Abstract:
PURPOSE OF REVIEW:Overall survival of patients with pancreatic cancer is strongly conditioned by tumor biology and the incidence of malnutrition and metabolic disorders. In this landscape, the assessment of body composition is crucial to properly manage the clinical implications of muscle wasting. The pathogenesis of this condition is the result of a complex interplay between cancer and the host. In particular, sarcopenia is induced by an inadequate nutritional intake, hormonal abnormalities, inflammation and imbalance between anabolic and catabolic pathways. RECENT FINDINGS:Recent evidences have highlighted the role of sarcopenia in cancer patients, revealing a prognostic impact on morbidity, mortality and survival. SUMMARY:The occurrence of sarcopenia could amplify chemotherapy-induced toxicities, prolong hospitalizations and reduce adherence to anticancer treatment, worsening quality of life and survival. Although considerable efforts have been made to develop treatment strategies, no effective interventions have been identified so far. Nevertheless, if promptly and adequately supported, pancreatic cancer might benefit from adopted dietary intervention to avoid further loss of lean mass.
journal_name
Curr Opin Support Palliat Carejournal_title
Current opinion in supportive and palliative careauthors
Basile D,Corvaja C,Caccialanza R,Aprile Gdoi
10.1097/SPC.0000000000000455subject
Has Abstractpub_date
2019-12-01 00:00:00pages
279-285issue
4eissn
1751-4258issn
1751-4266journal_volume
13pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:To summarize developments in the management of brain metastases over the past decade. RECENT FINDINGS:A few randomized trials have been published during the past decade examining the use of whole brain radiotherapy (WBRT) and radiosurgery (SRS) boost versus WBRT alone. Other recent trials have been p...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32834de714
更新日期:2012-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize current knowledge about gastrointestinal radiation toxicity, with emphasis on mechanisms and clinical diagnosis and management. RECENT FINDINGS:While there has been only modest change in cancer incidence and cancer mortality rates during the past 30 years, the number of cancer survivors ...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e3281108014
更新日期:2007-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Osteoarthritis is a complex and often painful disease that is inadequately controlled with current analgesics. This review discusses emerging targets and therapeutic approaches that may lead to the development of better analgesics. RECENT FINDINGS:Aberrant excitability in peripheral and central pain ...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000125
更新日期:2015-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Right-sided heart failure, which is often present in the setting of advanced heart failure, is associated with cardiac cachexia, the cardiorenal syndrome, and adverse outcomes. Improved understanding of venous congestion of the splanchnic circulation, which may play a key role in the pathogenesis of r...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000414
更新日期:2019-03-01 00:00:00
abstract:PURPOSE OF REVIEW:There are increasing numbers of adults with congenital heart disease (CHD) and these patients remain at long-term risk of complications and premature death. This review focuses on the changing picture of adult CHD with more complex patients surviving, the challenges of balancing life-prolonging interv...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32835c0707
更新日期:2013-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Myofascial pain syndrome is a chronic pain condition characterized by the presence of myofascial trigger point, a hyperirritable painful spot involving a limited number of muscle fibers. The literature suggest that myofascial trigger points should be considered peripheral pain generators and this crit...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章
doi:10.1097/SPC.0000000000000445
更新日期:2019-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Opioids are potent drugs for the treatment of severe pain, but they are burdened by detrimental side-effects, such as respiratory depression, addiction, sedation and constipation. Their clinical application is undisputed in acute (e.g. perioperative) and cancer pain, but their use in chronic nonmalign...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章
doi:10.1097/SPC.0000000000000495
更新日期:2020-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent advances in the diagnosis and treatment of many types of cancers have prolonged and improved the quality of life for cancer patients. With increased survival, metastatic spinal lesions are becoming much more of a functional and clinical problem. RECENT FINDINGS:Percutaneous vertebral augmentat...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32830c9060
更新日期:2008-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Despite recognition that opioids alleviate dyspnea in chronic obstructive pulmonary disease, many clinicians remain reluctant to use them outside of the final days of life. This article defines the term 'opioid responsiveness' as it pertains to dyspnea, and poses that it may be possible to predict mor...
