A review of disease activity measures for psoriatic arthritis: what is the best approach?

abstract：:Over the past few years, the therapeutic potential of Treg has been highlighted in the field of autoimmune diseases and after allogeneic transplantation. The first hurdle for the therapeutic use of Treg is their insufficient numbers in non-manipulated individuals, in particular when facing strong immune activation and...

journal_title：Expert review of clinical immunology

authors： Govender L,Pascual M,Golshayan D

更新日期：2014-09-01 00:00:00

abstract：INTRODUCTION:High mobility group protein box 1 (HMGB1) is a protein belonging to the alarmin family. HMGB1 has a relevant role in starting the inflammatory cascade by means of receptors, such as RAGE and TLR. HMGB1 supports transcription of many genes in interactions with many transcription factors, including NF-kB. Th...

journal_title：Expert review of clinical immunology

authors： Ciprandi G,Bellussi LM,Passali GC,Damiani V,Passali D

更新日期：2020-05-01 00:00:00

abstract：:In adulthood, new or recurrent asthma is caused by work in approximately 10% of cases. The term occupational asthma is reserved for those cases arising from respiratory hypersensitivity to a specific workplace agent; in others (work-exacerbated asthma) the mechanism is of nonspecific airway irritation on a background ...

journal_title：Expert review of clinical immunology

authors： Cullinan P

更新日期：2005-05-01 00:00:00

abstract：:In cross-sectional studies, vitamin D deficiency is frequent in spondyloarthritic patients and associated with increased spondyloarthritis (SpA) activity and structural damage. Experimental studies also show that vitamin D interferes with molecular pathways critically involved in SpA, especially regarding entheseal in...

journal_title：Expert review of clinical immunology

authors： Guillot X,Prati C,Wendling D

更新日期：2014-12-01 00:00:00

abstract：:Respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are a major health burden on society and current treatment modalities for these diseases have not significantly changed over the past 40 years. The only major pharmacological advancement for the treatment of these diseases has been ...

journal_title：Expert review of clinical immunology

authors： Venkatasamy R,Spina D

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Biological drugs, mainly interleukin (IL)-1 and IL-6 antagonists, but also tumor necrosis factor (TNF) inhibitors, have been used in the treatment of adult onset Still's disease patients (AOSD). METHODS:We summarised the available evidence for the effectiveness of biologic drugs in AOSD. A systematic review...

journal_title：Expert review of clinical immunology

authors： Ruscitti P,Ursini F,Cipriani P,De Sarro G,Giacomelli R

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:Allergic conditions such as asthma and atopic dermatitis have a high prevalence but represent a heterogeneous group of diseases despite similar clinical presentation and underlying pathophysiology. A better understanding of the phenotypes and endotypes of these diseases has driven rapid development of biol...

journal_title：Expert review of clinical immunology

authors： Manka LA,Wechsler ME

更新日期：2018-04-01 00:00:00

abstract：:Egg allergy is the second most frequent food allergy in children of the Western Countries, with an overall prevalence of 1-3%. Today strict avoidance diet is the only treatment, but its feasibility is difficult to obtain in childhood because of the large amount of egg proteins present in different foods. From 1998, a ...

journal_title：Expert review of clinical immunology

authors： Praticò AD,Mistrello G,La Rosa M,Del Giudice MM,Marseglia G,Salpietro C,Leonardi S

更新日期：2014-05-01 00:00:00

abstract：:Some chemotherapeutic agents and all radiation therapy generates reactive oxygen species (ROS), which induce apoptosis in cancer cells. As ROS play a role in drug-induced apoptosis, one might suspect that antioxidants may inhibit ROS and prevent apoptosis of cancer cells. In order to find an answer to whether or not t...

journal_title：Expert review of clinical immunology

authors： Akbas HS,Timur M,Ozben T

更新日期：2006-11-01 00:00:00

abstract：INTRODUCTION:Common variable immunodeficiency (CVID) comprises a large heterogeneous group of patients with primary antibody deficiency. Areas covered: The affected patients are characterized by increased susceptibility to infections and low levels of serum immunoglobulin. However, enteropathy, granulomatous organ infi...

journal_title：Expert review of clinical immunology

authors： Azizi G,Abolhassani H,Asgardoon MH,Alinia T,Yazdani R,Mohammadi J,Rezaei N,Ochs HD,Aghamohammadi A

更新日期：2017-02-01 00:00:00

abstract：INTRODUCTION:Biological agents have transformed psoriasis treatment by selectively targeting immune signaling molecules involved in psoriasis pathogenesis. While biologics offer the most effective treatment of moderate to severe psoriasis, they are not without complications. Some patients treated with biologics have po...

