Inhibition of pulmonary neutrophil trafficking during endotoxemia is dependent on the stimulus for migration.

abstract：:Pulmonary carbonic anhydrase (CA) activity plays important roles in carbon dioxide exchange, fluid secretion, and pH regulation. This study reports the use of molecular and immunologic techniques to characterize expression of the high-activity cytosolic isoenzyme CA II in rat lung tissue. Northern blot analysis of RNA...

journal_title：American journal of respiratory cell and molecular biology

authors： Fleming RE,Moxley MA,Waheed A,Crouch EC,Sly WS,Longmore WJ

更新日期：1994-05-01 00:00:00

abstract：:Fetal airway smooth muscle contracts to neural stimulation from early gestation. This study aimed to document the development of the nerves and ganglia within the bronchial tree of the fetal pig lung as the structural correlates for this function. The formation of these structures during lung development (pseudoglandu...

journal_title：American journal of respiratory cell and molecular biology

authors： Weichselbaum M,Sparrow MP

更新日期：1999-11-01 00:00:00

abstract：:Higher numbers of eosinophil/basophil colony-forming units (Eo/B CFU) are observed in blood of atopic individuals, and can be enhanced in atopic asthmatics by allergen-inhalation challenge. It is known that mature basophils and eosinophils synthesize cytokines relevant to allergic inflammation. To investigate the pote...

journal_title：American journal of respiratory cell and molecular biology

authors： Gauvreau GM,O'Byrne PM,Moqbel R,Velazquez J,Watson RM,Howie KJ,Denburg JA

更新日期：1998-07-01 00:00:00

abstract：:Epidemiologic studies have linked gestational vitamin D deficiency to respiratory diseases, although mechanisms have not been defined. We hypothesized that antenatal vitamin D deficiency would impair airway development and alveolarization in a mouse model. We studied the effect of antenatal vitamin D deficiency by ind...

journal_title：American journal of respiratory cell and molecular biology

authors： Saadoon A,Ambalavanan N,Zinn K,Ashraf AP,MacEwen M,Nicola T,Fanucchi MV,Harris WT

更新日期：2017-03-01 00:00:00

abstract：:The experiments described herein define a unique program of polarization of suspended human eosinophils stimulated with IL-5 family cytokines. We found that eosinophil granules and the nucleus move in opposite directions to form, respectively, a granular compartment and the nucleopod, a specialized uropod occupied by ...

journal_title：American journal of respiratory cell and molecular biology

authors： Han ST,Mosher DF

更新日期：2014-03-01 00:00:00

abstract：:Bombesin-like peptides within neuroepithelial cells elicit proliferation of normal and malignant airway epithelial cells. It is not clear that these peptides also elicit epithelial cell migration, a necessary component of airway repair after injury. We studied the effects of the bombesin analogues, gastrin releasing p...

journal_title：American journal of respiratory cell and molecular biology

authors： Kim JS,McKinnis VS,White SR

更新日期：1997-03-01 00:00:00

abstract：:Bacterial pneumonia is a common public health problem associated with significant mortality, morbidity, and cost. Neutrophils are usually the earliest leukocytes to respond to bacteria in the lungs. Neutrophils rapidly sequester in the pulmonary microvasculature and migrate into the lung parenchyma and alveolar spaces...

journal_title：American journal of respiratory cell and molecular biology

authors： Gomez JC,Yamada M,Martin JR,Dang H,Brickey WJ,Bergmeier W,Dinauer MC,Doerschuk CM

更新日期：2015-03-01 00:00:00

abstract：:T1alpha is a protein of unknown function that is expressed at the plasma membrane in epithelia involved in fluid transport, including type I alveolar epithelial cells, choroid plexus, and ciliary epithelium. The purpose of this study was to test the hypothesis that T1alpha functions as a water channel or a regulator o...

journal_title：American journal of respiratory cell and molecular biology

authors： Ma T,Yang B,Matthay MA,Verkman AS

更新日期：1998-07-01 00:00:00

abstract：:Adenosine concentrations are elevated in the lungs of patients with asthma and chronic obstructive pulmonary disease, where it balances between tissue repair and excessive airway remodeling. We previously demonstrated that the activation of the adenosine A2A receptor promotes epithelial wound closure. However, the mec...

journal_title：American journal of respiratory cell and molecular biology

authors： Allen-Gipson DS,Zimmerman MC,Zhang H,Castellanos G,O'Malley JK,Alvarez-Ramirez H,Kharbanda K,Sisson JH,Wyatt TA

更新日期：2013-05-01 00:00:00

abstract：:Lungs are repeatedly exposed to inhaled toxic insults, such as smoke, diesel exhaust, and microbes, which elicit cellular stress responses. The phosphorylation of eukaryotic translation initiation factor 2α by one of four stress-sensing kinases triggers a pathway called the integrated stress response that helps protec...

