Carbon monoxide and bilirubin: potential therapies for pulmonary/vascular injury and disease.

abstract：:Recent evidence suggests that tyrosine kinases play an important role in signal transduction mechanisms utilized by a range of different agonists in many cell types. We have investigated the effects of four different inhibitors of tyrosine kinases on IgE-dependent histamine release from human lung mast cells and basop...

journal_title：American journal of respiratory cell and molecular biology

authors： Lavens SE,Peachell PT,Warner JA

更新日期：1992-12-01 00:00:00

abstract：:Isoprostanes are prostaglandin-like molecules that accumulate in oxidative stress and also exert powerful biological effects on a wide variety of tissues. We investigated the effects of several different isoprostanes on contractions evoked by electrical field stimulation (EFS) in bovine trachealis, finding only 15-E2t...

journal_title：American journal of respiratory cell and molecular biology

authors： Paredes C,Tazzeo T,Janssen LJ

更新日期：2007-12-01 00:00:00

abstract：:Alveolar type II cells produce pulmonary surfactant and serve as the stem cell of the alveolar epithelium by proliferating and transforming into type I cells. The study of the differentiated function and proliferative capacity of type II cells in response to injury in vivo has been hindered by the complexity of the sy...

journal_title：American journal of respiratory cell and molecular biology

authors： Kinnard WV,Tuder R,Papst P,Fisher JH

更新日期：1994-10-01 00:00:00

abstract：:Although mast cell secretion has been intensively studied because of its pivotal role in allergic reactions and its advantages as a physiologic model, the molecular composition of the secretory machine is virtually unknown. In view of the guanine-nucleotide dependency of mast cell exocytosis and the participation of R...

journal_title：American journal of respiratory cell and molecular biology

authors： Tuvim MJ,Adachi R,Chocano JF,Moore RH,Lampert RM,Zera E,Romero E,Knoll BJ,Dickey BF

更新日期：1999-01-01 00:00:00

abstract：:Pure nicotine impairs macrophage killing of Mycobacterium tuberculosis (MTB), but it is not known whether the nicotine component in cigarette smoke (CS) plays a role. Moreover, the mechanisms by which nicotine impairs macrophage immunity against MTB have not been explored. To neutralize the effects of nicotine in CS e...

journal_title：American journal of respiratory cell and molecular biology

authors： Bai X,Stitzel JA,Bai A,Zambrano CA,Phillips M,Marrack P,Chan ED

更新日期：2017-09-01 00:00:00

abstract：:The inflammatory process plays a crucial role in the onset and progression of several lung pathologies, including cystic fibrosis (CF), and the involvement of NF-κB is widely recognized. The specific inhibition of NF-κB by decoy oligonucleotides delivered within the lung may be beneficial, although rationally designed...

journal_title：American journal of respiratory cell and molecular biology

authors： De Stefano D,Coletta C,Bianca Rd,Falcone L,d'Angelo I,Ungaro F,Quaglia F,Carnuccio R,Sorrentino R

更新日期：2013-08-01 00:00:00

abstract：:Cystic fibrosis (CF) is a lethal genetic disease characterized by progressive lung damage and airway obstruction. The majority of patients demonstrate airway hyperresponsiveness (AHR), which is associated with more rapid lung function decline. Recent studies in the neonatal CF pig demonstrated airway smooth muscle (AS...

journal_title：American journal of respiratory cell and molecular biology

authors： Kramer EL,Madala SK,Hudock KM,Davidson C,Clancy JP

更新日期：2020-05-01 00:00:00

abstract：:The pathological hallmarks of bronchopulmonary dysplasia (BPD), a chronic lung disease of premature infants, include inflammation, arrested alveolarization, and dysregulated angiogenesis. Severe BPD is often complicated by pulmonary hypertension (PH) that significantly increases morbidity and mortality. Glycogen synth...

