Adult and pediatric clinical trials of sublingual immunotherapy in the USA.

abstract：INTRODUCTION:Prediction of treatment outcome and clinical relapse in patients with inflammatory bowel disease (IBD), either ulcerative colitis (UC) or Crohn's disease (CD), is particularly important because therapeutics for IBD are not always effective and patients in remission could frequently relapse. Because undergo...

journal_title：Expert review of clinical immunology

authors： Kato J,Yoshida T,Hiraoka S

更新日期：2019-06-01 00:00:00

abstract：:Many immune regulators are now identified as having key roles at the embryo-maternal interface. Importantly, a cohort of cytokines, chemokines and growth factors are produced by the endometrial glands and secreted into the uterine cavity where they act both on the blastocyst and on the endometrial surface, changing ad...

journal_title：Expert review of clinical immunology

authors： Hannan NJ,Evans J,Salamonsen LA

更新日期：2011-11-01 00:00:00

abstract：:Introduction: For late stage organ failure patients, transplantation is the best option to increase life expectancy with a superior quality of life. Unfortunately, after transplantation many patients are at risk of cellular and antibody-mediated rejection (ABMR). The latter is initiated by donor specific antibodies (D...

journal_title：Expert review of clinical immunology

authors： Niu Q,Kraaijeveld R,Li Y,Mendoza Rojas A,Shi Y,Wang L,Van Besouw NM,Baan CC

更新日期：2019-12-01 00:00:00

abstract：INTRODUCTION:HAE is a very debilitating disease that causes significant distress for patients not only during an acute attack but also constant fear for a subsequent attack. It is important to address long-term prophylactic (LTP) therapy to prevent attacks, decrease morbidity and increase the quality of life. When disc...

journal_title：Expert review of clinical immunology

authors： Villavicencio MF,Craig T

更新日期：2020-05-01 00:00:00

abstract：INTRODUCTION:Secondary immunodeficiency is becoming a greater medical concern as the usage of immunosuppressive and biological treatments has increased. Individuals with certain medical conditions, such as hematological malignancies, can also have secondary immunodeficiency. Immunoglobulin replacement therapy (IGRT), w...

journal_title：Expert review of clinical immunology

authors： Patel V,Cowan J

更新日期：2020-07-01 00:00:00

abstract：:Immunology, similar to other areas of clinical science, is a data-rich discipline that involves a great deal of interaction between healthcare professionals and their patients. The focus of this editorial is to review the challenges and opportunities for mobile healthcare applications within immunology. It is clear th...

journal_title：Expert review of clinical immunology

authors： Gallagher J,O'Donoghue J,Car J

更新日期：2015-04-01 00:00:00

abstract：:Pigs are currently the preferred species for future organ xenotransplantation. With advances in the development of genetically modified pigs, clinical xenotransplantation is becoming closer to reality. In preclinical studies (pig-to-nonhuman primate), the xenotransplantation of livers from pigs transgenic for human CD...

journal_title：Expert review of clinical immunology

authors： Ekser B,Burlak C,Waldman JP,Lutz AJ,Paris LL,Veroux M,Robson SC,Rees MA,Ayares D,Gridelli B,Tector AJ,Cooper DK

更新日期：2012-09-01 00:00:00

abstract：:Lung fibrosis is a devastating disease that involves a variable degree of inflammation, alveolar epithelial injury, fibroblast hyperplasia and the deposition of extracellular matrix. Standard therapies that consist of corticosteroids and immunosuppressive agents offer little benefit and most patients experience a prog...

journal_title：Expert review of clinical immunology

authors： Moore BB,Peters-Golden M

更新日期：2006-01-01 00:00:00

abstract：:There is wide variability in the epidemiology and management of childhood asthma and related atopic diseases globally. Urbanized, affluent Western countries tend to have a higher prevalence of these diseases compared with Asian nations. However, recent studies have shown that the prevalence in Asia is increasing, alth...

journal_title：Expert review of clinical immunology

authors： Gerez IF,Lee BW,van Bever HP,Shek LP

更新日期：2010-03-01 00:00:00

abstract：:In cross-sectional studies, vitamin D deficiency is frequent in spondyloarthritic patients and associated with increased spondyloarthritis (SpA) activity and structural damage. Experimental studies also show that vitamin D interferes with molecular pathways critically involved in SpA, especially regarding entheseal in...

