听力与言语-语言病理学

行为科学

医学伦理学

  • NOX1 Promotes Mesothelial-Mesenchymal Transition Through Modulation of ROS-mediated Signaling.

    abstract::Pleural organization may occur after empyema or complicated parapneumonic effusion and can result in restrictive lung disease with pleural fibrosis (PF). Pleural mesothelial cells; PMCs, may contribute to PF through acquisition of a profibrotic phenotype; meso-mesenchymal transition (MesoMT), which is characterized by...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2020-0077OC

    authors: Qin W,Jeffers A,Owens S,Chauhan P,Komatsu S,Qian G,Guo X,Ikebe M,Idell S,Tucker TA

    更新日期:2021-01-29 00:00:00

  • Neutrophil Extracellular Traps Increase Airway Mucus Viscoelasticity and Slow Mucus Particle Transit.

    abstract::Mucus obstruction is a key feature of many inflammatory airway diseases. Neutrophil extracellular traps (NETs) are released upon neutrophil stimulation and consist of extracellular chromatin networks studded with cytotoxic proteins. When released in the airways, these NETs can become part of the airway mucus. We hypot...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2020-0168OC

    authors: Linssen RS,Chai G,Ma J,Kummarapurugu AB,van Woensel JBM,Bem RA,Kaler L,Duncan GA,Zhou L,Rubin BK,Xu Q

    更新日期:2021-01-01 00:00:00

  • CD44v3-positive Intermediate Progenitor Cells Contribute to Airway Goblet Cell Hyperplasia.

    abstract::In allergic airway diseases, intermediate progenitor cells (IPCs) increase in number in the surface epithelium. IPCs arise from basal cells, the origin of hallmark pathological changes, including goblet cell hyperplasia and mucus hypersecretion. Thus, targeting IPCs will benefit future treatment of allergic airway dis...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2020-0350OC

    authors: Lee SN,Kim SJ,Yoon SA,Song JM,Ahn JS,Kim HC,Choi AMK,Yoon JH

    更新日期:2020-12-02 00:00:00

  • Single-Nucleus RNA-Sequencing Profiling of Mouse Lung. Reduced Dissociation Bias and Improved Rare Cell-Type Detection Compared with Single-Cell RNA Sequencing.

    abstract::Single-cell RNA sequencing (scRNASeq) has advanced our understanding of lung biology, but its utility is limited by the need for fresh samples, loss of cell types by death or inadequate dissociation, and transcriptional stress responses induced during tissue digestion. Single-nucleus RNA sequencing (snRNASeq) has addr...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2020-0095MA

    authors: Koenitzer JR,Wu H,Atkinson JJ,Brody SL,Humphreys BD

    更新日期:2020-12-01 00:00:00

  • TOLL-interacting Protein in Pulmonary Diseases: Abiding by the Goldilocks Principle.

    abstract::Toll-interacting protein (TOLLIP) is an intracellular adaptor protein with diverse actions throughout the body. In a context- and cell type-specific manner, TOLLIP can function as an inhibitor of inflammation and endoplasmic reticulum stress, an activator of autophagy, or a critical regulator of intracellular vacuole ...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2020-0470TR

    authors: Li X,Goobie GC,Gregory AD,Kass DJ,Zhang Y

    更新日期:2020-11-24 00:00:00

  • Increasing Sphingolipid Synthesis Alleviates Airway Hyperreactivity.

    abstract::Impaired sphingolipid synthesis is linked genetically to childhood asthma and functionally to airway hyperreactivity (AHR). The objective was to investigate whether sphingolipid synthesis could be a target for asthma therapeutics. The effects of GlyH-101 and fenretinide via modulation of de novo sphingolipid synthesis...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2020-0194OC

    authors: Heras AF,Veerappan A,Silver RB,Emala CW,Worgall TS,Perez-Zoghbi J,Worgall S

    更新日期:2020-11-01 00:00:00

  • The Interplay of the Genetic Architecture, Aging, and Environmental Factors in the Pathogenesis of Idiopathic Pulmonary Fibrosis.

    abstract::Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing lung disease of indeterminate etiology and limited therapeutic options. The initiation, development, and progression of IPF are influenced by genetic predisposition, aging, and host and environmental factors, but the magnitude of the contribution of each of th...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2020-0373PS

    authors: Pardo A,Selman M

    更新日期:2020-09-18 00:00:00

  • Blockade of Pan-Fibroblast Growth Factor Receptors Mediates Bidirectional Effects in Lung Fibrosis.

