Denosumab: benefits of RANK ligand inhibition in cancer patients.

abstract：PURPOSE OF REVIEW:Determining which palliative interventions are appropriate within and between groups remains difficult because of the lack of prospective studies and heterogeneity in dyspnoea context, assessment and reporting. This review presents an evolution of dyspnoea theories, summarizes literature published dur...

journal_title：Current opinion in supportive and palliative care

authors： Williams M

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Osteoarthritis is a complex and often painful disease that is inadequately controlled with current analgesics. This review discusses emerging targets and therapeutic approaches that may lead to the development of better analgesics. RECENT FINDINGS:Aberrant excitability in peripheral and central pain ...

journal_title：Current opinion in supportive and palliative care

authors： Rahman W,Dickenson AH

更新日期：2015-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Patients' autonomy is seen as a major issue in modern medicine but requires the ability to understand and rate an issue without being influenced by others. However, near the end of life, patients often decide considering the consequences for their relatives. RECENT FINDINGS:Our study results and rece...

journal_title：Current opinion in supportive and palliative care

authors： Marx G,Owusu Boakye S,Jung A,Nauck F

更新日期：2014-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Patients with heart failure seem particularly suited to palliative care having needs that fall within the prototypical palliative care domains. Despite this there is still much debate as to who should respond to these needs and when. RECENT FINDINGS:Since the early 1990s many studies have been publis...

journal_title：Current opinion in supportive and palliative care

authors： O'Leary N

更新日期：2009-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The widespread use of prostate-specific antigen (PSA) resulted in stage migration of prostate cancer where androgen deprivation therapy (ADT) is administered for biochemical recurrence in patients following primary treatment. A proportion of these patients progress to a disease state termed nonmetasta...

journal_title：Current opinion in supportive and palliative care

authors： Traboulsi SL,Saad F

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:There are increasing numbers of adults with congenital heart disease (CHD) and these patients remain at long-term risk of complications and premature death. This review focuses on the changing picture of adult CHD with more complex patients surviving, the challenges of balancing life-prolonging interv...

journal_title：Current opinion in supportive and palliative care

authors： Bowater SE,Speakman JK,Thorne SA

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Young women (<45 years of age) diagnosed with breast cancer face increased risk of sexual dysfunction as a result of their cancer-directed treatment. We will review the recent literature examining this critical challenge and discuss current efforts to address sexual dysfunction. RECENT FINDINGS:In th...

journal_title：Current opinion in supportive and palliative care

authors： Zhou ES,Falk SJ,Bober SL

更新日期：2015-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The oligometastases is considered an intermediate state of the disease between localized and wide spread metastases. Local ablative therapy to oligometastatic prostate cancer is gaining significant traction and stereotactic body radiotherapy (SBRT) is an emerging treatment modality for this patient po...

journal_title：Current opinion in supportive and palliative care

authors： Niazi T,Elakshar S,Stroian G

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Many health professionals still believe that opioids shorten the lifespan of patients. This situation implies that the ethical doctrine of double effect is often invoked to justify their use in extreme circumstances. The objective of this study is to revise the evidence existing in the recently publis...

journal_title：Current opinion in supportive and palliative care

authors： López-Saca JM,Guzmán JL,Centeno C

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The balance between the rates of protein synthesis and protein degradation governs the maintenance of muscle mass in the body. The main purpose of this review is to highlight the latest understanding of the various pathways that maintain this balance between muscle atrophy and hypertrophy. RECENT FIN...

journal_title：Current opinion in supportive and palliative care

authors： Banerjee A,Guttridge DC

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Good communication is the cornerstone of interprofessional care teams providing optimized quality patient care. Over the last decade, advances in technology have provided tools to improve communication; however, opportunities still exist for innovation and implementation. RECENT FINDINGS:The literatu...

journal_title：Current opinion in supportive and palliative care

authors： D'Alimonte L,McLaney E,Di Prospero L

更新日期：2019-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize current knowledge on promising immunotherapeutic agents and to provide a brief outline of current use of immunotherapeutic agents in patients with locally advanced or metastatic renal cell carcinoma (RCC). RECENT FINDINGS:Immunotherapy with mAbs directed against programed death cell prot...

journal_title：Current opinion in supportive and palliative care

authors： Nazzani S,Bazinet A,Karakiewicz PI

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine the symptom burden in cancer patients during the last days of life, its impact on nutrition and hydration, and the role of artificial nutrition and hydration in the final days. RECENT FINDINGS:During the last days of life, cancer patients often experience progressive functional decline and...

journal_title：Current opinion in supportive and palliative care

authors： Hui D,Dev R,Bruera E

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite a limited understanding of the exact mechanism, corticosteroids are commonly employed for pain control in patients with bone metastases. The aim of this review was to evaluate the efficacy of corticosteroid-mediated pain control in patients with bone metastases associated with solid cancers. ...

journal_title：Current opinion in supportive and palliative care

authors： Lim FMY,Bobrowski A,Agarwal A,Silva MF

更新日期：2017-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on chemotherapy in the management of patients with advanced urothelial cancer, with a look towards the future and the next generation of clinical trials. RECENT FINDINGS:The recognition that the maximum benefit from conventional combination chemotherapy has been achieved has led t...

journal_title：Current opinion in supportive and palliative care

authors： Calabrò F,Sternberg CN

更新日期：2007-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The treatment of patients with metastatic urothelial carcinoma is evolving with recent advances holding promise for improved outcomes. Historically, patients with metastatic urothelial carcinoma had a poor prognosis with no standard treatment options in the second-line setting. Currently, with an incr...

