Effects of nitric oxide synthases in chronic allergic airway inflammation and remodeling.

abstract：:Nitric oxide (NO) is an important regulator of Na(+) reabsorption by pulmonary epithelial cells and therefore of alveolar fluid clearance. The mechanisms by which NO affects epithelial ion transport are poorly understood and vary from model to model. In this study, the effects of NO on sodium reabsorption by H441 cell...

journal_title：American journal of respiratory cell and molecular biology

authors： Althaus M,Pichl A,Clauss WG,Seeger W,Fronius M,Morty RE

更新日期：2011-01-01 00:00:00

abstract：:Neutrophil elastase (NE) is a major inflammatory mediator in cystic fibrosis (CF) that is a robust predictor of lung disease progression. NE directly causes airway injury via protease activity, and propagates persistent neutrophilic inflammation by up-regulation of neutrophil chemokine expression. Despite its key role...

journal_title：American journal of respiratory cell and molecular biology

authors： Griffin KL,Fischer BM,Kummarapurugu AB,Zheng S,Kennedy TP,Rao NV,Foster WM,Voynow JA

更新日期：2014-04-01 00:00:00

abstract：:Bleomycin-induced lung disease is characterized by cell injury followed by fibroblast proliferation. Cells respond to injury by synthesizing a family of heat shock proteins. These proteins are critical to cell survival, and those of the 70,000 MW group (hsp 70) are essential for cell division and proliferation. To eva...

journal_title：American journal of respiratory cell and molecular biology

authors： Moseley PL,York SJ,York J

更新日期：1989-08-01 00:00:00

abstract：:Inflammatory lung diseases are associated with increased production of matrix metalloproteinase-9 (MMP-9) from infiltrating granulocytes or from the respiratory epithelium, and inappropriate expression and activation of MMP-9 may be associated with tissue injury and airway remodeling. Inflammatory conditions also resu...

journal_title：American journal of respiratory cell and molecular biology

authors： Okamoto T,Valacchi G,Gohil K,Akaike T,van der Vliet A

更新日期：2002-10-01 00:00:00

abstract：:Acute lung injury (ALI) is a devastating disease with an overall mortality rate of 30 to 40%. The coagulation/fibrinolysis system is implicated in the pathogenesis of ALI. Thrombin-activatable fibronolysis inhibitor (TAFI) is an important component of the fibrinolysis system. Recent studies have shown that the active ...

journal_title：American journal of respiratory cell and molecular biology

authors： Naito M,Taguchi O,Kobayashi T,Takagi T,D'Alessandro-Gabazza CN,Matsushima Y,Boveda-Ruiz D,Gil-Bernabe P,Matsumoto T,Chelakkot-Govindalayathil AL,Toda M,Yasukawa A,Hataji O,Morser J,Takei Y,Gabazza EC

更新日期：2013-10-01 00:00:00

abstract：:Histamine is an important mediator in the pathogenesis of asthma. Variation in genes along the histamine production, response, and degradation pathway may be important in predicting response to antihistamines. We hypothesize that differences exist among single-nucleotide polymorphisms (SNPs) in genes of the histamine ...

journal_title：American journal of respiratory cell and molecular biology

authors： Anvari S,Vyhlidal CA,Dai H,Jones BL

更新日期：2015-12-01 00:00:00

abstract：:IL-1β is a potent proinflammatory cytokine that is implicated in the pathogenesis of acute respiratory distress syndrome. We hypothesized that LPS and mechanical ventilation (MV) together could lead to IL-1β secretion and the development of acute lung injury (ALI), and that this process would be dependent on caspase-1...

journal_title：American journal of respiratory cell and molecular biology

authors： Jones HD,Crother TR,Gonzalez-Villalobos RA,Jupelli M,Chen S,Dagvadorj J,Arditi M,Shimada K

更新日期：2014-02-01 00:00:00

abstract：:A comprehensive investigation of the morphology of human airway epithelial tight junctions was carried out by freeze-fracture electron microscopy using quantitative methods designed to analyze a range of junctional characteristics. Extrapulmonary bronchi that appeared grossly normal were taken at sites distant from tu...

journal_title：American journal of respiratory cell and molecular biology

authors： Godfrey RW,Severs NJ,Jeffery PK

更新日期：1992-04-01 00:00:00

abstract：:Fibronectin (FN) is an extracellular matrix protein that acts as a substrate for cell migration and adhesion during development. FN adheres to cells through a dimeric membrane protein, the FN receptor. Antibodies to FN and synthetic peptides that inhibit FN-receptor interaction inhibit gastrulation, block neural crest...

journal_title：American journal of respiratory cell and molecular biology

authors： Dean DC

更新日期：1989-07-01 00:00:00

abstract：:It is known that interleukin (IL)-23, an IL-12-family cytokine, can be released by certain antigen-presenting cells in response to bacterial pathogens. Recent in vitro studies indicate that this cytokine stimulates a unique subset of CD4 cells, the T helper cell (Th)17 subset, to produce and release the proinflammator...

