Abstract:
INTRODUCTION:Autoimmune Inner Ear Disease (AIED) can be of a primary or secondary type. To date, a clear pathogenesis of the disease is still not available. Focusing on the secondary forms of AIED, the aim of this review is to (i) assess and describe the hearing involvement in patients affected by autoimmune diseases, (ii) describe the possible association between clinical features (among serological/laboratory data and disease activity/duration) and hearing impairment, (iii) show evidence connecting the AIED types with various etiopathogenetic mechanisms. AREAS COVERED:A PRISMA-compliant systematic review was performed. Medline, Cochrane, Embase, and Cinahl were searched from 1st January 2015 through to 5th August 2020. Overall, 16 studies (involving 1043 participants) were included in the review. The data in the literature suggested that bilateral mild-to-moderate sensorineural hearing loss is a commonly reported clinical symptom of AIED. EXPERT OPINION:Patients with systemic autoimmune disorders present a cochlear injury which might be associated with the humoral and/or cellular immune response against the inner ear. To date, AIED pathogenesis remains an open issue, due to the rarity of these clinical entities and due to the difficulties in investigating the inner ear immunology, considering the inner ear inaccessibility for tissue sampling.
journal_name
Expert Rev Clin Immunoljournal_title
Expert review of clinical immunologyauthors
Corazzi V,Hatzopoulos S,Bianchini C,Skarżyńska MB,Pelucchi S,Skarżyński PH,Ciorba Adoi
10.1080/1744666X.2021.1879640subject
Has Abstractpub_date
2021-01-21 00:00:00eissn
1744-666Xissn
1744-8409pub_type
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