Prediction and management of cardiovascular outcomes in systemic lupus erythematosus.

abstract：:This article reports recent evidence on epidemiological data concerning monoclonal antibody (mAb) infusion-related anaphylaxis, as well as recent data on the correlation between mAb immunogenicity and safety profiles. Pathogenic mechanisms of mAb-related adverse reactions including hypersensitivity, IgE- and non-IgE-m...

journal_title：Expert review of clinical immunology

authors： Maggi E,Vultaggio A,Matucci A

更新日期：2011-01-01 00:00:00

abstract：:Evaluation of: Chung CP, Avalos I, Oeser A et al. High prevalence of the metabolic syndrome in patients with systemic lupus erythematosus: association with disease characteristic and cardiovascular risk factors. Ann. Rheum. Dis. 66(2), 208-214 (2007). Systemic lupus erythematosus is associated with higher rates of car...

journal_title：Expert review of clinical immunology

authors： Jara LJ,Medina G,Vega-Hinojosa O

更新日期：2007-03-01 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) is characterized by systemic synovitis causing joint destruction. With the development of biological disease-modifying anti-rheumatic drugs (bDMARDs) and combination of conventional DMARDs, clinical remission is perceived as an appropriate and realistic goal in many patients. Howe...

journal_title：Expert review of clinical immunology

authors： Kubo S,Nakayamada S,Tanaka Y

更新日期：2016-09-01 00:00:00

abstract：:Introduction: For late stage organ failure patients, transplantation is the best option to increase life expectancy with a superior quality of life. Unfortunately, after transplantation many patients are at risk of cellular and antibody-mediated rejection (ABMR). The latter is initiated by donor specific antibodies (D...

journal_title：Expert review of clinical immunology

authors： Niu Q,Kraaijeveld R,Li Y,Mendoza Rojas A,Shi Y,Wang L,Van Besouw NM,Baan CC

更新日期：2019-12-01 00:00:00

abstract：INTRODUCTION:HAE is a very debilitating disease that causes significant distress for patients not only during an acute attack but also constant fear for a subsequent attack. It is important to address long-term prophylactic (LTP) therapy to prevent attacks, decrease morbidity and increase the quality of life. When disc...

journal_title：Expert review of clinical immunology

authors： Villavicencio MF,Craig T

更新日期：2020-05-01 00:00:00

abstract：:In current clinical practice, immune reactivity of kidney transplant recipients is estimated by monitoring the levels of immunosuppressive drugs, and by functional and/or histological evaluation of the allograft. The availability of assays that could directly quantify the extent of the recipient's immune response towa...

journal_title：Expert review of clinical immunology

authors： Cravedi P,Mannon RB

更新日期：2009-09-01 00:00:00

abstract：INTRODUCTION:Biologic drugs have revolutionized the treatment of moderate to severe psoriasis in recent years because of their high efficacy and low risk of toxicity. However, even within the group of biologic therapies, there are differences related to the different mechanisms of action. Areas covered: We review the m...

journal_title：Expert review of clinical immunology

authors： Carrascosa JM,Del-Alcazar E

更新日期：2018-04-01 00:00:00

abstract：:Pigs are currently the preferred species for future organ xenotransplantation. With advances in the development of genetically modified pigs, clinical xenotransplantation is becoming closer to reality. In preclinical studies (pig-to-nonhuman primate), the xenotransplantation of livers from pigs transgenic for human CD...

journal_title：Expert review of clinical immunology

authors： Ekser B,Burlak C,Waldman JP,Lutz AJ,Paris LL,Veroux M,Robson SC,Rees MA,Ayares D,Gridelli B,Tector AJ,Cooper DK

更新日期：2012-09-01 00:00:00

abstract：:In recent years, new insights into the immunological pathways in multiple sclerosis (MS) have been detected. This increasing knowledge has led to more distinct treatment options in modifying the disease course of MS. In 2006, natalizumab, an alpha4-integrin monoclonal antibody, introduced a new era of MS treatment. An...

journal_title：Expert review of clinical immunology

authors： Reske D,Haupt WF

更新日期：2008-09-01 00:00:00

abstract：INTRODUCTION:Dupilumab is a treatment option newly licensed for adolescents with moderate to severe atopic dermatitis (AD). It reduces type 2 inflammation by blocking the shared receptor subunit for IL-4/-13. Dupilumab affects three disease mechanisms in atopic dermatitis: the skin barrier, the Th2-cell differentiation...