journal_title：American journal of respiratory cell and molecular biology

authors： Ivanov S,Bozinovski S,Bossios A,Valadi H,Vlahos R,Malmhäll C,Sjöstrand M,Kolls JK,Anderson GP,Lindén A

更新日期：2007-04-01 00:00:00

abstract：:We examined the ability of the human surfactant protein B (SP-B) promoter to confer cell specificity of transgene expression in an adenoviral vector. Using similar replication-deficient adenoviruses (rAd), we compared lacZ reporter gene expression driven by the human SP-B promoter (rAd.SPBlacZ) with the ubiquitously e...

journal_title：American journal of respiratory cell and molecular biology

authors： Strayer MS,Guttentag SH,Ballard PL

更新日期：1998-01-01 00:00:00

abstract：:Notch is an ancient cell-signaling system that regulates the specification of cell fate. This study examined the role of Notch in the epithelial-mesenchymal transition (EMT) and myofibroblast differentiation of cultured RLE-6TN cells (i.e., rat alveolar epithelial cells). The activation of Notch, either by ectopic exp...

journal_title：American journal of respiratory cell and molecular biology

authors： Aoyagi-Ikeda K,Maeno T,Matsui H,Ueno M,Hara K,Aoki Y,Aoki F,Shimizu T,Doi H,Kawai-Kowase K,Iso T,Suga T,Arai M,Kurabayashi M

更新日期：2011-07-01 00:00:00

abstract：:Motile cilia are essential for clearance of particulates and pathogens from airways. For effective transport, ciliary motor proteins and axonemal structures interact to generate the rhythmic, propulsive bending, but the mechanisms that produce a dynamic waveform remain incompletely understood. Biomechanical measures o...

journal_title：American journal of respiratory cell and molecular biology

authors： Oltean A,Schaffer AJ,Bayly PV,Brody SL

更新日期：2018-10-01 00:00:00

abstract：:Chronic airway infections with Pseudomonas aeruginosa determine morbidity in most individuals with cystic fibrosis (CF). P. aeruginosa may persist for decades in CF lungs, which provides a rare opportunity to study the long-term within-host evolution of a bacterial airway pathogen. In this work, we sought to resolve t...

journal_title：American journal of respiratory cell and molecular biology

authors： Klockgether J,Cramer N,Fischer S,Wiehlmann L,Tümmler B

更新日期：2018-08-01 00:00:00

abstract：:Surfactant is an apically-secreted surface-active material containing primarily disaturated phosphatidylcholine (DSPtdCho) that is released from alveolar epithelia into the alveolus. Surfactant deficiency is an important aspect of inflammatory lung disease and may result from extravasation of serum lipoproteins into t...

journal_title：American journal of respiratory cell and molecular biology

authors： Agassandian M,Mathur SN,Zhou J,Field FJ,Mallampalli RK

更新日期：2004-08-01 00:00:00

abstract：:Lung development is associated with a surge in surfactant phosphatidylcholine (PC) production to prepare the newborn for extrauterine breathing. This process is associated with a marked increase in the activity of the rate-regulatory surfactant enzyme, CTP:phosphocholine cytidylyltransferase (CCTalpha). To investigate...

journal_title：American journal of respiratory cell and molecular biology

authors： McCoy DM,Fisher K,Robichaud J,Ryan AJ,Mallampalli RK

更新日期：2006-09-01 00:00:00

abstract：:Lung granulomas are associated with numerous conditions, including inflammatory disorders, exposure to environmental pollutants, and infection. Osteopontin is a chemotactic cytokine produced by macrophages, and is implicated in extracellular matrix remodeling. Furthermore, osteopontin is up-regulated in granulomatous ...

journal_title：American journal of respiratory cell and molecular biology

authors： Huizar I,Malur A,Midgette YA,Kukoly C,Chen P,Ke PC,Podila R,Rao AM,Wingard CJ,Dobbs L,Barna BP,Kavuru MS,Thomassen MJ

更新日期：2011-10-01 00:00:00

abstract：:Specific changes in composition and content of lung extracellular matrix (ECM) proteoglycans (PGs) and hyaluronan (HA) have been observed during the acute response to damage in several forms of injury including infant respiratory distress syndrome (IRDS). These ECM components are thought to modulate the healing respon...

journal_title：American journal of respiratory cell and molecular biology

authors： Juul SE,Krueger RC Jr,Scofield L,Hershenson MB,Schwartz NB

更新日期：1995-12-01 00:00:00

abstract：:Heritable pulmonary arterial hypertension (HPAH) is a serious lung vascular disease caused by heterozygous mutations in the bone morphogenetic protein (BMP) pathway genes, BMPR2 and SMAD9. One noncanonical function of BMP signaling regulates biogenesis of a subset of microRNAs. We have previously shown that this funct...

journal_title：American journal of respiratory cell and molecular biology

authors： Drake KM,Dunmore BJ,McNelly LN,Morrell NW,Aldred MA

更新日期：2013-09-01 00:00:00

abstract：:A number of mechanisms participate in virus-induced asthma. Previously, we described enhanced basophil histamine release (HR) during an experimentally induced rhinovirus infection and after in vitro incubation of peripheral blood mononuclear cells (PBMC) with influenza virus. This study extends our previous observatio...

