Interleukin-13-dependent expression of matrix metalloproteinase-12 is required for the development of airway eosinophilia in mice.

abstract：:In the current study, we describe cytokine and Escherichia coli lipopolysaccharide (LPS) induction of nitric oxide (NO) synthase mRNA levels in cultured smooth muscle from rat pulmonary artery (RPASM). Exposure of RPASM to interleukin-1 beta, interferon-gamma, or LPS alone did not significantly affect NO synthesis, as...

journal_title：American journal of respiratory cell and molecular biology

authors： Nakayama DK,Geller DA,Lowenstein CJ,Chern HD,Davies P,Pitt BR,Simmons RL,Billiar TR

更新日期：1992-11-01 00:00:00

abstract：:The matrix glycoprotein, fibronectin, stimulates the proliferation of non-small cell lung carcinoma in vitro through α5β1 integrin receptor-mediated signals. However, the true role of fibronectin and its receptor in lung carcinogenesis in vivo remains unclear. To test this, we generated mouse Lewis lung carcinoma cell...

journal_title：American journal of respiratory cell and molecular biology

authors： Roman J,Ritzenthaler JD,Roser-Page S,Sun X,Han S

更新日期：2010-12-01 00:00:00

abstract：:Asbestos causes asbestosis and malignancies by mechanisms that are not fully established. Alveolar epithelial cell (AEC) injury and repair are crucial determinants of the fibrogenic potential of noxious agents such as asbestos. We previously showed that mitochondrial reactive oxygen species mediate asbestos-induced AE...

journal_title：American journal of respiratory cell and molecular biology

authors： Cheresh P,Morales-Nebreda L,Kim SJ,Yeldandi A,Williams DB,Cheng Y,Mutlu GM,Budinger GR,Ridge K,Schumacker PT,Bohr VA,Kamp DW

更新日期：2015-01-01 00:00:00

abstract：:LL-37 is a human cationic host defense peptide that is present in the specific granules of neutrophils, produced by epithelial cells from a variety of tissues, and is upregulated during inflammation, infection, and injury. It has been proposed to have a variety of antimicrobial functions, including both direct antimic...

journal_title：American journal of respiratory cell and molecular biology

authors： Lau YE,Bowdish DM,Cosseau C,Hancock RE,Davidson DJ

更新日期：2006-04-01 00:00:00

abstract：:The ability of Pseudomonas aeruginosa to form antibiotic-resistant biofilms is thought to account for the inability of current therapies to resolve bacterial infections in the lungs of patients with cystic fibrosis (CF). We recently described a system in which highly antibiotic-resistant P. aeruginosa biofilms grow on...

journal_title：American journal of respiratory cell and molecular biology

authors： Moreau-Marquis S,O'Toole GA,Stanton BA

更新日期：2009-09-01 00:00:00

abstract：:Lung structure undergoes rapid remodeling during late gestation as a functional respiratory unit is formed. To determine the role of collagen turnover in this process, particularly the basement membrane component, we studied the degradation of collagen in a series of fetal rats from day 18 of gestation to full term. D...

journal_title：American journal of respiratory cell and molecular biology

authors： Arden MG,Spearman MA,Adamson IY

更新日期：1993-07-01 00:00:00

abstract：:Acute lung injury induced by reactive oxygen gases such as ozone (O(3)) is focal and site-selective. To define patterns of acute epithelial injury along intrapulmonary airways, we developed a new analytic approach incorporating labeling of permeable cells, airway microdissection, and laser scanning confocal microscopy...

journal_title：American journal of respiratory cell and molecular biology

authors： Postlethwait EM,Joad JP,Hyde DM,Schelegle ES,Bric JM,Weir AJ,Putney LF,Wong VJ,Velsor LW,Plopper CG

更新日期：2000-02-01 00:00:00

abstract：:Interstitial lung disease is a devastating disease in humans that can be further complicated by the development of secondary pulmonary hypertension. Accumulating evidence indicates that the oxidant superoxide can contribute to the pathogenesis of both interstitial lung disease and pulmonary hypertension. We used a mod...

journal_title：American journal of respiratory cell and molecular biology

authors： Van Rheen Z,Fattman C,Domarski S,Majka S,Klemm D,Stenmark KR,Nozik-Grayck E

更新日期：2011-04-01 00:00:00

abstract：:The mammalian airways are sensitive to inhaled stimuli, and airway diseases are characterized by hypersensitivity to volatile stimuli, such as perfumes, industrial solvents, and others. However, the identity and function of the cells in the airway that can sense volatile chemicals remain uncertain, particularly in hum...

journal_title：American journal of respiratory cell and molecular biology

authors： Gu X,Karp PH,Brody SL,Pierce RA,Welsh MJ,Holtzman MJ,Ben-Shahar Y

更新日期：2014-03-01 00:00:00

abstract：:Opiate-like peptides can regulate many cellular functions. We now map [D-Ala(2)]deltorphin I (DADTI)-like immunoreactivity (DADTI-LI) in developing mouse lung and analyze potential functional roles. Most DADTI-LI-positive cells were alveolar cells negative for prosurfactant protein (proSP)-C immunoreactivity. Peak num...

