Upregulation of interleukin-4 receptor by interferon-gamma: enhanced interleukin-4-induced eotaxin-3 production in airway epithelium.

abstract：:Fibroblasts are the major mesenchymal cells present within the interstitium of the lung and are a major source of vascular endothelial growth factor (VEGF), which modulates the maintenance of pulmonary microvasculature. Prostaglandin E(2) (PGE(2)) acts on a set of E-prostanoid (EP) receptors that activate multiple sig...

journal_title：American journal of respiratory cell and molecular biology

authors： Nakanishi M,Sato T,Li Y,Nelson AJ,Farid M,Michalski J,Kanaji N,Wang X,Basma H,Patil A,Goraya J,Liu X,Togo S,L Toews M,Holz O,Muller KC,Magnussen H,Rennard SI

更新日期：2012-02-01 00:00:00

abstract：:We hypothesized that, as in animal models, localized deposition of antigen into the human lung would induce local inflammatory and immune responses in antigen-exposed sites. To test this hypothesis, segmental instillation of a well-characterized, highly immunogenic, soluble antigen, keyhole limpet hemocyanin (KLH) was...

journal_title：American journal of respiratory cell and molecular biology

authors： Weissman DN,Bice DE,Crowell RE,Schuyler MR

更新日期：1994-11-01 00:00:00

abstract：:Although hemolytic anemia-associated pulmonary hypertension (PH) and pulmonary arterial hypertension (PAH) are more common than the prevalence of idiopathic PAH alone, the role of hemolysis in the development of PAH is poorly characterized. We hypothesized that hemolysis independently contributes to PAH pathogenesis v...

journal_title：American journal of respiratory cell and molecular biology

authors： Rafikova O,Williams ER,McBride ML,Zemskova M,Srivastava A,Nair V,Desai AA,Langlais PR,Zemskov E,Simon M,Mandarino LJ,Rafikov R

更新日期：2018-09-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMN) release gelatinase B in response to variable stimuli. Gelatinase B degrades basement membrane components in vitro, and inhibition of matrix metalloproteinase activity blunts PMN migration through a prototype basement membrane (Matrigel) and amnionic membranes. Accordingly, it has bee...

journal_title：American journal of respiratory cell and molecular biology

authors： Betsuyaku T,Shipley JM,Liu Z,Senior RM

更新日期：1999-06-01 00:00:00

abstract：:Lung fibrosis has been postulated to be mediated by the production of macrophage-derived growth factors that are both mitogenic and chemotactic for fibroblasts. In vitro studies from our laboratory demonstrated that alveolar and interstitial macrophages treated with iron and asbestos release platelet-derived growth fa...

journal_title：American journal of respiratory cell and molecular biology

authors： Osornio-Vargas AR,Kalter VG,Badgett A,Hernández-Rodríguez N,Aguilar-Delfín I,Brody AR

更新日期：1993-05-01 00:00:00

abstract：:New approaches for improving tuberculosis (TB) control using adjunct host-directed cellular and repurposed drug therapies are needed. Autophagy plays a crucial role in the response to TB, and a variety of autophagy-inducing drugs that are currently available for various medical conditions may serve as an adjunct treat...

journal_title：American journal of respiratory cell and molecular biology

authors： Juárez E,Carranza C,Sánchez G,González M,Chávez J,Sarabia C,Torres M,Sada E

更新日期：2016-12-01 00:00:00

abstract：:Primary hamster tracheal surface epithelial (HTSE) cells carry mucin-like glycoproteins on the apical surface which are releasable by neutrophil elastase. In some cancer cells, mucins are localized on the cell surface and have been shown to be encoded by the MUC1 mucin gene. The objectives of the present experiments w...

journal_title：American journal of respiratory cell and molecular biology

authors： Park H,Hyun SW,Kim KC

更新日期：1996-08-01 00:00:00

abstract：:We examined the mechanisms underlying tachyphylaxis to beta-adrenergic receptor agonists (beta-agonists) in tracheal smooth muscle. Simultaneous measurements of isometric tension and intracellular Ca2+ concentration ([Ca2+]i) using fura-2-loaded guinea pig tracheas showed that the inhibitory effects of isoproterenol (...

journal_title：American journal of respiratory cell and molecular biology

authors： Kume H,Ishikawa T,Oguma T,Ito S,Shimokata K,Kotlikoff MI

更新日期：2003-09-01 00:00:00

abstract：:Alveolar type (AT)I and ATII cells are central to maintaining normal alveolar fluid homeostasis. When disrupted, they contribute to the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome. Research on ATII cells has been limited by the inability to propagate primary cells in vitro to study ...

journal_title：American journal of respiratory cell and molecular biology

authors： Bove PF,Dang H,Cheluvaraju C,Jones LC,Liu X,O'Neal WK,Randell SH,Schlegel R,Boucher RC

更新日期：2014-04-01 00:00:00

abstract：:Although it is known that surfactant lipids and proteins are altered in patients with Pseudomonas aeruginosa infections, the mechanisms and implications of these alterations are not clear. In this study, the effects of P. aeruginosa on the surfactant large aggregate fraction were examined using an in vitro surface are...