journal_title：Expert review of clinical immunology

authors： Senner S,Seegräber M,Frey S,Kendziora B,Eicher L,Wollenberg A

更新日期：2020-07-01 00:00:00

abstract：:Some chemotherapeutic agents and all radiation therapy generates reactive oxygen species (ROS), which induce apoptosis in cancer cells. As ROS play a role in drug-induced apoptosis, one might suspect that antioxidants may inhibit ROS and prevent apoptosis of cancer cells. In order to find an answer to whether or not t...

journal_title：Expert review of clinical immunology

authors： Akbas HS,Timur M,Ozben T

更新日期：2006-11-01 00:00:00

abstract：:Unbalanced immune cell populations or immune cell infiltration of the liver can disrupt the immune-privileged state of the liver, resulting in liver injury or fibrosis. Therefore, the treatment for liver diseases involves not only hepatic regeneration but also immunological regulation. Recent studies demonstrated that...

journal_title：Expert review of clinical immunology

authors： Cui L,Shi Y,Han Y,Fan D

更新日期：2014-09-01 00:00:00

abstract：:The course of inflammatory bowel diseases is heterogeneous and varies over time. Therefore, the search for predictive factors has increasingly become the focus of research. Mucosal healing has emerged as an important objective, as evidence indicates that it is associated with improved disease outcome. Nevertheless, ma...

journal_title：Expert review of clinical immunology

authors： Miheller P,Mandel MD,Mullner K,Lakatos PL

更新日期：2013-09-01 00:00:00

abstract：:In adulthood, new or recurrent asthma is caused by work in approximately 10% of cases. The term occupational asthma is reserved for those cases arising from respiratory hypersensitivity to a specific workplace agent; in others (work-exacerbated asthma) the mechanism is of nonspecific airway irritation on a background ...

journal_title：Expert review of clinical immunology

authors： Cullinan P

更新日期：2005-05-01 00:00:00

abstract：INTRODUCTION:Remestemcel-L, a third-party, off-the-shelf preparation of bone-marrow derived mesenchymal stromal cells (MSCs), has been developed for experimental use in acute graft-versus-host disease (aGvHD) and other immune-mediated conditions. Several preclinical and clinical studies have indeed suggested the potent...

journal_title：Expert review of clinical immunology

authors： Locatelli F,Algeri M,Trevisan V,Bertaina A

更新日期：2017-01-01 00:00:00

abstract：:Takayasu arteritis (TA) is a rare, chronic inflammatory disease that mainly affects the aorta and its primary branches. Initially described in young women from the Far East, it has become evident that TA is found worldwide, in both genders, and in a broader age range of patients than previously appreciated. Although t...

journal_title：Expert review of clinical immunology

authors： Maksimowicz-McKinnon K

更新日期：2009-07-01 00:00:00

abstract：:Patients with sarcoidosis can be subgrouped according to organ engagement and clinical manifestations. One such subgroup is Löfgren's syndrome (LS), constituting a distinct group of sarcoidosis patients with typical clinical manifestations, separate genetic associations and an immune response that seems to differ from...

journal_title：Expert review of clinical immunology

authors： Grunewald J

更新日期：2012-01-01 00:00:00

abstract：:Immunology, similar to other areas of clinical science, is a data-rich discipline that involves a great deal of interaction between healthcare professionals and their patients. The focus of this editorial is to review the challenges and opportunities for mobile healthcare applications within immunology. It is clear th...

journal_title：Expert review of clinical immunology

authors： Gallagher J,O'Donoghue J,Car J

更新日期：2015-04-01 00:00:00

abstract：:Mounting evidence suggests insulin is an important and potentially initiating antigen in the pathogenesis of Type 1 diabetes. High-affinity insulin antibodies are found early in disease development and appear to predict progression. Insulin is the only Type 1 diabetes auto-antigen with exclusive pancreatic expression ...

journal_title：Expert review of clinical immunology

authors： Wicklow BA,Polychronakos C

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:The transcription factors signal transducer and activator of transcription (STAT) 1 and STAT3 fulfill fundamental functions in nonimmune and immune cells. The description and follow-up of patients with germline mutations that result in either loss-of-function or gain-of-function have contributed to our und...