journal_title：Expert review of clinical immunology

authors： Guillot X,Prati C,Wendling D

更新日期：2014-12-01 00:00:00

abstract：:Ovarian cancer is the leading cause of death from gynecologic malignancy in the United States. While the treatment options have improved with conventional cytotoxic chemotherapy and advanced surgical techniques, disease recurrence is common and fatal in nearly all cases. Current evidence suggests that the immune syste...

journal_title：Expert review of clinical immunology

authors： Menderes G,Schwab CL,Black J,Santin AD

更新日期：2016-06-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory systemic disease characterized by symmetric arthritis leading to progressive erosion of cartilage and bone. Psoriatic arthritis and ankylosing spondylitis are also inflammatory arthritides that belong to the spondyloarthritides. Disease-modifying anti-rheumatic drugs...

journal_title：Expert review of clinical immunology

authors： Voulgari PV

更新日期：2010-09-01 00:00:00

abstract：:Conventional myeloablative conditioning regimens prior to hematopoietic cell transplantation (HCT) are associated with significant transplant-related morbidity and mortality in children affected by primary immunodeficiency disorders. Reduced-intensity conditioning regimens have been extensively used without severe acu...

journal_title：Expert review of clinical immunology

authors： Chiesa R,Veys P

更新日期：2012-03-01 00:00:00

abstract：INTRODUCTION:Psoriasis is a common, chronic, immune-mediated inflammatory disorder. The disease is associated with several co-morbidities including cardiovascular disease, metabolic syndrome, and psychiatric disorders. It is important to identify and treat these co-morbidities because they have a strongly negative effe...

journal_title：Expert review of clinical immunology

authors： Lønnberg AS,Skov L

更新日期：2017-01-01 00:00:00

abstract：:Leptospirosis is re-emerging as a worldwide zoonosis and is caused by bacteria of the genus Leptospira. Human leptospirosis is associated with high temperature and humidity. Laboratory tests are indispensible for the early diagnosis and proper disease management. The demand for suitable leptospirosis point-of-care dia...

journal_title：Expert review of clinical immunology

authors： Schreier S,Doungchawee G,Chadsuthi S,Triampo D,Triampo W

更新日期：2013-03-01 00:00:00

abstract：:Epidemiological and clinical studies have suggested that the pathogenesis of inflammatory bowel disease (IBD) is strongly influenced by genetic predisposition. Beyond the limitations of linkage analysis, multiple genome-wide association studies, their meta-analyses, and targeted genotyping array techniques have broade...

journal_title：Expert review of clinical immunology

authors： Ye BD,McGovern DP

更新日期：2016-10-01 00:00:00

abstract：:Introduction: The metabolic syndrome (MetS) is now recognized as a chronic proinflammatory and prothrombotic state that aggravates insulin resistance, oxidative injury, and cardiovascular risk. MetS is more prevalent in patients with systemic lupus erythematosus (SLE), a prototype of systemic autoimmune disease associ...

journal_title：Expert review of clinical immunology

authors： Mok CC

更新日期：2019-07-01 00:00:00

abstract：INTRODUCTION:Secukinumab, an interleukin-17A (IL-17A) antagonist, is the first non-TNF alpha inhibitor agent licensed for ankylosing spondylitis (AS), which opens up a new era of alternative cytokine targets beyond TNF. Areas covered: This review explores the pathophysiology and scientific evidence behind the use of th...

journal_title：Expert review of clinical immunology

authors： Dubash S,Bridgewood C,McGonagle D,Marzo-Ortega H

更新日期：2019-02-01 00:00:00

abstract：:Epigenetic modifications of gene expression comprise modifications of DNA by DNA methylation and modifications of the histone proteins by acetylation, methylation, SUMOylation or phosphorylation. DNA methylation in the promoter region of genes represses gene transcription. Histone modifications influence the structure...

journal_title：Expert review of clinical immunology

authors： Jüngel A,Distler JH,Gay S,Distler O

更新日期：2011-07-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) is an IL-7-related cytokine expressed predominantly by barrier epithelial cells. TSLP is a potent activator of several cell types, including myeloid-derived dendritic cells, monocytes/macrophages and mast cells. Recent studies have revealed an important role for TSLP in the initiati...

journal_title：Expert review of clinical immunology

authors： Miazgowicz MM,Headley MB,Larson RP,Ziegler SF

更新日期：2009-09-01 00:00:00

abstract：:Hashimoto's thyroiditis (HT) is the most prevalent thyroid autoimmune disorder, characterized by the presence of specific thyroid autoantibodies (TAb). The development of autoimmunity, including TAb production and clinical presentation of HT, is determined by a complex interplay of genetic susceptibility and several e...

