Focus on the potential effects of treatments for spondylarthritides on cardiovascular risk.

abstract：:Evaluation of: Chung CP, Avalos I, Oeser A et al. High prevalence of the metabolic syndrome in patients with systemic lupus erythematosus: association with disease characteristic and cardiovascular risk factors. Ann. Rheum. Dis. 66(2), 208-214 (2007). Systemic lupus erythematosus is associated with higher rates of car...

journal_title：Expert review of clinical immunology

authors： Jara LJ,Medina G,Vega-Hinojosa O

更新日期：2007-03-01 00:00:00

abstract：INTRODUCTION:Psoriasis is a common, chronic, immune-mediated inflammatory disorder. The disease is associated with several co-morbidities including cardiovascular disease, metabolic syndrome, and psychiatric disorders. It is important to identify and treat these co-morbidities because they have a strongly negative effe...

journal_title：Expert review of clinical immunology

authors： Lønnberg AS,Skov L

更新日期：2017-01-01 00:00:00

abstract：:The measuring tools for disease activity of rheumatoid arthritis have long been adapted for assessing the disease activity of psoriatic arthritis (PsA), particularly as regards peripheral arthritis. However, because of the multifactorial aspects and multiple domains of PsA, such as axial and peripheral joints, skin an...

journal_title：Expert review of clinical immunology

authors： Her M,Kavanaugh A

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Biological drugs, mainly interleukin (IL)-1 and IL-6 antagonists, but also tumor necrosis factor (TNF) inhibitors, have been used in the treatment of adult onset Still's disease patients (AOSD). METHODS:We summarised the available evidence for the effectiveness of biologic drugs in AOSD. A systematic review...

journal_title：Expert review of clinical immunology

authors： Ruscitti P,Ursini F,Cipriani P,De Sarro G,Giacomelli R

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:Remestemcel-L, a third-party, off-the-shelf preparation of bone-marrow derived mesenchymal stromal cells (MSCs), has been developed for experimental use in acute graft-versus-host disease (aGvHD) and other immune-mediated conditions. Several preclinical and clinical studies have indeed suggested the potent...

journal_title：Expert review of clinical immunology

authors： Locatelli F,Algeri M,Trevisan V,Bertaina A

更新日期：2017-01-01 00:00:00

abstract：:Systemic lupus erythematosus is an autoimmune disorder that can affect every organ system and cause a wide range of signs and symptoms. The precise pathogenic mechanism of disease remains uncertain, but it is clearly complex and involves the activation and deregulation of many components of the immune system. Certain ...

journal_title：Expert review of clinical immunology

authors： Vilas-Boas A,Bakshi J,Isenberg DA

更新日期：2015-01-01 00:00:00

abstract：:Glucocorticoids are indispensable for the treatment of systemic inflammatory diseases such as rheumatoid arthritis (RA), though their beneficial effects have to be balanced with potential complications arising from high doses, prolonged use or dose splitting. A glucocorticoid formulation (modified-release prednisone) ...

journal_title：Expert review of clinical immunology

authors： Alten R

更新日期：2012-02-01 00:00:00

abstract：:Some chemotherapeutic agents and all radiation therapy generates reactive oxygen species (ROS), which induce apoptosis in cancer cells. As ROS play a role in drug-induced apoptosis, one might suspect that antioxidants may inhibit ROS and prevent apoptosis of cancer cells. In order to find an answer to whether or not t...

journal_title：Expert review of clinical immunology

authors： Akbas HS,Timur M,Ozben T

更新日期：2006-11-01 00:00:00

abstract：:Patients with sarcoidosis can be subgrouped according to organ engagement and clinical manifestations. One such subgroup is Löfgren's syndrome (LS), constituting a distinct group of sarcoidosis patients with typical clinical manifestations, separate genetic associations and an immune response that seems to differ from...

journal_title：Expert review of clinical immunology

authors： Grunewald J

更新日期：2012-01-01 00:00:00

abstract：:Introduction: The metabolic syndrome (MetS) is now recognized as a chronic proinflammatory and prothrombotic state that aggravates insulin resistance, oxidative injury, and cardiovascular risk. MetS is more prevalent in patients with systemic lupus erythematosus (SLE), a prototype of systemic autoimmune disease associ...

