Abstract:
PURPOSE OF REVIEW:Chemotherapy is a first-line treatment for many cancers; however, its use is hampered by a long list of side-effects. Gastrointestinal mucositis is a common and debilitating side-effect of anticancer therapy contributing to dose reductions, delays and cessation of treatment, greatly impacting clinical outcomes. The underlying pathophysiology of gastrointestinal mucositis is complex and likely involves several overlapping inflammatory, secretory and neural mechanisms, yet research investigating the role of innervation in gastrointestinal mucositis is scarce. This review provides an overview of the current literature surrounding chemotherapy-induced enteric neurotoxicity and discusses its implications on gastrointestinal mucositis. RECENT FINDINGS:Damage to the intrinsic nervous system of the gastrointestinal tract, the enteric nervous system (ENS), occurs following chemotherapeutic administration, leading to altered gastrointestinal functions. Chemotherapeutic drugs have various mechanisms of actions on the ENS. Oxidative stress, direct toxicity and inflammation have been identified as mechanisms involved in chemotherapy-induced ENS damage. Enteric neuroprotection has proven to be beneficial to reduce gastrointestinal dysfunction in animal models of oxaliplatin-induced enteric neuropathy. SUMMARY:Understanding of the ENS role in chemotherapy-induced mucositis requires further investigation and might lead to the development of more effective therapeutic interventions for prevention and treatment of chemotherapy-induced gastrointestinal side-effects.
journal_name
Curr Opin Support Palliat Carejournal_title
Current opinion in supportive and palliative careauthors
McQuade RM,Al Thaalibi M,Nurgali Kdoi
10.1097/SPC.0000000000000515subject
Has Abstractpub_date
2020-09-01 00:00:00pages
293-300issue
3eissn
1751-4258issn
1751-4266pii
01263393-202009000-00020journal_volume
14pub_type
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journal_title:Current opinion in supportive and palliative care
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journal_title:Current opinion in supportive and palliative care
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journal_title:Current opinion in supportive and palliative care
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journal_title:Current opinion in supportive and palliative care
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journal_title:Current opinion in supportive and palliative care
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journal_title:Current opinion in supportive and palliative care
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journal_title:Current opinion in supportive and palliative care
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journal_title:Current opinion in supportive and palliative care
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journal_title:Current opinion in supportive and palliative care
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journal_title:Current opinion in supportive and palliative care
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journal_title:Current opinion in supportive and palliative care
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journal_title:Current opinion in supportive and palliative care
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更新日期:2009-03-01 00:00:00
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journal_title:Current opinion in supportive and palliative care
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doi:10.1097/SPC.0b013e32835843d7
更新日期:2012-12-01 00:00:00
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journal_title:Current opinion in supportive and palliative care
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journal_title:Current opinion in supportive and palliative care
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journal_title:Current opinion in supportive and palliative care
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