Pneumocystis carinii expresses an active Rtt109 histone acetyltransferase.

abstract：:Interleukin-5 (IL-5) is important in the control of differentiation, migration, and activation of eosinophils. In order to study the role of IL-5 in the development of eosinophilic inflammation of the airways, we have used a monoclonal antibody to murine IL-5 (TRFK-5) in a murine model of allergic pulmonary inflammati...

journal_title：American journal of respiratory cell and molecular biology

authors： Kung TT,Stelts DM,Zurcher JA,Adams GK 3rd,Egan RW,Kreutner W,Watnick AS,Jones H,Chapman RW

更新日期：1995-09-01 00:00:00

abstract：:Amiodarone interferes with the endocytic pathway, inhibits proteolysis, and causes the formation of vacuoles, but uptake and intracellular distribution of the drug, origin of vacuoles, and functional consequences of amiodarone accumulation remain unclear. Our objective was to study amiodarone uptake, clarify the origi...

journal_title：American journal of respiratory cell and molecular biology

authors： Stadler K,Ha HR,Ciminale V,Spirli C,Saletti G,Schiavon M,Bruttomesso D,Bigler L,Follath F,Pettenazzo A,Baritussio A

更新日期：2008-08-01 00:00:00

abstract：:The complement system plays a critical role in immune responses against pathogens. However, its identity and regulation in the lung are not fully understood. This study aimed to explore the role of tripartite motif protein (TRIM) 72 in regulating complement receptor (CR) of the Ig superfamily (CRIg) in alveolar macrop...

journal_title：American journal of respiratory cell and molecular biology

authors： Nagre N,Cong X,Terrazas C,Pepper I,Schreiber JM,Fu H,Sill JM,Christman JW,Satoskar AR,Zhao X

更新日期：2018-06-01 00:00:00

abstract：:Hypervascularity is known as an important element of airway remodeling in bronchial asthma. However, it remains obscure how allergic inflammation relates to angiogenesis in the lung. In this study, we examined the in vitro effects of inflammatory cytokines on endothelial cell functions, particularly angiogenesis. Huma...

journal_title：American journal of respiratory cell and molecular biology

authors： Matsuda A,Fukuda S,Matsumoto K,Saito H

更新日期：2008-02-01 00:00:00

abstract：:Recent evidence from genetic experiments in yeast and from studies using guanosine triphosphate (GTP) analogues in mammalian cells suggests a key role for low-molecular-mass GTP-binding proteins (LMM-GBPs) (Mr 19 to 28 kD) in processes of intracellular vesicular sorting and secretion. Assembly and exocytosis of the la...

journal_title：American journal of respiratory cell and molecular biology

authors： Rubins JB,Panchenko M,Shannon TM,Dickey BF

更新日期：1992-03-01 00:00:00

abstract：:Infections with bacteria and viruses such as adenovirus are a feature of chronic lung diseases such as chronic obstructive pulmonary diseases (COPD), and may be instrumental in the generation of disease exacerbations. We have previously shown in acute models that elafin (a lung natural chemotactic molecule for macroph...

journal_title：American journal of respiratory cell and molecular biology

authors： Roghanian A,Williams SE,Sheldrake TA,Brown TI,Oberheim K,Xing Z,Howie SE,Sallenave JM

更新日期：2006-05-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a potent peptide growth factor specific for vascular endothelial cells, which promotes neovascularization and increases vascular permeability in vivo. Enhanced microvascular permeability and edema are common characteristics of inflammatory and neoplastic disorders. Two proi...

journal_title：American journal of respiratory cell and molecular biology

authors： Nauck M,Roth M,Tamm M,Eickelberg O,Wieland H,Stulz P,Perruchoud AP

更新日期：1997-04-01 00:00:00

abstract：:Pure nicotine impairs macrophage killing of Mycobacterium tuberculosis (MTB), but it is not known whether the nicotine component in cigarette smoke (CS) plays a role. Moreover, the mechanisms by which nicotine impairs macrophage immunity against MTB have not been explored. To neutralize the effects of nicotine in CS e...

journal_title：American journal of respiratory cell and molecular biology

authors： Bai X,Stitzel JA,Bai A,Zambrano CA,Phillips M,Marrack P,Chan ED

更新日期：2017-09-01 00:00:00

abstract：:Bombesin-like peptides within neuroepithelial cells elicit proliferation of normal and malignant airway epithelial cells. It is not clear that these peptides also elicit epithelial cell migration, a necessary component of airway repair after injury. We studied the effects of the bombesin analogues, gastrin releasing p...

journal_title：American journal of respiratory cell and molecular biology

authors： Kim JS,McKinnis VS,White SR

更新日期：1997-03-01 00:00:00

abstract：:Airway epithelial cells produce a number of chemokines, including eotaxins. Among the three known eotaxins, T helper (Th) type 2 cytokines have been observed to induce the expression of eotaxin-3 mRNA. This study investigated the effect of interferon (IFN)-gamma, a Th1 cytokine, on Th2 cytokine-induced eotaxin-3 produ...