journal_title：American journal of respiratory cell and molecular biology

authors： Hummler SC,Rong M,Chen S,Hehre D,Alapati D,Wu S

更新日期：2013-05-01 00:00:00

abstract：:Pulmonary artery hypertension (PAH) is a rare and fatal disorder that involves extensive remodeling of the pulmonary arteries mediated by hyperproliferation of pulmonary artery smooth muscle cells (PASMCs). Aberrant platelet-derived growth factor (PDGF) activity can lead to hyperproliferation of PASMCs; however, littl...

journal_title：American journal of respiratory cell and molecular biology

authors： Chen J,Guo J,Cui X,Dai Y,Tang Z,Qu J,Raj JU,Hu Q,Gou D

更新日期：2018-02-01 00:00:00

abstract：:It is known that interleukin (IL)-23, an IL-12-family cytokine, can be released by certain antigen-presenting cells in response to bacterial pathogens. Recent in vitro studies indicate that this cytokine stimulates a unique subset of CD4 cells, the T helper cell (Th)17 subset, to produce and release the proinflammator...

journal_title：American journal of respiratory cell and molecular biology

authors： Ivanov S,Bozinovski S,Bossios A,Valadi H,Vlahos R,Malmhäll C,Sjöstrand M,Kolls JK,Anderson GP,Lindén A

更新日期：2007-04-01 00:00:00

abstract：:Heritable pulmonary arterial hypertension (HPAH) is a serious lung vascular disease caused by heterozygous mutations in the bone morphogenetic protein (BMP) pathway genes, BMPR2 and SMAD9. One noncanonical function of BMP signaling regulates biogenesis of a subset of microRNAs. We have previously shown that this funct...

journal_title：American journal of respiratory cell and molecular biology

authors： Drake KM,Dunmore BJ,McNelly LN,Morrell NW,Aldred MA

更新日期：2013-09-01 00:00:00

abstract：:IL-13 is a T-helper class 2 cytokine that induces goblet cell hyperplasia and mucus production in airway epithelial cells. Because macrolide antibiotics are known to have immunomodulatory and mucoregulatory properties, the aim of this study was to examine the effect of clarithromycin on IL-13-induced goblet cell hyper...

journal_title：American journal of respiratory cell and molecular biology

authors： Tanabe T,Kanoh S,Tsushima K,Yamazaki Y,Kubo K,Rubin BK

更新日期：2011-11-01 00:00:00

abstract：:IL-15 has recently been shown to induce the differentiation of functional dendritic cells (DCs) from human peripheral blood monocytes. Since DCs lay in close proximity to epithelial cells in the airway mucosa, we investigated whether airway epithelial cells release IL-15 in response to inflammatory stimuli and thereby...

journal_title：American journal of respiratory cell and molecular biology

authors： Regamey N,Obregon C,Ferrari-Lacraz S,van Leer C,Chanson M,Nicod LP,Geiser T

更新日期：2007-07-01 00:00:00

abstract：:Pseudomonas aeruginosa, which may cause severe lung infections, secretes a metalloelastase that may interfere with the assay of neutrophil elastase and cathepsin G in lung secretions. Using nuclear magnetic resonance spectroscopy, we have shown that P. aeruginosa elastase (PsE) cleaves succinyl-Ala3-p-nitroanilide bet...

journal_title：American journal of respiratory cell and molecular biology

authors： Pelletier A,Dimicoli JL,Boudier C,Bieth JG

更新日期：1989-07-01 00:00:00

abstract：:Airway infections or irritant exposures during early postnatal periods may contribute to the onset of childhood asthma. The purpose of this study was to examine critical periods of postnatal airway development during which ozone (O(3)) exposure leads to heightened neural responses. Rats were exposed to O(3) (2 ppm) or...

journal_title：American journal of respiratory cell and molecular biology

authors： Hunter DD,Wu Z,Dey RD

更新日期：2010-12-01 00:00:00

abstract：:The primary function of neutrophils in host defense is to contain and eradicate invading microbial pathogens. This is achieved through a series of swift and highly coordinated responses culminating in ingestion (phagocytosis) and killing of invading microbes. While these tasks are usually performed without injury to h...