journal_title：American journal of respiratory cell and molecular biology

authors： Beatty AL,Malloy JL,Wright JR

更新日期：2005-02-01 00:00:00

abstract：:Patients with systemic hypertension of various etiologies maintain their pulmonary artery pressures within normal limits. We have reported in isolated perfused rat lungs that low basal tone appears to be regulated by nitric oxide (NO)-dependent and -independent mechanisms of soluble guanylate cyclase activation, and s...

journal_title：American journal of respiratory cell and molecular biology

authors： Itani MM,Talerico MG,Pino PA,Burke-Wolin T

更新日期：1996-10-01 00:00:00

abstract：:We have previously shown that long-term treatment of airway smooth muscle (ASM) cells with a combination of TNF-alpha and IFN-gamma impaired steroid anti-inflammatory action through the up-regulation of glucocorticoid receptor beta isoform (GRbeta) (Mol Pharmacol 2006;69:588-596). We here found that steroid actions co...

journal_title：American journal of respiratory cell and molecular biology

authors： Tliba O,Damera G,Banerjee A,Gu S,Baidouri H,Keslacy S,Amrani Y

更新日期：2008-04-01 00:00:00

abstract：:We examined the contribution of the leukocyte function-associated antigen (LFA-1) in a murine model of lung inflammation determined by exposure to the thermophilic actinomycete Faeni rectivirgula. The exposure generated a large influx of cells in the bronchoalveolar space and in the lung parenchyma, as seen from enhan...

journal_title：American journal of respiratory cell and molecular biology

authors： Denis M,Bisson D

更新日期：1994-05-01 00:00:00

abstract：:Prenatal nicotine exposure impairs normal lung development and leads to diminished pulmonary function after birth. Previous work from our laboratory has demonstrated that nicotine alters lung development by affecting a nonneuronal cholinergic autocrine loop that is expressed in lung. Bronchial epithelial cells (BECs) ...

journal_title：American journal of respiratory cell and molecular biology

authors： Fu XW,Lindstrom J,Spindel ER

更新日期：2009-07-01 00:00:00

abstract：:SLC6A14-mediated l-arginine transport has been shown to augment the residual anion channel activity of the major mutant, F508del-CFTR, in the murine gastrointestinal tract. It is not yet known if this transporter augments residual and pharmacological corrected F508del-CFTR in primary airway epithelia. We sought to det...

journal_title：American journal of respiratory cell and molecular biology

authors： Ahmadi S,Wu YS,Li M,Ip W,Lloyd-Kuzik A,Di Paola M,Du K,Xia S,Lew A,Bozoky Z,Forman-Kay J,Bear CE,Gonska T

更新日期：2019-12-01 00:00:00

abstract：:We have developed a method to harvest and culture Clara cells isolated from guinea pig lungs. Their identity was confirmed by the presence of CC16kD protein specific for these cells; we studied their capacity to generate endothelin 1 (ET-1). Using monoclonal antibody and immunofluorescence techniques, ET-1 was localiz...

journal_title：American journal of respiratory cell and molecular biology

authors： Laporte J,D'Orléans-Juste P,Sirois P

更新日期：1996-04-01 00:00:00

abstract：:The purpose of this study was to characterize basolateral anion channels in Calu-3 and normal human bronchial epithelial cells, and their role in anion secretion. Patch clamp studies identified an outwardly rectifying Cl- channel (ORCC), which could be activated by the adenosine receptor agonist 5'-(N-ethylcarboxamido...

journal_title：American journal of respiratory cell and molecular biology

authors： Szkotak AJ,Man SF,Duszyk M

更新日期：2003-12-01 00:00:00

abstract：:In rat models of Gram-negative pneumonia, pulmonary emigration of neutrophils (polymorphonuclear leukocytes [PMNs]) is blocked when rats are made endotoxemic by an intravenous administration of endotoxin (lipopolysaccharide [LPS]). To test whether dysfunctional PMN migratory responses in the endotoxemic rat are specif...

journal_title：American journal of respiratory cell and molecular biology

authors： Wagner JG,Driscoll KE,Roth RA

更新日期：1999-04-01 00:00:00

abstract：:The effects of repeated ozone exposures on the development of immune responses toward ovalbumin (OVA) were investigated in BALB/c and C57BL/6 mice. Ozone exposures (180 to 500 microg/m(3); 4 h, three times/wk for 4 wk) were combined with a protocol of OVA-aerosol exposure (1% OVA). Immediate cutaneous hypersensitivity...

journal_title：American journal of respiratory cell and molecular biology

authors： Neuhaus-Steinmetz U,Uffhausen F,Herz U,Renz H

更新日期：2000-08-01 00:00:00

abstract：:The cellular events involved in generating the hypoxic pulmonary vasoconstriction response are not clearly understood, in part because of the multitude of factors that alter pulmonary vascular tone. The goal of the present studies was to determine if a cell culture preparation containing vascular smooth muscle (VSM) c...