journal_title：American journal of respiratory cell and molecular biology

authors： Yamamoto S,Kobayashi I,Tsuji K,Nishi N,Muro E,Miyazaki M,Zaitsu M,Inada S,Ichimaru T,Hamasaki Y

更新日期：2004-10-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system and exerts its actions via both ionotropic (GABA(A)) and metabotropic (GABA(B)) receptors. The GABA(B) receptor is a dimer composed of R1 and R2 components and classically couples to the heterotrimeric G(i) ...

journal_title：American journal of respiratory cell and molecular biology

authors： Mizuta K,Osawa Y,Mizuta F,Xu D,Emala CW

更新日期：2008-09-01 00:00:00

abstract：:Elevated concentrations of CO2 (hypercapnia) lead to alveolar epithelial dysfunction by promoting Na,K-ATPase endocytosis. In the present report, we investigated whether the CO2/HCO3(-) activated soluble adenylyl cyclase (sAC) regulates this process. We found that hypercapnia increased the production of cyclic adenosi...

journal_title：American journal of respiratory cell and molecular biology

authors： Lecuona E,Sun H,Chen J,Trejo HE,Baker MA,Sznajder JI

更新日期：2013-05-01 00:00:00

abstract：:To identify relationships amongst tracheal and alveolar epithelial cells during lung development, we used conditional systems controlled by the rat CCSP and human SFTPC gene promoters to express Cre-recombinase in the developing mouse lung, thereby permanently labeling cells by expression of alkaline phosphatase or gr...

journal_title：American journal of respiratory cell and molecular biology

authors： Perl AK,Wert SE,Loudy DE,Shan Z,Blair PA,Whitsett JA

更新日期：2005-11-01 00:00:00

abstract：:Remodeling of the airways, as occurs in asthmatic patients, is associated with the continual presence of inflammatory mediators and Th2 cytokines, especially interleukin (IL)-13, during cycles of epithelial injury and repair. In this study, we examined the effect of IL-13 on well-differentiated normal human bronchial ...

journal_title：American journal of respiratory cell and molecular biology

authors： Booth BW,Adler KB,Bonner JC,Tournier F,Martin LD

更新日期：2001-12-01 00:00:00

abstract：:Chlamydia infections are frequent causes of respiratory illness, particularly pneumonia in infants, and are linked to permanent reductions in lung function and the induction of asthma. However, the immune responses that protect against early-life infection and the mechanisms that lead to chronic lung disease are incom...

journal_title：American journal of respiratory cell and molecular biology

authors： Starkey MR,Nguyen DH,Brown AC,Essilfie AT,Kim RY,Yagita H,Horvat JC,Hansbro PM

更新日期：2016-04-01 00:00:00

abstract：:Bacterial pneumonia is a common public health problem associated with significant mortality, morbidity, and cost. Neutrophils are usually the earliest leukocytes to respond to bacteria in the lungs. Neutrophils rapidly sequester in the pulmonary microvasculature and migrate into the lung parenchyma and alveolar spaces...

journal_title：American journal of respiratory cell and molecular biology

authors： Gomez JC,Yamada M,Martin JR,Dang H,Brickey WJ,Bergmeier W,Dinauer MC,Doerschuk CM

更新日期：2015-03-01 00:00:00

abstract：:The effects of repeated ozone exposures on the development of immune responses toward ovalbumin (OVA) were investigated in BALB/c and C57BL/6 mice. Ozone exposures (180 to 500 microg/m(3); 4 h, three times/wk for 4 wk) were combined with a protocol of OVA-aerosol exposure (1% OVA). Immediate cutaneous hypersensitivity...

journal_title：American journal of respiratory cell and molecular biology

authors： Neuhaus-Steinmetz U,Uffhausen F,Herz U,Renz H

更新日期：2000-08-01 00:00:00

abstract：:Development of gene transfer vectors with regulated, lung-specific expression will be a useful tool for studying lung biology and developing gene therapies. In this study we constructed a series of lentiviral vectors with regulatory elements predicted to produce lung-specific transgene expression: the surfactant prote...

journal_title：American journal of respiratory cell and molecular biology

authors： Hendrickson B,Senadheera D,Mishra S,Bui KC,Wang X,Chan B,Petersen D,Pepper K,Lutzko C

更新日期：2007-10-01 00:00:00

abstract：:Although several studies have demonstrated that the pulmonary collectins surfactant protein (SP)-A and SP-D contribute to innate immunity by enhancing pathogen phagocytosis, the role of SP-A and SP-D in regulating production of free radicals and cytokines is controversial. We hypothesized that the state and mechanism ...

journal_title：American journal of respiratory cell and molecular biology

authors： Stamme C,Walsh E,Wright JR

更新日期：2000-12-01 00:00:00

abstract：:Primary pulmonary hypertension is characterized by increased pulmonary vascular resistance and smooth muscle proliferation. Stable analogs are increasingly being used to treat this disease, although no data exists comparing their effects on proliferation. We therefore investigated the antiproliferative activity of sev...