journal_title:Current opinion in supportive and palliative care
pub_type: 社论,评审
doi:10.1097/spc.0b013e3283392788
更新日期:2010-06-01 00:00:00
abstract:PURPOSE OF REVIEW:This review summarizes recent developments in the management of gastrointestinal symptoms experienced by cancer patients and provides a framework for education, assessment and monitoring, and treatment. RECENT FINDINGS:Although many viable treatment options exist, gastrointestinal symptoms - particul...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32834f689d
更新日期:2012-03-01 00:00:00
abstract:PURPOSE OF REVIEW:In the last 10 years, metastatic castration-resistant prostate cancer (mCRPC) treatment has completely changed. Several new agents have been shown to increase mCRPC patients' overall survival. The importance to define castration-resistant prostate cancer as metastatic and to enable earlier detection o...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000076
更新日期:2014-09-01 00:00:00
abstract:PURPOSE OF REVIEW:This review aims to synthesize recent findings on anticipatory grief in caregivers, referring to its phenomenology, assessment and clinical interventions. RECENT FINDINGS:Recent literature illustrates the wide scope of the current use of the term anticipatory grief, reflecting caregivers' experiences...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000321
更新日期:2018-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The primary cause of overdose death in the United States is related to pharmaceutical opioids. A few particular populations that struggle with adverse outcomes related to opioid abuse are those in palliative care, those with chronic pain, and those receiving pain treatments secondary to cancer or chem...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000333
更新日期:2018-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Cancer cachexia remains understudied and there are no standard treatments available despite the publication of an international consensus definition and the completion of several large phase III intervention trials in the past 6 years. In September 2015, The University of Rochester Cancer Center NCORP...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000301
更新日期:2017-12-01 00:00:00
abstract:PURPOSE OF REVIEW:This review summarizes recent developments in the palliative management of gastrointestinal symptoms experienced by advanced cancer patients and provides a framework for detailing that encompasses education, assessment and monitoring, and treatment. RECENT FINDINGS:Although many viable treatment opti...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32832531ce
更新日期:2009-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To review recent research on cancer-related cognitive impairment (CRCI) in children, including correlational studies and interventions in which outcomes have included cognitive test performance, neuroimaging or academic performance. RECENT FINDINGS:Impairments in processing speed, working memory, exe...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000258
更新日期:2017-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Patients' autonomy is seen as a major issue in modern medicine but requires the ability to understand and rate an issue without being influenced by others. However, near the end of life, patients often decide considering the consequences for their relatives. RECENT FINDINGS:Our study results and rece...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000096
更新日期:2014-12-01 00:00:00
abstract:PURPOSE OF REVIEW:This article describes the role of the PD-1 axis and reviews current data and future directions inhibiting PD-1 and PD-L1 in breast cancer. RECENT FINDINGS:Four phase I monotherapy expansion trials in patients with metastatic breast cancer have demonstrated low but durable single agent responses to P...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000243
更新日期:2016-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Cross-sectional (C-S) imaging is now commonly used to measure body composition in clinical studies. This review highlights the advantages, limitations and suggested future directions for this technique. RECENT FINDINGS:Current understanding of C-S imaging reproducibility, tissue identification and se...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32834c49eb
更新日期:2011-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Despite a limited understanding of the exact mechanism, corticosteroids are commonly employed for pain control in patients with bone metastases. The aim of this review was to evaluate the efficacy of corticosteroid-mediated pain control in patients with bone metastases associated with solid cancers. ...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000263
更新日期:2017-06-01 00:00:00
abstract:PURPOSE OF REVIEW:To examine the symptom burden in cancer patients during the last days of life, its impact on nutrition and hydration, and the role of artificial nutrition and hydration in the final days. RECENT FINDINGS:During the last days of life, cancer patients often experience progressive functional decline and...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000171
更新日期:2015-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Bone metastases in prostate cancer are often the cause of significant morbidity in patients with castrate-resistant disease, and several studies have shown significant pain palliation with systemic radionuclide treatment. The purpose of this review is to discuss the place of radionuclides in the dynam...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e328355e082
更新日期:2012-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Determining which palliative interventions are appropriate within and between groups remains difficult because of the lack of prospective studies and heterogeneity in dyspnoea context, assessment and reporting. This review presents an evolution of dyspnoea theories, summarizes literature published dur...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e328345d4a1
更新日期:2011-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to synthesize recent literature regarding the provision of palliative care to patients during and following allogeneic hematopoietic stem cell transplantation (HSCT), highlighting factors which mediate impairments in health-related quality of life in this patient populati...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000327
更新日期:2018-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize current knowledge on promising immunotherapeutic agents and to provide a brief outline of current use of immunotherapeutic agents in patients with locally advanced or metastatic renal cell carcinoma (RCC). RECENT FINDINGS:Immunotherapy with mAbs directed against programed death cell prot...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000363
更新日期:2018-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this paper is to consolidate the literature around pain assessment and management in older adults with dementia and to make recommendations for future research and practice developments. This review is provided following the introduction of guidelines for the assessment of pain that wer...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e3282ffb406
更新日期:2008-06-01 00:00:00
abstract:PURPOSE OF REVIEW:This review describes the role of lung volume reduction surgery (LVRS) for the management of refractory dyspnea and other debilitating conditions in patients with chronic obstructive pulmonary disease. Recent studies, including a randomized trial comparing LVRS to medical therapy, are analyzed. RECEN...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32832ad5e1
更新日期:2009-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Patients with heart failure seem particularly suited to palliative care having needs that fall within the prototypical palliative care domains. Despite this there is still much debate as to who should respond to these needs and when. RECENT FINDINGS:Since the early 1990s many studies have been publis...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e328332e808
更新日期:2009-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Palliative sedation has been the subject of intensive debate since its first appearance in 1990. In a 2010 review of palliative sedation, the following areas were identified as lacking in consensus: inconsistent terminology, its use in nonphysical suffering, the ongoing experience of distress, and con...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000224
更新日期:2016-09-01 00:00:00
abstract:PURPOSE OF REVIEW:RANK ligand (RANKL) plays a central role in the cancer-induced bone destruction that results from bone metastasis. The RANKL inhibitor denosumab was recently approved for the prevention of skeletal-related events (SREs) in patients with bone metastases from solid tumors. This review summarizes recent ...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e328349731c
更新日期:2011-09-01 00:00:00