Abstract:
:Introduction: Patients affected by Inborn Errors of Immunity (IEI) represent a potential group-at-risk in the current COVID-19 pandemic. Studies on large and small cohorts of IEI reported a huge variability clinical manifestations associated to SARS-Cov-2, ranging from asymptomatic, mild, moderate/severe to death. A great impulse to improve remote assistance programs and to switch to home-based treatment to reduce mobility and face to face contacts has been implemented. Areas covered: The authors completed a comprehensive review of the literature by searching the PubMed database for studies on large and small cohorts and case reports of IEI patients with COVID-19, with the aim to provide useful information for their clinical management during the COVID-19 pandemic. Expert opinion: Surprisingly, a low number of IEI patients affected by SARS-Cov-2 were reported with a risk to die for COVID-19 overlapping that of the general population. The low number might be explained by the choice of most physicians to inform early in the pandemic about safety measures, to switch most of the IEI patients to home therapy and to remote assistance. The guidelines issued by the scientific societies and periodically updated, represent the best tool for the clinical management of IEI patients.
journal_name
Expert Rev Clin Immunoljournal_title
Expert review of clinical immunologyauthors
Quinti I,Mezzaroma I,Milito Cdoi
10.1080/1744666X.2021.1873767subject
Has Abstractpub_date
2021-01-15 00:00:00pages
1-6eissn
1744-666Xissn
1744-8409pub_type
杂志文章abstract:INTRODUCTION:More women with autoimmune and inflammatory conditions are being treated with monoclonal antibody biologics (mAbs) during their pregnancy, to maintain clinical remission. The use of anti-tumor necrosis factor alpha agents in pregnancy appears to be safe but less is known regarding other mAbs, such as anti-...
journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1080/1744666X.2019.1561282
更新日期:2019-03-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 评论,杂志文章
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1586/1744666X.2014.875468
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1080/1744666X.2019.1601556
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1080/1744666X.2016.1213631
更新日期:2017-01-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2011-09-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章
doi:10.1586/eci.11.47
更新日期:2011-09-01 00:00:00
abstract:INTRODUCTION:High mobility group protein box 1 (HMGB1) is a protein belonging to the alarmin family. HMGB1 has a relevant role in starting the inflammatory cascade by means of receptors, such as RAGE and TLR. HMGB1 supports transcription of many genes in interactions with many transcription factors, including NF-kB. Th...
journal_title:Expert review of clinical immunology
pub_type: 杂志文章
doi:10.1080/1744666X.2020.1752668
更新日期:2020-05-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2019-10-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章
doi:10.1586/1744666X.3.6.913
更新日期:2007-11-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2010-05-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,meta分析,评审
doi:10.1080/1744666X.2017.1375853
更新日期:2017-11-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1586/1744666X.2016.1147957
更新日期:2016-06-01 00:00:00
abstract::Some chemotherapeutic agents and all radiation therapy generates reactive oxygen species (ROS), which induce apoptosis in cancer cells. As ROS play a role in drug-induced apoptosis, one might suspect that antioxidants may inhibit ROS and prevent apoptosis of cancer cells. In order to find an answer to whether or not t...
journal_title:Expert review of clinical immunology
pub_type: 杂志文章
doi:10.1586/1744666X.2.6.931
更新日期:2006-11-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Expert review of clinical immunology
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更新日期:2019-12-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-07-01 00:00:00
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pub_type: 杂志文章
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2015-02-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章
doi:10.1586/1744666X.1.2.263
更新日期:2005-07-01 00:00:00