Given that hypertension in adulthood has its onset in childhood, it is not surprising that the prevalence of hypertension among adolescents has also increased in recent years. However, there are limited data on the prevalence of hypertension and also the new AAP guideline has not yet been applied to the Indo...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2020/4262034
更新日期:2020-09-16 00:00:00
abstract:Background:Angiopoietin-like protein 3 (ANGPTL3) plays a pivotal role in lipid metabolism and angiogenesis, and there is growing interest regarding the association between ANGPTL3 and coronary artery disease (CAD). This study aims to investigate whether ANGPTL3 levels can be used to predict the future occurrence of maj...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2020/2980954
更新日期:2020-03-27 00:00:00
abstract::Poor eating habits may represent cardiovascular risk factors since high intake of fat and saturated fatty acids contributes to dyslipidemia, obesity, diabetes mellitus, and hypertension. Thus, nutritional interventions are recognized as important strategies for primary prevention of hypertension and as adjuvants to ph...
journal_title:International journal of hypertension
pub_type: 杂志文章,评审
doi:10.1155/2016/6791519
更新日期:2016-01-01 00:00:00
abstract::Background. Developing interventions to improve medication adherence may depend upon discovery of novel behavioral risk factors for nonadherence. Objective. Explore the effects of emotional response (ER) on adherence to antihypertensive medication and on systolic blood pressure (SBP) improvement. Design. We studied 10...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2013/358562
更新日期:2013-01-01 00:00:00
abstract::Objectives. To determine the changes in blood pressure levels and antihypertensive medication use in the postrenal transplantation period compared to pretransplantation one. Methods. A comparative cross-sectional study was carried out on renal transplant recipients at the Kenyatta National Hospital, a national referra...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2016/8450596
更新日期:2016-01-01 00:00:00
abstract::Our aim was to investigate factors predicting blood pressure (BP) variability during diagnostic cerebral angiography and associations between BP variability and clinical outcomes in patients with acute and subacute ischemic stroke and intracranial artery stenosis. 114 patients with ischemic stroke and intracranial art...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2020/6214581
更新日期:2020-09-01 00:00:00
abstract::Introduction. The purpose of this observational cross-sectional study was to assess left ventricular mass (LVM) in prehypertensive individuals in comparison to normotensives and to determine if central blood pressure (BP) correlates better with LVM index (LVMI) than brachial BP. Methods and Result. Brachial and centra...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2015/742658
更新日期:2015-01-01 00:00:00