Hypoxic contraction of cultured pulmonary vascular smooth muscle cells.

abstract：:Cystic fibrosis (CF) is characterized by a dramatic neutrophil recruitment and repeated Pseudomonas infections in the lungs. To evaluate cytokine releasibility by airway epithelial cells in the context of CF, we studied primary nasal epithelial cells isolated from the upper airways and continuous epithelial cell lines...

journal_title：American journal of respiratory cell and molecular biology

authors： Bédard M,McClure CD,Schiller NL,Francoeur C,Cantin A,Denis M

更新日期：1993-10-01 00:00:00

abstract：:Tissue inhibitors of metalloproteinases (TIMPs) are multifunctional proteins that have the capacity to modify cellular activities and to modulate matrix turnover. We demonstrate that TIMP-1 messenger RNA (mRNA) and protein expression are selectively and markedly increased in a murine model of bleomycin-induced pulmona...

journal_title：American journal of respiratory cell and molecular biology

authors： Madtes DK,Elston AL,Kaback LA,Clark JG

更新日期：2001-05-01 00:00:00

abstract：:Oxidants in cigarette smoke inhibit pathogen recognition receptor function and phagocytosis, but the molecular basis of this inhibition remains obscure. We sought to identify the inhibitory mechanisms that impair alveolar macrophage function. Balb/c mice were acutely exposed to four cigarettes for 4 hours before treat...

journal_title：American journal of respiratory cell and molecular biology

authors： Bozinovski S,Vlahos R,Zhang Y,Lah LC,Seow HJ,Mansell A,Anderson GP

更新日期：2011-08-01 00:00:00

abstract：:The lung epithelium constitutes a selective barrier that separates the airways from the aqueous interstitial compartment. Regulated barrier function controls water and ion transport across the epithelium and is essential for maintaining lung function. Tight junctions (TJs) seal the epithelial barrier and determine the...

journal_title：American journal of respiratory cell and molecular biology

authors： Kielgast F,Schmidt H,Braubach P,Winkelmann VE,Thompson KE,Frick M,Dietl P,Wittekindt OH

更新日期：2016-05-01 00:00:00

abstract：:Endothelin-1 is a potent bronchoconstrictor peptide with pro-inflammatory and growth-promoting properties. After exposure of sensitized Brown-Norway rats to six repeated ovalbumin exposures, there was an increase in pro-endothelin (ET)-1 messenger RNA compared with saline-exposed control rats 24 h after the final expo...

journal_title：American journal of respiratory cell and molecular biology

authors： Salmon M,Liu YC,Mak JC,Rousell J,Huang TJ,Hisada T,Nicklin PL,Chung KF

更新日期：2000-11-01 00:00:00

abstract：:We previously described a reduction of silica-induced lung fibrosis in interleukin-10-deficient mice (IL-10-/-) (Huaux and colleagues; Am. J. Respir. Cell Mol. Biol. 1998;18:51-59). In the present study, we further dissect the exact functions of IL-10 in experimental silicosis. The reduced lung fibrotic response to si...

journal_title：American journal of respiratory cell and molecular biology

authors： Barbarin V,Arras M,Misson P,Delos M,McGarry B,Phan SH,Lison D,Huaux F

更新日期：2004-07-01 00:00:00

abstract：:Epithelial-mesenchymal cell interactions and factors that control normal lung development are key players in lung injury, repair, and fibrosis. A number of studies have investigated the roles and sources of epithelial progenitors during lung regeneration; such information, however, is limited in lung fibroblasts. Thus...

journal_title：American journal of respiratory cell and molecular biology

authors： Green J,Endale M,Auer H,Perl AK

更新日期：2016-04-01 00:00:00

abstract：:Human alveolar macrophages (HAM) express FcalphaR receptors for immunoglobulin (Ig)A which could link humoral and cellular branches of lung immunity. Here, we investigate the effects of polymeric (p-IgA) and secretory (S-IgA) IgA interaction with Fc(alpha)R on lipopolysaccharide (LPS)- and phorbol myristate acetate (P...

