Brain metastases: what's new with an old problem?

abstract：PURPOSE OF REVIEW:There are increasing numbers of adults with congenital heart disease (CHD) and these patients remain at long-term risk of complications and premature death. This review focuses on the changing picture of adult CHD with more complex patients surviving, the challenges of balancing life-prolonging interv...

journal_title：Current opinion in supportive and palliative care

authors： Bowater SE,Speakman JK,Thorne SA

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Sequential anthracycline/taxane regimens are routinely used as neoadjuvant therapy (NAT) for locally advanced breast cancer. Unfortunately, the majority of patients do not achieve a pathological complete response (pCR). Efforts to improve pCR rates include the addition of novel targeted agents. The pu...

journal_title：Current opinion in supportive and palliative care

authors： Wilson S,Chia S

更新日期：2014-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review compares the catabolic actions of tumour necrosis factor-alpha (TNF-alpha) and proteolysis-inducing factor (PIF) and their involvement in human cancer cachexia. RECENT FINDINGS:TNF-alpha has a direct catabolic effect on skeletal muscle and adipose tissue, whereas PIF only has an effect on...

journal_title：Current opinion in supportive and palliative care

authors： Tisdale MJ

更新日期：2008-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Myofascial pain syndrome is a chronic pain condition characterized by the presence of myofascial trigger point, a hyperirritable painful spot involving a limited number of muscle fibers. The literature suggest that myofascial trigger points should be considered peripheral pain generators and this crit...

journal_title：Current opinion in supportive and palliative care

authors： Barbero M,Schneebeli A,Koetsier E,Maino P

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Pelvic pain is a common complaint of women that is frequently poorly managed. This review considers the current understanding of the mechanisms of pain perception and the development of chronic pain in the context of three gynaecological pain conditions. Recent advances in the management of these cond...

journal_title：Current opinion in supportive and palliative care

authors： Vincent K

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite its increasing prevalence and high mortality risk, heart failure is widely regarded as 'treatable'. Aggressive measures are employed even in its end stages. This review explores the clinical characteristics of heart failure, patterns of clinician response, and new data that may help to surmoun...

journal_title：Current opinion in supportive and palliative care

authors： Stuart B

更新日期：2007-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Cachexia, also known as disease-associated wasting, is an important factor in the mortality of many patients with diseases such as cancer, as well as renal and congestive heart failure. Yet the syndrome is not yet well defined, making diagnosis difficult and often subjective on the part of the physici...

journal_title：Current opinion in supportive and palliative care

authors： Fletcher AL,Marks DL

更新日期：2007-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize current knowledge on promising immunotherapeutic agents and to provide a brief outline of current use of immunotherapeutic agents in patients with locally advanced or metastatic renal cell carcinoma (RCC). RECENT FINDINGS:Immunotherapy with mAbs directed against programed death cell prot...

journal_title：Current opinion in supportive and palliative care

authors： Nazzani S,Bazinet A,Karakiewicz PI

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on chemotherapy in the management of patients with advanced urothelial cancer, with a look towards the future and the next generation of clinical trials. RECENT FINDINGS:The recognition that the maximum benefit from conventional combination chemotherapy has been achieved has led t...

journal_title：Current opinion in supportive and palliative care

authors： Calabrò F,Sternberg CN

更新日期：2007-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This article describes the role of the PD-1 axis and reviews current data and future directions inhibiting PD-1 and PD-L1 in breast cancer. RECENT FINDINGS:Four phase I monotherapy expansion trials in patients with metastatic breast cancer have demonstrated low but durable single agent responses to P...

journal_title：Current opinion in supportive and palliative care

authors： Dawood S,Rugo HS

更新日期：2016-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes recent developments in the management of gastrointestinal symptoms experienced by cancer patients and provides a framework for education, assessment and monitoring, and treatment. RECENT FINDINGS:Although many viable treatment options exist, gastrointestinal symptoms - particul...

journal_title：Current opinion in supportive and palliative care

authors： Rangwala F,Zafar SY,Abernethy AP

更新日期：2012-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss three emerging areas of research triggering new hypotheses for mechanisms of dyspnea. RECENT FINDINGS:There has been an emphasis on the importance of lung volumes in evaluating symptoms and lung function in patients with chronic obstructive pulmonary disease. Dyspnea intensity seems to mor...

journal_title：Current opinion in supportive and palliative care

authors： Rock LK,Schwartzstein RM

更新日期：2007-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Cross-sectional (C-S) imaging is now commonly used to measure body composition in clinical studies. This review highlights the advantages, limitations and suggested future directions for this technique. RECENT FINDINGS:Current understanding of C-S imaging reproducibility, tissue identification and se...

journal_title：Current opinion in supportive and palliative care

authors： MacDonald AJ,Greig CA,Baracos V

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The serotonergic system has long been linked to migraine but recent studies highlight how much is still unclear about this link. And recent data add to the uncertainty of where/how triptans act and why they are headache specific. RECENT FINDINGS:Markers of 5HT levels in the brains of migraine patient...

journal_title：Current opinion in supportive and palliative care

authors： Dussor G

更新日期：2014-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Constipation is a common symptom in palliative care patients that can generate considerable suffering due to both unpleasant physical symptoms and psychological preoccupations that may arise. There is uncertainty about the choice from varying recommendations for management of constipation and a varyin...

