Dominant oncogenes and tumor suppressor genes in the pathogenesis of lung cancer.

abstract：:Serum contains a number of polypeptide growth factors, hormones, and soluble matrix components and may influence the state of differentiation of epithelial cells in general and of alveolar epithelial cells (AEC) in particular. To evaluate the influence of sera on the transition from the type II toward the type I cell ...

journal_title：American journal of respiratory cell and molecular biology

authors： Borok Z,Hami A,Danto SI,Zabski SM,Crandall ED

更新日期：1995-01-01 00:00:00

abstract：:The experiments described herein define a unique program of polarization of suspended human eosinophils stimulated with IL-5 family cytokines. We found that eosinophil granules and the nucleus move in opposite directions to form, respectively, a granular compartment and the nucleopod, a specialized uropod occupied by ...

journal_title：American journal of respiratory cell and molecular biology

authors： Han ST,Mosher DF

更新日期：2014-03-01 00:00:00

abstract：:The precise role of each nitric oxide (NO) synthase (NOS) isoform in the pathobiology of asthma is not well established. Our objective was to investigate the contribution of constitutive NO synthase (cNOS) and inducible NOS (iNOS) isoforms to lung mechanics and inflammatory and remodeling responses in an experimental ...

journal_title：American journal of respiratory cell and molecular biology

authors： Prado CM,Leick-Maldonado EA,Yano L,Leme AS,Capelozzi VL,Martins MA,Tibério IF

更新日期：2006-10-01 00:00:00

abstract：:Important characteristics of chronic obstructive pulmonary disease (COPD) include airway and vascular remodeling, the molecular mechanisms of which are poorly understood. We assessed the role of fibroblast growth factors (FGF) in pulmonary vascular remodeling by examining the expression pattern of FGF-1, FGF-2, and th...

journal_title：American journal of respiratory cell and molecular biology

authors： Kranenburg AR,De Boer WI,Van Krieken JH,Mooi WJ,Walters JE,Saxena PR,Sterk PJ,Sharma HS

更新日期：2002-11-01 00:00:00

abstract：:PS-341 is a highly selective and potent proteasome inhibitor that is cytotoxic to various types of cancer. However, no objective response was seen in a clinical trial with PS-341 as a single agent in non-small cell lung cancer. Its antitumor activity is limited by the simultaneously activated antiapoptosis pathway. Re...

journal_title：American journal of respiratory cell and molecular biology

authors： Lee KH,Jang AH,Yoo CG

更新日期：2015-09-01 00:00:00

abstract：:The extracellular signal-regulated kinases 1 and 2 (ERK1/2) are phosphorylated after inhalation of asbestos. The effect of blocking this signaling pathway in lung epithelium is unclear. Asbestos-exposed transgenic mice expressing a dominant-negative mitogen-activated protein kinase kinase-1 (dnMEK1) (i.e., the upstrea...

journal_title：American journal of respiratory cell and molecular biology

authors： Manning CB,Sabo-Attwood T,Robledo RF,Macpherson MB,Rincón M,Vacek P,Hemenway D,Taatjes DJ,Lee PJ,Mossman BT

更新日期：2008-05-01 00:00:00

abstract：:Acute lung injury (ALI) is a devastating disease with an overall mortality rate of 30 to 40%. The coagulation/fibrinolysis system is implicated in the pathogenesis of ALI. Thrombin-activatable fibronolysis inhibitor (TAFI) is an important component of the fibrinolysis system. Recent studies have shown that the active ...

journal_title：American journal of respiratory cell and molecular biology

authors： Naito M,Taguchi O,Kobayashi T,Takagi T,D'Alessandro-Gabazza CN,Matsushima Y,Boveda-Ruiz D,Gil-Bernabe P,Matsumoto T,Chelakkot-Govindalayathil AL,Toda M,Yasukawa A,Hataji O,Morser J,Takei Y,Gabazza EC