journal_title：American journal of respiratory cell and molecular biology

authors： Ouadrhiri Y,Pilette C,Monteiro RC,Vaerman JP,Sibille Y

更新日期：2002-03-01 00:00:00

abstract：:Vascular remodeling is an important pathological feature of pulmonary arterial hypertension (PAH), which leads to increased pulmonary vascular resistance, with marked proliferation of pulmonary artery smooth muscle cells (SMC) and/or endothelial cells (EC). Successful treatment of experimental PAH with a platelet-deri...

journal_title：American journal of respiratory cell and molecular biology

authors： Sakao S,Tatsumi K,Voelkel NF

更新日期：2010-12-01 00:00:00

abstract：:We have reported that von Hippel-Lindau protein (pVHL) expression is elevated in human and mouse fibrotic lungs and that overexpression of pVHL stimulates fibroblast proliferation. We sought to determine whether loss of pVHL in fibroblasts prevents injury and fibrosis in mice that are treated with bleomycin. We genera...

journal_title：American journal of respiratory cell and molecular biology

authors： Zhou Q,Chen T,Zhang W,Bozkanat M,Li Y,Xiao L,van Breemen RB,Christman JW,Sznajder JI,Zhou G

更新日期：2016-05-01 00:00:00

abstract：:Despite respiratory syncytial virus (RSV) bronchiolitis remaining the most common cause of lower respiratory tract disease in infants worldwide, treatment has progressed little in the past 30 years. The aim of our study was to determine whether post-infection administration of de novo pyrimidine synthesis inhibitors c...

journal_title：American journal of respiratory cell and molecular biology

authors： Davis IC,Lazarowski ER,Chen FP,Hickman-Davis JM,Sullender WM,Matalon S

更新日期：2007-10-01 00:00:00

abstract：:Morphologic changes are reported to occur in rat lung vasculature after 3 days of hypoxia. We have previously shown that immunoreactivity for the vasodilator calcitonin gene-related peptide (CGRP) is increased in pulmonary endocrine cells by 7 days of hypoxia. Because these cells may be among the earliest mediators of...

journal_title：American journal of respiratory cell and molecular biology

authors： Roncalli M,Springall DR,Maggioni M,Moradoghli-Haftvani A,Winter RJ,Zhao L,Coggi G,Polak JM

更新日期：1993-11-01 00:00:00

abstract：:Tissue factor (TF) is best known as a cellular initiator of coagulation, but it is also a multifunctional protein that has been implicated in multiple pathophysiologic conditions, including asthma. In the lung, airway epithelial cells express TF, but it is unknown how TF expression is regulated by asthma-associated me...

journal_title：American journal of respiratory cell and molecular biology

authors： Mitchel JA,Antoniak S,Lee JH,Kim SH,McGill M,Kasahara DI,Randell SH,Israel E,Shore SA,Mackman N,Park JA

更新日期：2016-04-01 00:00:00

abstract：:Macrophage inflammatory proteins 1 alpha and 2 (MIP-1 alpha, MIP-2) are members of a growing family of cytokines thought to play a role in host defense. MIP-1 alpha and MIP-2 were previously identified in the mouse and shown to stimulate inflammatory cell recruitment. To better understand the potential role of MIP-1 a...

journal_title：American journal of respiratory cell and molecular biology

authors： Driscoll KE,Hassenbein DG,Carter J,Poynter J,Asquith TN,Grant RA,Whitten J,Purdon MP,Takigiku R

更新日期：1993-03-01 00:00:00

abstract：:T lymphocytes and alveolar macrophages accumulating in the lower respiratory tract of patients with pulmonary sarcoidosis are known to be activated to produce several cytokines, presumably leading to granuloma formation within the lung. We hypothesized that these cells produce colony-stimulating factors (CSFs), which ...

