Abstract:
PURPOSE OF REVIEW:Delirium is the most common and distressing neuropsychiatric syndrome in cancer patients. Few evidence-based treatment options are available due to the paucity of high quality of studies. In this review, we shall examine the literature on the use of neuroleptics to treat delirium in patients with advanced cancer. Specifically, we will discuss the randomized controlled trials that examined neuroleptics in the front line setting, and studies that explore second-line options for patients with persistent agitation. RECENT FINDINGS:Contemporary management of delirium includes identification and management of any potentially reversible causes, coupled with nonpharmacological approaches. For patients who do not respond adequately to these measures, pharmacologic measures may be required. Haloperidol is often recommended as the first-line treatment option, and other neuroleptics such as olanzapine, risperidone, and quetiapine represent potential alternatives. For patients with persistent delirium despite first-line neuroleptics, the treatment strategies include escalating the dose of the same neuroleptic, rotation to another neuroleptic, or combination therapy (i.e., the addition of a second neuroleptic or other agent). We will discuss the advantages and disadvantages of each approach, and the available evidence to support each strategy. SUMMARY:Adequately powered, randomized trials involving proper control interventions are urgently needed to define the optimal treatment strategies for delirium in the oncology setting.
journal_name
Curr Opin Support Palliat Carejournal_title
Current opinion in supportive and palliative careauthors
Hui D,Dev R,Bruera Edoi
10.1097/SPC.0000000000000236subject
Has Abstractpub_date
2016-12-01 00:00:00pages
316-323issue
4eissn
1751-4258issn
1751-4266journal_volume
10pub_type
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000130
更新日期:2015-06-01 00:00:00
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e3283460b05
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e328355e082
更新日期:2012-09-01 00:00:00
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000156
更新日期:2015-09-01 00:00:00
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e3282f53146
更新日期:2008-03-01 00:00:00
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journal_title:Current opinion in supportive and palliative care
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更新日期:2018-03-01 00:00:00
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e328349731c
更新日期:2011-09-01 00:00:00
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journal_title:Current opinion in supportive and palliative care
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更新日期:2012-06-01 00:00:00
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32832ad5e1
更新日期:2009-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent advances in the diagnosis and treatment of many types of cancers have prolonged and improved the quality of life for cancer patients. With increased survival, metastatic spinal lesions are becoming much more of a functional and clinical problem. RECENT FINDINGS:Percutaneous vertebral augmentat...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32830c9060
更新日期:2008-09-01 00:00:00
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e328345a3ff
更新日期:2011-06-01 00:00:00
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000412
更新日期:2019-03-01 00:00:00
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e3283523f19
更新日期:2012-06-01 00:00:00
abstract:PURPOSE OF REVIEW:An overview on breakthrough cancer pain (BTCP), including inherent limitations of the terminology, assessment, clinical presentation, and treatment options. RECENT FINDINGS:The estimated prevalence of BTCP is dependent on the defined cutoffs for controlled background pain and the magnitude of the pai...
journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章
doi:10.1097/SPC.0000000000000494
更新日期:2020-06-01 00:00:00
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32835c48e5
更新日期:2013-03-01 00:00:00
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0000000000000258
更新日期:2017-03-01 00:00:00
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32834de714
更新日期:2012-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Dyspnea is the most common symptom in interstitial lung disease, yet little is known about its management. This review summarizes the available evidence for the treatment of dyspnea in interstitial lung disease. RECENT FINDINGS:The management of dyspnea in interstitial lung disease remains a challeng...
journal_title:Current opinion in supportive and palliative care
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
doi:10.1097/SPC.0b013e32833ef813
更新日期:2010-12-01 00:00:00
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
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更新日期:2015-09-01 00:00:00
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
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更新日期:2008-06-01 00:00:00
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
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更新日期:2013-09-01 00:00:00
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
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更新日期:2017-09-01 00:00:00
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章
doi:10.1097/SPC.0000000000000495
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
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journal_title:Current opinion in supportive and palliative care
pub_type: 杂志文章,评审
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更新日期:2009-12-01 00:00:00