Abstract:
:Mouse models provide powerful tools for studying the mechanisms underlying the dysfunction of the autonomic reflex control of cardiovascular function and those involved in cardiovascular diseases. The established murine model of two-kidney, one-clip (2K1C) angiotensin II-dependent hypertension represents a useful tool for studying the neural control of cardiovascular function. In this paper, we discuss the main contributions from our laboratory and others regarding cardiac-autonomic imbalance and baroreflex dysfunction. We show recent data from the angiotensin-dependent hypertensive mouse demonstrating DNA damage and oxidative stress using the comet assay and flow cytometry, respectively. Finally, we highlight the relationships between angiotensin and peripheral and central nervous system areas of cardiovascular control and oxidative stress in the 2K1C hypertensive mouse.
journal_name
Int J Hypertensjournal_title
International journal of hypertensionauthors
Campagnaro BP,Gava AL,Meyrelles SS,Vasquez ECdoi
10.1155/2012/968123subject
Has Abstractpub_date
2012-01-01 00:00:00pages
968123eissn
2090-0384issn
2090-0392journal_volume
2012pub_type
杂志文章abstract::Hypertension remains a public health burden despite advances in its management. Hence, the search for further risk stratification tools and prevention and new treatment approaches continues. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with hypertension. Interestingly, riboflavin, as a ...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2020/4267246
更新日期:2020-02-13 00:00:00
abstract::Background. Developing interventions to improve medication adherence may depend upon discovery of novel behavioral risk factors for nonadherence. Objective. Explore the effects of emotional response (ER) on adherence to antihypertensive medication and on systolic blood pressure (SBP) improvement. Design. We studied 10...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2013/358562
更新日期:2013-01-01 00:00:00
abstract::The purpose of this cross-sectional study was to investigate the association of periodontitis and/or tooth loss with hypertension by excluding the common confounders. Eighty-one Tanzanian women who were aged 46-58 years, nonsmokers, nonalcoholic drinkers, and on no medication underwent clinical examination. Multiple-r...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2011/695719
更新日期:2011-01-01 00:00:00
abstract::Silent cerebral white matter lesions (WMLs) are a common finding on magnetic resonance imaging of the brain in the elderly. However, in patients with hypertension, WMLs tend to occur earlier in life and appear to be more severe. There is a body of evidence that supports the idea that WMLs in asymptomatic hypertensive ...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2011/478710
更新日期:2011-01-01 00:00:00
abstract:Background:Hypertension imposes stresses on many organs like heart and kidney. However, studies that show the effect of hypertension on the lungs are limited. Objective:To assess pulmonary function status of hypertensive patients aged 30-64 years at Zewditu Memorial Hospital, 2017. Methods:Hospital based comparative ...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2018/5492680
更新日期:2018-11-12 00:00:00
abstract::Our aim was to investigate factors predicting blood pressure (BP) variability during diagnostic cerebral angiography and associations between BP variability and clinical outcomes in patients with acute and subacute ischemic stroke and intracranial artery stenosis. 114 patients with ischemic stroke and intracranial art...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2020/6214581
更新日期:2020-09-01 00:00:00
abstract::Mitochondrial dysfunction is implicated in many cardiovascular diseases, including hypertension, and may be associated with an overactive renin-angiotensin system (RAS). Angiotensin (Ang) II, a potent vasoconstrictor hormone of the RAS, also impairs baroreflex and mitochondrial function. Most deleterious cardiovascula...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2013/136028
更新日期:2013-01-01 00:00:00
abstract::Essential hypertension is characterized by increased peripheral vascular resistance to blood flow. The endothelium is a crucial regulator of vascular tone. Its function is impaired in patients with hypertension, with reduced vasodilation, increased vascular tone associated with a proinflammatory and prothrombotic stat...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2011/281240
更新日期:2011-01-01 00:00:00
abstract::Sympathetic activation in chronic renal failure (CRF) is a major mechanism leading to the progression of renal disease and hypertension. In the present study, we tested the hypothesis that in CRF increased reactive oxygen species (ROS) production in the RVLM mediated by enhanced circulating Angiotensin II (Ang II) is ...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2010/219358
更新日期:2011-01-04 00:00:00
abstract::[This corrects the article DOI: 10.1155/2019/6709817.]. ...
