Epithelial Myeloid-Differentiation Factor 88 Is Dispensable during Klebsiella Pneumonia.

abstract：:Zn may have an important protective role in the respiratory epithelium and Zn deficiency may enhance airway inflammation and epithelial damage. The effects of mild nutritional Zn deficiency on airway hyperresponsiveness (AHR) and airway inflammation in mice sensitized and challenged with ovalbumin (OVA) to induce an a...

journal_title：American journal of respiratory cell and molecular biology

authors： Truong-Tran AQ,Ruffin RE,Foster PS,Koskinen AM,Coyle P,Philcox JC,Rofe AM,Zalewski PD

更新日期：2002-09-01 00:00:00

abstract：:The development of multiple organ failure in patients with hemorrhagic shock is significantly influenced by patient age. Adenosine monophosphate-activated protein kinase (AMPK) is a crucial regulator of energy homeostasis, which coordinates metabolic repair during cellular stress. We investigated whether AMPK-regulate...

journal_title：American journal of respiratory cell and molecular biology

authors： Klingbeil LR,Kim P,Piraino G,O'Connor M,Hake PW,Wolfe V,Zingarelli B

更新日期：2017-05-01 00:00:00

abstract：:Endothelin, an endothelium-derived vasoconstrictor peptide, has recently been reported to exist in airway epithelial cells. To elucidate a possible role of endothelin on epithelial functions, we studied the effects of this peptide on ciliary beat frequency (CBF) and electrical properties of canine cultured tracheal ep...

journal_title：American journal of respiratory cell and molecular biology

authors： Tamaoki J,Kanemura T,Sakai N,Isono K,Kobayashi K,Takizawa T

更新日期：1991-05-01 00:00:00

abstract：:After localized lung immunization and challenge, antigen-specific antibody continues to be produced in the immunized lung lobes of dogs for years after the last antigen exposure. Lavage fluid from immunized lung lobes contains significantly more antigen-specific antibody than lavage fluid from control lung lobes, and ...

journal_title：American journal of respiratory cell and molecular biology

authors： Bice DE,Jones SE,Muggenburg BA

更新日期：1993-06-01 00:00:00

abstract：:The cellular events involved in generating the hypoxic pulmonary vasoconstriction response are not clearly understood, in part because of the multitude of factors that alter pulmonary vascular tone. The goal of the present studies was to determine if a cell culture preparation containing vascular smooth muscle (VSM) c...

journal_title：American journal of respiratory cell and molecular biology

authors： Murray TR,Chen L,Marshall BE,Macarak EJ

更新日期：1990-11-01 00:00:00

abstract：:Pulmonary accumulation of fibroblasts and myofibroblasts in idiopathic pulmonary fibrosis/usual interstitial pneumonia (IFP/UIP) has been linked to (1) increased migration of a circulating pool of fibrocytes, (2) cell proliferation, and (3) resistance to apoptosis. The mechanism of physiologic apoptosis of lung fibrob...

journal_title：American journal of respiratory cell and molecular biology

authors： Frankel SK,Cosgrove GP,Cha SI,Cool CD,Wynes MW,Edelman BL,Brown KK,Riches DW

更新日期：2006-03-01 00:00:00

abstract：:We examined the potential of several epithelial-derived factors to enhance neutrophil activation and survival. Neutrophils incubated in the presence of supernatants from nasal-derived primary epithelial cultures had significantly increased survival compared with neutrophils cultured in media alone. Of the cytokines re...

journal_title：American journal of respiratory cell and molecular biology

authors： Daffern PJ,Jagels MA,Hugli TE

更新日期：1999-08-01 00:00:00

abstract：:Bleomycin-induced lung disease is characterized by cell injury followed by fibroblast proliferation. Cells respond to injury by synthesizing a family of heat shock proteins. These proteins are critical to cell survival, and those of the 70,000 MW group (hsp 70) are essential for cell division and proliferation. To eva...