    abstract::FGFs (fibroblast growth factors) are major factors associated with the pathogenesis of pulmonary fibrosis. On the one hand, nintedanib, a tyrosine kinase inhibitor targeting several growth factor receptors, including the FGF receptor (FGFR), has been approved for the treatment of idiopathic pulmonary fibrosis. On the ...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2019-0090OC

    authors: Morizumi S,Sato S,Koyama K,Okazaki H,Chen Y,Goto H,Kagawa K,Ogawa H,Nishimura H,Kawano H,Toyoda Y,Uehara H,Nishioka Y

    更新日期:2020-09-01 00:00:00

  • The Transient Receptor Potential Channel Vanilloid 1 Is Critical in Innate Airway Epithelial Responses to Protease Allergens.

    abstract::The airway epithelium plays a critical role in innate responses to airborne allergens by secreting IL-1 family cytokines such as IL-1α and IL-33 as alarmins that subsequently orchestrate appropriate immune responses. Previous studies revealed that epithelial IL-33 secretion by allergens such as Alternaria alternata or...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2019-0170OC

    authors: Schiffers C,Hristova M,Habibovic A,Dustin CM,Danyal K,Reynaert NL,Wouters EFM,van der Vliet A

    更新日期:2020-08-01 00:00:00

  • Active mTOR in Lung Epithelium Promotes Epithelial-Mesenchymal Transition and Enhances Lung Fibrosis.

    abstract::The mTOR pathway is one of the key signal cascades in the pathogenesis of idiopathic pulmonary fibrosis. Previous studies have mainly focused on this pathway in the fibroblasts and/or myofibroblasts, but not in the epithelial cells. In this study, we sought to investigate the role of the mTOR pathway in lung epithelia...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2019-0255OC

    authors: Saito M,Mitani A,Ishimori T,Miyashita N,Isago H,Mikami Y,Noguchi S,Tarui M,Nagase T

    更新日期:2020-06-01 00:00:00

  • Applications and Approaches for Three-Dimensional Precision-Cut Lung Slices. Disease Modeling and Drug Discovery.

    abstract::Chronic lung diseases (CLDs), such as chronic obstructive pulmonary disease, interstitial lung disease, and lung cancer, are among the leading causes of morbidity globally and impose major health and financial burdens on patients and society. Effective treatments are scarce, and relevant human model systems to effecti...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章,评审

    doi:10.1165/rcmb.2019-0276TR

    authors: Alsafadi HN,Uhl FE,Pineda RH,Bailey KE,Rojas M,Wagner DE,Königshoff M

    更新日期:2020-06-01 00:00:00

  • Subacute TGFβ Exposure Drives Airway Hyperresponsiveness in Cystic Fibrosis Mice through the PI3K Pathway.

    abstract::Cystic fibrosis (CF) is a lethal genetic disease characterized by progressive lung damage and airway obstruction. The majority of patients demonstrate airway hyperresponsiveness (AHR), which is associated with more rapid lung function decline. Recent studies in the neonatal CF pig demonstrated airway smooth muscle (AS...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2019-0158OC

    authors: Kramer EL,Madala SK,Hudock KM,Davidson C,Clancy JP

    更新日期:2020-05-01 00:00:00

  • Inhalation of Stachybotrys chartarum Fragments Induces Pulmonary Arterial Remodeling.

    abstract::Stachybotrys chartarum is a fungal contaminant within the built environment and a respiratory health concern in the United States. The objective of this study was to characterize the mechanisms influencing pulmonary immune responses to repeatedly inhaled S. chartarum. Groups of B6C3F1/N mice repeatedly inhaled viable ...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2019-0221OC

    authors: Croston TL,Lemons AR,Barnes MA,Goldsmith WT,Orandle MS,Nayak AP,Germolec DR,Green BJ,Beezhold DH

    更新日期:2020-05-01 00:00:00

  • SPEF2- and HYDIN-Mutant Cilia Lack the Central Pair-associated Protein SPEF2, Aiding Primary Ciliary Dyskinesia Diagnostics.