journal_title：American journal of respiratory cell and molecular biology

authors： Itoh A,Yamaguchi E,Kuzumaki N,Okazaki N,Furuya K,Abe S,Kawakami Y

更新日期：1990-09-01 00:00:00

abstract：:We studied the relative roles of Duox2-derived reactive oxygen species (ROS) in host defense against influenza A virus (IAV) infection in normal human nasal epithelial cells and mouse nasal mucosa. We found that Duox2 primarily generated ROS rapidly after IAV infection in normal human nasal epithelial cells and that k...

journal_title：American journal of respiratory cell and molecular biology

authors： Kim HJ,Kim CH,Kim MJ,Ryu JH,Seong SY,Kim S,Lim SJ,Holtzman MJ,Yoon JH

更新日期：2015-10-01 00:00:00

abstract：:Little is known about whether maternal immune status during pregnancy influences asthma development in the child. We measured cytokine production in supernatants from mitogen-stimulated peripheral blood immune cells collected during and after pregnancy from the mothers of children enrolled in the Tucson Infant Immune ...

journal_title：American journal of respiratory cell and molecular biology

authors： Rothers J,Stern DA,Lohman IC,Spangenberg A,Wright AL,DeVries A,Vercelli D,Halonen M

更新日期：2018-11-01 00:00:00

abstract：:The primary function of neutrophils in host defense is to contain and eradicate invading microbial pathogens. This is achieved through a series of swift and highly coordinated responses culminating in ingestion (phagocytosis) and killing of invading microbes. While these tasks are usually performed without injury to h...

journal_title：American journal of respiratory cell and molecular biology

authors： Zemans RL,Colgan SP,Downey GP

更新日期：2009-05-01 00:00:00

abstract：:β(2)-Adrenoceptor (β2AR) agonists are the most effective class of bronchodilators and a mainstay of asthma management. The first potent β2AR agonist discovered and widely used in reversing the airway constriction associated with asthma exacerbation was the endogenous activator of the β2AR, epinephrine. In this study, ...

journal_title：American journal of respiratory cell and molecular biology

authors： Thanawala VJ,Forkuo GS,Al-Sawalha N,Azzegagh Z,Nguyen LP,Eriksen JL,Tuvim MJ,Lowder TW,Dickey BF,Knoll BJ,Walker JK,Bond RA

更新日期：2013-02-01 00:00:00

abstract：:Previous studies have shown that a single exposure of animals to ozone (O3) can induce protection or adaptation to the acute injurious effects of a subsequent O3 challenge. Although a number of mechanisms have been proposed to account for this response, none appear to be fully explanatory. We examined the role interle...

journal_title：American journal of respiratory cell and molecular biology

authors： McKinney WJ,Jaskot RH,Richards JH,Costa DL,Dreher KL

更新日期：1998-05-01 00:00:00

abstract：:Interleukin-13 (IL-13) is one of the central mediators for development of airway hyperresponsiveness in asthma. However, its effect on bronchial smooth muscle (BSM) is not well known. Recent studies revealed an involvement of RhoA/Rho-kinase in BSM contraction, and this pathway has now been proposed as a new target fo...

journal_title：American journal of respiratory cell and molecular biology

authors： Chiba Y,Nakazawa S,Todoroki M,Shinozaki K,Sakai H,Misawa M

更新日期：2009-02-01 00:00:00

abstract：:In the current study, we describe cytokine and Escherichia coli lipopolysaccharide (LPS) induction of nitric oxide (NO) synthase mRNA levels in cultured smooth muscle from rat pulmonary artery (RPASM). Exposure of RPASM to interleukin-1 beta, interferon-gamma, or LPS alone did not significantly affect NO synthesis, as...

journal_title：American journal of respiratory cell and molecular biology

authors： Nakayama DK,Geller DA,Lowenstein CJ,Chern HD,Davies P,Pitt BR,Simmons RL,Billiar TR

更新日期：1992-11-01 00:00:00

abstract：:To reach the sites of inflammation, neutrophils traverse the endothelium, its underlying basement membrane, and other barriers depending on the localization of the insulting agent. Whether neutrophil elastase (NE) plays a role in neutrophil recruitment to inflamed sites is still debatable. By exploiting mice deficient...