journal_title：American journal of respiratory cell and molecular biology

authors： Huftel MA,Swensen CA,Borcherding WR,Dick EC,Hong R,Kita H,Gleich GJ,Busse WW

更新日期：1992-10-01 00:00:00

abstract：:Macrophages are the primary lung phagocyte and are instrumental in maintenance of a sterile, noninflamed microenvironment. IFNs are produced in response to bacterial and viral infection, and activate the macrophage to efficiently counteract and remove pathogenic invaders. Respiratory syncytial virus (RSV) inhibits IFN...

journal_title：American journal of respiratory cell and molecular biology

authors： Senft AP,Taylor RH,Lei W,Campbell SA,Tipper JL,Martinez MJ,Witt TL,Clay CC,Harrod KS

更新日期：2010-04-01 00:00:00

abstract：:Monkey Clara cell 10 kDa protein (CC10) was purified from monkey lung lavage. This protein showed an apparent molecular weight of about 10 kDa and 5 kDa under non-reducing and reducing conditions, respectively, as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. From the amino acid sequence dat...

journal_title：American journal of respiratory cell and molecular biology

authors： Hashimoto S,Nakagawa K,Sueishi K

更新日期：1996-09-01 00:00:00

abstract：:The role of guanine nucleotide-binding proteins in the induction of prostacyclin synthesis by stimulated endothelial cells is incompletely understood. We report that sodium fluoride (NaF), a potent activator of cellular guanine nucleotide-binding proteins, affected time- and concentration-dependent generation of prost...

journal_title：American journal of respiratory cell and molecular biology

authors： Garcia JG,Dominguez J,English D

更新日期：1991-08-01 00:00:00

abstract：:The present study utilized the monocrotaline (MCT) model of pulmonary hypertension in rats to examine temporal alterations in steady-state levels of basement membrane (BM) component mRNA and deposition of protein using Northern analysis and immunohistochemistry, respectively. MCT (60 mg/kg, subcutaneous) produced sust...

journal_title：American journal of respiratory cell and molecular biology

authors： Lipke DW,Arcot SS,Gillespie MN,Olson JW

更新日期：1993-10-01 00:00:00

abstract：:Since the lung is repeatedly subjected to injury by pathogens and toxicants, maintenance of pulmonary homeostasis requires rapid repair of its epithelial surfaces. Ciliated bronchiolar epithelial cells, previously considered as terminally differentiated, underwent squamous cell metaplasia within hours after bronchiola...

journal_title：American journal of respiratory cell and molecular biology

authors： Park KS,Wells JM,Zorn AM,Wert SE,Laubach VE,Fernandez LG,Whitsett JA

更新日期：2006-02-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) is a cytokine implicated in wound healing and in the pathogenesis of pulmonary fibrosis. TGF-beta stimulates myofibroblast differentiation characterized by expression of contractile smooth muscle (SM)-specific proteins such as SM-alpha-actin. In the present study, we examined...

journal_title：American journal of respiratory cell and molecular biology

authors： Sandbo N,Kregel S,Taurin S,Bhorade S,Dulin NO

更新日期：2009-09-01 00:00:00

abstract：:Species in the genus Pneumocystis can cause severe pneumonia in immune-compromised hosts. The identification of specific targets present in Pneumocystis species, but lacking in mammalian hosts, is paramount to developing new means to treat this infection. One such potential protein is Rtt109, which is a type of histon...

journal_title：American journal of respiratory cell and molecular biology

authors： Kottom TJ,Han J,Zhang Z,Limper AH

更新日期：2011-06-01 00:00:00

abstract：:The pathological hallmarks of bronchopulmonary dysplasia (BPD), a chronic lung disease of premature infants, include inflammation, arrested alveolarization, and dysregulated angiogenesis. Severe BPD is often complicated by pulmonary hypertension (PH) that significantly increases morbidity and mortality. Glycogen synth...

journal_title：American journal of respiratory cell and molecular biology

authors： Hummler SC,Rong M,Chen S,Hehre D,Alapati D,Wu S

更新日期：2013-05-01 00:00:00

abstract：:Heme oxygenase (HO)-1, an inducible, low-molecular-weight stress protein, confers cellular and tissue protection in multiple models of injury and disease, including oxidative or inflammatory lung injury, ischemia/reperfusion (I/R) injuries, and vascular injury/disease. The tissue protection provided by HO-1 potentiall...

journal_title：American journal of respiratory cell and molecular biology

authors： Ryter SW,Morse D,Choi AM

更新日期：2007-02-01 00:00:00

abstract：:The inflammatory process plays a crucial role in the onset and progression of several lung pathologies, including cystic fibrosis (CF), and the involvement of NF-κB is widely recognized. The specific inhibition of NF-κB by decoy oligonucleotides delivered within the lung may be beneficial, although rationally designed...

journal_title：American journal of respiratory cell and molecular biology

authors： De Stefano D,Coletta C,Bianca Rd,Falcone L,d'Angelo I,Ungaro F,Quaglia F,Carnuccio R,Sorrentino R

更新日期：2013-08-01 00:00:00