Abstract:
Background:Epoxide hydrolase 2 (EPHX2) gene coding for soluble epoxide hydrolase is a potential candidate in the pathogenesis of hypertension. Objectives:We aimed to assess the association of a missense mutation, R287Q, in EPHX2) gene coding for soluble epoxide hydrolase is a potential candidate in the pathogenesis of hypertension. Methods:This study involved 782 patients with primary hypertension and 458 healthy controls. Genotyping was done using TaqMan technique. Activity of soluble epoxide hydrolase fusion proteins was evaluated by the conversion of 11,12-EET to corresponding 11,12-DHET using ELISA kit. Results:After taking carriers of R287Q variant GG genotype as a reference, those with GA genotype had a significantly reduced risk of hypertension (adjusted odds ratio: 0.72, 95% confidence interval: 0.56 to 0.93, P = 0.013). Five significant risk factors were identified, including age, body mass index, total cholesterol, homocysteine, and R287Q variant. These five risk factors for hypertension were represented in a nomogram, with a descent prediction accuracy (C-index: 0.833, P = 0.013). Five significant risk factors were identified, including age, body mass index, total cholesterol, homocysteine, and R287Q variant. These five risk factors for hypertension were represented in a nomogram, with a descent prediction accuracy (C-index: 0.833. Conclusions:We provide evidence that R287Q mutation in EPHX2 gene was associated with reduced risk of primary hypertension and low activity of soluble epoxide hydrolase.EPHX2) gene coding for soluble epoxide hydrolase is a potential candidate in the pathogenesis of hypertension.
journal_name
Int J Hypertensjournal_title
International journal of hypertensionauthors
Ma L,Zhao H,Yu M,Wen Y,Zhao T,Yan M,Liu Q,Jiang Y,Cao Y,Li P,Niu Wdoi
10.1155/2020/2351547subject
Has Abstractpub_date
2020-02-28 00:00:00pages
2351547eissn
2090-0384issn
2090-0392journal_volume
2020pub_type
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journal_title:International journal of hypertension
pub_type: 杂志文章
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journal_title:International journal of hypertension
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journal_title:International journal of hypertension
pub_type: 杂志文章
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abstract::[This corrects the article DOI: 10.1155/2019/6709817.]. ...
journal_title:International journal of hypertension
pub_type: 已发布勘误
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abstract::Blood pressure (BP) tracking from childhood to adulthood has two aspects: the ranking stability relative to others over time and the prediction of future values. This study investigates BP tracking in children and adolescents in Germany in the context of hypertension risk factors. BP was measured and analyzed in 2542 ...
journal_title:International journal of hypertension
pub_type: 杂志文章
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2010/137206
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journal_title:International journal of hypertension
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journal_title:International journal of hypertension
pub_type: 杂志文章,评审
doi:10.1155/2019/9021017
更新日期:2019-04-07 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章,评审
doi:10.1155/2020/3014693
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journal_title:International journal of hypertension
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2012/968123
更新日期:2012-01-01 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2018/5492680
更新日期:2018-11-12 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2012/274851
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2018/8163824
更新日期:2018-09-18 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2018/8637101
更新日期:2018-01-29 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2015/697275
更新日期:2015-01-01 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2012/951734
更新日期:2012-01-01 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2013/538017
更新日期:2013-01-01 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2015/742658
更新日期:2015-01-01 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2016/8450596
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journal_title:International journal of hypertension
pub_type: 杂志文章
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2016/9146870
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2010/410794
更新日期:2010-06-21 00:00:00
abstract::Mitochondrial dysfunction is implicated in many cardiovascular diseases, including hypertension, and may be associated with an overactive renin-angiotensin system (RAS). Angiotensin (Ang) II, a potent vasoconstrictor hormone of the RAS, also impairs baroreflex and mitochondrial function. Most deleterious cardiovascula...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2013/136028
更新日期:2013-01-01 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2011/837817
更新日期:2011-01-20 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2020/2980954
更新日期:2020-03-27 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
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更新日期:2019-01-23 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
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更新日期:2010-03-23 00:00:00