Abstract:
PURPOSE OF REVIEW:Agents used for systemic chemotherapy can alter normal bone homeostasis through mechanisms that affect both osteoblast and osteoclast function. The identification of those agents that influence maintenance of the bone-remodeling compartment is an important component of the drug development and testing process. This brief review focuses on preclinical and clinical data illustrating the effect of several classes of chemotherapeutic agents on skeletal development and bone remodeling. RECENT FINDINGS:New preclinical data demonstrate that several classes of chemotherapeutic agents, including histone deacetylase inhibitors and proteasome inhibitors, alter osteoblast and osteoclast function. Preclinical data on retinoic acid analogues demonstrate that these agents inhibit osteoclastogenesis. In addition, a dose-dependent effect of methotrexate treatment on growth plate thickness and primary spongiosa height in rats has been demonstrated. Two recently published analyses of clinical data from trials of bortezomib in myeloma patients found increased biochemical markers of bone formation and evidence of increased bone deposition after bortezomib treatment. SUMMARY:Several classes of chemotherapeutic agents alter bone metabolism and negatively impact bone homeostasis. Bone mineral density (BMD) monitoring guidelines for patients receiving systemic chemotherapy are not established. Limited guidelines exist for BMD monitoring in patients receiving long-term hormonal modulation; however, the negative effect of other chemotherapeutic agents on the skeleton is underappreciated.
journal_name
Curr Opin Support Palliat Carejournal_title
Current opinion in supportive and palliative careauthors
Silbermann R,Roodman GDdoi
10.1097/SPC.0b013e328349c524subject
Has Abstractpub_date
2011-09-01 00:00:00pages
251-7issue
3eissn
1751-4258issn
1751-4266journal_volume
5pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:The serotonergic system has long been linked to migraine but recent studies highlight how much is still unclear about this link. And recent data add to the uncertainty of where/how triptans act and why they are headache specific. RECENT FINDINGS:Markers of 5HT levels in the brains of migraine patient...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000044
更新日期:2014-06-01 00:00:00
abstract:PURPOSE OF REVIEW:RANK ligand (RANKL) plays a central role in the cancer-induced bone destruction that results from bone metastasis. The RANKL inhibitor denosumab was recently approved for the prevention of skeletal-related events (SREs) in patients with bone metastases from solid tumors. This review summarizes recent ...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e328349731c
更新日期:2011-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Sequential anthracycline/taxane regimens are routinely used as neoadjuvant therapy (NAT) for locally advanced breast cancer. Unfortunately, the majority of patients do not achieve a pathological complete response (pCR). Efforts to improve pCR rates include the addition of novel targeted agents. The pu...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000022
更新日期:2014-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This review summarizes recent developments in the palliative management of gastrointestinal symptoms experienced by advanced cancer patients and provides a framework for detailing that encompasses education, assessment and monitoring, and treatment. RECENT FINDINGS:Although many viable treatment opti...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32832531ce
更新日期:2009-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Effective communication in cancer care requires complex communication skills of healthcare professionals (HCPs), which can be advanced by communication skills training (CST). The number of empirical studies on CST has grown steadily over the last decade. However, controversies on CST abound. The aim o...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章
doi:10.1097/SPC.0000000000000409
更新日期:2019-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To discuss three emerging areas of research triggering new hypotheses for mechanisms of dyspnea. RECENT FINDINGS:There has been an emphasis on the importance of lung volumes in evaluating symptoms and lung function in patients with chronic obstructive pulmonary disease. Dyspnea intensity seems to mor...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e3282ef5e74
更新日期:2007-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The palliative care needs of people with interstitial lung disease (ILD) have recently been highlighted by the National Institute for Health and Care Excellence. All people with progressive ILD should receive best supportive care to improve symptom control and quality of life and where possible this s...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000285
更新日期:2017-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The widespread use of prostate-specific antigen (PSA) resulted in stage migration of prostate cancer where androgen deprivation therapy (ADT) is administered for biochemical recurrence in patients following primary treatment. A proportion of these patients progress to a disease state termed nonmetasta...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000356
更新日期:2018-09-01 00:00:00
abstract:PURPOSE OF REVIEW:This review examines recent literature on the psychosocial needs of and interventions for young women. We focus on the active treatment period given the toxicity of treatment, the incidence of anxiety, and depressive symptoms in these women during treatment. This review summarizes research relevant to...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000161
更新日期:2015-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The review is based on a Medline literature search using key words relating to male urogenital/pelvic pain for the years 2009-2011. RECENT FINDINGS:The review covers those studies relating to cause, ongoing mechanisms and treatments. SUMMARY:The review highlights that the patients are often polysymp...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e3283523f19
更新日期:2012-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Care near the end of life is expensive and frequently not aligned with the expressed preferences of decedents, creating an opportunity to improve value, or increase quality while lowering cost. This review examines publications from 2017 and 2018 on interventions and policies associated with high-valu...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000392
更新日期:2018-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Dyspnea is the most common symptom in interstitial lung disease, yet little is known about its management. This review summarizes the available evidence for the treatment of dyspnea in interstitial lung disease. RECENT FINDINGS:The management of dyspnea in interstitial lung disease remains a challeng...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e3283392b51
更新日期:2010-06-01 00:00:00
abstract:PURPOSE OF REVIEW:In the past 20 years, several papers have been published concerning healthcare transition from pediatric after-care to long-term follow-up in adult health service for childhood cancer survivors. Initially, the papers were optimistic and included guidelines and models of care. However, after this optim...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32836484bb