journal_title：Current opinion in supportive and palliative care

authors： Alimohamed NS,Sridhar SS

更新日期：2015-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To emphasize that the management of wounds represents a significant component within the overall supportive and palliative care of patients with advanced illness. It is also intended to clarify the linguistics that are commonly used around patients with wounds. RECENT FINDINGS:New paradigms for wound...

journal_title：Current opinion in supportive and palliative care

authors： Maida V

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews the most recent studies that examine the efficacy of psychostimulants for the relief of symptoms such as asthenia and depression in cancer patients. RECENT FINDINGS:Although most research to date has focused on the use of methylphenidate for the relief of symptoms such as astheni...

journal_title：Current opinion in supportive and palliative care

authors： Portela MA,Rubiales AS,Centeno C

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To understand the mechanisms of muscle wasting and how inhibiting myostatin signaling affects them. RECENT FINDINGS:Myostatin signaling is critical for the understanding of the pathogenesis of muscle wasting as blocking signaling mitigates muscle losses in rodent models of catabolic diseases includin...

journal_title：Current opinion in supportive and palliative care

authors： Han HQ,Mitch WE

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Effective communication in cancer care requires complex communication skills of healthcare professionals (HCPs), which can be advanced by communication skills training (CST). The number of empirical studies on CST has grown steadily over the last decade. However, controversies on CST abound. The aim o...

journal_title：Current opinion in supportive and palliative care

authors： Bos-van den Hoek DW,Visser LNC,Brown RF,Smets EMA,Henselmans I

更新日期：2019-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Death is the inevitable consequence of life. Although clinicians are unlikely to accurately pinpoint when death is likely to occur in the people they care for, the death in a person with a diagnosis of malignant and nonmalignant tends to involve a period of predictable progressive clinical and functio...

journal_title：Current opinion in supportive and palliative care

authors： Watts T,Willis D,Noble S,Johnston B

更新日期：2019-12-01 00:00:00

abstract：PURPOSE OF REVIEW:As the number of female cancer survivors continues to grow, there is a growing need to bridge the gap between the high rate of women's cancer-related sexual dysfunction and the lack of attention and intervention available to the majority of survivors who suffer from sexual problems. Previously identif...

journal_title：Current opinion in supportive and palliative care

authors： Bober SL,Reese JB,Barbera L,Bradford A,Carpenter KM,Goldfarb S,Carter J

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The palliative care needs of people with interstitial lung disease (ILD) have recently been highlighted by the National Institute for Health and Care Excellence. All people with progressive ILD should receive best supportive care to improve symptom control and quality of life and where possible this s...

journal_title：Current opinion in supportive and palliative care

authors： Bajwah S,Yorke J

更新日期：2017-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review describes the advances in trial methodology and presents new methodologies to meet some of the challenges of conducting trials in a palliative care setting. To describe why this review is timely and relevant. RECENT FINDINGS:This review discusses the process required to conduct trials of ...

journal_title：Current opinion in supportive and palliative care

authors： Davis MP,Mitchell GK

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Developments in the management of pulmonary arterial hypertension have significantly improved prognosis changing this from an acute to a chronic disease. Despite optimal treatment many patients still have a high-symptom burden both because of the disease and the side-effects of therapy, consequently t...

journal_title：Current opinion in supportive and palliative care

authors： Gin-Sing W

更新日期：2017-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Cancer cachexia remains understudied and there are no standard treatments available despite the publication of an international consensus definition and the completion of several large phase III intervention trials in the past 6 years. In September 2015, The University of Rochester Cancer Center NCORP...

journal_title：Current opinion in supportive and palliative care

authors： Dunne RF,Mustian KM,Garcia JM,Dale W,Hayward R,Roussel B,Buschmann MM,Caan BJ,Cole CL,Fleming FJ,Chakkalakal JV,Linehan DC,Hezel AF,Mohile SG

更新日期：2017-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Cross-sectional (C-S) imaging is now commonly used to measure body composition in clinical studies. This review highlights the advantages, limitations and suggested future directions for this technique. RECENT FINDINGS:Current understanding of C-S imaging reproducibility, tissue identification and se...

journal_title：Current opinion in supportive and palliative care

authors： MacDonald AJ,Greig CA,Baracos V

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:In the last 10 years, metastatic castration-resistant prostate cancer (mCRPC) treatment has completely changed. Several new agents have been shown to increase mCRPC patients' overall survival. The importance to define castration-resistant prostate cancer as metastatic and to enable earlier detection o...

journal_title：Current opinion in supportive and palliative care

authors： Beauregard JM,Pouliot F

更新日期：2014-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Palliative sedation has been the subject of intensive debate since its first appearance in 1990. In a 2010 review of palliative sedation, the following areas were identified as lacking in consensus: inconsistent terminology, its use in nonphysical suffering, the ongoing experience of distress, and con...

journal_title：Current opinion in supportive and palliative care

authors： Henry B

更新日期：2016-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes recent developments in the management of gastrointestinal symptoms experienced by cancer patients and provides a framework for education, assessment and monitoring, and treatment. RECENT FINDINGS:Although many viable treatment options exist, gastrointestinal symptoms - particul...

journal_title：Current opinion in supportive and palliative care

authors： Rangwala F,Zafar SY,Abernethy AP

更新日期：2012-03-01 00:00:00