Catabolic mediators of cancer cachexia.

abstract：PURPOSE OF REVIEW:This review describes the advances in trial methodology and presents new methodologies to meet some of the challenges of conducting trials in a palliative care setting. To describe why this review is timely and relevant. RECENT FINDINGS:This review discusses the process required to conduct trials of ...

journal_title：Current opinion in supportive and palliative care

authors： Davis MP,Mitchell GK

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Highlight the difficulties patients, physicians, and the global economy face in relation to treatment of structural heart diseases. It is easy to be carried away by the excitement of medical advancement; however, it is difficult to demonstrate restraint. Transcatheter aortic valve replacement (TAVR) i...

journal_title：Current opinion in supportive and palliative care

authors： German KS,Kalra A

更新日期：2019-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Right-sided heart failure, which is often present in the setting of advanced heart failure, is associated with cardiac cachexia, the cardiorenal syndrome, and adverse outcomes. Improved understanding of venous congestion of the splanchnic circulation, which may play a key role in the pathogenesis of r...

journal_title：Current opinion in supportive and palliative care

authors： Polsinelli VB,Marteau L,Shah SJ

更新日期：2019-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The study provides a review of current evidence about the role of complex nonpharmacological strategies in managing the multidimensional components of the breathlessness experience for individuals with life-limiting conditions. RECENT FINDINGS:Evidence continues to demonstrate the significant impact ...

journal_title：Current opinion in supportive and palliative care

authors： Yates P,Zhao I

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This article describes the role of the PD-1 axis and reviews current data and future directions inhibiting PD-1 and PD-L1 in breast cancer. RECENT FINDINGS:Four phase I monotherapy expansion trials in patients with metastatic breast cancer have demonstrated low but durable single agent responses to P...

journal_title：Current opinion in supportive and palliative care

authors： Dawood S,Rugo HS

更新日期：2016-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Mixed methods research designs have been recognized as important in addressing complexity and are recommended particularly in the development and evaluation of complex interventions. This article reports a review of studies in palliative care published between 2010 and March 2012 that combine qualitat...

journal_title：Current opinion in supportive and palliative care

authors： Seymour J

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:International bodies acknowledge that palliative care principles and access to palliative care services should be offered to persons living with and dying from advanced illness such as heart failure. Without an appropriately trained workforce, however, appropriate goals of care and associated reductio...

journal_title：Current opinion in supportive and palliative care

authors： Millerick Y,Armstrong I

更新日期：2015-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite its increasing prevalence and high mortality risk, heart failure is widely regarded as 'treatable'. Aggressive measures are employed even in its end stages. This review explores the clinical characteristics of heart failure, patterns of clinician response, and new data that may help to surmoun...

journal_title：Current opinion in supportive and palliative care

authors： Stuart B

更新日期：2007-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes recent developments in the palliative management of gastrointestinal symptoms experienced by advanced cancer patients and provides a framework for detailing that encompasses education, assessment and monitoring, and treatment. RECENT FINDINGS:Although many viable treatment opti...

journal_title：Current opinion in supportive and palliative care

authors： Abernethy AP,Wheeler JL,Zafar SY

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Many health professionals still believe that opioids shorten the lifespan of patients. This situation implies that the ethical doctrine of double effect is often invoked to justify their use in extreme circumstances. The objective of this study is to revise the evidence existing in the recently publis...

journal_title：Current opinion in supportive and palliative care

authors： López-Saca JM,Guzmán JL,Centeno C

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent advances in the diagnosis and treatment of many types of cancers have prolonged and improved the quality of life for cancer patients. With increased survival, metastatic spinal lesions are becoming much more of a functional and clinical problem. RECENT FINDINGS:Percutaneous vertebral augmentat...

journal_title：Current opinion in supportive and palliative care

authors： Siemionow K,Lieberman IH

更新日期：2008-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss the psychosocial support of people affected by cancer anorexia, drawing on recent publications. RECENT FINDINGS:Recent studies describe the problem of distress in response to cancer anorexia. There are propositions of appropriate support and calls for the development of psychosocial interv...

journal_title：Current opinion in supportive and palliative care

authors： Hopkinson JB

更新日期：2010-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review describes the role of lung volume reduction surgery (LVRS) for the management of refractory dyspnea and other debilitating conditions in patients with chronic obstructive pulmonary disease. Recent studies, including a randomized trial comparing LVRS to medical therapy, are analyzed. RECEN...

journal_title：Current opinion in supportive and palliative care

authors： Shah AA,D'Amico TA

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Cross-sectional (C-S) imaging is now commonly used to measure body composition in clinical studies. This review highlights the advantages, limitations and suggested future directions for this technique. RECENT FINDINGS:Current understanding of C-S imaging reproducibility, tissue identification and se...

journal_title：Current opinion in supportive and palliative care

authors： MacDonald AJ,Greig CA,Baracos V

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Sequential anthracycline/taxane regimens are routinely used as neoadjuvant therapy (NAT) for locally advanced breast cancer. Unfortunately, the majority of patients do not achieve a pathological complete response (pCR). Efforts to improve pCR rates include the addition of novel targeted agents. The pu...

journal_title：Current opinion in supportive and palliative care

authors： Wilson S,Chia S

更新日期：2014-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Palliative sedation has been the subject of intensive debate since its first appearance in 1990. In a 2010 review of palliative sedation, the following areas were identified as lacking in consensus: inconsistent terminology, its use in nonphysical suffering, the ongoing experience of distress, and con...

