Abstract:
:Sodium transport through various nephron segments is quite important in regulating sodium reabsorption and blood pressure. Among several regulators of this process, insulin acts on almost all the nephron segments and is a strong enhancer of sodium reabsorption. Sodium-proton exchanger type 3 (NHE3) is a main regulator of sodium reabsorption in the luminal side of proximal tubule. In the basolateral side of the proximal tubule, sodium-bicarbonate cotransporter (NBCe1) mediates sodium and bicarbonate exit from tubular cells. In the distal nephron and the connecting tubule, epithelial sodium channel (ENaC) is of great importance to sodium reabsorption. NHE3, NBCe1, and ENaC are all regulated by insulin. Recently with-no-lysine (WNK) kinases, responsible for familial hypertension, stimulating sodium reabsorption in the distal nephron, have been found to be also regulated by insulin. We will discuss the regulation of renal sodium transport by insulin and its roles in the pathogenesis of hypertension in insulin resistance.
journal_name
Int J Hypertensjournal_title
International journal of hypertensionauthors
Horita S,Seki G,Yamada H,Suzuki M,Koike K,Fujita Tdoi
10.4061/2011/391762subject
Has Abstractpub_date
2011-01-01 00:00:00pages
391762eissn
2090-0384issn
2090-0392journal_volume
2011pub_type
杂志文章abstract:Objectives:Prevalence of hypertension has not been studied in the Ethiopian HIV-infected population, which represents 60% of the patients in our AIDS unit. Our aim was to identify risk factors and characterize the prevalence of hypertension in the population monitored at our unit. Methods:A retrospective chart review ...
journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2018/8637101
更新日期:2018-01-29 00:00:00
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journal_title:International journal of hypertension
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doi:10.4061/2011/695719
更新日期:2011-01-01 00:00:00
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journal_title:International journal of hypertension
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2013/358562
更新日期:2013-01-01 00:00:00
abstract::Primary aldosteronism is a main cause of secondary hypertension which can be effectively treated. The screening test for primary aldosteronism is benefit for minimizing damage to the patient. In the previous retrospective study, we obtained the optimal cutoff value of aldosterone-to-renin ratio detected by chemilumine...
journal_title:International journal of hypertension
pub_type: 杂志文章
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更新日期:2020-08-27 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2011/257168
更新日期:2011-02-22 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:International journal of hypertension
pub_type: 杂志文章
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journal_title:International journal of hypertension
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doi:10.1155/2018/5492680
更新日期:2018-11-12 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2010/647147
更新日期:2010-03-23 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2018/8429891
更新日期:2018-09-26 00:00:00
abstract::[This corrects the article DOI: 10.1155/2019/6709817.]. ...
journal_title:International journal of hypertension
pub_type: 已发布勘误
doi:10.1155/2019/2907675
更新日期:2019-10-13 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2020/5710281
更新日期:2020-09-10 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2012/274851
更新日期:2012-01-01 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2015/697275
更新日期:2015-01-01 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2015/742658
更新日期:2015-01-01 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.4061/2010/410794
更新日期:2010-06-21 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2013/538017
更新日期:2013-01-01 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
doi:10.1155/2018/7864564
更新日期:2018-10-04 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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doi:10.1155/2020/4262034
更新日期:2020-09-16 00:00:00
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journal_title:International journal of hypertension
pub_type: 杂志文章
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更新日期:2018-07-26 00:00:00
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更新日期:2020-09-01 00:00:00
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