Toll-like receptor 4 potentiates Ca2+-dependent secretion of electrolytes from swine tracheal glands.

abstract：:The purpose of this review is to give a comprehensive overview of transgenic mouse lines suitable for studying gene function and cellular lineage relationships in lung development, homeostasis, injury, and repair. Many of the mouse strains reviewed in this Perspective have been widely shared within the lung research c...

journal_title：American journal of respiratory cell and molecular biology

authors： Rawlins EL,Perl AK

更新日期：2012-03-01 00:00:00

abstract：:IL-15 has recently been shown to induce the differentiation of functional dendritic cells (DCs) from human peripheral blood monocytes. Since DCs lay in close proximity to epithelial cells in the airway mucosa, we investigated whether airway epithelial cells release IL-15 in response to inflammatory stimuli and thereby...

journal_title：American journal of respiratory cell and molecular biology

authors： Regamey N,Obregon C,Ferrari-Lacraz S,van Leer C,Chanson M,Nicod LP,Geiser T

更新日期：2007-07-01 00:00:00

abstract：:Pleural organization may occur after empyema or complicated parapneumonic effusion and can result in restrictive lung disease with pleural fibrosis (PF). Pleural mesothelial cells; PMCs, may contribute to PF through acquisition of a profibrotic phenotype; meso-mesenchymal transition (MesoMT), which is characterized by...

journal_title：American journal of respiratory cell and molecular biology

authors： Qin W,Jeffers A,Owens S,Chauhan P,Komatsu S,Qian G,Guo X,Ikebe M,Idell S,Tucker TA

更新日期：2021-01-29 00:00:00

abstract：:Silicosis is a chronic lung disease induced by the inhalation of crystalline silica. Exposure of cultured macrophages to crystalline silica leads to cell death; however, the mechanism of cell-particle interaction, the fate of particles, and the cause of death are unknown. Time-lapse imaging shows that mouse macrophage...

journal_title：American journal of respiratory cell and molecular biology

authors： Gilberti RM,Joshi GN,Knecht DA

更新日期：2008-11-01 00:00:00

abstract：:Pulmonary infection with an exaggerated inflammatory response is the major cause of morbidity and mortality in cystic fibrosis (CF). The objective of this study was to determine whether differences in the innate immune system underlie the exaggerated immune response in CF. We established a model that recapitulates the...

journal_title：American journal of respiratory cell and molecular biology

authors： Bruscia EM,Zhang PX,Ferreira E,Caputo C,Emerson JW,Tuck D,Krause DS,Egan ME

更新日期：2009-03-01 00:00:00

abstract：:It is generally important to elucidate airway epithelial cell lineages and to identify multipotent progenitors as targets for gene therapy. Stem (S) cells are typically present in specialized compartments spatially proximal to their differentiated progeny, but an equivalent paradigm has not been demonstrated in the ai...

journal_title：American journal of respiratory cell and molecular biology

authors： Borthwick DW,Shahbazian M,Krantz QT,Dorin JR,Randell SH

更新日期：2001-06-01 00:00:00

abstract：:Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that plays an important proinflammatory role in asthmatic airways. Corticosteroids are first-line antiinflammatories in asthma; however, their repressive effects on S1P-induced cytokine secretion have not been investigated. To address this, our in vitro study r...

journal_title：American journal of respiratory cell and molecular biology

authors： Che W,Parmentier J,Seidel P,Manetsch M,Ramsay EE,Alkhouri H,Ge Q,Armour CL,Ammit AJ

更新日期：2014-02-01 00:00:00

abstract：:Lung structure undergoes rapid remodeling during late gestation as a functional respiratory unit is formed. To determine the role of collagen turnover in this process, particularly the basement membrane component, we studied the degradation of collagen in a series of fetal rats from day 18 of gestation to full term. D...

journal_title：American journal of respiratory cell and molecular biology

authors： Arden MG,Spearman MA,Adamson IY

更新日期：1993-07-01 00:00:00

abstract：:The oleic acid (OA) model of acute lung injury in rats is characterized by a massive and rapid influx of polymorphonuclear neutrophils (PMN) within 1 h, with a peak inflammatory response at 4 h and resolution by 72 h. We hypothesized that PMN apoptosis is involved in the resolution of OA-induced acute lung injury. To ...

journal_title：American journal of respiratory cell and molecular biology

authors： Hussain N,Wu F,Zhu L,Thrall RS,Kresch MJ

更新日期：1998-12-01 00:00:00

abstract：:Mycobacterium avium (MAV) and M. abscessus (MAB) are ubiquitous environmental organisms increasingly recognized to cause chronic lung disease in patients with apparently normal immune function. Little is yet known about their human pathophysiology. Our objective was to examine cytokine and chemokine responses (protein...

journal_title：American journal of respiratory cell and molecular biology

authors： Sampaio EP,Elloumi HZ,Zelazny A,Ding L,Paulson ML,Sher A,Bafica AL,Shea YR,Holland SM