journal_title：Current opinion in supportive and palliative care

authors： Clemens KE,Klaschik E

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review describes the role of lung volume reduction surgery (LVRS) for the management of refractory dyspnea and other debilitating conditions in patients with chronic obstructive pulmonary disease. Recent studies, including a randomized trial comparing LVRS to medical therapy, are analyzed. RECEN...

journal_title：Current opinion in supportive and palliative care

authors： Shah AA,D'Amico TA

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The palliative care needs of people with interstitial lung disease (ILD) have recently been highlighted by the National Institute for Health and Care Excellence. All people with progressive ILD should receive best supportive care to improve symptom control and quality of life and where possible this s...

journal_title：Current opinion in supportive and palliative care

authors： Bajwah S,Yorke J

更新日期：2017-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Experienced breathlessness and recalled breathlessness are two different entities, which may be associated with different factors and might have different impacts on function for the individual. The aim was to review the knowledge from the last 2 years concerning experienced breathlessness and recalle...

journal_title：Current opinion in supportive and palliative care

authors： Sandberg J,Ekström M

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Patients' autonomy is seen as a major issue in modern medicine but requires the ability to understand and rate an issue without being influenced by others. However, near the end of life, patients often decide considering the consequences for their relatives. RECENT FINDINGS:Our study results and rece...

journal_title：Current opinion in supportive and palliative care

authors： Marx G,Owusu Boakye S,Jung A,Nauck F

更新日期：2014-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The treatment of patients with metastatic urothelial carcinoma is evolving with recent advances holding promise for improved outcomes. Historically, patients with metastatic urothelial carcinoma had a poor prognosis with no standard treatment options in the second-line setting. Currently, with an incr...

journal_title：Current opinion in supportive and palliative care

authors： Alimohamed NS,Sridhar SS

更新日期：2015-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines recent literature on the psychosocial needs of and interventions for young women. We focus on the active treatment period given the toxicity of treatment, the incidence of anxiety, and depressive symptoms in these women during treatment. This review summarizes research relevant to...

journal_title：Current opinion in supportive and palliative care

authors： Fernandes-Taylor S,Adesoye T,Bloom JR

更新日期：2015-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Bone metastases in prostate cancer are often the cause of significant morbidity in patients with castrate-resistant disease, and several studies have shown significant pain palliation with systemic radionuclide treatment. The purpose of this review is to discuss the place of radionuclides in the dynam...

journal_title：Current opinion in supportive and palliative care

authors： Vengalil S,O'Sullivan JM,Parker CC

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Mixed methods research designs have been recognized as important in addressing complexity and are recommended particularly in the development and evaluation of complex interventions. This article reports a review of studies in palliative care published between 2010 and March 2012 that combine qualitat...

journal_title：Current opinion in supportive and palliative care

authors： Seymour J

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The widespread use of prostate-specific antigen (PSA) resulted in stage migration of prostate cancer where androgen deprivation therapy (ADT) is administered for biochemical recurrence in patients following primary treatment. A proportion of these patients progress to a disease state termed nonmetasta...

journal_title：Current opinion in supportive and palliative care

authors： Traboulsi SL,Saad F

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To understand the mechanisms of muscle wasting and how inhibiting myostatin signaling affects them. RECENT FINDINGS:Myostatin signaling is critical for the understanding of the pathogenesis of muscle wasting as blocking signaling mitigates muscle losses in rodent models of catabolic diseases includin...

journal_title：Current opinion in supportive and palliative care

authors： Han HQ,Mitch WE

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To emphasize that the management of wounds represents a significant component within the overall supportive and palliative care of patients with advanced illness. It is also intended to clarify the linguistics that are commonly used around patients with wounds. RECENT FINDINGS:New paradigms for wound...

journal_title：Current opinion in supportive and palliative care

authors： Maida V

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Death is the inevitable consequence of life. Although clinicians are unlikely to accurately pinpoint when death is likely to occur in the people they care for, the death in a person with a diagnosis of malignant and nonmalignant tends to involve a period of predictable progressive clinical and functio...

journal_title：Current opinion in supportive and palliative care

authors： Watts T,Willis D,Noble S,Johnston B

更新日期：2019-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Young women (<45 years of age) diagnosed with breast cancer face increased risk of sexual dysfunction as a result of their cancer-directed treatment. We will review the recent literature examining this critical challenge and discuss current efforts to address sexual dysfunction. RECENT FINDINGS:In th...

journal_title：Current opinion in supportive and palliative care

authors： Zhou ES,Falk SJ,Bober SL

更新日期：2015-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Patients with heart failure seem particularly suited to palliative care having needs that fall within the prototypical palliative care domains. Despite this there is still much debate as to who should respond to these needs and when. RECENT FINDINGS:Since the early 1990s many studies have been publis...

journal_title：Current opinion in supportive and palliative care

authors： O'Leary N

更新日期：2009-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Gastrointestinal toxicity during chemotherapy is frequent. Symptomatic therapies for gastrointestinal toxicity, which do not address the underlying cause, may result in inadequate symptom control. With advances in curative treatment regimens, it becomes more important to minimize treatment toxicity wh...

journal_title：Current opinion in supportive and palliative care

authors： Andreyev HJ

更新日期：2010-03-01 00:00:00