journal_title：American journal of respiratory cell and molecular biology

authors： Clapp LH,Finney P,Turcato S,Tran S,Rubin LJ,Tinker A

更新日期：2002-02-01 00:00:00

abstract：:Epithelial-mesenchymal cell interactions and factors that control normal lung development are key players in lung injury, repair, and fibrosis. A number of studies have investigated the roles and sources of epithelial progenitors during lung regeneration; such information, however, is limited in lung fibroblasts. Thus...

journal_title：American journal of respiratory cell and molecular biology

authors： Green J,Endale M,Auer H,Perl AK

更新日期：2016-04-01 00:00:00

abstract：:An understanding of the molecular pathogenesis of lung cancer has evolved from classic cytogenetic studies and the use of restriction fragment length polymorphisms to encompass the definition of specific genetic abnormalities associated with this disease. Activation of the dominant class of oncogenes is frequent, with...

journal_title：American journal of respiratory cell and molecular biology

authors： Viallet J,Minna JD

更新日期：1990-03-01 00:00:00

abstract：:Extracellular signal-regulated kinases (ERKs) phosphorylate and regulate cytoskeletal components of contractile cells and have been implicated in integrin-mediated adhesion. In this study, we examined the contributions of adherence, cell flattening, and cytoskeletal reorganization to adhesion-induced ERK activation in...

journal_title：American journal of respiratory cell and molecular biology

authors： Heuertz RM,Hamann KJ,Hershenson MB,Leff AR

更新日期：1997-10-01 00:00:00

abstract：:It is generally important to elucidate airway epithelial cell lineages and to identify multipotent progenitors as targets for gene therapy. Stem (S) cells are typically present in specialized compartments spatially proximal to their differentiated progeny, but an equivalent paradigm has not been demonstrated in the ai...

journal_title：American journal of respiratory cell and molecular biology

authors： Borthwick DW,Shahbazian M,Krantz QT,Dorin JR,Randell SH

更新日期：2001-06-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha), a major product of alveolar macrophages (AM), has been implicated in many pulmonary diseases. Histamine, a mediator important in pulmonary inflammation, has been demonstrated to regulate the production of TNF-alpha by monocytes. In this study, we show that human AM and monocyte...

journal_title：American journal of respiratory cell and molecular biology

authors： Rowe J,Finlay-Jones JJ,Nicholas TE,Bowden J,Morton S,Hart PH

更新日期：1997-08-01 00:00:00

abstract：:Specific changes in composition and content of lung extracellular matrix (ECM) proteoglycans (PGs) and hyaluronan (HA) have been observed during the acute response to damage in several forms of injury including infant respiratory distress syndrome (IRDS). These ECM components are thought to modulate the healing respon...

journal_title：American journal of respiratory cell and molecular biology

authors： Juul SE,Krueger RC Jr,Scofield L,Hershenson MB,Schwartz NB

更新日期：1995-12-01 00:00:00

abstract：:The effects of surfactant, surfactant lipids, and surfactant protein A (SP-A) on the surface phagocytosis of [3H]thymidine-labeled Staphylococcus aureus (SAE) by rat alveolar macrophages were studied. Alveolar macrophages only ingest SAE when the bacteria are opsonized with rat serum prior to incubation with alveolar ...

journal_title：American journal of respiratory cell and molecular biology

authors： van Iwaarden F,Welmers B,Verhoef J,Haagsman HP,van Golde LM

更新日期：1990-01-01 00:00:00

abstract：:Airway epithelial cell defenses to viral infections are often compromised in disease or injury. Danger molecules, including ATP, are released during infection and contribute to nucleotide receptor-dependent inflammatory responses, largely through P2X(7). Although respiratory epithelium has been shown to express a vari...

journal_title：American journal of respiratory cell and molecular biology

authors： Shi L,Manthei DM,Guadarrama AG,Lenertz LY,Denlinger LC

更新日期：2012-09-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR) γ is critical for alveolar macrophage (AM) function. Chronic alcohol abuse causes AM phagocytic dysfunction and susceptibility to respiratory infections by stimulating nicotinamide adenine dinucleotide oxidases (Nox), transforming growth factor-β1, and oxidative stress...

journal_title：American journal of respiratory cell and molecular biology

authors： Yeligar SM,Mehta AJ,Harris FL,Brown LA,Hart CM

更新日期：2016-07-01 00:00:00

abstract：:In the present study, we sought to elucidate the mechanisms by which monocytes migrate into the pleural space in the presence of anaphylatoxins in tuberculous pleural effusion (TPE). Monocytes in both pleural effusion and blood were counted, and their phenotypic characteristics were analyzed. Activation of the complem...

journal_title：American journal of respiratory cell and molecular biology

authors： Luo L,Li X,Hu X,Hu C,Tang W,Deng S,Feng J

更新日期：2019-04-01 00:00:00