journal_title：Expert review of clinical immunology

authors： Cline A,Hill D,Lewallen R,Feldman SR

更新日期：2016-12-01 00:00:00

abstract：:Hashimoto's thyroiditis (HT) is the most prevalent thyroid autoimmune disorder, characterized by the presence of specific thyroid autoantibodies (TAb). The development of autoimmunity, including TAb production and clinical presentation of HT, is determined by a complex interplay of genetic susceptibility and several e...

journal_title：Expert review of clinical immunology

authors： Zaletel K

更新日期：2007-03-01 00:00:00

abstract：:Systemic lupus erythematosus is an autoimmune disorder that can affect every organ system and cause a wide range of signs and symptoms. The precise pathogenic mechanism of disease remains uncertain, but it is clearly complex and involves the activation and deregulation of many components of the immune system. Certain ...

journal_title：Expert review of clinical immunology

authors： Vilas-Boas A,Bakshi J,Isenberg DA

更新日期：2015-01-01 00:00:00

abstract：:Although training and exercise have several benefits, overdoing it might not necessarily be a good thing. For instance, elite athletes have an increased risk for asthma and allergy. Several mechanisms can be implicated for this risk, which include the interplay between environmental training factors and athlete's pers...

journal_title：Expert review of clinical immunology

authors： Silva D,Moreira A

更新日期：2015-01-01 00:00:00

abstract：:In recent years, new insights into the immunological pathways in multiple sclerosis (MS) have been detected. This increasing knowledge has led to more distinct treatment options in modifying the disease course of MS. In 2006, natalizumab, an alpha4-integrin monoclonal antibody, introduced a new era of MS treatment. An...

journal_title：Expert review of clinical immunology

authors： Reske D,Haupt WF

更新日期：2008-09-01 00:00:00

abstract：:Introduction: CD4 + T regulatory cells (Tregs) have been described as the most potent immunosuppressive cells in the human body. They have been found to control autoimmunity, and clinical attempts have been made to apply them to treat autoimmune diseases. Some specific pathways utilized by Tregs in the regulation of i...

journal_title：Expert review of clinical immunology

authors： Ryba-Stanisławowska M,Sakowska J,Zieliński M,Ławrynowicz U,Trzonkowski P

更新日期：2019-07-01 00:00:00

abstract：:The 12/15-lipoxygenase (LO) cascade governs the generation of 12-hydroperoxy-eicosatetraenoic acid (HPETE) and 15-HPETE from arachidonic acid. The 5-LO pathway plays a fundamental role in the biosynthesis of leukotrienes, essential inflammatory lipid mediators. Cyclooxygenase (COX)-1 and -2 biosynthetic pathways are r...

journal_title：Expert review of clinical immunology

authors： Zhao L,Grosser T,Fries S,Kadakia L,Wang H,Zhao J,Falotico R

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:X-linked agammaglobulinemia (XLA) is characterized by the absence of immunoglobulin and B cells. Patients suffer from recurrent bacterial infections from early childhood, and require lifelong immunoglobulin replacement therapy. Mutations in BTK (Bruton's Tyrosine Kinase) are associated with this phenotype. S...

journal_title：Expert review of clinical immunology

authors： Carrillo-Tapia E,García-García E,Herrera-González NE,Yamazaki-Nakashimada MA,Staines-Boone AT,Segura-Mendez NH,Scheffler-Mendoza SC,O Farrill-Romanillos P,Gonzalez-Serrano ME,Rodriguez-Alba JC,Santos-Argumedo L,Berron-Ruiz L,Sanc

更新日期：2018-01-01 00:00:00

abstract：:Introduction: The metabolic syndrome (MetS) is now recognized as a chronic proinflammatory and prothrombotic state that aggravates insulin resistance, oxidative injury, and cardiovascular risk. MetS is more prevalent in patients with systemic lupus erythematosus (SLE), a prototype of systemic autoimmune disease associ...

journal_title：Expert review of clinical immunology

authors： Mok CC

更新日期：2019-07-01 00:00:00

abstract：INTRODUCTION:Adalimumab, an inhibitor of tumor necrosis factor-alpha (TNFα), is the only systemic non-corticosteroid agent which has been approved by the US Food and Drug Administration (FDA) for the treatment of non-infectious uveitis. Areas covered: The aim of this review is to summarize the research which demonstrat...