journal_title：American journal of respiratory cell and molecular biology

authors： Moseley PL,York SJ,York J

更新日期：1989-08-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/APO-2L) is a member of the tumor necrosis factor family that induces apoptosis in a variety of transformed cell lines and in normal human hepatocytes and brain cells. Soluble TRAIL at high concentrations was found to induce apoptotic death in normal human ...

journal_title：American journal of respiratory cell and molecular biology

authors： Yurovsky VV

更新日期：2003-02-01 00:00:00

abstract：:Redox imbalance has been implicated in the pathogenesis of many acute and chronic lung diseases. The b-Zip transcription factor Nrf2 acts via an antioxidant/electrophilic response element to regulate antioxidants and maintain cellular redox homeostasis. Our previous studies have shown that Nrf2-deficient mice (Nrf2(-/...

journal_title：American journal of respiratory cell and molecular biology

authors： Reddy NM,Kleeberger SR,Cho HY,Yamamoto M,Kensler TW,Biswal S,Reddy SP

更新日期：2007-07-01 00:00:00

abstract：:Neutrophil-associated inflammation during Pseudomonas aeruginosa lung infection is a determinant of morbidity in cystic fibrosis (CF). Neutrophil apoptosis is a key factor in inflammation resolution and is controlled by cytosolic proliferating cell nuclear antigen (PCNA). p21/Waf1, a cyclin-dependent kinase inhibitor,...

journal_title：American journal of respiratory cell and molecular biology

authors： Martin C,Ohayon D,Alkan M,Mocek J,Pederzoli-Ribeil M,Candalh C,Thevenot G,Millet A,Tamassia N,Cassatella MA,Thieblemont N,Burgel PR,Witko-Sarsat V

更新日期：2016-05-01 00:00:00

abstract：:Recent studies have indicated that, during the development of pulmonary hypertension (PH), there is a switch from oxidative phosphorylation to glycolysis in the pulmonary endothelium. However, the mechanisms underlying this phenomenon have not been elucidated. Endothelin (ET)-1, an endothelial-derived vasoconstrictor ...

journal_title：American journal of respiratory cell and molecular biology

authors： Sun X,Kumar S,Sharma S,Aggarwal S,Lu Q,Gross C,Rafikova O,Lee SG,Dasarathy S,Hou Y,Meadows ML,Han W,Su Y,Fineman JR,Black SM

更新日期：2014-06-01 00:00:00

abstract：:Techniques are described for visualizing intracellular tropoelastin at the light level using immunofluorescence and immunogold techniques. Best results were obtained with B5 fixative on cells permeabilized with acetone. Using either formaldehyde or paraformaldehyde for fixation (instead of B5) resulted in both less re...

journal_title：American journal of respiratory cell and molecular biology

authors： Grosso LE,Whitehouse LA,Mecham RP

更新日期：1990-07-01 00:00:00

abstract：:Chlamydia infections are frequent causes of respiratory illness, particularly pneumonia in infants, and are linked to permanent reductions in lung function and the induction of asthma. However, the immune responses that protect against early-life infection and the mechanisms that lead to chronic lung disease are incom...

journal_title：American journal of respiratory cell and molecular biology

authors： Starkey MR,Nguyen DH,Brown AC,Essilfie AT,Kim RY,Yagita H,Horvat JC,Hansbro PM

更新日期：2016-04-01 00:00:00

abstract：:Stimulated migration of eosinophils out of the bloodstream and into the lung is key in the development of tissue eosinophilia and inflammation in asthma. Platelet-activating factor (PAF) has been implicated as an important inflammatory mediator in asthma pathogenesis in part because of its chemotactic capacity. We the...

journal_title：American journal of respiratory cell and molecular biology

authors： Casale TB,Erger RA,Little MM

更新日期：1993-01-01 00:00:00

abstract：:Previous studies have shown that polymorphonuclear leukocytes (PMN) are delayed in the pulmonary capillaries by the presence of cigarette smoke. To determine if the PMN delayed by smoking are activated, we estimated the in vivo expression of CD11/CD18 and L-selectin on the surface of PMN in lungs and peripheral blood ...