    abstract::Primary ciliary dyskinesia (PCD) is a genetically heterogeneous chronic destructive airway disease. PCD is traditionally diagnosed by nasal nitric oxide measurement, analysis of ciliary beating, transmission electron microscopy (TEM), and/or genetic testing. In most genetic PCD variants, laterality defects can occur. ...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2019-0086OC

    authors: Cindrić S,Dougherty GW,Olbrich H,Hjeij R,Loges NT,Amirav I,Philipsen MC,Marthin JK,Nielsen KG,Sutharsan S,Raidt J,Werner C,Pennekamp P,Dworniczak B,Omran H

    更新日期:2020-03-01 00:00:00

  • Cigarette Smoking Exacerbates Skeletal Muscle Injury without Compromising Its Regenerative Capacity.

    abstract::Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease negatively impacts quality of life and survival. Cigarette smoking (CS) is the major risk factor for chronic obstructive pulmonary disease and skeletal muscle dysfunction; however, how CS affects skeletal muscle function remains enigmat...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2019-0106OC

    authors: Chan SMH,Cerni C,Passey S,Seow HJ,Bernardo I,van der Poel C,Dobric A,Brassington K,Selemidis S,Bozinovski S,Vlahos R

    更新日期:2020-02-01 00:00:00

  • Rats with a Human Mutation of NFU1 Develop Pulmonary Hypertension.

    abstract::NFU1 is a mitochondrial protein that is involved in the biosynthesis of iron-sulfur clusters, and its genetic modification is associated with disorders of mitochondrial energy metabolism. Patients with autosomal-recessive inheritance of the NFU1 mutation G208C have reduced activity of the respiratory chain Complex II ...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2019-0065OC

    authors: Niihori M,Eccles CA,Kurdyukov S,Zemskova M,Varghese MV,Stepanova AA,Galkin A,Rafikov R,Rafikova O

    更新日期:2020-02-01 00:00:00

  • Augmentation of Cystic Fibrosis Transmembrane Conductance Regulator Function in Human Bronchial Epithelial Cells via SLC6A14-Dependent Amino Acid Uptake. Implications for Treatment of Cystic Fibrosis.

    abstract::SLC6A14-mediated l-arginine transport has been shown to augment the residual anion channel activity of the major mutant, F508del-CFTR, in the murine gastrointestinal tract. It is not yet known if this transporter augments residual and pharmacological corrected F508del-CFTR in primary airway epithelia. We sought to det...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2019-0094OC

    authors: Ahmadi S,Wu YS,Li M,Ip W,Lloyd-Kuzik A,Di Paola M,Du K,Xia S,Lew A,Bozoky Z,Forman-Kay J,Bear CE,Gonska T

    更新日期:2019-12-01 00:00:00

  • Biased TAS2R Bronchodilators Inhibit Airway Smooth Muscle Growth by Downregulating Phosphorylated Extracellular Signal-regulated Kinase 1/2.

    abstract::Bitter taste receptor (TAS2R) agonists dilate airways by receptor-dependent smooth muscle relaxation. Besides their coupling to relaxation, we have found that human airway smooth muscle (HASM) cell TAS2Rs activate (phosphorylate) extracellular signal-related kinase 1/2 (ERK1/2), but the cellular effects are not known....

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2018-0189OC

    authors: Kim D,Cho S,Castaño MA,Panettieri RA,Woo JA,Liggett SB

    更新日期:2019-05-01 00:00:00

  • Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution.

    abstract::Genome-wide association studies (GWAS) have identified multiple associations with emphysema apicobasal distribution (EABD), but the biological functions of these variants are unknown. To characterize the functions of EABD-associated variants, we integrated GWAS results with 1) expression quantitative trait loci (eQTL)...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2018-0110OC

    authors: Boueiz A,Pham B,Chase R,Lamb A,Lee S,Naing ZZC,Cho MH,Parker MM,Sakornsakolpat P,Hersh CP,Crapo JD,Stergachis AB,Tal-Singer R,DeMeo DL,Silverman EK,Zhou X,Castaldi PJ,COPDGene investigators, by Core Units:, ECLIPSE Inve

    更新日期:2019-04-01 00:00:00

  • Anaphylatoxins Enhance Recruitment of Nonclassical Monocytes via Chemokines Produced by Pleural Mesothelial Cells in Tuberculous Pleural Effusion.