journal_title：Expert review of clinical immunology

authors： LaMattina KC,Goldstein DA

更新日期：2017-03-01 00:00:00

abstract：:The Fifth International Congress on Familial Mediterranean Fever and Systemic Autoinflammatory Diseases (Rome, Italy, 4-8 April, 2008) reviewed developments in the field of innate immunity and discussed their relevance to the pathogenesis of associated diseases. The meeting gathered over 300 participants from 32 count...

journal_title：Expert review of clinical immunology

authors： Touitou I,Savic S,Mathews RJ,Grateau G,McDermott MF

更新日期：2008-07-01 00:00:00

abstract：:Methotrexate (MTX) is the key treatment in juvenile idiopathic arthritis (JIA). Nevertheless, MTX is not always sufficiently efficacious and can lead to adverse effects, which compromises complete disease control. In such cases, combination therapies with biologicals are given, even at MTX start, before knowing the pa...

journal_title：Expert review of clinical immunology

authors： Ćalasan MB,Wulffraat NM

更新日期：2014-07-01 00:00:00

abstract：:The term refractory lupus nephritis is generally used to indicate cases that do not respond to traditional treatment. However, the clinical presentation of lupus nephritis is variable and the time to response depends on the typology of the underlying renal syndrome. The criteria and the time for response are different...

journal_title：Expert review of clinical immunology

authors： Moroni G,Ponticelli C

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:Chronic rhinosinusitis (CRS) is a common upper airway disease with a prevalence of greater than 10% of the general population. Although the pathogenesis of CRS remains poorly understood, there is growing evidence indicating that epithelial physical barrier defects play an important role in CRS pathogenesis...

journal_title：Expert review of clinical immunology

authors： Jiao J,Wang C,Zhang L

更新日期：2019-06-01 00:00:00

abstract：:Specific allergen immunotherapy has been practiced for allergic rhinoconjunctivitis for over 100 years and is the only treatment option that is disease modifying. In the USA, immunotherapy is usually administered via subcutaneous injection; this is the only route with a US FDA-approved formulation. There is growing in...

journal_title：Expert review of clinical immunology

authors： Park D,Daher N,Blaiss MS

更新日期：2012-08-01 00:00:00

abstract：:During pregnancy and after delivery, the maternal thyroid gland faces several metabolic, hemodynamic and immunologic changes. In this article we first summarize the current knowledge on the physiologic adaptation of the healthy thyroid to pregnancy, including variations of thyroid-stimulating hormone and free thyroid ...

journal_title：Expert review of clinical immunology

authors： Gaberšček S,Zaletel K

更新日期：2011-09-01 00:00:00

abstract：:Background: The etiology of allergic rhinitis includes an increase in cytokine levels, including IL- 4, IL-13, IL-17, and reduction in B7 homologous 1 (B7-H1) or programmed cell death-1 ligand-1 (PD-L1), a new member of the CD28: B7 stimulant molecule family. The aim of this study was to determine the relationship bet...

journal_title：Expert review of clinical immunology

authors： Nasiri Kalmarzi R,Fakhimi R,Manouchehri F,Ataee P,Naleini N,Babaei E,Azadi N,Rabeti K,Kooti W

更新日期：2019-08-01 00:00:00

abstract：:Since its introduction to the antirejection armamentarium in 1994, tacrolimus has become the workhorse of transplant professionals for avoidance of solid organ transplant rejection. Not only does tacrolimus have potent immunosuppressive qualities that prevent rejection, but dosing is straight forward and it is general...

journal_title：Expert review of clinical immunology

authors： Scalea JR,Levi ST,Ally W,Brayman KL

更新日期：2016-01-01 00:00:00

abstract：:Dendritic cell (DC) immunotherapy is a clinical reality. Despite two decades of considerable data demonstrating the feasibility of using DCs to prolong transplant allograft survival and to prevent autoimmunity, only now are these cells entering clinical trials in humans. Type 1 diabetes is the first autoimmune disorde...

journal_title：Expert review of clinical immunology

authors： Phillips B,Giannoukakis N,Trucco M

更新日期：2009-05-01 00:00:00

abstract：:The past decade has been an exciting period for clinical research and patient care in rheumatoid arthritis. This is mostly due to targeted biologic agents that have changed the outcome of this disease. Certolizumab pegol (Cimzia(®), UCB Inc., GA, USA), which targets TNF-α with a different mechanism of action than wide...

journal_title：Expert review of clinical immunology

authors： Patel AM,Moreland LW

更新日期：2010-11-01 00:00:00