The brain Renin-Angiotensin system and mitochondrial function: influence on blood pressure and baroreflex in transgenic rat strains.

Abstract:

:Mitochondrial dysfunction is implicated in many cardiovascular diseases, including hypertension, and may be associated with an overactive renin-angiotensin system (RAS). Angiotensin (Ang) II, a potent vasoconstrictor hormone of the RAS, also impairs baroreflex and mitochondrial function. Most deleterious cardiovascular actions of Ang II are thought to be mediated by NADPH-oxidase- (NOX-) derived reactive oxygen species (ROS) that may also stimulate mitochondrial oxidant release and alter redox-sensitive signaling pathways in the brain. Within the RAS, the actions of Ang II are counterbalanced by Ang-(1-7), a vasodilatory peptide known to mitigate against increased oxidant stress. A balance between Ang II and Ang-(1-7) within the brain dorsal medulla contributes to maintenance of normal blood pressure and proper functioning of the arterial baroreceptor reflex for control of heart rate. We propose that Ang-(1-7) may negatively regulate the redox signaling pathways activated by Ang II to maintain normal blood pressure, baroreflex, and mitochondrial function through attenuating ROS (NOX-generated and/or mitochondrial).

journal_name

Int J Hypertens

authors

Nautiyal M,Arnold AC,Chappell MC,Diz DI

doi

10.1155/2013/136028

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

136028

eissn

2090-0384

issn

2090-0392

journal_volume

2013

pub_type

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