journal_title：American journal of respiratory cell and molecular biology

authors： Hirche TO,Atkinson JJ,Bahr S,Belaaouaj A

更新日期：2004-04-01 00:00:00

abstract：:Pulmonary accumulation of fibroblasts and myofibroblasts in idiopathic pulmonary fibrosis/usual interstitial pneumonia (IFP/UIP) has been linked to (1) increased migration of a circulating pool of fibrocytes, (2) cell proliferation, and (3) resistance to apoptosis. The mechanism of physiologic apoptosis of lung fibrob...

journal_title：American journal of respiratory cell and molecular biology

authors： Frankel SK,Cosgrove GP,Cha SI,Cool CD,Wynes MW,Edelman BL,Brown KK,Riches DW

更新日期：2006-03-01 00:00:00

abstract：:Recently, investigators demonstrated associations between fine particulate matter (PM)-associated metals and adverse health effects. Residual oil fly ash (ROFA), a waste product of fossil fuel combustion from boilers, is rich in the transition metals Fe, Ni, and V, and when released as a fugitive particle, is an impor...

journal_title：American journal of respiratory cell and molecular biology

authors： Farraj AK,Hazari MS,Haykal-Coates N,Lamb C,Winsett DW,Ge Y,Ledbetter AD,Carll AP,Bruno M,Ghio A,Costa DL

更新日期：2011-02-01 00:00:00

abstract：:IL-11 and IL-11 receptor (R)alpha are induced by Th2 cytokines. However, the role(s) of endogenous IL-11 in antigen-induced Th2 inflammation has not been fully defined. We hypothesized that IL-11, signaling via IL-11Ralpha, plays an important role in aeroallergen-induced Th2 inflammation and mucus metaplasia. To test ...

journal_title：American journal of respiratory cell and molecular biology

authors： Lee CG,Hartl D,Matsuura H,Dunlop FM,Scotney PD,Fabri LJ,Nash AD,Chen NY,Tang CY,Chen Q,Homer RJ,Baca M,Elias JA

更新日期：2008-12-01 00:00:00

abstract：:An understanding of the molecular pathogenesis of lung cancer has evolved from classic cytogenetic studies and the use of restriction fragment length polymorphisms to encompass the definition of specific genetic abnormalities associated with this disease. Activation of the dominant class of oncogenes is frequent, with...

journal_title：American journal of respiratory cell and molecular biology

authors： Viallet J,Minna JD

更新日期：1990-03-01 00:00:00

abstract：:Alveolar type II cells produce pulmonary surfactant and serve as the stem cell of the alveolar epithelium by proliferating and transforming into type I cells. The study of the differentiated function and proliferative capacity of type II cells in response to injury in vivo has been hindered by the complexity of the sy...

journal_title：American journal of respiratory cell and molecular biology

authors： Kinnard WV,Tuder R,Papst P,Fisher JH

更新日期：1994-10-01 00:00:00

abstract：:Neutrophil-associated inflammation during Pseudomonas aeruginosa lung infection is a determinant of morbidity in cystic fibrosis (CF). Neutrophil apoptosis is a key factor in inflammation resolution and is controlled by cytosolic proliferating cell nuclear antigen (PCNA). p21/Waf1, a cyclin-dependent kinase inhibitor,...

journal_title：American journal of respiratory cell and molecular biology

authors： Martin C,Ohayon D,Alkan M,Mocek J,Pederzoli-Ribeil M,Candalh C,Thevenot G,Millet A,Tamassia N,Cassatella MA,Thieblemont N,Burgel PR,Witko-Sarsat V

更新日期：2016-05-01 00:00:00

abstract：:Quantitative measurement of [3H]thymidine [( 3H]TdR) incorporation into cultured cells is widely used as an indicator of cell proliferation. The observation that adult type II cells are able to incorporate large amounts of [3H]TdR despite the fact that they are not proliferating raised the question of the meaning of [...

journal_title：American journal of respiratory cell and molecular biology

authors： Clement A,Riedel N,Brody JS

更新日期：1990-08-01 00:00:00