Abstract:
PURPOSE OF REVIEW:Sequential anthracycline/taxane regimens are routinely used as neoadjuvant therapy (NAT) for locally advanced breast cancer. Unfortunately, the majority of patients do not achieve a pathological complete response (pCR). Efforts to improve pCR rates include the addition of novel targeted agents. The purpose of this article is to review recent developments in this area and to demonstrate the clinical and research advantages of a neoadjuvant platform for the evaluation of novel targeted therapy. RECENT FINDINGS:Dual human epidermal growth factor 2 (HER2)-targeting concurrent with chemotherapy has demonstrated superiority over chemotherapy with trastuzumab alone. Bevacizumab appears to have a modest effect on pCR rates and its role in neoadjuvant treatment remains uncertain. Despite promising preclinical signals, mTOR inhibition in combination with chemotherapy has yet to yield a benefit in the neoadjuvant setting and trials are ongoing. In contrast, mTOR inhibition in combination with endocrine therapy has demonstrated potential as NAT. SUMMARY:Dual HER2-targeting considerably improves pCR rates. Thus, far incorporation of non-HER2 targeted agents has been less successful. NAT provides an opportunity to evaluate novel agents, and thereby assist the development of a rationale adjuvant strategy, and facilitates the collection of samples for correlative research into breast cancer biology and predictive biomarkers/pathways.
journal_name
Curr Opin Support Palliat Carejournal_title
Current opinion in supportive and palliative careauthors
Wilson S,Chia Sdoi
10.1097/SPC.0000000000000022subject
Has Abstractpub_date
2014-03-01 00:00:00pages
64-9issue
1eissn
1751-4258issn
1751-4266journal_volume
8pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Good communication is the cornerstone of interprofessional care teams providing optimized quality patient care. Over the last decade, advances in technology have provided tools to improve communication; however, opportunities still exist for innovation and implementation. RECENT FINDINGS:The literatu...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000412
更新日期:2019-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Death is the inevitable consequence of life. Although clinicians are unlikely to accurately pinpoint when death is likely to occur in the people they care for, the death in a person with a diagnosis of malignant and nonmalignant tends to involve a period of predictable progressive clinical and functio...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000463
更新日期:2019-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Determining which palliative interventions are appropriate within and between groups remains difficult because of the lack of prospective studies and heterogeneity in dyspnoea context, assessment and reporting. This review presents an evolution of dyspnoea theories, summarizes literature published dur...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e328345d4a1
更新日期:2011-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Despite recognition that opioids alleviate dyspnea in chronic obstructive pulmonary disease, many clinicians remain reluctant to use them outside of the final days of life. This article defines the term 'opioid responsiveness' as it pertains to dyspnea, and poses that it may be possible to predict mor...
journal_title:Current opinion in supportive and palliative care
pub_type: 社论,评审
doi:10.1097/spc.0b013e3283392788
更新日期:2010-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Mixed methods research designs have been recognized as important in addressing complexity and are recommended particularly in the development and evaluation of complex interventions. This article reports a review of studies in palliative care published between 2010 and March 2012 that combine qualitat...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e328358214e
更新日期:2012-12-01 00:00:00
abstract:PURPOSE OF REVIEW:This mixed-method, rapid review of published research from 2014 to 2019 aims to explore the experiences of pre and postbereaved carers, and the information that they receive in the acute hospital setting. The quality of articles was evaluated using a standardized quality matrix. The techniques of conc...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000462
更新日期:2019-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Gastrointestinal toxicity during chemotherapy is frequent. Symptomatic therapies for gastrointestinal toxicity, which do not address the underlying cause, may result in inadequate symptom control. With advances in curative treatment regimens, it becomes more important to minimize treatment toxicity wh...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32833575cc
更新日期:2010-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Osteoarthritis is a complex and often painful disease that is inadequately controlled with current analgesics. This review discusses emerging targets and therapeutic approaches that may lead to the development of better analgesics. RECENT FINDINGS:Aberrant excitability in peripheral and central pain ...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000125
更新日期:2015-06-01 00:00:00
abstract:PURPOSE OF REVIEW:This review examines recent literature on the psychosocial needs of and interventions for young women. We focus on the active treatment period given the toxicity of treatment, the incidence of anxiety, and depressive symptoms in these women during treatment. This review summarizes research relevant to...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000161
更新日期:2015-09-01 00:00:00
abstract:PURPOSE OF REVIEW:As the number of female cancer survivors continues to grow, there is a growing need to bridge the gap between the high rate of women's cancer-related sexual dysfunction and the lack of attention and intervention available to the majority of survivors who suffer from sexual problems. Previously identif...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000186
更新日期:2016-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Opioids are potent drugs for the treatment of severe pain, but they are burdened by detrimental side-effects, such as respiratory depression, addiction, sedation and constipation. Their clinical application is undisputed in acute (e.g. perioperative) and cancer pain, but their use in chronic nonmalign...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章
doi:10.1097/SPC.0000000000000495
更新日期:2020-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Pelvic pain is a common complaint of women that is frequently poorly managed. This review considers the current understanding of the mechanisms of pain perception and the development of chronic pain in the context of three gynaecological pain conditions. Recent advances in the management of these cond...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e3283460b05
更新日期:2011-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this paper is to consolidate the literature around pain assessment and management in older adults with dementia and to make recommendations for future research and practice developments. This review is provided following the introduction of guidelines for the assessment of pain that wer...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e3282ffb406
