Abstract:
:Hashimoto's thyroiditis (HT) is the most prevalent thyroid autoimmune disorder, characterized by the presence of specific thyroid autoantibodies (TAb). The development of autoimmunity, including TAb production and clinical presentation of HT, is determined by a complex interplay of genetic susceptibility and several endogenous and environmental factors, which are discussed in this article. During the progression of the disease, TAb production precedes clinical manifestations, although the correlation between TAb concentrations and thyroid function is weak. We do not treat euthyroid HT patients despite elevated TAb; while in hypothyroidism, replacement therapy with l-thyroxine is required. Until now, an effective approach to prevent TAb production and the development of clinical disease has not yet been established. However, further identification of risk factors and their interaction may help in the prevention of thyroid autoimmunity.
journal_name
Expert Rev Clin Immunoljournal_title
Expert review of clinical immunologyauthors
Zaletel Kdoi
10.1586/1744666X.3.2.217subject
Has Abstractpub_date
2007-03-01 00:00:00pages
217-23issue
2eissn
1744-666Xissn
1744-8409journal_volume
3pub_type
杂志文章abstract::Although a large part of the population suffers from allergies, a cure is not yet available. Allergen-specific immunotherapy (AIT) offers promise for these patients. AIT has proven successful in insect and venom allergies; however, for food allergy this is still unclear. In this editorial we focus on the recent advanc...
journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2010-11-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章
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更新日期:2020-07-01 00:00:00
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journal_title:Expert review of clinical immunology
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pub_type: 评论,杂志文章
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更新日期:2007-05-01 00:00:00
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章
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更新日期:2006-11-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章
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