journal_title：American journal of respiratory cell and molecular biology

authors： Sunday ME,Haley KJ,Emanuel RL,Torday JS,Asokananthan N,Sikorski KA,Tooyama I,Kimura H,Renda T,Erspamer V

更新日期：2001-10-01 00:00:00

abstract：:Enhanced protein tyrosine phosphorylation is associated with changes in vascular permeability through formation and dissolution of adherens junctions and regulation of stress fiber formation. Inhibition of the protein tyrosine phosphorylase SH2 domain-containing protein tyrosine phosphatase 2 (SHP2) increases tyrosine...

journal_title：American journal of respiratory cell and molecular biology

authors： Chichger H,Braza J,Duong H,Harrington EO

更新日期：2015-06-01 00:00:00

abstract：:Vascular remodeling is an important pathological feature of pulmonary arterial hypertension (PAH), which leads to increased pulmonary vascular resistance, with marked proliferation of pulmonary artery smooth muscle cells (SMC) and/or endothelial cells (EC). Successful treatment of experimental PAH with a platelet-deri...

journal_title：American journal of respiratory cell and molecular biology

authors： Sakao S,Tatsumi K,Voelkel NF

更新日期：2010-12-01 00:00:00

abstract：:Alveolar epithelial cells are directly exposed to acute and chronic fluctuations in alveolar oxygen tension. Previously, we found that the oxygen-binding protein hemoglobin is expressed in alveolar Type II cells (ATII). Here, we report that ATII cells also express a number of highly specific transcription factors and ...

journal_title：American journal of respiratory cell and molecular biology

authors： Grek CL,Newton DA,Spyropoulos DD,Baatz JE

更新日期：2011-04-01 00:00:00

abstract：:We investigated the effects of cultured epithelial cells and supernatants on resting membrane potential and excitatory neuroeffector transmission in smooth muscle cells of dog trachea and bronchioles. The mean resting membrane potential of the mucosa-free tracheal smooth muscle cells was -59.5 +/- 1.5 mV (+/- SD). App...

journal_title：American journal of respiratory cell and molecular biology

authors： Matsumoto K,Aizawa H,Inoue R,Hamano S,Ikeda S,Xie Z,Hirata M,Hara N,Ito Y

更新日期：1994-03-01 00:00:00

abstract：:Surfactant lines the alveolar surface and prevents alveolar collapse. Derangements of surfactant cause respiratory failure and interstitial lung diseases. The collectins, surfactant proteins A and D, are also important in innate host defense. However, surfactant regulation in the postnatal lung is poorly understood. W...

journal_title：American journal of respiratory cell and molecular biology

authors： Koth LL,Alex B,Hawgood S,Nead MA,Sheppard D,Erle DJ,Morris DG

更新日期：2007-12-01 00:00:00

abstract：:Na(+) absorption and Cl(-) secretion are in equilibrium to maintain an appropriate airway surface fluid volume and ensure appropriate mucociliary clearance. In cystic fibrosis, this equilibrium is disrupted by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene resulting in the absence of ...

journal_title：American journal of respiratory cell and molecular biology

authors： Caci E,Melani R,Pedemonte N,Yueksekdag G,Ravazzolo R,Rosenecker J,Galietta LJ,Zegarra-Moran O

更新日期：2009-02-01 00:00:00

abstract：:Wheeze is a common symptom in infants, but not all wheezers develop asthma. Indeed, up to 50% of wheezing children outgrow their symptoms by school age. How to predict if early wheeze will become asthma is still a matter of vivid debate. In this work, we sought to assess the clinical and pathological factors that migh...

journal_title：American journal of respiratory cell and molecular biology

authors： Bonato M,Bazzan E,Snijders D,Tinè M,Biondini D,Turato G,Balestro E,Papi A,Cosio MG,Barbato A,Baraldo S,Saetta M

更新日期：2018-10-01 00:00:00

abstract：:Pneumocystis is an important fungal pathogen that causes life-threatening pneumonia in patients with AIDS and malignancy. Lung fungal pathogens are recognized by C-type lectin receptors (CLRs), which bind specific ligands and stimulate innate immune responses. The CLR Dectin-1 was previously shown to mediate immune re...

journal_title：American journal of respiratory cell and molecular biology

authors： Kottom TJ,Hebrink DM,Jenson PE,Marsolek PL,Wüthrich M,Wang H,Klein B,Yamasaki S,Limper AH

更新日期：2018-02-01 00:00:00

abstract：:Prenatal nicotine exposure impairs normal lung development and leads to diminished pulmonary function after birth. Previous work from our laboratory has demonstrated that nicotine alters lung development by affecting a nonneuronal cholinergic autocrine loop that is expressed in lung. Bronchial epithelial cells (BECs) ...

