New frontiers in reproductive immunology research: bringing bedside problems to the bench.

abstract：:Inflammatory bowel disease includes ulcerative colitis and Crohn's disease, which are both inflammatory disorders of the gastrointestinal tract. Both types of inflammatory bowel disease have a complex etiology, resulting from a genetically determined susceptibility interacting with environmental factors, including the...

journal_title：Expert review of clinical immunology

authors： Ferguson LR

更新日期：2013-08-01 00:00:00

abstract：:Over the past few years, the therapeutic potential of Treg has been highlighted in the field of autoimmune diseases and after allogeneic transplantation. The first hurdle for the therapeutic use of Treg is their insufficient numbers in non-manipulated individuals, in particular when facing strong immune activation and...

journal_title：Expert review of clinical immunology

authors： Govender L,Pascual M,Golshayan D

更新日期：2014-09-01 00:00:00

abstract：:Introduction: Patients affected by Inborn Errors of Immunity (IEI) represent a potential group-at-risk in the current COVID-19 pandemic. Studies on large and small cohorts of IEI reported a huge variability clinical manifestations associated to SARS-Cov-2, ranging from asymptomatic, mild, moderate/severe to death. A g...

journal_title：Expert review of clinical immunology

authors： Quinti I,Mezzaroma I,Milito C

更新日期：2021-01-15 00:00:00

abstract：:Intravenous immunoglobulin (IVIg) products are derived from pooled human plasma from thousands of donors and have been used for the treatment of primary immunodeficiency disorders for more than 30 years. IVIg products are also effective in the treatment of autoimmune and inflammatory disorders, however, the precise me...

journal_title：Expert review of clinical immunology

authors： Jordan SC,Toyoda M,Vo AA

更新日期：2011-05-01 00:00:00

abstract：:Psoriatic arthritis (PsA) is a chronic inflammatory joint disease occurring in 6-39% of patients with psoriasis. Standard therapy of PsA includes nonsteroidal anti-inflammatory drugs, intra-articular steroids and disease-modifying antirheumatic drugs. Failure of standard therapy is an indication for anti-TNF-alpha the...

journal_title：Expert review of clinical immunology

authors： Poddubnyy DA,Rudwaleit M

更新日期：2009-11-01 00:00:00

abstract：:Although training and exercise have several benefits, overdoing it might not necessarily be a good thing. For instance, elite athletes have an increased risk for asthma and allergy. Several mechanisms can be implicated for this risk, which include the interplay between environmental training factors and athlete's pers...

journal_title：Expert review of clinical immunology

authors： Silva D,Moreira A

更新日期：2015-01-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) is an IL-7-related cytokine expressed predominantly by barrier epithelial cells. TSLP is a potent activator of several cell types, including myeloid-derived dendritic cells, monocytes/macrophages and mast cells. Recent studies have revealed an important role for TSLP in the initiati...

journal_title：Expert review of clinical immunology

authors： Miazgowicz MM,Headley MB,Larson RP,Ziegler SF

更新日期：2009-09-01 00:00:00

abstract：:Antiphospholipid syndrome is an autoimmune disease characterized by venous and/or arterial thrombosis and/or recurrent fetal loss and the presence of antiphospholid antibodies. Among the causes of death of antiphospholipid syndrome there are the myocardial infarction and stroke. Comorbidities could worsen the evolutio...

journal_title：Expert review of clinical immunology

authors： Muniz Caldas CA,Freire de Carvalho J

更新日期：2013-10-01 00:00:00

abstract：:Atherosclerosis is the major cause of cardiovascular disease (CVD), which represents the major cause of death. During recent years, it has become clear that atherosclerosis is a chronic inflammatory condition where immunity could play an important role. Usually, it is when atherosclerotic plaques rupture that CVD foll...

journal_title：Expert review of clinical immunology

authors： Frostegård J

更新日期：2015-02-01 00:00:00

abstract：:Data generated using high-throughput DNA microarrays are changing the way we think about systemic lupus erythematosus (SLE). The identification of an interferon gene-expression signature in the majority of patients with SLE, especially those with severe SLE, has stimulated substantial interest in targeting the interfe...

journal_title：Expert review of clinical immunology

authors： Gaffney PM,Moser KL,Baechler EC

更新日期：2007-11-01 00:00:00

abstract：:Animal models and clinical studies of asthma have generated important insights into the first effector phase leading to the development of allergic airway disease and bronchial hyper-reactivity. In contrast, mechanisms related to asthma chronicity or persistence are less well understood. The CD4(+) T-helper 2 lymphocy...