更新日期:2013-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize current knowledge about gastrointestinal radiation toxicity, with emphasis on mechanisms and clinical diagnosis and management. RECENT FINDINGS:While there has been only modest change in cancer incidence and cancer mortality rates during the past 30 years, the number of cancer survivors ...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e3281108014
更新日期:2007-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Experienced breathlessness and recalled breathlessness are two different entities, which may be associated with different factors and might have different impacts on function for the individual. The aim was to review the knowledge from the last 2 years concerning experienced breathlessness and recalle...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000448
更新日期:2019-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent advances in the diagnosis and treatment of many types of cancers have prolonged and improved the quality of life for cancer patients. With increased survival, metastatic spinal lesions are becoming much more of a functional and clinical problem. RECENT FINDINGS:Percutaneous vertebral augmentat...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32830c9060
更新日期:2008-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The oligometastases is considered an intermediate state of the disease between localized and wide spread metastases. Local ablative therapy to oligometastatic prostate cancer is gaining significant traction and stereotactic body radiotherapy (SBRT) is an emerging treatment modality for this patient po...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000371
更新日期:2018-09-01 00:00:00
abstract:PURPOSE OF THE REVIEW:The purpose of review is to critically present the evidence supporting the use of olanzapine, an atypical antipsychotic, as an antiemetic for cancer and chemotherapy-induced nausea and vomiting (CINV). RECENT FINDINGS:Two phase III clinical studies demonstrated superior efficacy of olanzapine in ...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000206
更新日期:2016-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Palliative sedation has been the subject of intensive debate since its first appearance in 1990. In a 2010 review of palliative sedation, the following areas were identified as lacking in consensus: inconsistent terminology, its use in nonphysical suffering, the ongoing experience of distress, and con...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000224
更新日期:2016-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Chemotherapy is a first-line treatment for many cancers; however, its use is hampered by a long list of side-effects. Gastrointestinal mucositis is a common and debilitating side-effect of anticancer therapy contributing to dose reductions, delays and cessation of treatment, greatly impacting clinical...
journal_title:Current opinion in supportive and palliative care
pub_type: 社论
doi:10.1097/SPC.0000000000000515
更新日期:2020-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Bone metastases in prostate cancer are often the cause of significant morbidity in patients with castrate-resistant disease, and several studies have shown significant pain palliation with systemic radionuclide treatment. The purpose of this review is to discuss the place of radionuclides in the dynam...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e328355e082
更新日期:2012-09-01 00:00:00
abstract:PURPOSE OF REVIEW:As the number of female cancer survivors continues to grow, there is a growing need to bridge the gap between the high rate of women's cancer-related sexual dysfunction and the lack of attention and intervention available to the majority of survivors who suffer from sexual problems. Previously identif...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000186
更新日期:2016-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To discuss the psychosocial support of people affected by cancer anorexia, drawing on recent publications. RECENT FINDINGS:Recent studies describe the problem of distress in response to cancer anorexia. There are propositions of appropriate support and calls for the development of psychosocial interv...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32833ef813
更新日期:2010-12-01 00:00:00
abstract:PURPOSE OF REVIEW:This review describes the role of lung volume reduction surgery (LVRS) for the management of refractory dyspnea and other debilitating conditions in patients with chronic obstructive pulmonary disease. Recent studies, including a randomized trial comparing LVRS to medical therapy, are analyzed. RECEN...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32832ad5e1
更新日期:2009-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Radiation therapy-induced nausea and vomiting (RINV) are common and troublesome symptoms among patients receiving radiation therapy for gastrointestinal cancers. Their impact on function, quality of life and, ultimately, cancer control warrant a review of their incidence, underlying mechanisms, treatm...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000130
更新日期:2015-06-01 00:00:00
abstract:PURPOSE OF REVIEW:To review recent research on cancer-related cognitive impairment (CRCI) in children, including correlational studies and interventions in which outcomes have included cognitive test performance, neuroimaging or academic performance. RECENT FINDINGS:Impairments in processing speed, working memory, exe...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000258
更新日期:2017-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To emphasize that the management of wounds represents a significant component within the overall supportive and palliative care of patients with advanced illness. It is also intended to clarify the linguistics that are commonly used around patients with wounds. RECENT FINDINGS:New paradigms for wound...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32835c48e5
更新日期:2013-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To examine the symptom burden in cancer patients during the last days of life, its impact on nutrition and hydration, and the role of artificial nutrition and hydration in the final days. RECENT FINDINGS:During the last days of life, cancer patients often experience progressive functional decline and...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000171
更新日期:2015-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Osteoarthritis is a complex and often painful disease that is inadequately controlled with current analgesics. This review discusses emerging targets and therapeutic approaches that may lead to the development of better analgesics. RECENT FINDINGS:Aberrant excitability in peripheral and central pain ...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000125
更新日期:2015-06-01 00:00:00
abstract:PURPOSE OF REVIEW:There are increasing numbers of adults with congenital heart disease (CHD) and these patients remain at long-term risk of complications and premature death. This review focuses on the changing picture of adult CHD with more complex patients surviving, the challenges of balancing life-prolonging interv...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32835c0707
更新日期:2013-03-01 00:00:00