更新日期：2013-10-01 00:00:00

abstract：:Lung morphometry was introduced over 50 years ago to provide quantitative evaluation of the lung structure. The existing parameters, such as mean linear intercept and destructive index, suffer from simplistic data interpretation and a subjective data acquisition process. To overcome these existing shortcomings, parenc...

journal_title：American journal of respiratory cell and molecular biology

authors： Xiao R,Goldklang MP,D'Armiento JM

更新日期：2016-11-01 00:00:00

abstract：:We have previously reported that medium conditioned by hypoxic pulmonary artery endothelial cells (ECCM) contains a factor of small molecular weight that inhibits the growth of pulmonary artery smooth muscle cells (SMC). We postulated that this factor might be a breakdown product of ATP and, therefore, measured the le...

journal_title：American journal of respiratory cell and molecular biology

authors： Hassoun PM,Shedd AL,Lanzillo JJ,Thappa V,Landman MJ,Fanburg BL

更新日期：1992-06-01 00:00:00

abstract：:Pseudomonas aeruginosa, which may cause severe lung infections, secretes a metalloelastase that may interfere with the assay of neutrophil elastase and cathepsin G in lung secretions. Using nuclear magnetic resonance spectroscopy, we have shown that P. aeruginosa elastase (PsE) cleaves succinyl-Ala3-p-nitroanilide bet...

journal_title：American journal of respiratory cell and molecular biology

authors： Pelletier A,Dimicoli JL,Boudier C,Bieth JG

更新日期：1989-07-01 00:00:00

abstract：:Smoking cigarettes is the major risk factor for chronic obstructive pulmonary disease (COPD). COPD is a condition associated with chronic pulmonary inflammation, characterized by macrophage activation, neutrophil recruitment, and cell injury. Many substances contained in cigarette smoke, including reactive oxygen spec...

journal_title：American journal of respiratory cell and molecular biology

authors： Facchinetti F,Amadei F,Geppetti P,Tarantini F,Di Serio C,Dragotto A,Gigli PM,Catinella S,Civelli M,Patacchini R

更新日期：2007-11-01 00:00:00

abstract：:The etiology of acute lung injury is complex and associated with numerous, chemically diverse precipitating factors. During acute lung injury in mice, one key event is epithelial cell injury that leads to reduced surfactant biosynthesis. We have previously reported that transgenic mice that express transforming growth...

journal_title：American journal of respiratory cell and molecular biology

authors： Bein K,Wesselkamper SC,Liu X,Dietsch M,Majumder N,Concel VJ,Medvedovic M,Sartor MA,Henning LN,Venditto C,Borchers MT,Barchowsky A,Weaver TE,Tichelaar JW,Prows DR,Korfhagen TR,Hardie WD,Bachurski CJ,Leikauf GD

更新日期：2009-08-01 00:00:00

abstract：:Vascular remodeling is an important pathological feature of pulmonary arterial hypertension (PAH), which leads to increased pulmonary vascular resistance, with marked proliferation of pulmonary artery smooth muscle cells (SMC) and/or endothelial cells (EC). Successful treatment of experimental PAH with a platelet-deri...

journal_title：American journal of respiratory cell and molecular biology

authors： Sakao S,Tatsumi K,Voelkel NF

更新日期：2010-12-01 00:00:00

abstract：:Previous studies have shown that polymorphonuclear leukocytes (PMN) are delayed in the pulmonary capillaries by the presence of cigarette smoke. To determine if the PMN delayed by smoking are activated, we estimated the in vivo expression of CD11/CD18 and L-selectin on the surface of PMN in lungs and peripheral blood ...

journal_title：American journal of respiratory cell and molecular biology

authors： Klut ME,Doerschuk CM,Van Eeden SF,Burns AR,Hogg JC

更新日期：1993-07-01 00:00:00

abstract：:Although it is known that surfactant lipids and proteins are altered in patients with Pseudomonas aeruginosa infections, the mechanisms and implications of these alterations are not clear. In this study, the effects of P. aeruginosa on the surfactant large aggregate fraction were examined using an in vitro surface are...