journal_title：Expert review of clinical immunology

authors： Mok CC

更新日期：2019-07-01 00:00:00

abstract：:Many immune regulators are now identified as having key roles at the embryo-maternal interface. Importantly, a cohort of cytokines, chemokines and growth factors are produced by the endometrial glands and secreted into the uterine cavity where they act both on the blastocyst and on the endometrial surface, changing ad...

journal_title：Expert review of clinical immunology

authors： Hannan NJ,Evans J,Salamonsen LA

更新日期：2011-11-01 00:00:00

abstract：:Naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) expressing forkhead transcript factor box P3 have been established as a key regulator for the control of autoimmunity. A growing body of experiments in animal models has provided compelling evidence that the adoptive transfer of CD4(+)CD25(+) Tregs can cure ...

journal_title：Expert review of clinical immunology

authors： Jiang S,Lechler RI,Lombardi G

更新日期：2006-05-01 00:00:00

abstract：:Immunology, similar to other areas of clinical science, is a data-rich discipline that involves a great deal of interaction between healthcare professionals and their patients. The focus of this editorial is to review the challenges and opportunities for mobile healthcare applications within immunology. It is clear th...

journal_title：Expert review of clinical immunology

authors： Gallagher J,O'Donoghue J,Car J

更新日期：2015-04-01 00:00:00

abstract：:Inflammatory bowel disease includes ulcerative colitis and Crohn's disease, which are both inflammatory disorders of the gastrointestinal tract. Both types of inflammatory bowel disease have a complex etiology, resulting from a genetically determined susceptibility interacting with environmental factors, including the...

journal_title：Expert review of clinical immunology

authors： Ferguson LR

更新日期：2013-08-01 00:00:00

abstract：:Nonsedating antihistamines are a first-line therapy in the management of allergic rhinitis. They relieve the majority of the histamine-mediated symptoms of the condition, including rhinorrhea, sneezing, and pruritus. The nonsedating antihistamine desloratadine is effective in alleviating the symptoms of both seasonal ...

journal_title：Expert review of clinical immunology

authors： Schenkel EJ

更新日期：2006-07-01 00:00:00

abstract：:Introduction: Inflammasomes are large multimeric intracellular complexes that are capable of maturation and secretion of pro-inflammatory cytokines, IL-1β and IL-18, in response to danger signal molecules. As a member of the inflammasome family, the NLRP3 inflammasome has recently been under intense investigation reve...

journal_title：Expert review of clinical immunology

authors： Gouravani M,Khalili N,Razi S,Keshavarz-Fathi M,Khalili N,Rezaei N

更新日期：2020-02-01 00:00:00

abstract：:During pregnancy and after delivery, the maternal thyroid gland faces several metabolic, hemodynamic and immunologic changes. In this article we first summarize the current knowledge on the physiologic adaptation of the healthy thyroid to pregnancy, including variations of thyroid-stimulating hormone and free thyroid ...

journal_title：Expert review of clinical immunology

authors： Gaberšček S,Zaletel K

更新日期：2011-09-01 00:00:00

abstract：:Although training and exercise have several benefits, overdoing it might not necessarily be a good thing. For instance, elite athletes have an increased risk for asthma and allergy. Several mechanisms can be implicated for this risk, which include the interplay between environmental training factors and athlete's pers...

journal_title：Expert review of clinical immunology

authors： Silva D,Moreira A

更新日期：2015-01-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) is an IL-7-related cytokine expressed predominantly by barrier epithelial cells. TSLP is a potent activator of several cell types, including myeloid-derived dendritic cells, monocytes/macrophages and mast cells. Recent studies have revealed an important role for TSLP in the initiati...

journal_title：Expert review of clinical immunology

authors： Miazgowicz MM,Headley MB,Larson RP,Ziegler SF

更新日期：2009-09-01 00:00:00

abstract：INTRODUCTION:Biological agents have transformed psoriasis treatment by selectively targeting immune signaling molecules involved in psoriasis pathogenesis. While biologics offer the most effective treatment of moderate to severe psoriasis, they are not without complications. Some patients treated with biologics have po...

journal_title：Expert review of clinical immunology

authors： Cline A,Hill D,Lewallen R,Feldman SR

更新日期：2016-12-01 00:00:00

abstract：:Psoriatic arthritis (PsA) is a chronic inflammatory joint disease occurring in 6-39% of patients with psoriasis. Standard therapy of PsA includes nonsteroidal anti-inflammatory drugs, intra-articular steroids and disease-modifying antirheumatic drugs. Failure of standard therapy is an indication for anti-TNF-alpha the...

