Abstract：
PURPOSE OF REVIEW:Gastrointestinal toxicity during chemotherapy is frequent. Symptomatic therapies for gastrointestinal toxicity, which do not address the underlying cause, may result in inadequate symptom control. With advances in curative treatment regimens, it becomes more important to minimize treatment toxicity which otherwise may compromise optimal chemotherapy and the chance of cure. RECENT FINDINGS:For decades, oncologists have concentrated on delineating the pathological processes, which occur within the gastrointestinal tract during chemotherapy treatment. However, pathological change does not in itself cause symptoms. Symptoms only arise when physiological functions are altered. In immunosuppressed patients, it is a priority to exclude infection as a cause for symptoms. In the presence of diarrhoea, the best investigative paradigm for this is stool culture, upper gastrointestinal endoscopy with duodenal biopsies and duodenal aspirate combined with flexible sigmoidoscopy and left colonic biopsies. Once infection has been excluded, although large studies have not been performed, case series repeatedly suggest that gastrointestinal symptoms arising during cancer chemotherapy can often be cured if newly acquired, gastrointestinal physiological deficits are identified. SUMMARY:Although many physiological changes induced by chemotherapy may be relatively transient and settle weeks or months after the end of treatment, during chemotherapy, their manifestations can be protean and severe. A systematic failure to research the frequency with which physiological causes of the symptoms are amenable to treatment has denied many patients' logical therapies for their chemotherapy-induced symptoms, and as a result, it is likely that symptomatic treatments are frequently suboptimal.
journal_name
Curr Opin Support Palliat Carejournal_title
Current opinion in supportive and palliative careauthors
Andreyev HJdoi
10.1097/SPC.0b013e32833575ccsubject
Has Abstractpub_date
2010-03-01 00:00:00pages
19-25issue
1eissn
1751-4258issn
1751-4266journal_volume
4pub_type
杂志文章,评审abstract：PURPOSE OF THE REVIEW:The purpose of review is to critically present the evidence supporting the use of olanzapine, an atypical antipsychotic, as an antiemetic for cancer and chemotherapy-induced nausea and vomiting (CINV). RECENT FINDINGS:Two phase III clinical studies demonstrated superior efficacy of olanzapine in ...
journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0000000000000206
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journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0000000000000455
更新日期：2019-12-01 00:00:00
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journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0b013e3282ffb406
更新日期：2008-06-01 00:00:00
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journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0000000000000125
更新日期：2015-06-01 00:00:00
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journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0000000000000186
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journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0000000000000412
更新日期：2019-03-01 00:00:00
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journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0b013e3282f1aad1
更新日期：2007-10-01 00:00:00
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journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0000000000000301
更新日期：2017-12-01 00:00:00
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journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0b013e3282f53146
更新日期：2008-03-01 00:00:00
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journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0b013e3281108014
更新日期：2007-04-01 00:00:00
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journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0000000000000171
更新日期：2015-12-01 00:00:00
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journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章
doi：10.1097/SPC.0000000000000409
更新日期：2019-03-01 00:00:00
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journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0000000000000113
更新日期：2015-03-01 00:00:00
abstract：PURPOSE OF REVIEW:Mixed methods research designs have been recognized as important in addressing complexity and are recommended particularly in the development and evaluation of complex interventions. This article reports a review of studies in palliative care published between 2010 and March 2012 that combine qualitat...
journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0b013e328358214e
更新日期：2012-12-01 00:00:00
abstract：PURPOSE OF REVIEW:The serotonergic system has long been linked to migraine but recent studies highlight how much is still unclear about this link. And recent data add to the uncertainty of where/how triptans act and why they are headache specific. RECENT FINDINGS:Markers of 5HT levels in the brains of migraine patient...
journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0000000000000044
更新日期：2014-06-01 00:00:00
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journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0b013e3283392b51
更新日期：2010-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Care near the end of life is expensive and frequently not aligned with the expressed preferences of decedents, creating an opportunity to improve value, or increase quality while lowering cost. This review examines publications from 2017 and 2018 on interventions and policies associated with high-valu...
journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0000000000000392
更新日期：2018-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Opioids are potent drugs for the treatment of severe pain, but they are burdened by detrimental side-effects, such as respiratory depression, addiction, sedation and constipation. Their clinical application is undisputed in acute (e.g. perioperative) and cancer pain, but their use in chronic nonmalign...
journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章
doi：10.1097/SPC.0000000000000495
更新日期：2020-06-01 00:00:00
abstract：PURPOSE OF REVIEW:The palliative care needs of people with interstitial lung disease (ILD) have recently been highlighted by the National Institute for Health and Care Excellence. All people with progressive ILD should receive best supportive care to improve symptom control and quality of life and where possible this s...
journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
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journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0b013e32834c49eb
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journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0b013e32832ad5e1
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journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
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更新日期：2019-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Delirium is the most common and distressing neuropsychiatric syndrome in cancer patients. Few evidence-based treatment options are available due to the paucity of high quality of studies. In this review, we shall examine the literature on the use of neuroleptics to treat delirium in patients with adva...
journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0000000000000236
更新日期：2016-12-01 00:00:00
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journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0b013e32833ef813
更新日期：2010-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Young women (<45 years of age) diagnosed with breast cancer face increased risk of sexual dysfunction as a result of their cancer-directed treatment. We will review the recent literature examining this critical challenge and discuss current efforts to address sexual dysfunction. RECENT FINDINGS:In th...
journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0000000000000156
更新日期：2015-09-01 00:00:00
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journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0b013e32835843d7
更新日期：2012-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Highlight the difficulties patients, physicians, and the global economy face in relation to treatment of structural heart diseases. It is easy to be carried away by the excitement of medical advancement; however, it is difficult to demonstrate restraint. Transcatheter aortic valve replacement (TAVR) i...
journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0000000000000407
更新日期：2019-03-01 00:00:00
abstract：PURPOSE OF REVIEW:Death is the inevitable consequence of life. Although clinicians are unlikely to accurately pinpoint when death is likely to occur in the people they care for, the death in a person with a diagnosis of malignant and nonmalignant tends to involve a period of predictable progressive clinical and functio...
journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0000000000000463
更新日期：2019-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Despite recognition that opioids alleviate dyspnea in chronic obstructive pulmonary disease, many clinicians remain reluctant to use them outside of the final days of life. This article defines the term 'opioid responsiveness' as it pertains to dyspnea, and poses that it may be possible to predict mor...
journal_title：Current opinion in supportive and palliative care
pub_type： 社论,评审
doi：10.1097/spc.0b013e3283392788
更新日期：2010-06-01 00:00:00
abstract：PURPOSE OF REVIEW:The primary cause of overdose death in the United States is related to pharmaceutical opioids. A few particular populations that struggle with adverse outcomes related to opioid abuse are those in palliative care, those with chronic pain, and those receiving pain treatments secondary to cancer or chem...
journal_title：Current opinion in supportive and palliative care
pub_type： 杂志文章,评审
doi：10.1097/SPC.0000000000000333
更新日期：2018-06-01 00:00:00