journal_title：American journal of respiratory cell and molecular biology

authors： Beatty AL,Malloy JL,Wright JR

更新日期：2005-02-01 00:00:00

abstract：:Recent evidence suggests that tyrosine kinases play an important role in signal transduction mechanisms utilized by a range of different agonists in many cell types. We have investigated the effects of four different inhibitors of tyrosine kinases on IgE-dependent histamine release from human lung mast cells and basop...

journal_title：American journal of respiratory cell and molecular biology

authors： Lavens SE,Peachell PT,Warner JA

更新日期：1992-12-01 00:00:00

abstract：:DNA double-strand breaks (DSBs) can result in cell death or genetic alterations when cells are subjected to radiation, exposure to toxins, or other environmental stresses. A complex DNA-damage-response pathway is activated to repair the damage, and the inability to repair these breaks can lead to carcinogenesis. One o...

journal_title：American journal of respiratory cell and molecular biology

authors： Msiska Z,Pacurari M,Mishra A,Leonard SS,Castranova V,Vallyathan V

更新日期：2010-08-01 00:00:00

abstract：:Human tracheal gland serous (HTGS) cells are now considered one principal pulmonary target for the gene therapy of cystic fibrosis (CF). We developed a CF tracheal gland serous cell line, CF-KM4, obtained by the transformation of primary cultures of CF tracheal gland serous cells homozygous for the DeltaF508 mutation ...

journal_title：American journal of respiratory cell and molecular biology

authors： Kammouni W,Moreau B,Becq F,Saleh A,Pavirani A,Figarella C,Merten MD

更新日期：1999-04-01 00:00:00

abstract：:Opiate-like peptides can regulate many cellular functions. We now map [D-Ala(2)]deltorphin I (DADTI)-like immunoreactivity (DADTI-LI) in developing mouse lung and analyze potential functional roles. Most DADTI-LI-positive cells were alveolar cells negative for prosurfactant protein (proSP)-C immunoreactivity. Peak num...

journal_title：American journal of respiratory cell and molecular biology

authors： Sunday ME,Haley KJ,Emanuel RL,Torday JS,Asokananthan N,Sikorski KA,Tooyama I,Kimura H,Renda T,Erspamer V

更新日期：2001-10-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF alpha) is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils, and it can promote mediator and cytokine release, adhesion molecule expression, and granulocyte migration. Therefore, we induced an IgE-mediated response in ...

journal_title：American journal of respiratory cell and molecular biology

authors： Casale TB,Costa JJ,Galli SJ

更新日期：1996-07-01 00:00:00

abstract：:Mucus hypersecretion is characteristic of chronic airway diseases. However, regulatory mechanisms are poorly understood. Human airway epithelial cells grown on permeable supports at the air-liquid interface (ALI) develop a mucociliary morphology resembling that found in vivo. Such cultures provide a model for studying...

journal_title：American journal of respiratory cell and molecular biology

authors： Bernacki SH,Nelson AL,Abdullah L,Sheehan JK,Harris A,Davis CW,Randell SH

更新日期：1999-04-01 00:00:00

abstract：:The application of conditional reprogramming culture (CRC) methods to nasal airway epithelial cells would allow more wide-spread incorporation of primary airway epithelial culture models into complex lung disease research. In this study, we adapted the CRC method to nasal airway epithelial cells, investigated the grow...

journal_title：American journal of respiratory cell and molecular biology

authors： Reynolds SD,Rios C,Wesolowska-Andersen A,Zhuang Y,Pinter M,Happoldt C,Hill CL,Lallier SW,Cosgrove GP,Solomon GM,Nichols DP,Seibold MA