journal_title：American journal of respiratory cell and molecular biology

authors： Zemans RL,Colgan SP,Downey GP

更新日期：2009-05-01 00:00:00

abstract：:Alveolar macrophages (AMs) play an important role in the regulation of the local immune reactivity in the lung. It was previously shown that exposure of rats to mild inescapable electrical footshock stress (20 min, 4 shocks/min, 5 s/shock, 0.8 mAmp) leads to apparent changes in the activity of AMs upon stimulation, re...

journal_title：American journal of respiratory cell and molecular biology

authors： Broug-Holub E,Persoons JH,Schornagel K,Mastbergen SC,Kraal G

更新日期：1998-11-01 00:00:00

abstract：:Although neutrophil migration from the systemic circulation involves the beta2- (or CD18) integrin family, the existence of an alternative, CD18-independent route of neutrophil extravasation to tissues has been demonstrated in animal models. The molecular interactions involved in this alternative migratory route have ...

journal_title：American journal of respiratory cell and molecular biology

authors： Mackarel AJ,Russell KJ,Brady CS,FitzGerald MX,O'Connor CM

更新日期：2000-08-01 00:00:00

abstract：:β-Arrestin-2 (βarr2) is a ubiquitously expressed cytosolic protein that terminates G protein-coupled receptor signaling and transduces G protein-independent signaling. We previously showed that mice lacking βarr2 do not develop an asthma phenotype when sensitized to, and challenged with, allergens. The current study e...

journal_title：American journal of respiratory cell and molecular biology

authors： Chen M,Hegde A,Choi YH,Theriot BS,Premont RT,Chen W,Walker JK

更新日期：2015-09-01 00:00:00

abstract：:The objective of this study was to define phenotypic changes of antigen-presenting cells (APCs) and T cells in a murine model of antigen-induced airways inflammation that involves intraperitoneal sensitization with ovalbumin (OVA)/adjuvant followed by antigen aerosolization. We investigated the APC and T-cell compartm...

journal_title：American journal of respiratory cell and molecular biology

authors： Gajewska BU,Swirski FK,Alvarez D,Ritz SA,Goncharova S,Cundall M,Snider DP,Coyle AJ,Gutierrez-Ramos JC,Stämpfli MR,Jordana M

更新日期：2001-09-01 00:00:00

abstract：:Opiate-like peptides can regulate many cellular functions. We now map [D-Ala(2)]deltorphin I (DADTI)-like immunoreactivity (DADTI-LI) in developing mouse lung and analyze potential functional roles. Most DADTI-LI-positive cells were alveolar cells negative for prosurfactant protein (proSP)-C immunoreactivity. Peak num...

journal_title：American journal of respiratory cell and molecular biology

authors： Sunday ME,Haley KJ,Emanuel RL,Torday JS,Asokananthan N,Sikorski KA,Tooyama I,Kimura H,Renda T,Erspamer V

更新日期：2001-10-01 00:00:00

abstract：:Acute lung injury (ALI) is a devastating disease with an overall mortality rate of 30 to 40%. The coagulation/fibrinolysis system is implicated in the pathogenesis of ALI. Thrombin-activatable fibronolysis inhibitor (TAFI) is an important component of the fibrinolysis system. Recent studies have shown that the active ...

journal_title：American journal of respiratory cell and molecular biology

authors： Naito M,Taguchi O,Kobayashi T,Takagi T,D'Alessandro-Gabazza CN,Matsushima Y,Boveda-Ruiz D,Gil-Bernabe P,Matsumoto T,Chelakkot-Govindalayathil AL,Toda M,Yasukawa A,Hataji O,Morser J,Takei Y,Gabazza EC

更新日期：2013-10-01 00:00:00

abstract：:The transcription factor (TF) Foxp2 has been shown to partially repress surfactant protein C (SP-C) transcription, presumably through interaction of an independent repressor domain with a conserved Foxp2 consensus site in the SP-C promoter. We explored the role of interactions between Foxp2 and the homeodomain TF Nkx2...