journal_title：American journal of respiratory cell and molecular biology

authors： van 't Wout EF,Hiemstra PS,Marciniak SJ

更新日期：2014-06-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMN) and eosinophils (Eos) are important cellular participants in a variety of acute and chronic inflammatory reactions in the airway. Histologic evidence has implicated direct interactions between these two subsets of leukocytes and airway epithelial cells during inflammation. A comprehe...

journal_title：American journal of respiratory cell and molecular biology

authors： Jagels MA,Daffern PJ,Zuraw BL,Hugli TE

更新日期：1999-09-01 00:00:00

abstract：:Clara-cell populations show a high degree of variation in susceptibility to injury by bioactivated cytotoxicants. Because glutathione (GSH) is critical for detoxification of electrophilic metabolites, heterogeneity in Clara cell GSH levels may lead to a wide range of cytotoxic responses. This study was designed to def...

journal_title：American journal of respiratory cell and molecular biology

authors： West JA,Chichester CH,Buckpitt AR,Tyler NK,Brennan P,Helton C,Plopper CG

更新日期：2000-07-01 00:00:00

abstract：:Although it is known that surfactant lipids and proteins are altered in patients with Pseudomonas aeruginosa infections, the mechanisms and implications of these alterations are not clear. In this study, the effects of P. aeruginosa on the surfactant large aggregate fraction were examined using an in vitro surface are...

journal_title：American journal of respiratory cell and molecular biology

authors： Beatty AL,Malloy JL,Wright JR

更新日期：2005-02-01 00:00:00

abstract：:CTP:phosphocholine cytidylyltransferase (CT) is the rate-limiting enzyme in the biosynthesis by type II pneumocytes of phosphatidylcholine (PC), the predominant phospholipid in lung surfactant. Augmentation of endogenous CT activity might therefore result in enhanced surfactant PC production. To test this hypothesis, ...

journal_title：American journal of respiratory cell and molecular biology

authors： Li J,Marsh JJ,Spragg RG

更新日期：2002-06-01 00:00:00

abstract：:Lung injury is a frequent consequence of oxygen (O2) therapy administered to newborns and adults with respiratory distress. Acute exposure to hyperoxia results in a well-described pathophysiologic response in the lungs. Because inflammation is an important component of pulmonary O2 toxicity, we have an interest in ide...

journal_title：American journal of respiratory cell and molecular biology

authors： Piedboeuf B,Gamache M,Frenette J,Horowitz S,Baldwin HS,Petrov P

更新日期：1998-10-01 00:00:00

abstract：:Vascular remodeling is an important pathological feature of pulmonary arterial hypertension (PAH), which leads to increased pulmonary vascular resistance, with marked proliferation of pulmonary artery smooth muscle cells (SMC) and/or endothelial cells (EC). Successful treatment of experimental PAH with a platelet-deri...

journal_title：American journal of respiratory cell and molecular biology

authors： Sakao S,Tatsumi K,Voelkel NF

更新日期：2010-12-01 00:00:00

abstract：:Serum contains a number of polypeptide growth factors, hormones, and soluble matrix components and may influence the state of differentiation of epithelial cells in general and of alveolar epithelial cells (AEC) in particular. To evaluate the influence of sera on the transition from the type II toward the type I cell ...

journal_title：American journal of respiratory cell and molecular biology

authors： Borok Z,Hami A,Danto SI,Zabski SM,Crandall ED

更新日期：1995-01-01 00:00:00

abstract：:Hydrogen peroxide (H(2)O(2)) is found in exhaled breath and is produced by airway epithelia. In addition, H(2)O(2) is a necessary substrate for the airway lactoperoxidase (LPO) anti-infection system. To investigate the source of H(2)O(2) produced by airway epithelia, PCR was used to screen nicotinamide adenine dinucle...

journal_title：American journal of respiratory cell and molecular biology

authors： Forteza R,Salathe M,Miot F,Forteza R,Conner GE

更新日期：2005-05-01 00:00:00

abstract：:Successful phagolysosomal maturation is an important innate immune response to intracellular infection. However, Mycobacterium tuberculosis (Mtb) can manipulate and inhibit this host response to ensure survival within its niche cell. We investigate the role of the anti-inflammatory cytokine IL-10 on Mtb-phagosome matu...

journal_title：American journal of respiratory cell and molecular biology

authors： O'Leary S,O'Sullivan MP,Keane J

更新日期：2011-07-01 00:00:00

abstract：:Previously it was reported that hyperoxia induced death of the human lung adenocarcinoma cell line (A549 cells) by necrosis, not by apoptosis. This study examined proliferation and death of untransformed human small airway epithelial (SAE) cells in normoxia or hyperoxia in comparison with A549 cells. We tested the hyp...