更新日期：2016-09-01 00:00:00

abstract：:Aging is associated with metabolic diseases such as type 2 diabetes mellitus, cardiovascular disease, cancer, and neurodegeneration. Aging contributes to common processes including metabolic dysfunction, DNA damage, and reactive oxygen species generation. Although glycolysis has been linked to cell growth and prolifer...

journal_title：American journal of respiratory cell and molecular biology

authors： Cho SJ,Moon JS,Lee CM,Choi AM,Stout-Delgado HW

更新日期：2017-04-01 00:00:00

abstract：:Recent evidence from genetic experiments in yeast and from studies using guanosine triphosphate (GTP) analogues in mammalian cells suggests a key role for low-molecular-mass GTP-binding proteins (LMM-GBPs) (Mr 19 to 28 kD) in processes of intracellular vesicular sorting and secretion. Assembly and exocytosis of the la...

journal_title：American journal of respiratory cell and molecular biology

authors： Rubins JB,Panchenko M,Shannon TM,Dickey BF

更新日期：1992-03-01 00:00:00

abstract：:Airway allergen exposure induces inflammation among individuals with atopy that is characterized by altered airway gene expression, elevated levels of T helper type 2 cytokines, mucus hypersecretion, and airflow obstruction. To identify the genetic determinants of the airway allergen response, we employed a systems ge...

journal_title：American journal of respiratory cell and molecular biology

authors： Kelada SN,Carpenter DE,Aylor DL,Chines P,Rutledge H,Chesler EJ,Churchill GA,Pardo-Manuel de Villena F,Schwartz DA,Collins FS

更新日期：2014-09-01 00:00:00

abstract：:Transformation-related protein 63-expressing (p63(+)) basal cells are confined to the trachea in the mouse lung. However, after influenza virus infection or bleomycin treatment, patches of p63(+) cells were observed in the damaged lung parenchyma. To address whether the newly induced p63(+) cells are derived from the ...

journal_title：American journal of respiratory cell and molecular biology

authors： Zheng D,Yin L,Chen J

更新日期：2014-03-01 00:00:00

abstract：:Surfactant is an apically-secreted surface-active material containing primarily disaturated phosphatidylcholine (DSPtdCho) that is released from alveolar epithelia into the alveolus. Surfactant deficiency is an important aspect of inflammatory lung disease and may result from extravasation of serum lipoproteins into t...

journal_title：American journal of respiratory cell and molecular biology

authors： Agassandian M,Mathur SN,Zhou J,Field FJ,Mallampalli RK

更新日期：2004-08-01 00:00:00

abstract：:The pathological hallmarks of bronchopulmonary dysplasia (BPD), a chronic lung disease of premature infants, include inflammation, arrested alveolarization, and dysregulated angiogenesis. Severe BPD is often complicated by pulmonary hypertension (PH) that significantly increases morbidity and mortality. Glycogen synth...

journal_title：American journal of respiratory cell and molecular biology

authors： Hummler SC,Rong M,Chen S,Hehre D,Alapati D,Wu S

更新日期：2013-05-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) expression and PGE2 secretion from human airway smooth muscle cells (hASMCs) may contribute to β2-adrenoceptor hyporesponsiveness, a clinical feature observed in some patients with asthma. hASMCs from patients with asthma exhibit elevated expression of cytokine-responsive genes, and in some in...

journal_title：American journal of respiratory cell and molecular biology

authors： Comer BS,Camoretti-Mercado B,Kogut PC,Halayko AJ,Solway J,Gerthoffer WT

更新日期：2015-04-01 00:00:00

abstract：:Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are major causes of acute respiratory failure with high rates of morbidity and mortality. Although surfactant protein (SP)-D plays a critical role in pulmonary innate immunity and several clinical studies suggest that this protein...

journal_title：American journal of respiratory cell and molecular biology

authors： King BA,Kingma PS

更新日期：2011-05-01 00:00:00