更新日期:2008-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Overall survival of patients with pancreatic cancer is strongly conditioned by tumor biology and the incidence of malnutrition and metabolic disorders. In this landscape, the assessment of body composition is crucial to properly manage the clinical implications of muscle wasting. The pathogenesis of t...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000455
更新日期:2019-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The treatment of patients with metastatic urothelial carcinoma is evolving with recent advances holding promise for improved outcomes. Historically, patients with metastatic urothelial carcinoma had a poor prognosis with no standard treatment options in the second-line setting. Currently, with an incr...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000158
更新日期:2015-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To emphasize that the management of wounds represents a significant component within the overall supportive and palliative care of patients with advanced illness. It is also intended to clarify the linguistics that are commonly used around patients with wounds. RECENT FINDINGS:New paradigms for wound...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32835c48e5
更新日期:2013-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Chronic breathlessness is a troublesome symptom experienced by people with advanced malignant and nonmalignant disease. Disease-directed therapies are often insufficient in the management of chronic breathlessness. Therefore, pharmacological and nonpharmacological breathlessness-specific interventions...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000449
更新日期:2019-09-01 00:00:00
abstract:PURPOSE OF REVIEW:An overview on breakthrough cancer pain (BTCP), including inherent limitations of the terminology, assessment, clinical presentation, and treatment options. RECENT FINDINGS:The estimated prevalence of BTCP is dependent on the defined cutoffs for controlled background pain and the magnitude of the pai...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章
doi:10.1097/SPC.0000000000000494
更新日期:2020-06-01 00:00:00
abstract:PURPOSE OF REVIEW:To understand the mechanisms of muscle wasting and how inhibiting myostatin signaling affects them. RECENT FINDINGS:Myostatin signaling is critical for the understanding of the pathogenesis of muscle wasting as blocking signaling mitigates muscle losses in rodent models of catabolic diseases includin...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32834bddf9
更新日期:2011-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Many health professionals still believe that opioids shorten the lifespan of patients. This situation implies that the ethical doctrine of double effect is often invoked to justify their use in extreme circumstances. The objective of this study is to revise the evidence existing in the recently publis...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e328365763a
更新日期:2013-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Across all jurisdictions in which assisted dying is legally permissible, cancer is the primary reported underlying diagnosis. Therefore, oncologists are likely to be asked about assisted dying and should be equipped to respond to inquiries or requests for assisted dying. Because Medical Assistance in ...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000411
更新日期:2019-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to synthesize recent literature regarding the provision of palliative care to patients during and following allogeneic hematopoietic stem cell transplantation (HSCT), highlighting factors which mediate impairments in health-related quality of life in this patient populati...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000327
更新日期:2018-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The palliative care needs of people with interstitial lung disease (ILD) have recently been highlighted by the National Institute for Health and Care Excellence. All people with progressive ILD should receive best supportive care to improve symptom control and quality of life and where possible this s...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000285
更新日期:2017-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Experienced breathlessness and recalled breathlessness are two different entities, which may be associated with different factors and might have different impacts on function for the individual. The aim was to review the knowledge from the last 2 years concerning experienced breathlessness and recalle...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000448
更新日期:2019-09-01 00:00:00
abstract:PURPOSE OF REVIEW:International bodies acknowledge that palliative care principles and access to palliative care services should be offered to persons living with and dying from advanced illness such as heart failure. Without an appropriately trained workforce, however, appropriate goals of care and associated reductio...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000113
更新日期:2015-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews the status of guidelines and recommendations for communication between patients with cancer and healthcare providers (HCPs) concerning fertility issues. RECENT FINDINGS:The timing, the type of information provided, and the openness of HCPs can all affect how patients with cancer ...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000413
更新日期:2019-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The review is based on a Medline literature search using key words relating to male urogenital/pelvic pain for the years 2009-2011. RECENT FINDINGS:The review covers those studies relating to cause, ongoing mechanisms and treatments. SUMMARY:The review highlights that the patients are often polysymp...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e3283523f19
更新日期:2012-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Breathlessness is a high-volume problem with 10% of adults experiencing the symptom daily placing a heavy burden on the health and wider economy. As it worsens, they enter the specialist and hospital-based symptom services where costs quickly escalate and people may find themselves in a place not of t...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000284
更新日期:2017-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Constipation is a common symptom in palliative care patients that can generate considerable suffering due to both unpleasant physical symptoms and psychological preoccupations that may arise. There is uncertainty about the choice from varying recommendations for management of constipation and a varyin...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e3282f53146
更新日期:2008-03-01 00:00:00
abstract:PURPOSE OF THE REVIEW:The purpose of review is to critically present the evidence supporting the use of olanzapine, an atypical antipsychotic, as an antiemetic for cancer and chemotherapy-induced nausea and vomiting (CINV). RECENT FINDINGS:Two phase III clinical studies demonstrated superior efficacy of olanzapine in ...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000206
更新日期:2016-06-01 00:00:00