journal_title：American journal of respiratory cell and molecular biology

authors： Fu XW,Lindstrom J,Spindel ER

更新日期：2009-07-01 00:00:00

abstract：:Nontypable Haemophilus influenzae (NTHI) is being increasingly recognized as a cause of both adult pneumonia and acute infectious exacerbations in chronic bronchitis. We used a mouse model to study the immune enhancement of pulmonary clearance of NTHI after a primary immunization. BALB/c mice were immunized with whole...

journal_title：American journal of respiratory cell and molecular biology

authors： McGehee JL,Radolf JD,Toews GB,Hansen EJ

更新日期：1989-09-01 00:00:00

abstract：:The cystic fibrosis transmembrane conductance regulator (CFTR) serves a pivotal role in normal epithelial homeostasis; its absence leads to destruction of exocrine tissues, including those of the gastrointestinal tract and lung. Acute regulation of CFTR protein in response to environmental stimuli occurs at several le...

journal_title：American journal of respiratory cell and molecular biology

authors： Guimbellot JS,Fortenberry JA,Siegal GP,Moore B,Wen H,Venglarik C,Chen YF,Oparil S,Sorscher EJ,Hong JS

更新日期：2008-11-01 00:00:00

abstract：:Polymorphonuclear neutrophil (PMN) migration across basement membrane is thought to be dependent on the degradation of membrane constituents. PMN gelatinase B, a metalloproteinase able to degrade type IV collagen, may be involved in this phenomenon. PMN gelatinase B is released in the extracellular medium as a latent ...

journal_title：American journal of respiratory cell and molecular biology

authors： Delclaux C,Delacourt C,D'Ortho MP,Boyer V,Lafuma C,Harf A

更新日期：1996-03-01 00:00:00

abstract：:A comprehensive investigation of the morphology of human airway epithelial tight junctions was carried out by freeze-fracture electron microscopy using quantitative methods designed to analyze a range of junctional characteristics. Extrapulmonary bronchi that appeared grossly normal were taken at sites distant from tu...

journal_title：American journal of respiratory cell and molecular biology

authors： Godfrey RW,Severs NJ,Jeffery PK

更新日期：1992-04-01 00:00:00

abstract：:Histamine was one of the first inflammatory mediators thought to be important in the pathophysiology of asthma, but it is not now thought to be a mediator with primary importance in airway constriction. However, histamine has several effects that may be relevant. One of these effects, its immunoregulatory role, has be...

journal_title：American journal of respiratory cell and molecular biology

authors： Bissonnette EY

更新日期：1996-06-01 00:00:00

abstract：:Idiopathic pneumonia syndrome (IPS) is a significant clinical problem encountered among patients treated with bone marrow transplantation (BMT). IPS is identified as an inflammatory lung disease characterized by diffuse interstitial pneumonitis and alveolitis leading to interstitial fibrosis in the absence of an ident...

journal_title：American journal of respiratory cell and molecular biology

authors： Shankar G,Scott Bryson J,Darrell Jennings C,Kaplan AM,Cohen DA

更新日期：1999-06-01 00:00:00

abstract：:Clara cell secretory protein (CCSP), or CC10, is an inhibitor of secretory phospholipase A2 which may be produced by phagocytic cells and by a variety of other cells in the airway. Tumor necrosis factor-alpha (TNF-alpha) is capable of activating phospholipases and inducing the expression of a variety of genes in the a...

journal_title：American journal of respiratory cell and molecular biology

authors： Yao XL,Levine SJ,Cowan MJ,Logun C,Shelhamer JH

更新日期：1998-10-01 00:00:00

abstract：:Influenza virus attaches primarily to ciliated cells in mature airways epithelium. This process is mediated by a viral envelope glycoprotein (hemagglutinin) that binds to sialic acid-containing receptors in the apical membrane of host cells. The purpose of this study was to determine the cellular distribution of these...

journal_title：American journal of respiratory cell and molecular biology

authors： Piazza FM,Carson JL,Hu SC,Leigh MW

更新日期：1991-01-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system and exerts its actions via both ionotropic (GABA(A)) and metabotropic (GABA(B)) receptors. The GABA(B) receptor is a dimer composed of R1 and R2 components and classically couples to the heterotrimeric G(i) ...

journal_title：American journal of respiratory cell and molecular biology

authors： Mizuta K,Osawa Y,Mizuta F,Xu D,Emala CW

更新日期：2008-09-01 00:00:00

abstract：:Modification of tyrosine residues and formation of 3-nitrotyrosine is one of the most commonly identified effects of reactive nitrogen species on proteins. In this study we evaluated the presence and localization of tyrosine nitration in various ventilatory and limb muscles. We also assessed the contribution of the ne...

journal_title：American journal of respiratory cell and molecular biology

authors： Barreiro E,Comtois AS,Gea J,Laubach VE,Hussain SN

更新日期：2002-04-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/APO-2L) is a member of the tumor necrosis factor family that induces apoptosis in a variety of transformed cell lines and in normal human hepatocytes and brain cells. Soluble TRAIL at high concentrations was found to induce apoptotic death in normal human ...

journal_title：American journal of respiratory cell and molecular biology

authors： Yurovsky VV

更新日期：2003-02-01 00:00:00