Updates in opioid and nonopioid treatment for chronic breathlessness.

Abstract:

PURPOSE OF REVIEW:Chronic breathlessness is a troublesome symptom experienced by people with advanced malignant and nonmalignant disease. Disease-directed therapies are often insufficient in the management of chronic breathlessness. Therefore, pharmacological and nonpharmacological breathlessness-specific interventions should be considered for select patients. RECENT FINDINGS:There is some evidence to support the use of low-dose opioids (≤30 mg morphine equivalents per day) for the relief of breathlessness in the short term. However, additional studies are needed to understand the efficacy of opioids for chronic breathlessness in the long term.Nonopioid therapies, including inspiratory muscle training, fan-to-face therapy, L-menthol and inhaled nebulized furosemide show some promise for the relief of breathlessness in advanced disease. There is insufficient evidence to support the use of anxiolytics and benzodiazepines and cannabis for chronic breathlessness. SUMMARY:More research is needed to identify therapies for the management of chronic breathlessness.

authors

Abdallah SJ,Jensen D,Lewthwaite H

doi

10.1097/SPC.0000000000000449

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

167-173

issue

3

eissn

1751-4258

issn

1751-4266

journal_volume

13

pub_type

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