journal_title：Current opinion in supportive and palliative care

authors： Henry B

更新日期：2016-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Bone metastases in prostate cancer are often the cause of significant morbidity in patients with castrate-resistant disease, and several studies have shown significant pain palliation with systemic radionuclide treatment. The purpose of this review is to discuss the place of radionuclides in the dynam...

journal_title：Current opinion in supportive and palliative care

authors： Vengalil S,O'Sullivan JM,Parker CC

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews the status of guidelines and recommendations for communication between patients with cancer and healthcare providers (HCPs) concerning fertility issues. RECENT FINDINGS:The timing, the type of information provided, and the openness of HCPs can all affect how patients with cancer ...

journal_title：Current opinion in supportive and palliative care

authors： Shen S,Zelkowitz P,Rosberger Z

更新日期：2019-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this paper is to consolidate the literature around pain assessment and management in older adults with dementia and to make recommendations for future research and practice developments. This review is provided following the introduction of guidelines for the assessment of pain that wer...

journal_title：Current opinion in supportive and palliative care

authors： Schofield P

更新日期：2008-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The treatment of patients with metastatic urothelial carcinoma is evolving with recent advances holding promise for improved outcomes. Historically, patients with metastatic urothelial carcinoma had a poor prognosis with no standard treatment options in the second-line setting. Currently, with an incr...

journal_title：Current opinion in supportive and palliative care

authors： Alimohamed NS,Sridhar SS

更新日期：2015-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Opioids are potent drugs for the treatment of severe pain, but they are burdened by detrimental side-effects, such as respiratory depression, addiction, sedation and constipation. Their clinical application is undisputed in acute (e.g. perioperative) and cancer pain, but their use in chronic nonmalign...

journal_title：Current opinion in supportive and palliative care

authors： Stein C

更新日期：2020-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Cancer cachexia remains understudied and there are no standard treatments available despite the publication of an international consensus definition and the completion of several large phase III intervention trials in the past 6 years. In September 2015, The University of Rochester Cancer Center NCORP...

journal_title：Current opinion in supportive and palliative care

authors： Dunne RF,Mustian KM,Garcia JM,Dale W,Hayward R,Roussel B,Buschmann MM,Caan BJ,Cole CL,Fleming FJ,Chakkalakal JV,Linehan DC,Hezel AF,Mohile SG

更新日期：2017-12-01 00:00:00

abstract：PURPOSE OF REVIEW:AYA patients with cancer have a unique set of psychosocial and support needs to compared with their younger and older counterparts. Digital health interventions overcome many of the barriers to AYA participation in behavioral health interventions. Due to the rapid shifts in digital health, it is impor...

journal_title：Current opinion in supportive and palliative care

authors： Viola A,Panigrahi G,Devine KA

更新日期：2020-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Breathlessness is a high-volume problem with 10% of adults experiencing the symptom daily placing a heavy burden on the health and wider economy. As it worsens, they enter the specialist and hospital-based symptom services where costs quickly escalate and people may find themselves in a place not of t...

journal_title：Current opinion in supportive and palliative care

authors： Baxter N

更新日期：2017-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Dyspnea is the most common symptom in interstitial lung disease, yet little is known about its management. This review summarizes the available evidence for the treatment of dyspnea in interstitial lung disease. RECENT FINDINGS:The management of dyspnea in interstitial lung disease remains a challeng...

journal_title：Current opinion in supportive and palliative care

authors： Ryerson CJ,Collard HR,Pantilat SZ

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Radiation therapy-induced nausea and vomiting (RINV) are common and troublesome symptoms among patients receiving radiation therapy for gastrointestinal cancers. Their impact on function, quality of life and, ultimately, cancer control warrant a review of their incidence, underlying mechanisms, treatm...

journal_title：Current opinion in supportive and palliative care

authors： Dennis K,Poon M,Chow E

更新日期：2015-06-01 00:00:00

abstract：PURPOSE OF REVIEW:It is difficult to hold an organized view of psychological research related to chronic pain. There are many different theories and variables and the volume of literature is vast. The purpose of this review is to highlight some key trends in this research in 2010. RECENT FINDINGS:We conducted a search...

journal_title：Current opinion in supportive and palliative care

authors： McCracken LM,Thompson M

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Pelvic pain is a common complaint of women that is frequently poorly managed. This review considers the current understanding of the mechanisms of pain perception and the development of chronic pain in the context of three gynaecological pain conditions. Recent advances in the management of these cond...

journal_title：Current opinion in supportive and palliative care

authors： Vincent K

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to synthesize recent literature regarding the provision of palliative care to patients during and following allogeneic hematopoietic stem cell transplantation (HSCT), highlighting factors which mediate impairments in health-related quality of life in this patient populati...

journal_title：Current opinion in supportive and palliative care

authors： Mitchell SA

更新日期：2018-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Across all jurisdictions in which assisted dying is legally permissible, cancer is the primary reported underlying diagnosis. Therefore, oncologists are likely to be asked about assisted dying and should be equipped to respond to inquiries or requests for assisted dying. Because Medical Assistance in ...

journal_title：Current opinion in supportive and palliative care

authors： Selby D,Bean S

更新日期：2019-03-01 00:00:00