    abstract::In the present study, we sought to elucidate the mechanisms by which monocytes migrate into the pleural space in the presence of anaphylatoxins in tuberculous pleural effusion (TPE). Monocytes in both pleural effusion and blood were counted, and their phenotypic characteristics were analyzed. Activation of the complem...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2018-0075OC

    authors: Luo L,Li X,Hu X,Hu C,Tang W,Deng S,Feng J

    更新日期:2019-04-01 00:00:00

  • How the Respiratory Epithelium Senses and Reacts to Influenza Virus.

    abstract::The human lung is constantly exposed to the environment and potential pathogens. As the interface between host and environment, the respiratory epithelium has evolved sophisticated sensing mechanisms as part of its defense against pathogens. In this review, we examine how the respiratory epithelium senses and responds...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章,评审

    doi:10.1165/rcmb.2018-0247TR

    authors: Benam KH,Denney L,Ho LP

    更新日期:2019-03-01 00:00:00

  • Impairment of Fatty Acid Oxidation in Alveolar Epithelial Cells Mediates Acute Lung Injury.

    abstract::Profound impairment in cellular oxygen consumption, referred to as cytopathic dysoxia, is one of the pathological hallmarks in the lungs of patients with pathogen-induced acute lung injury (ALI). However, the underlying mechanism for this functional defect remains largely unexplored. In this study, we found that prima...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2018-0152OC

    authors: Cui H,Xie N,Banerjee S,Ge J,Guo S,Liu G

    更新日期:2019-02-01 00:00:00

  • Maternal Cytokine Profiles during Pregnancy Predict Asthma in Children of Mothers without Asthma.

    abstract::Little is known about whether maternal immune status during pregnancy influences asthma development in the child. We measured cytokine production in supernatants from mitogen-stimulated peripheral blood immune cells collected during and after pregnancy from the mothers of children enrolled in the Tucson Infant Immune ...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2017-0410OC

    authors: Rothers J,Stern DA,Lohman IC,Spangenberg A,Wright AL,DeVries A,Vercelli D,Halonen M

    更新日期:2018-11-01 00:00:00

  • All-trans Retinoic Acid Augments Autophagy during Intracellular Bacterial Infection.

    abstract::Vitamin A deficiency strongly predicts the risk of developing tuberculosis (TB) in individuals exposed to Mycobacterium tuberculosis (Mtb). The burden of antibiotic-resistant TB is increasing globally; therefore, there is an urgent need to develop host-directed adjunctive therapies to treat TB. Alveolar macrophages, t...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2017-0382OC

    authors: Coleman MM,Basdeo SA,Coleman AM,Cheallaigh CN,Peral de Castro C,McLaughlin AM,Dunne PJ,Harris J,Keane J

    更新日期:2018-11-01 00:00:00

  • Quantifying Ciliary Dynamics during Assembly Reveals Stepwise Waveform Maturation in Airway Cells.

    abstract::Motile cilia are essential for clearance of particulates and pathogens from airways. For effective transport, ciliary motor proteins and axonemal structures interact to generate the rhythmic, propulsive bending, but the mechanisms that produce a dynamic waveform remain incompletely understood. Biomechanical measures o...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2017-0436OC

    authors: Oltean A,Schaffer AJ,Bayly PV,Brody SL

    更新日期:2018-10-01 00:00:00

  • Clinical and Pathologic Factors Predicting Future Asthma in Wheezing Children. A Longitudinal Study.

    abstract::Wheeze is a common symptom in infants, but not all wheezers develop asthma. Indeed, up to 50% of wheezing children outgrow their symptoms by school age. How to predict if early wheeze will become asthma is still a matter of vivid debate. In this work, we sought to assess the clinical and pathological factors that migh...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2018-0009OC

    authors: Bonato M,Bazzan E,Snijders D,Tinè M,Biondini D,Turato G,Balestro E,Papi A,Cosio MG,Barbato A,Baraldo S,Saetta M

    更新日期:2018-10-01 00:00:00

  • Hemolysis-induced Lung Vascular Leakage Contributes to the Development of Pulmonary Hypertension.

    abstract::Although hemolytic anemia-associated pulmonary hypertension (PH) and pulmonary arterial hypertension (PAH) are more common than the prevalence of idiopathic PAH alone, the role of hemolysis in the development of PAH is poorly characterized. We hypothesized that hemolysis independently contributes to PAH pathogenesis v...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2017-0308OC

    authors: Rafikova O,Williams ER,McBride ML,Zemskova M,Srivastava A,Nair V,Desai AA,Langlais PR,Zemskov E,Simon M,Mandarino LJ,Rafikov R