journal_title：American journal of respiratory cell and molecular biology

authors： Klut ME,Doerschuk CM,Van Eeden SF,Burns AR,Hogg JC

更新日期：1993-07-01 00:00:00

abstract：:The purpose of this study was to examine the relationship between hyperpnea-induced mucosal injury, bronchovascular hyperpermeability, and airway reactivity. Hyperpnea-induced bronchoconstriction was assessed by measuring peripheral airway resistance (Rp) in anesthetized mechanically ventilated male mongrel dogs. Eith...

journal_title：American journal of respiratory cell and molecular biology

authors： Freed AN,Omori C,Schofield BH,Mitzner W

更新日期：1994-12-01 00:00:00

abstract：:Surface airway epithelium is frequently injured by noxious inhaled agents, epithelial wound repair may be an important process by which the epithelial barrier integrity is maintained. To evaluate the role of surface airway cells in the wound repair process, we developed an in vitro wounding model of human nasal epithe...

journal_title：American journal of respiratory cell and molecular biology

authors： Zahm JM,Chevillard M,Puchelle E

更新日期：1991-09-01 00:00:00

abstract：:IL-11 and IL-11 receptor (R)alpha are induced by Th2 cytokines. However, the role(s) of endogenous IL-11 in antigen-induced Th2 inflammation has not been fully defined. We hypothesized that IL-11, signaling via IL-11Ralpha, plays an important role in aeroallergen-induced Th2 inflammation and mucus metaplasia. To test ...

journal_title：American journal of respiratory cell and molecular biology

authors： Lee CG,Hartl D,Matsuura H,Dunlop FM,Scotney PD,Fabri LJ,Nash AD,Chen NY,Tang CY,Chen Q,Homer RJ,Baca M,Elias JA

更新日期：2008-12-01 00:00:00

abstract：:The genetic determinants underlying susceptibility to acute lung injury have not been identified. Recently, we found that the strain distribution pattern for mean survival time (MST) to three irritants-ozone, ultrafine Teflon, and nickel sulfate- was shared between inbred mouse strains. For ozone-induced acute lung in...

journal_title：American journal of respiratory cell and molecular biology

authors： Prows DR,Leikauf GD

更新日期：2001-06-01 00:00:00

abstract：:Studies in animals and in human atopic skin suggest that allergen challenge may activate acute tissue remodeling changes via transforming growth factor-beta pathways. We determined whether inhalational allergen challenge in subjects with mild asthma induces similar acute changes to the airway epithelial mesenchymal tr...

journal_title：American journal of respiratory cell and molecular biology

authors： Phipps S,Benyahia F,Ou TT,Barkans J,Robinson DS,Kay AB

更新日期：2004-12-01 00:00:00

abstract：:Thy-1 is a glycosylphosphytidylinositol-linked cell-surface glycoprotein present on a subset of lung fibroblasts, which plays an important role in postnatal alveolarization. In the present study, we define the role of Thy-1 in pulmonary lipofibroblast differentiation and in the regulation of lipid homeostasis via pero...

journal_title：American journal of respiratory cell and molecular biology

authors： Varisco BM,Ambalavanan N,Whitsett JA,Hagood JS

更新日期：2012-06-01 00:00:00

abstract：:Airway neutrophilia is a prominent feature of chronic obstructive pulmonary disease. As cigarette smoke (CS) and epidermal growth factor (EGF) both cause release of interleukin-8 (IL-8) from epithelial cells in vitro, we investigated whether autocrine ligands for the EGF receptor (EGFR) are involved in this proinflamm...

journal_title：American journal of respiratory cell and molecular biology

authors： Richter A,O'Donnell RA,Powell RM,Sanders MW,Holgate ST,Djukanović R,Davies DE