journal_title：American journal of respiratory cell and molecular biology

authors： Zhou B,Zhong Q,Minoo P,Li C,Ann DK,Frenkel B,Morrisey EE,Crandall ED,Borok Z

更新日期：2008-06-01 00:00:00

abstract：:Klebsiella pneumoniae is a common cause of pneumonia. Previous studies have documented an important role for Toll-like receptors (TLRs) expressed by myeloid cells in the recognition of K. pneumoniae and the initiation of a protective immune response. Lung epithelial cells also express TLRs and can participate in innat...

journal_title：American journal of respiratory cell and molecular biology

authors： Anas AA,Claushuis TAM,Mohan RA,Christoffels VM,Aidinis V,Florquin S,Van't Veer C,Hou B,de Vos AF,van der Poll T

更新日期：2017-05-01 00:00:00

abstract：:To identify mechanisms that allow p185HER2 expression in lung cancer, we performed Western, Southern, and Northern blot analyses of 14 cell lines derived from human non-small cell lung carcinomas and one cell line derived from a human mesothelioma. Human bronchiole epithelial cells and rat type II pneumocytes were fou...

journal_title：American journal of respiratory cell and molecular biology

authors： Kern JA,Robinson RA,Gazdar A,Torney L,Weiner DB

更新日期：1992-04-01 00:00:00

abstract：:We investigated the expression and function of matrix metalloproteinase-12 (MMP-12) in a model of allergic airway inflammation. Mice were sensitized mucosally by exposure to aerosolized ovalbumin (OVA) daily over a period of 10 d in the context of adenovirus-mediated granulocyte macrophage colony-stimulating factor (G...

journal_title：American journal of respiratory cell and molecular biology

authors： Pouladi MA,Robbins CS,Swirski FK,Cundall M,McKenzie AN,Jordana M,Shapiro SD,Stämpfli MR

更新日期：2004-01-01 00:00:00

abstract：:Endothelin-1 is a potent bronchoconstrictor peptide with pro-inflammatory and growth-promoting properties. After exposure of sensitized Brown-Norway rats to six repeated ovalbumin exposures, there was an increase in pro-endothelin (ET)-1 messenger RNA compared with saline-exposed control rats 24 h after the final expo...

journal_title：American journal of respiratory cell and molecular biology

authors： Salmon M,Liu YC,Mak JC,Rousell J,Huang TJ,Hisada T,Nicklin PL,Chung KF

更新日期：2000-11-01 00:00:00

abstract：:Infections with bacteria and viruses such as adenovirus are a feature of chronic lung diseases such as chronic obstructive pulmonary diseases (COPD), and may be instrumental in the generation of disease exacerbations. We have previously shown in acute models that elafin (a lung natural chemotactic molecule for macroph...

journal_title：American journal of respiratory cell and molecular biology

authors： Roghanian A,Williams SE,Sheldrake TA,Brown TI,Oberheim K,Xing Z,Howie SE,Sallenave JM

更新日期：2006-05-01 00:00:00

abstract：:Hydrogen sulfide (H2S), a novel signaling gasotransmitter in the respiratory system, may have antiinflammatory properties in the lung. We examined the preventive and therapeutic effects of H2S on ozone-induced features of lung inflammation and emphysema. C57/BL6 mice were exposed to ozone or filtered air over 6 weeks....

journal_title：American journal of respiratory cell and molecular biology

authors： Li F,Zhang P,Zhang M,Liang L,Sun X,Li M,Tang Y,Bao A,Gong J,Zhang J,Adcock I,Chung KF,Zhou X

更新日期：2016-07-01 00:00:00

abstract：:Previous studies have demonstrated that high tidal volumes can cause interstitial and alveolar edema, with degradation of pulmonary epithelial barrier integrity. Separate studies have shown that F-actin disruption and decreased intracellular ATP (ATP(i)) levels in the nonpulmonary epithelium can increase tight junctio...

journal_title：American journal of respiratory cell and molecular biology

authors： Cavanaugh KJ Jr,Oswari J,Margulies SS

更新日期：2001-11-01 00:00:00