journal_title：Expert review of clinical immunology

authors： Poddubnyy DA,Rudwaleit M

更新日期：2009-11-01 00:00:00

abstract：:In this review, recent changes in both treatments and outcomes of rheumatoid arthritis (RA) in Japan were analyzed by viewing the National Database of Rheumatic Diseases by iR-net, one of the largest clinical databases for RA patients in Japan. Regarding drug therapy, the use of methotrexate has been continuously incr...

journal_title：Expert review of clinical immunology

authors： Saeki Y,Matsui T,Saisho K,Tohma S

更新日期：2012-07-01 00:00:00

abstract：:Antiphospholipid syndrome is an autoimmune disease characterized by venous and/or arterial thrombosis and/or recurrent fetal loss and the presence of antiphospholid antibodies. Among the causes of death of antiphospholipid syndrome there are the myocardial infarction and stroke. Comorbidities could worsen the evolutio...

journal_title：Expert review of clinical immunology

authors： Muniz Caldas CA,Freire de Carvalho J

更新日期：2013-10-01 00:00:00

abstract：:Specific allergen immunotherapy has been practiced for allergic rhinoconjunctivitis for over 100 years and is the only treatment option that is disease modifying. In the USA, immunotherapy is usually administered via subcutaneous injection; this is the only route with a US FDA-approved formulation. There is growing in...

journal_title：Expert review of clinical immunology

authors： Park D,Daher N,Blaiss MS

更新日期：2012-08-01 00:00:00

abstract：INTRODUCTION:Biologic drugs have revolutionized the treatment of moderate to severe psoriasis in recent years because of their high efficacy and low risk of toxicity. However, even within the group of biologic therapies, there are differences related to the different mechanisms of action. Areas covered: We review the m...

journal_title：Expert review of clinical immunology

authors： Carrascosa JM,Del-Alcazar E

更新日期：2018-04-01 00:00:00

abstract：:Background: The etiology of allergic rhinitis includes an increase in cytokine levels, including IL- 4, IL-13, IL-17, and reduction in B7 homologous 1 (B7-H1) or programmed cell death-1 ligand-1 (PD-L1), a new member of the CD28: B7 stimulant molecule family. The aim of this study was to determine the relationship bet...

journal_title：Expert review of clinical immunology

authors： Nasiri Kalmarzi R,Fakhimi R,Manouchehri F,Ataee P,Naleini N,Babaei E,Azadi N,Rabeti K,Kooti W

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Allergic diseases are among the most common diseases in humans. Besides allergen avoidance, allergen-specific immunotherapy is the only causative treatment option. During recent years, many innovations of this therapy have emerged. METHODS:Selective literature research in Medline and PubMed, under the inclu...

journal_title：Expert review of clinical immunology

authors： Klimek L,Pfaar O

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:Methylation pattern of gene modification is essential for the differentiation of T regulatory cells (Tregs) and 5-Aza-2'-deoxycytidine is a common inhibitor of methylation. This study aimed to investigate the potential effects of Treg polarizing conditions and 5-Aza-2'-deoxycytidine treatment in the differen...

journal_title：Expert review of clinical immunology

authors： Fang Y,Yuan XD,Liu HH,Xiang L,Chen LM,Fan YC,Gao S,Wang K

更新日期：2021-01-13 00:00:00

abstract：:Introduction: The present status of amifampridine (AFP) for the treatment of Lambert-Eaton myasthenic syndrome (LEMS) is reviewed. Areas covered: All relevant literature identified through a PubMed search under treatment of LEMS, aminopyridine, and amifampridine are reviewed. An expert opinion on AFP was formulated. E...

journal_title：Expert review of clinical immunology

authors： Oh SJ

更新日期：2019-10-01 00:00:00

abstract：:In the 1990s, elucidation of the primary amino acid sequence of several major allergens using molecular cloning techniques opened the door to T-cell epitope mapping studies. Such analyses underscored the complexity of the allergen-specific T-cell repertoire and the challenges to using allergen-derived peptides to iden...

journal_title：Expert review of clinical immunology

authors： Woodfolk JA

更新日期：2006-03-01 00:00:00