更新日期：2008-10-01 00:00:00

abstract：:Alveolar epithelial cells are directly exposed to acute and chronic fluctuations in alveolar oxygen tension. Previously, we found that the oxygen-binding protein hemoglobin is expressed in alveolar Type II cells (ATII). Here, we report that ATII cells also express a number of highly specific transcription factors and ...

journal_title：American journal of respiratory cell and molecular biology

authors： Grek CL,Newton DA,Spyropoulos DD,Baatz JE

更新日期：2011-04-01 00:00:00

abstract：:Since the lung is repeatedly subjected to injury by pathogens and toxicants, maintenance of pulmonary homeostasis requires rapid repair of its epithelial surfaces. Ciliated bronchiolar epithelial cells, previously considered as terminally differentiated, underwent squamous cell metaplasia within hours after bronchiola...

journal_title：American journal of respiratory cell and molecular biology

authors： Park KS,Wells JM,Zorn AM,Wert SE,Laubach VE,Fernandez LG,Whitsett JA

更新日期：2006-02-01 00:00:00

abstract：:The acceleration of chronic obstructive pulmonary disease (COPD) by cigarette smoke (CS) in individuals with severe genetic deficiency of α(1)-antitrypsin (Z-AT [Glu342Lys]) exemplifies the critical importance of gene-environmental interactions to the development of COPD. We investigated the molecular basis for the in...

journal_title：American journal of respiratory cell and molecular biology

authors： Alam S,Li Z,Janciauskiene S,Mahadeva R

更新日期：2011-08-01 00:00:00

abstract：:Cigarette smoke (CS) is the main causative factor of chronic obstructive pulmonary disease (COPD). Current research supports the concept that airway inflammation is central to the development and progression of the disease. Studies have demonstrated that neutrophils are increased in COPD lungs and that neutrophil-asso...

journal_title：American journal of respiratory cell and molecular biology

authors： Cardini S,Dalli J,Fineschi S,Perretti M,Lungarella G,Lucattelli M

更新日期：2012-09-01 00:00:00

abstract：:Multiple cytokines play a role in the orchestration of inflammation in inflammatory airway diseases, such as chronic obstructive pulmonary disease, through the recruitment, activation and survival of inflammatory cells. Lymphokines secreted from T cells regulate the pattern of inflammation, whereas proinflammatory cyt...

journal_title：American journal of respiratory cell and molecular biology

authors： Barnes PJ

更新日期：2009-12-01 00:00:00

abstract：:We investigated the expression and function of matrix metalloproteinase-12 (MMP-12) in a model of allergic airway inflammation. Mice were sensitized mucosally by exposure to aerosolized ovalbumin (OVA) daily over a period of 10 d in the context of adenovirus-mediated granulocyte macrophage colony-stimulating factor (G...

journal_title：American journal of respiratory cell and molecular biology

authors： Pouladi MA,Robbins CS,Swirski FK,Cundall M,McKenzie AN,Jordana M,Shapiro SD,Stämpfli MR

更新日期：2004-01-01 00:00:00

abstract：:Cigarette smoking and aging are major risk factors for chronic obstructive pulmonary disease. An unsolved question is whether elderly lungs are particularly vulnerable to cigarette smoke (CS) exposure. In this study, we used a mouse model to test the hypothesis that aging increases the susceptibility to CS-induced pul...

journal_title：American journal of respiratory cell and molecular biology

authors： Moriyama C,Betsuyaku T,Ito Y,Hamamura I,Hata J,Takahashi H,Nasuhara Y,Nishimura M

更新日期：2010-03-01 00:00:00

abstract：:The cellular events involved in generating the hypoxic pulmonary vasoconstriction response are not clearly understood, in part because of the multitude of factors that alter pulmonary vascular tone. The goal of the present studies was to determine if a cell culture preparation containing vascular smooth muscle (VSM) c...

journal_title：American journal of respiratory cell and molecular biology

authors： Murray TR,Chen L,Marshall BE,Macarak EJ

更新日期：1990-11-01 00:00:00

abstract：:The transcription factor (TF) Foxp2 has been shown to partially repress surfactant protein C (SP-C) transcription, presumably through interaction of an independent repressor domain with a conserved Foxp2 consensus site in the SP-C promoter. We explored the role of interactions between Foxp2 and the homeodomain TF Nkx2...

journal_title：American journal of respiratory cell and molecular biology

authors： Zhou B,Zhong Q,Minoo P,Li C,Ann DK,Frenkel B,Morrisey EE,Crandall ED,Borok Z

更新日期：2008-06-01 00:00:00

abstract：:The chemokine TARC is a ligand for the chemokine receptor CCR4 expressed on T helper (Th)2-type CD4 T cells. Allergic airway inflammation is characterized by a local increase in cells secreting Th2-type cytokines. We hypothesized that bronchial epithelial cells may be a source of chemokines known to chemoattract Th2 c...