journal_title：Expert review of clinical immunology

authors： Olbrich P,Freeman AF

更新日期：2018-12-01 00:00:00

abstract：:Conventional myeloablative conditioning regimens prior to hematopoietic cell transplantation (HCT) are associated with significant transplant-related morbidity and mortality in children affected by primary immunodeficiency disorders. Reduced-intensity conditioning regimens have been extensively used without severe acu...

journal_title：Expert review of clinical immunology

authors： Chiesa R,Veys P

更新日期：2012-03-01 00:00:00

abstract：INTRODUCTION:Chronic rhinosinusitis (CRS) is a broad clinical syndrome linked by mucosal inflammation. Primary treatment modalities are corticosteroids and antibiotics with surgery an option for failures, but the level of supporting evidence is generally low. The primary reason is that CRS is a symptom complex and not ...

journal_title：Expert review of clinical immunology

authors： Ghogomu N,Kern R

更新日期：2017-03-01 00:00:00

abstract：:Specific allergen immunotherapy has been practiced for allergic rhinoconjunctivitis for over 100 years and is the only treatment option that is disease modifying. In the USA, immunotherapy is usually administered via subcutaneous injection; this is the only route with a US FDA-approved formulation. There is growing in...

journal_title：Expert review of clinical immunology

authors： Park D,Daher N,Blaiss MS

更新日期：2012-08-01 00:00:00

abstract：:The measuring tools for disease activity of rheumatoid arthritis have long been adapted for assessing the disease activity of psoriatic arthritis (PsA), particularly as regards peripheral arthritis. However, because of the multifactorial aspects and multiple domains of PsA, such as axial and peripheral joints, skin an...

journal_title：Expert review of clinical immunology

authors： Her M,Kavanaugh A

更新日期：2014-09-01 00:00:00

abstract：:Inflammatory bowel diseases share common pathogenetic mechanisms that are not yet completely understood. It is clear, however, that the expression and production of cytokines in response to inflammation plays a key role in mediating the migration of activated leukocytes. The process of angiogenesis and the expression ...

journal_title：Expert review of clinical immunology

authors： Fiorino G,Correale C,Fries W,Repici A,Malesci A,Danese S

更新日期：2010-07-01 00:00:00

abstract：:Idealized gene therapy of autoimmune diseases would mean getting the right drug to the right place at the right time to affect the right mechanism of action. In other words, a specific gene therapy strategy needs to have functional, spatial and temporal specificity. Functional specificity implies targeting the cellula...

journal_title：Expert review of clinical immunology

authors： Creusot RJ,Fathman CG,Müller-Ladner U,Tarner IH

更新日期：2005-09-01 00:00:00

abstract：:In this review, recent changes in both treatments and outcomes of rheumatoid arthritis (RA) in Japan were analyzed by viewing the National Database of Rheumatic Diseases by iR-net, one of the largest clinical databases for RA patients in Japan. Regarding drug therapy, the use of methotrexate has been continuously incr...

journal_title：Expert review of clinical immunology

authors： Saeki Y,Matsui T,Saisho K,Tohma S

更新日期：2012-07-01 00:00:00

abstract：:Beclomethasone dipropionate is a corticosteroid with topical activity for inflammatory disorders at mucosal surfaces. Oral beclomethasone dipropionate (orBec) has demonstrated activity in gastrointestinal acute graft-versus-host disease (aGVHD) associated with hematopoietic cell transplantation. Since the GI tract is ...

journal_title：Expert review of clinical immunology

authors： Hockenbery DM

更新日期：2007-09-01 00:00:00

abstract：INTRODUCTION:New generations of small molecules are being developed for the treatment of ulcerative colitis. Among them, tofatinib (a Janus kinase (JAK) inhibitor) has demonstrated efficacy for inducing and maintaining remission and achieving mucosal healing with a reasonable safety profile. Oral administration is attr...

journal_title：Expert review of clinical immunology

authors： Fernández-Clotet A,Castro-Poceiro J,Panés J

更新日期：2018-11-01 00:00:00

abstract：:Introduction: The present status of amifampridine (AFP) for the treatment of Lambert-Eaton myasthenic syndrome (LEMS) is reviewed. Areas covered: All relevant literature identified through a PubMed search under treatment of LEMS, aminopyridine, and amifampridine are reviewed. An expert opinion on AFP was formulated. E...

journal_title：Expert review of clinical immunology

authors： Oh SJ

更新日期：2019-10-01 00:00:00