    更新日期:2018-09-01 00:00:00

  • Long-Term Microevolution of Pseudomonas aeruginosa Differs between Mildly and Severely Affected Cystic Fibrosis Lungs.

    abstract::Chronic airway infections with Pseudomonas aeruginosa determine morbidity in most individuals with cystic fibrosis (CF). P. aeruginosa may persist for decades in CF lungs, which provides a rare opportunity to study the long-term within-host evolution of a bacterial airway pathogen. In this work, we sought to resolve t...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2017-0356OC

    authors: Klockgether J,Cramer N,Fischer S,Wiehlmann L,Tümmler B

    更新日期:2018-08-01 00:00:00

  • Microparticulate Caspase 1 Regulates Gasdermin D and Pulmonary Vascular Endothelial Cell Injury.

    abstract::Lung endothelial cell apoptosis and injury occur throughout all stages of acute lung injury/acute respiratory distress syndrome and impact disease progression. Caspases 1, 4, and 5 are essential for completion of the apoptotic program known as pyroptosis that also involves proinflammatory cytokines. Because gasdermin ...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2017-0393OC

    authors: Mitra S,Exline M,Habyarimana F,Gavrilin MA,Baker PJ,Masters SL,Wewers MD,Sarkar A

    更新日期:2018-07-01 00:00:00

  • Novel Mechanism for Nicotinamide Phosphoribosyltransferase Inhibition of TNF-α-mediated Apoptosis in Human Lung Endothelial Cells.

    abstract::Nicotinamide phosphoribosyltransferase (NAMPT) exists as both intracellular NAMPT and extracellular NAMPT (eNAMPT) proteins. eNAMPT is secreted into the blood and functions as a cytokine/enzyme (cytozyme) that activates NF-κB signaling via ligation of Toll-like receptor 4 (TLR4), further serving as a biomarker for inf...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2017-0155OC

    authors: Oita RC,Camp SM,Ma W,Ceco E,Harbeck M,Singleton P,Messana J,Sun X,Wang T,Garcia JGN

    更新日期:2018-07-01 00:00:00

  • Inhibition of Macrophage Complement Receptor CRIg by TRIM72 Polarizes Innate Immunity of the Lung.

    abstract::The complement system plays a critical role in immune responses against pathogens. However, its identity and regulation in the lung are not fully understood. This study aimed to explore the role of tripartite motif protein (TRIM) 72 in regulating complement receptor (CR) of the Ig superfamily (CRIg) in alveolar macrop...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2017-0236OC

    authors: Nagre N,Cong X,Terrazas C,Pepper I,Schreiber JM,Fu H,Sill JM,Christman JW,Satoskar AR,Zhao X

    更新日期:2018-06-01 00:00:00

  • Lysyl Oxidase-Like 1 Protein Deficiency Protects Mice from Adenoviral Transforming Growth Factor-β1-induced Pulmonary Fibrosis.

    abstract::Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by excessive deposition of extracellular matrix (ECM) in the lung parenchyma. The abnormal ECM deposition slowly overtakes normal lung tissue, disturbing gas exchange and leading to respiratory failure and death. ECM cross-linking and subsequen...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2017-0252OC

    authors: Bellaye PS,Shimbori C,Upagupta C,Sato S,Shi W,Gauldie J,Ask K,Kolb M

    更新日期:2018-04-01 00:00:00

  • The Long Noncoding RNA LnRPT Is Regulated by PDGF-BB and Modulates the Proliferation of Pulmonary Artery Smooth Muscle Cells.

    abstract::Pulmonary artery hypertension (PAH) is a rare and fatal disorder that involves extensive remodeling of the pulmonary arteries mediated by hyperproliferation of pulmonary artery smooth muscle cells (PASMCs). Aberrant platelet-derived growth factor (PDGF) activity can lead to hyperproliferation of PASMCs; however, littl...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2017-0111OC

    authors: Chen J,Guo J,Cui X,Dai Y,Tang Z,Qu J,Raj JU,Hu Q,Gou D

    更新日期:2018-02-01 00:00:00

  • Dectin-2 Is a C-Type Lectin Receptor that Recognizes Pneumocystis and Participates in Innate Immune Responses.