更新日期：2002-07-01 00:00:00

abstract：:Lipoxins (LX) are proresolving mediators that augment host defense against bacterial infection. Here, we investigated roles for LX in lung clearance of the fungal pathogen Cryptococcus neoformans (Cne). After intranasal inoculation of 5,000 CFU Cne, C57BL/6 and C.B-17 mice exhibited strain-dependent differences in Cne...

journal_title：American journal of respiratory cell and molecular biology

authors： Colby JK,Gott KM,Wilder JA,Levy BD

更新日期：2016-01-01 00:00:00

abstract：:Pulmonary fibrosis is an enigmatic and devastating disease with few treatment options, now thought to result from abnormal wound healing in the lung in response to injury. We have previously noted a role for the chemokine interferon gamma-inducible protein of 10 kD (IP-10)/CXC chemokine ligand 10 in the regulation of ...

journal_title：American journal of respiratory cell and molecular biology

authors： Tager AM,Kradin RL,LaCamera P,Bercury SD,Campanella GS,Leary CP,Polosukhin V,Zhao LH,Sakamoto H,Blackwell TS,Luster AD

更新日期：2004-10-01 00:00:00

abstract：:The complement system plays a critical role in immune responses against pathogens. However, its identity and regulation in the lung are not fully understood. This study aimed to explore the role of tripartite motif protein (TRIM) 72 in regulating complement receptor (CR) of the Ig superfamily (CRIg) in alveolar macrop...

journal_title：American journal of respiratory cell and molecular biology

authors： Nagre N,Cong X,Terrazas C,Pepper I,Schreiber JM,Fu H,Sill JM,Christman JW,Satoskar AR,Zhao X

更新日期：2018-06-01 00:00:00

abstract：:Polymorphonuclear neutrophil (PMN) migration across basement membrane is thought to be dependent on the degradation of membrane constituents. PMN gelatinase B, a metalloproteinase able to degrade type IV collagen, may be involved in this phenomenon. PMN gelatinase B is released in the extracellular medium as a latent ...

journal_title：American journal of respiratory cell and molecular biology

authors： Delclaux C,Delacourt C,D'Ortho MP,Boyer V,Lafuma C,Harf A

更新日期：1996-03-01 00:00:00

abstract：:Although neutrophils play critical roles in innate immunity, in excess these cells cause severe tissue damage. Thus, neutrophil activation must be tightly regulated to prevent indiscriminant damage. Previously, we reported that mice lacking matrix metalloproteinase (MMP) 7 are protected from lung injury owing to marke...

journal_title：American journal of respiratory cell and molecular biology

authors： Gill SE,Nadler ST,Li Q,Frevert CW,Park PW,Chen P,Parks WC

更新日期：2016-08-01 00:00:00

abstract：:We have previously observed that mice exposed to cigarette smoke and treated with exogenous alpha(1)-antitrypsin (A1AT) were protected against the development of emphysema and against smoke-induced increases in serum TNF-alpha. To investigate possible mechanisms behind this latter observation, we cultured alveolar mac...

journal_title：American journal of respiratory cell and molecular biology

authors： Churg A,Wang X,Wang RD,Meixner SC,Pryzdial EL,Wright JL

更新日期：2007-08-01 00:00:00

abstract：:Acute lung injury (ALI) is a devastating disease with an overall mortality rate of 30 to 40%. The coagulation/fibrinolysis system is implicated in the pathogenesis of ALI. Thrombin-activatable fibronolysis inhibitor (TAFI) is an important component of the fibrinolysis system. Recent studies have shown that the active ...

journal_title：American journal of respiratory cell and molecular biology

authors： Naito M,Taguchi O,Kobayashi T,Takagi T,D'Alessandro-Gabazza CN,Matsushima Y,Boveda-Ruiz D,Gil-Bernabe P,Matsumoto T,Chelakkot-Govindalayathil AL,Toda M,Yasukawa A,Hataji O,Morser J,Takei Y,Gabazza EC

更新日期：2013-10-01 00:00:00