journal_title：Expert review of clinical immunology

authors： Zaletel K

更新日期：2007-03-01 00:00:00

abstract：:Takayasu arteritis (TA) is a rare, chronic inflammatory disease that mainly affects the aorta and its primary branches. Initially described in young women from the Far East, it has become evident that TA is found worldwide, in both genders, and in a broader age range of patients than previously appreciated. Although t...

journal_title：Expert review of clinical immunology

authors： Maksimowicz-McKinnon K

更新日期：2009-07-01 00:00:00

abstract：INTRODUCTION:Psoriasis is a complex disease in which the alteration of the IL-23/Th17 axis appears to be crucial for its pathogenic mechanisms, and anti-IL17 agents are rapidly becoming important therapeutic tools. Brodalumab, a fully human Chinese hamster ovary cell-derived immunoglobulin G2 (IgG2) anti-IL-17RA monocl...

journal_title：Expert review of clinical immunology

authors： Galluzzo M,D'adamio S,Bianchi L,Talamonti M

更新日期：2016-12-01 00:00:00

abstract：:Although training and exercise have several benefits, overdoing it might not necessarily be a good thing. For instance, elite athletes have an increased risk for asthma and allergy. Several mechanisms can be implicated for this risk, which include the interplay between environmental training factors and athlete's pers...

journal_title：Expert review of clinical immunology

authors： Silva D,Moreira A

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Autoimmune Inner Ear Disease (AIED) can be of a primary or secondary type. To date, a clear pathogenesis of the disease is still not available. Focusing on the secondary forms of AIED, the aim of this review is to (i) assess and describe the hearing involvement in patients affected by autoimmune diseases, ...

journal_title：Expert review of clinical immunology

authors： Corazzi V,Hatzopoulos S,Bianchini C,Skarżyńska MB,Pelucchi S,Skarżyński PH,Ciorba A

更新日期：2021-01-21 00:00:00

abstract：OBJECTIVES:Impairment in early B-cell development can cause a predominantly antibody deficiency with severe depletion of peripheral B-cells. Mutations in the gene encoding for Bruton's-tyrosine-kinase (BTK) and the components of the pre-B-cell receptor complex or downstream signaling molecules have been related to this...

journal_title：Expert review of clinical immunology

authors： Abolhassani H,Vitali M,Lougaris V,Giliani S,Parvaneh N,Parvaneh L,Mirminachi B,Cheraghi T,Khazaei H,Mahdaviani SA,Kiaei F,Tavakolinia N,Mohammadi J,Negahdari B,Rezaei N,Hammarstrom L,Plebani A,Aghamohammadi A

更新日期：2016-01-01 00:00:00

abstract：:Antiphospholipid antibodies (aPL Abs) are associated with thrombosis in patients with the antiphospholipid syndrome (APS). There is strong evidence that aPL Abs are pathogenic in vivo from studies in animal models. Furthermore, there are now convincing data indicating that activation of complement is involved in those...

journal_title：Expert review of clinical immunology

authors： Pierangeli SS

更新日期：2008-03-01 00:00:00

abstract：INTRODUCTION:Janus kinase (JAK) inhibitors are emerging treatments in dermatology. Also known as JAKinibs, these agents target JAK-signal transducers and activators of transcription (JAK-STAT) pathway for intracellular signaling. Among the various immune-mediated inflammatory skin diseases that the JAK-STAT pathway pla...

journal_title：Expert review of clinical immunology

authors： Crowley EL,Nezamololama N,Papp K,Gooderham MJ

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION:Allergic rhinitis (AR) is among the most common chronic conditions affecting both children and adults. It is the cause of significant morbidity from the symptoms and interference with sleep. It results in major impairment of performance both at school and at work. In the U.S. and certain parts of Europe, r...

journal_title：Expert review of clinical immunology

authors： Nelson HS

更新日期：2018-12-01 00:00:00

abstract：:Treatment of idiopathic membranous nephropathy (IMN) is controversial. However, two randomized controlled trials (RCTs) reported that treatment with steroids alternated with an alkylating agent achieved significantly more remissions and better renal survival at 10 years in comparison with untreated controls. Short-ter...

journal_title：Expert review of clinical immunology

authors： Ponticelli C

更新日期：2013-01-01 00:00:00