journal_title:International journal of hypertension
pub_type: 已发布勘误
doi:10.1155/2019/2907675
更新日期:2019-10-13 00:00:00
abstract::Organic nitrates are a group of very effective anti-ischemic drugs. They are used for the treatment of patients with stable angina, acute myocardial infarction, and chronic congestive heart failure. A major therapeutic limitation inherent to organic nitrates is the development of tolerance, which occurs during chronic...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2012/842632
更新日期:2012-01-01 00:00:00
abstract::This study examined the relationships between SES and diabetes and hypertension for Korean adults using the Korean National Health and Nutritional Examination Survey. To handle the four dummy dependent variables: Diabetes and Hypertension, Diabetes alone, Hypertension alone, and Diabetes or Hypertension, four differen...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2010/410794
更新日期:2010-06-21 00:00:00
abstract::In 288 men and women from general population in a cross-sectional survey, all neuropsychological tests were negatively associated with age; memory and executive function were also positively related with education. The hypertensives (HT) were less efficient than the normotensives (NT) in the test of memory with interf...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2012/274851
更新日期:2012-01-01 00:00:00
abstract:Background:Given that hypertension in adulthood has its onset in childhood, it is not surprising that the prevalence of hypertension among adolescents has also increased in recent years. However, there are limited data on the prevalence of hypertension and also the new AAP guideline has not yet been applied to the Indo...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2020/4262034
更新日期:2020-09-16 00:00:00
abstract::Accumulating evidence from animal models and human studies of essential hypertension suggest that brain regulation of the vasculature is impacted by the disease. Human neuroimaging findings suggest that the brain may be an early target of the disease. This observation reinforces earlier research suggesting that psycho...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2012/701385
更新日期:2012-01-01 00:00:00
abstract::Resistant hypertension (RHTN) is defined as blood pressure (BP) that remains uncontrolled in spite of intake of ≥3 antihypertensive medications, ideally prescribed at optimal doses and one of which is a diuretic. The incidence of primary aldosteronism (PA) in patients with RHTN is estimated in prospective studies to b...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2011/837817
更新日期:2011-01-20 00:00:00
abstract::It has been previously documented that carotid intima-media thickness (cIMT) is a predictor of cardiovascular disease. The aim of this study was to identify clinical parameters associated with an increased cIMT treated hypertensive women. Female patients (n = 116) with essential hypertension, aged 40-65 years, were in...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2012/257501
更新日期:2012-01-01 00:00:00
abstract:Introduction:Hypertension, particularly pulse pressure [PP] is a major risk factor for end-stage renal disease. However, the effect of individual components of hypertension namely PP, systolic [SBP] and diastolic blood pressure [DBP] on kidney function, in the general African population is unknown. Methods:Data were c...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2018/7864564
更新日期:2018-10-04 00:00:00
abstract:Background:Epoxide hydrolase 2 (EPHX2) gene coding for soluble epoxide hydrolase is a potential candidate in the pathogenesis of hypertension. Objectives:We aimed to assess the association of a missense mutation, R287Q, in EPHX2) gene coding for soluble epoxide hydrolase is a potential candidate in the pathogenesis of...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2020/2351547
更新日期:2020-02-28 00:00:00
abstract:Background:Angiopoietin-like protein 3 (ANGPTL3) plays a pivotal role in lipid metabolism and angiogenesis, and there is growing interest regarding the association between ANGPTL3 and coronary artery disease (CAD). This study aims to investigate whether ANGPTL3 levels can be used to predict the future occurrence of maj...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2020/2980954
更新日期:2020-03-27 00:00:00
abstract::Endothelial dysfunction is one of the main characteristics of chronic hypertension and it is characterized by impaired nitric oxide (NO) bioactivity determined by increased levels of reactive oxygen species. Endothelial function is usually evaluated by measuring the vasodilation induced by the local NO production stim...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2012/187526
更新日期:2012-01-01 00:00:00
abstract::Introduction. The purpose of this observational cross-sectional study was to assess left ventricular mass (LVM) in prehypertensive individuals in comparison to normotensives and to determine if central blood pressure (BP) correlates better with LVM index (LVMI) than brachial BP. Methods and Result. Brachial and centra...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2015/742658
更新日期:2015-01-01 00:00:00
abstract::Poor eating habits may represent cardiovascular risk factors since high intake of fat and saturated fatty acids contributes to dyslipidemia, obesity, diabetes mellitus, and hypertension. Thus, nutritional interventions are recognized as important strategies for primary prevention of hypertension and as adjuvants to ph...
journal_title:International journal of hypertension
pub_type: 杂志文章,评审
doi:10.1155/2016/6791519
更新日期:2016-01-01 00:00:00
abstract:Background:Hypertension is a major cardiovascular risk factor that is linked with fatal complications and is an overwhelming global challenge. Primary prevention is a key to control hypertension with identification of major risk factors. This study was aimed at assessing the prevalence and factors associated with hyper...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2019/9878437
更新日期:2019-05-15 00:00:00
abstract::Increasing blood pressure has a continuum of adverse risk for cardiovascular events. Traditionally this single measure was used to determine who to treat and how vigorously. However, estimating absolute risk rather than measurement of a single risk factor such as blood pressure is a superior method to identify who is ...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2011/595791
更新日期:2011-01-01 00:00:00
abstract::Blood pressure (BP) tracking from childhood to adulthood has two aspects: the ranking stability relative to others over time and the prediction of future values. This study investigates BP tracking in children and adolescents in Germany in the context of hypertension risk factors. BP was measured and analyzed in 2542 ...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2018/8429891
更新日期:2018-09-26 00:00:00
abstract::The aim of this study was to establish whether an independent relationship exists between CD4 count and hypertension and if this relationship is modified or confounded by the body mass index (BMI). Methods. A secondary data analysis of a cross-sectional study on 200 HIV/AIDS patients at a referral hospital in Cameroon...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2018/1691474
更新日期:2018-01-22 00:00:00
abstract::Hypertension is known as the major risk factor for cardiovascular mortality and morbidity. Antihypertensive agents are directed to prevent many of the harmful effects of elevated blood pressure, yet medication nonadherence hinders the effectiveness of these therapies. Nowadays the use of mobile phone has vastly spread...
journal_title:International journal of hypertension
pub_type: 杂志文章,评审
doi:10.1155/2019/9021017
更新日期:2019-04-07 00:00:00
abstract::Objectives. To determine the changes in blood pressure levels and antihypertensive medication use in the postrenal transplantation period compared to pretransplantation one. Methods. A comparative cross-sectional study was carried out on renal transplant recipients at the Kenyatta National Hospital, a national referra...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2016/8450596
更新日期:2016-01-01 00:00:00
abstract:Purpose:To compare several anthropometric indices in the prediction of hypertension among adults. Methods:This is a cross-sectional study. Five hundred and eighteen adult men and women (40.9 ± 10.5 years; 1.62 ± .09 m; 72.3 ± 15.6 kg) volunteered to participate and underwent blood pressure and anthropometric measures....
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2018/8396570
更新日期:2018-06-05 00:00:00