journal_title：American journal of respiratory cell and molecular biology

authors： Murray TR,Chen L,Marshall BE,Macarak EJ

更新日期：1990-11-01 00:00:00

abstract：:Enhanced protein tyrosine phosphorylation is associated with changes in vascular permeability through formation and dissolution of adherens junctions and regulation of stress fiber formation. Inhibition of the protein tyrosine phosphorylase SH2 domain-containing protein tyrosine phosphatase 2 (SHP2) increases tyrosine...

journal_title：American journal of respiratory cell and molecular biology

authors： Chichger H,Braza J,Duong H,Harrington EO

更新日期：2015-06-01 00:00:00

abstract：:Heme oxygenase (HO)-1, an inducible, low-molecular-weight stress protein, confers cellular and tissue protection in multiple models of injury and disease, including oxidative or inflammatory lung injury, ischemia/reperfusion (I/R) injuries, and vascular injury/disease. The tissue protection provided by HO-1 potentiall...

journal_title：American journal of respiratory cell and molecular biology

authors： Ryter SW,Morse D,Choi AM

更新日期：2007-02-01 00:00:00

abstract：:Eotaxins-1, -2, and -3 mediate the recruitment of blood-borne eosinophils to allergically inflamed tissues by binding CC chemokine receptor (CCR) 3. Mast cells (MCs) are resident tissue cells that also express CCR3. In the present study, we demonstrate that human (h) MCs in nasal polyps and cultured cord blood-derived...

journal_title：American journal of respiratory cell and molecular biology

authors： Price KS,Friend DS,Mellor EA,De Jesus N,Watts GF,Boyce JA

更新日期：2003-04-01 00:00:00

abstract：:Degradation of preexisting and newly synthesized extracellular matrix is thought to play an important role in tissue remodeling. The current study evaluated whether thrombin and TNF-alpha/IL-1beta could collaboratively induce collagen degradation by human fetal lung fibroblasts (HFL-1) and adult bronchial fibroblasts ...

journal_title：American journal of respiratory cell and molecular biology

authors： Fang Q,Liu X,Al-Mugotir M,Kobayashi T,Abe S,Kohyama T,Rennard SI

更新日期：2006-12-01 00:00:00

abstract：:Alveolar macrophages (AM) express gelatinase B, a member of the matrix metalloproteinase family involved in the degradation and remodeling of extracellular matrix components. We evaluated the expression of gelatinase B in the course of idiopathic pulmonary fibrosis (IPF) by studying alveolar macrophages in culture AM ...

journal_title：American journal of respiratory cell and molecular biology

authors： Lemjabbar H,Gosset P,Lechapt-Zalcman E,Franco-Montoya ML,Wallaert B,Harf A,Lafuma C

更新日期：1999-05-01 00:00:00

abstract：:Cyclic adenosine monophosphate (cAMP) was the original "second messenger" to be discovered. Its formation is promoted by adenylyl cyclase activation after ligation of G protein-coupled receptors by ligands including hormones, autocoids, prostaglandins, and pharmacologic agents. Increases in intracellular cAMP generall...

journal_title：American journal of respiratory cell and molecular biology

authors： Serezani CH,Ballinger MN,Aronoff DM,Peters-Golden M

更新日期：2008-08-01 00:00:00

abstract：:Tissue inhibitors of metalloproteinases (TIMPs) are multifunctional proteins that have the capacity to modify cellular activities and to modulate matrix turnover. We demonstrate that TIMP-1 messenger RNA (mRNA) and protein expression are selectively and markedly increased in a murine model of bleomycin-induced pulmona...

journal_title：American journal of respiratory cell and molecular biology

authors： Madtes DK,Elston AL,Kaback LA,Clark JG

更新日期：2001-05-01 00:00:00

abstract：:The present study utilized the monocrotaline (MCT) model of pulmonary hypertension in rats to examine temporal alterations in steady-state levels of basement membrane (BM) component mRNA and deposition of protein using Northern analysis and immunohistochemistry, respectively. MCT (60 mg/kg, subcutaneous) produced sust...

journal_title：American journal of respiratory cell and molecular biology

authors： Lipke DW,Arcot SS,Gillespie MN,Olson JW

更新日期：1993-10-01 00:00:00

abstract：:While elastin degradation is a hallmark of pulmonary emphysema, it is likely that elastin synthesis also occurs. However, the supramolecular structure and function of the newly synthesized elastin are abnormal. Very little is known about the regulation of elastin synthesis during the development of emphysema when prom...

journal_title：American journal of respiratory cell and molecular biology

authors： McGowan SE,McNamer R

更新日期：1990-10-01 00:00:00

abstract：:Airway epithelial cell defenses to viral infections are often compromised in disease or injury. Danger molecules, including ATP, are released during infection and contribute to nucleotide receptor-dependent inflammatory responses, largely through P2X(7). Although respiratory epithelium has been shown to express a vari...

journal_title：American journal of respiratory cell and molecular biology

authors： Shi L,Manthei DM,Guadarrama AG,Lenertz LY,Denlinger LC

更新日期：2012-09-01 00:00:00