journal_title：Expert review of clinical immunology

authors： Aronica MA,Vogel N

更新日期：2005-11-01 00:00:00

abstract：:Introduction: The present status of amifampridine (AFP) for the treatment of Lambert-Eaton myasthenic syndrome (LEMS) is reviewed. Areas covered: All relevant literature identified through a PubMed search under treatment of LEMS, aminopyridine, and amifampridine are reviewed. An expert opinion on AFP was formulated. E...

journal_title：Expert review of clinical immunology

authors： Oh SJ

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:High mobility group protein box 1 (HMGB1) is a protein belonging to the alarmin family. HMGB1 has a relevant role in starting the inflammatory cascade by means of receptors, such as RAGE and TLR. HMGB1 supports transcription of many genes in interactions with many transcription factors, including NF-kB. Th...

journal_title：Expert review of clinical immunology

authors： Ciprandi G,Bellussi LM,Passali GC,Damiani V,Passali D

更新日期：2020-05-01 00:00:00

abstract：:Hashimoto's thyroiditis (HT) is the most prevalent thyroid autoimmune disorder, characterized by the presence of specific thyroid autoantibodies (TAb). The development of autoimmunity, including TAb production and clinical presentation of HT, is determined by a complex interplay of genetic susceptibility and several e...

journal_title：Expert review of clinical immunology

authors： Zaletel K

更新日期：2007-03-01 00:00:00

abstract：INTRODUCTION:New generations of small molecules are being developed for the treatment of ulcerative colitis. Among them, tofatinib (a Janus kinase (JAK) inhibitor) has demonstrated efficacy for inducing and maintaining remission and achieving mucosal healing with a reasonable safety profile. Oral administration is attr...

journal_title：Expert review of clinical immunology

authors： Fernández-Clotet A,Castro-Poceiro J,Panés J

更新日期：2018-11-01 00:00:00

abstract：:The past years have seen the publication of several studies on seronegative spondylarthritides (SpA) and cardiovascular risk as a result of new insights into the connection between inflammation and atherogenesis. Although the overall cardiovascular disease is a complex entity, chronic inflammation of SpA is known to c...

journal_title：Expert review of clinical immunology

authors： Ingegnoli F,Gualtierotti R,Artusi C,Lubrano E

更新日期：2014-02-01 00:00:00

abstract：:Leptospirosis is re-emerging as a worldwide zoonosis and is caused by bacteria of the genus Leptospira. Human leptospirosis is associated with high temperature and humidity. Laboratory tests are indispensible for the early diagnosis and proper disease management. The demand for suitable leptospirosis point-of-care dia...

journal_title：Expert review of clinical immunology

authors： Schreier S,Doungchawee G,Chadsuthi S,Triampo D,Triampo W

更新日期：2013-03-01 00:00:00

abstract：:In cross-sectional studies, vitamin D deficiency is frequent in spondyloarthritic patients and associated with increased spondyloarthritis (SpA) activity and structural damage. Experimental studies also show that vitamin D interferes with molecular pathways critically involved in SpA, especially regarding entheseal in...

journal_title：Expert review of clinical immunology

authors： Guillot X,Prati C,Wendling D

更新日期：2014-12-01 00:00:00

abstract：:In recent years, new insights into the immunological pathways in multiple sclerosis (MS) have been detected. This increasing knowledge has led to more distinct treatment options in modifying the disease course of MS. In 2006, natalizumab, an alpha4-integrin monoclonal antibody, introduced a new era of MS treatment. An...

journal_title：Expert review of clinical immunology

authors： Reske D,Haupt WF

更新日期：2008-09-01 00:00:00

abstract：:Although a large part of the population suffers from allergies, a cure is not yet available. Allergen-specific immunotherapy (AIT) offers promise for these patients. AIT has proven successful in insect and venom allergies; however, for food allergy this is still unclear. In this editorial we focus on the recent advanc...

journal_title：Expert review of clinical immunology

authors： Jongejan L,van Ree R,Poulsen LK

更新日期：2016-01-01 00:00:00

abstract：:Severe active refractory ulcerative colitis is a potentially life-threatening disease. The introduction of intensive steroid treatment and early surgery has reduced mortality in recent years. Ciclosporin and infliximab are effective rescue therapies in steroid refractory colitis. A head-to-head study proposed by Lahar...