    abstract::Pneumocystis is an important fungal pathogen that causes life-threatening pneumonia in patients with AIDS and malignancy. Lung fungal pathogens are recognized by C-type lectin receptors (CLRs), which bind specific ligands and stimulate innate immune responses. The CLR Dectin-1 was previously shown to mediate immune re...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2016-0335OC

    authors: Kottom TJ,Hebrink DM,Jenson PE,Marsolek PL,Wüthrich M,Wang H,Klein B,Yamasaki S,Limper AH

    更新日期:2018-02-01 00:00:00

  • Multitissue Transcriptomics Delineates the Diversity of Airway T Cell Functions in Asthma.

    abstract::Asthma arises from the complex interplay of inflammatory pathways in diverse cell types and tissues. We sought to undertake a comprehensive transcriptomic assessment of the epithelium and airway T cells that remain understudied in asthma and investigate interactions between multiple cells and tissues. Epithelial brush...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2017-0162OC

    authors: Singhania A,Wallington JC,Smith CG,Horowitz D,Staples KJ,Howarth PH,Gadola SD,Djukanović R,Woelk CH,Hinks TSC

    更新日期:2018-02-01 00:00:00

  • Semaphorins and Their Roles in Airway Biology: Potential as Therapeutic Targets.

    abstract::Semaphorins are a large family of proteins originally identified as axon guidance cues that play a crucial role in neural development. They are also ubiquitously expressed beyond the nervous system and contribute to regulation of essential cell functions, such as cell migration, proliferation, and adhesion. Binding of...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章,评审

    doi:10.1165/rcmb.2017-0171TR

    authors: Movassagh H,Khadem F,Gounni AS

    更新日期:2018-01-01 00:00:00

  • IFN-γ Influences Epithelial Antiviral Responses via Histone Methylation of the RIG-I Promoter.

    abstract::The asthmatic lung is prone to respiratory viral infections that exacerbate the symptoms of the underlying disease. Recent work has suggested that a deficient T-helper cell type 1 response in early life may lead to these aberrant antiviral responses. To study the development of long-term dysregulation of innate respon...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2016-0392OC

    authors: Spalluto CM,Singhania A,Cellura D,Woelk CH,Sanchez-Elsner T,Staples KJ,Wilkinson TMA

    更新日期:2017-10-01 00:00:00

  • Nicotine Impairs Macrophage Control of Mycobacterium tuberculosis.

    abstract::Pure nicotine impairs macrophage killing of Mycobacterium tuberculosis (MTB), but it is not known whether the nicotine component in cigarette smoke (CS) plays a role. Moreover, the mechanisms by which nicotine impairs macrophage immunity against MTB have not been explored. To neutralize the effects of nicotine in CS e...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2016-0270OC

    authors: Bai X,Stitzel JA,Bai A,Zambrano CA,Phillips M,Marrack P,Chan ED

    更新日期:2017-09-01 00:00:00

  • Integrated Stress Response Mediates Epithelial Injury in Mechanical Ventilation.

    abstract::Ventilator-induced lung injury (VILI) is a severe complication of mechanical ventilation that can lead to acute respiratory distress syndrome. VILI is characterized by damage to the epithelial barrier with subsequent pulmonary edema and profound hypoxia. Available lung-protective ventilator strategies offer only a mod...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2016-0404OC

    authors: Dolinay T,Himes BE,Shumyatcher M,Lawrence GG,Margulies SS

    更新日期:2017-08-01 00:00:00

  • A Novel Antifibrotic Mechanism of Nintedanib and Pirfenidone. Inhibition of Collagen Fibril Assembly.

    abstract::Idiopathic pulmonary fibrosis (IPF) is characterized by excessive deposition of extracellular matrix, in particular, collagens. Two IPF therapeutics, nintedanib and pirfenidone, decelerate lung function decline, but their underlying mechanisms of action are poorly understood. In this study, we sought to analyze their ...

    journal_title:American journal of respiratory cell and molecular biology

    pub_type: 杂志文章

    doi:10.1165/rcmb.2016-0217OC

    authors: Knüppel L,Ishikawa Y,Aichler M,Heinzelmann K,Hatz R,Behr J,Walch A,Bächinger HP,Eickelberg O,Staab-Weijnitz CA

    更新日期:2017-07-01 00:00:00

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