journal_title：American journal of respiratory cell and molecular biology

authors： Berin MC,Eckmann L,Broide DH,Kagnoff MF

更新日期：2001-04-01 00:00:00

abstract：:Rat alveolar type II pneumocytes, in situ, label with Maclura pomifera agglutinin (MPA), a plant lectin that recognizes alpha-galactosyl oligosaccharide residues of glycoproteins and glycolipids. To study the glycoproteins recognized by the lectin, MPA lectin affinity chromatography was used to isolate a novel glycopr...

journal_title：American journal of respiratory cell and molecular biology

authors： Lwebuga-Mukasa JS

更新日期：1991-06-01 00:00:00

abstract：:Genetic epidemiology studies of end-stage lung disease are potentially hindered by low numbers of participants due to early death of patients from the underlying disease, or due to exclusion from studies after patients have had lung transplants, because of concern about bias of genotype data due to chimerism. The numb...

journal_title：American journal of respiratory cell and molecular biology

authors： DeMeo DL,Reilly JJ,Ginns LC,Sylvia JS,Silverman EK

更新日期：2005-10-01 00:00:00

abstract：:Recent evidence suggests that the surface fluid secreted by human airway epithelial cells contains antimicrobial activity. The identification of the factor(s) responsible for the antibacterial activity in airway surface fluid may bring new insights into lung defense mechanisms and the pathogenesis of disease. Defensin...

journal_title：American journal of respiratory cell and molecular biology

authors： McCray PB Jr,Bentley L

更新日期：1997-03-01 00:00:00

abstract：:Wheeze is a common symptom in infants, but not all wheezers develop asthma. Indeed, up to 50% of wheezing children outgrow their symptoms by school age. How to predict if early wheeze will become asthma is still a matter of vivid debate. In this work, we sought to assess the clinical and pathological factors that migh...

journal_title：American journal of respiratory cell and molecular biology

authors： Bonato M,Bazzan E,Snijders D,Tinè M,Biondini D,Turato G,Balestro E,Papi A,Cosio MG,Barbato A,Baraldo S,Saetta M

更新日期：2018-10-01 00:00:00

abstract：:The doxycycline-inducible, gene regulatory system allows tight control of transgene expression for the study of organ development and disease pathogenesis. Multiple recent reports have employed this model to investigate various lung diseases including emphysema. For our study, we used this transgenic system to test wh...

journal_title：American journal of respiratory cell and molecular biology

authors： Sisson TH,Hansen JM,Shah M,Hanson KE,Du M,Ling T,Simon RH,Christensen PJ

更新日期：2006-05-01 00:00:00

abstract：:The human lung accumulates iron with senescence. Smoking escalates the accumulation of iron, and we have demonstrated regional variability in the accumulation of iron in smokers' lungs. Iron has been reported to influence the production of a number of proinflammatory mediators, including human interleukin (IL)-1beta. ...

journal_title：American journal of respiratory cell and molecular biology

authors： O'Brien-Ladner AR,Nelson SR,Murphy WJ,Blumer BM,Wesselius LJ

更新日期：2000-07-01 00:00:00

abstract：:Macrolides have been shown to be effective in treating diffuse panbronchiolitis (DPB), although the precise modes of action remain unclear. At sites of airway inflammation, respiratory epithelium is considered an active participant in regulating neutrophil survival. We therefore examined the effect of erythromycin, cl...

journal_title：American journal of respiratory cell and molecular biology

authors： Yamasawa H,Oshikawa K,Ohno S,Sugiyama Y

更新日期：2004-04-01 00:00:00

abstract：:Airway epithelial cells produce a number of chemokines, including eotaxins. Among the three known eotaxins, T helper (Th) type 2 cytokines have been observed to induce the expression of eotaxin-3 mRNA. This study investigated the effect of interferon (IFN)-gamma, a Th1 cytokine, on Th2 cytokine-induced eotaxin-3 produ...

journal_title：American journal of respiratory cell and molecular biology

authors： Yamamoto S,Kobayashi I,Tsuji K,Nishi N,Muro E,Miyazaki M,Zaitsu M,Inada S,Ichimaru T,Hamasaki Y

更新日期：2004-10-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a major disease of the lungs. It primarily occurs after a prolonged period of cigarette smoking. Chronic inflammation of airways and the alveolar space as well as lung tissue destruction are the hallmarks of COPD. Recently it has been shown that cellular senescence might...

journal_title：American journal of respiratory cell and molecular biology

authors： Kumar M,Seeger W,Voswinckel R

更新日期：2014-09-01 00:00:00

abstract：:Nitrogen dioxide (NO2) is a pollutant of both outdoor and indoor atmospheres that has the potential to alter alveolar epithelial permeability. In order to assess alterations in the protein content of alveolar lining fluid induced by brief (3-h) exposures to low-level NO2, normal volunteers were exposed sequentially to...

journal_title：American journal of respiratory cell and molecular biology

authors： Frampton MW,Finkelstein JN,Roberts NJ Jr,Smeglin AM,Morrow PE,Utell MJ

更新日期：1989-12-01 00:00:00