journal_title：Expert review of clinical immunology

authors： Rizzello F,Praticò C,Calabrese C,Gionchetti P

更新日期：2013-06-01 00:00:00

abstract：INTRODUCTION:Secukinumab, an interleukin-17A (IL-17A) antagonist, is the first non-TNF alpha inhibitor agent licensed for ankylosing spondylitis (AS), which opens up a new era of alternative cytokine targets beyond TNF. Areas covered: This review explores the pathophysiology and scientific evidence behind the use of th...

journal_title：Expert review of clinical immunology

authors： Dubash S,Bridgewood C,McGonagle D,Marzo-Ortega H

更新日期：2019-02-01 00:00:00

abstract：:Graft-versus-host disease (GVHD) remains a significant complication that greatly enhances morbidity and mortality associated with hematopoietic stem cell transplantation. Key immunoregulatory molecules have been implicated in the pathogenesis of GVHD, but the mechanisms by which these molecules affect the incidence an...

journal_title：Expert review of clinical immunology

authors： Conway SE,Abdi R

更新日期：2009-09-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory systemic disease characterized by symmetric arthritis leading to progressive erosion of cartilage and bone. Psoriatic arthritis and ankylosing spondylitis are also inflammatory arthritides that belong to the spondyloarthritides. Disease-modifying anti-rheumatic drugs...

journal_title：Expert review of clinical immunology

authors： Voulgari PV

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Biological drugs, mainly interleukin (IL)-1 and IL-6 antagonists, but also tumor necrosis factor (TNF) inhibitors, have been used in the treatment of adult onset Still's disease patients (AOSD). METHODS:We summarised the available evidence for the effectiveness of biologic drugs in AOSD. A systematic review...

journal_title：Expert review of clinical immunology

authors： Ruscitti P,Ursini F,Cipriani P,De Sarro G,Giacomelli R

更新日期：2017-11-01 00:00:00

abstract：:Specific allergen immunotherapy has been practiced for allergic rhinoconjunctivitis for over 100 years and is the only treatment option that is disease modifying. In the USA, immunotherapy is usually administered via subcutaneous injection; this is the only route with a US FDA-approved formulation. There is growing in...

journal_title：Expert review of clinical immunology

authors： Park D,Daher N,Blaiss MS

更新日期：2012-08-01 00:00:00

abstract：:Neonates have little immunological memory and a developing immune system, which increases their vulnerability to infectious agents. Recent advances in the understanding of neonatal immunity indicate that both innate and adaptive responses are dependent on precursor frequency of lymphocytes, antigenic dose and mode of ...

journal_title：Expert review of clinical immunology

authors： Basha S,Surendran N,Pichichero M

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:X-linked agammaglobulinemia (XLA) is characterized by the absence of immunoglobulin and B cells. Patients suffer from recurrent bacterial infections from early childhood, and require lifelong immunoglobulin replacement therapy. Mutations in BTK (Bruton's Tyrosine Kinase) are associated with this phenotype. S...

journal_title：Expert review of clinical immunology

authors： Carrillo-Tapia E,García-García E,Herrera-González NE,Yamazaki-Nakashimada MA,Staines-Boone AT,Segura-Mendez NH,Scheffler-Mendoza SC,O Farrill-Romanillos P,Gonzalez-Serrano ME,Rodriguez-Alba JC,Santos-Argumedo L,Berron-Ruiz L,Sanc

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:Autoimmune Inner Ear Disease (AIED) can be of a primary or secondary type. To date, a clear pathogenesis of the disease is still not available. Focusing on the secondary forms of AIED, the aim of this review is to (i) assess and describe the hearing involvement in patients affected by autoimmune diseases, ...

journal_title：Expert review of clinical immunology

authors： Corazzi V,Hatzopoulos S,Bianchini C,Skarżyńska MB,Pelucchi S,Skarżyński PH,Ciorba A

更新日期：2021-01-21 00:00:00

abstract：:Nonsedating antihistamines are a first-line therapy in the management of allergic rhinitis. They relieve the majority of the histamine-mediated symptoms of the condition, including rhinorrhea, sneezing, and pruritus. The nonsedating antihistamine desloratadine is effective in alleviating the symptoms of both seasonal ...

journal_title：Expert review of clinical immunology

authors： Schenkel EJ

更新日期：2006-07-01 00:00:00