journal_title：American journal of respiratory cell and molecular biology

authors： Jyonouchi H,Sun S,Abiru T,Chareancholvanich S,Ingbar DH

更新日期：1998-09-01 00:00:00

abstract：:Toll-interacting protein (TOLLIP) is an intracellular adaptor protein with diverse actions throughout the body. In a context- and cell type-specific manner, TOLLIP can function as an inhibitor of inflammation and endoplasmic reticulum stress, an activator of autophagy, or a critical regulator of intracellular vacuole ...

journal_title：American journal of respiratory cell and molecular biology

authors： Li X,Goobie GC,Gregory AD,Kass DJ,Zhang Y

更新日期：2020-11-24 00:00:00

abstract：:To assess the temporal and spatial expression of the matrix-associated proteoglycan, biglycan, in a model of chronic hyperoxia-induced lung injury, changes in mRNA and protein were examined using Northern blot analyses and immunohistochemistry. Newborn rats were exposed to 85% or 100% oxygen for 6 and 4 wk, respective...

journal_title：American journal of respiratory cell and molecular biology

authors： Veness-Meehan KA,Rhodes DN,Stiles AD

更新日期：1994-11-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) expression and PGE2 secretion from human airway smooth muscle cells (hASMCs) may contribute to β2-adrenoceptor hyporesponsiveness, a clinical feature observed in some patients with asthma. hASMCs from patients with asthma exhibit elevated expression of cytokine-responsive genes, and in some in...

journal_title：American journal of respiratory cell and molecular biology

authors： Comer BS,Camoretti-Mercado B,Kogut PC,Halayko AJ,Solway J,Gerthoffer WT

更新日期：2015-04-01 00:00:00

abstract：:The prevalence of asthma has increased in recent years, and is characterized by airway hyperresponsiveness and inflammation. Many patients report using alternative therapies to self-treat asthma symptoms as adjuncts to short-acting and long-acting β-agonists and inhaled corticosteroids (ICS). As many as 40% of patient...

journal_title：American journal of respiratory cell and molecular biology

authors： Townsend EA,Siviski ME,Zhang Y,Xu C,Hoonjan B,Emala CW

更新日期：2013-02-01 00:00:00

abstract：:Oxidants in cigarette smoke inhibit pathogen recognition receptor function and phagocytosis, but the molecular basis of this inhibition remains obscure. We sought to identify the inhibitory mechanisms that impair alveolar macrophage function. Balb/c mice were acutely exposed to four cigarettes for 4 hours before treat...

journal_title：American journal of respiratory cell and molecular biology

authors： Bozinovski S,Vlahos R,Zhang Y,Lah LC,Seow HJ,Mansell A,Anderson GP

更新日期：2011-08-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis is a lethal parenchymal lung disease characterized by denudation of the lung epithelium, fibroblast proliferation, and collagen deposition. Cellular changes underlying disease progression involve injury to alveolar epithelial cells, epithelial to mesenchymal transition, proliferation of a...

journal_title：American journal of respiratory cell and molecular biology

authors： Shukla MN,Rose JL,Ray R,Lathrop KL,Ray A,Ray P

更新日期：2009-06-01 00:00:00

abstract：:The alveolar epithelium is a critical target for pulmonary viruses and can produce proinflammatory cytokines and chemokines upon viral infection. However, the molecular interactions between virus-infected alveolar epithelial cells and inflammatory cells, including polymorphonuclear leukocytes (PMNs), have not been tho...

journal_title：American journal of respiratory cell and molecular biology

authors： Rzepka JP,Haick AK,Miura TA

更新日期：2012-06-01 00:00:00

abstract：:Cyclic adenosine monophosphate (cAMP) was the original "second messenger" to be discovered. Its formation is promoted by adenylyl cyclase activation after ligation of G protein-coupled receptors by ligands including hormones, autocoids, prostaglandins, and pharmacologic agents. Increases in intracellular cAMP generall...

journal_title：American journal of respiratory cell and molecular biology

authors： Serezani CH,Ballinger MN,Aronoff DM,Peters-Golden M

更新日期：2008-08-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a potent peptide growth factor specific for vascular endothelial cells, which promotes neovascularization and increases vascular permeability in vivo. Enhanced microvascular permeability and edema are common characteristics of inflammatory and neoplastic disorders. Two proi...

journal_title：American journal of respiratory cell and molecular biology

authors： Nauck M,Roth M,Tamm M,Eickelberg O,Wieland H,Stulz P,Perruchoud AP

更新日期：1997-04-01 00:00:00

abstract：:Human alveolar macrophages (HAM) express FcalphaR receptors for immunoglobulin (Ig)A which could link humoral and cellular branches of lung immunity. Here, we investigate the effects of polymeric (p-IgA) and secretory (S-IgA) IgA interaction with Fc(alpha)R on lipopolysaccharide (LPS)- and phorbol myristate acetate (P...

journal_title：American journal of respiratory cell and molecular biology

authors： Ouadrhiri Y,Pilette C,Monteiro RC,Vaerman JP,Sibille Y

更新日期：2002-03-01 00:00:00