The integrated stress response in lung disease.

abstract：:Adenosine concentrations are elevated in the lungs of patients with asthma and chronic obstructive pulmonary disease, where it balances between tissue repair and excessive airway remodeling. We previously demonstrated that the activation of the adenosine A2A receptor promotes epithelial wound closure. However, the mec...

journal_title：American journal of respiratory cell and molecular biology

authors： Allen-Gipson DS,Zimmerman MC,Zhang H,Castellanos G,O'Malley JK,Alvarez-Ramirez H,Kharbanda K,Sisson JH,Wyatt TA

更新日期：2013-05-01 00:00:00

abstract：:We examined the contribution of the leukocyte function-associated antigen (LFA-1) in a murine model of lung inflammation determined by exposure to the thermophilic actinomycete Faeni rectivirgula. The exposure generated a large influx of cells in the bronchoalveolar space and in the lung parenchyma, as seen from enhan...

journal_title：American journal of respiratory cell and molecular biology

authors： Denis M,Bisson D

更新日期：1994-05-01 00:00:00

abstract：:Bronchiolitis obliterans (BO) is an increasingly important lung disease characterized by fibroproliferative airway lesions and decrements in lung function. Occupational exposure to the artificial food flavoring ingredient diacetyl, commonly used to impart a buttery flavor to microwave popcorn, has been associated with...

journal_title：American journal of respiratory cell and molecular biology

authors： Brass DM,Gwinn WM,Valente AM,Kelly FL,Brinkley CD,Nagler AE,Moseley MA,Morgan DL,Palmer SM,Foster MW

更新日期：2017-06-01 00:00:00

abstract：:Mutations in the p53 gene have been implicated to play an important role in the development of various human cancers. To evaluate the importance of p53 in lung cancer, a transgenic mouse model was established by utilizing the Clara cell secretory protein (CCSP) promoter to target the expression of a dominant-negative ...

journal_title：American journal of respiratory cell and molecular biology

authors： Tchou-Wong KM,Jiang Y,Yee H,LaRosa J,Lee TC,Pellicer A,Jagirdar J,Gordon T,Goldberg JD,Rom WN

更新日期：2002-08-01 00:00:00

abstract：:The objective of this study was to define phenotypic changes of antigen-presenting cells (APCs) and T cells in a murine model of antigen-induced airways inflammation that involves intraperitoneal sensitization with ovalbumin (OVA)/adjuvant followed by antigen aerosolization. We investigated the APC and T-cell compartm...

journal_title：American journal of respiratory cell and molecular biology

authors： Gajewska BU,Swirski FK,Alvarez D,Ritz SA,Goncharova S,Cundall M,Snider DP,Coyle AJ,Gutierrez-Ramos JC,Stämpfli MR,Jordana M

更新日期：2001-09-01 00:00:00

abstract：:Studies in animals and in human atopic skin suggest that allergen challenge may activate acute tissue remodeling changes via transforming growth factor-beta pathways. We determined whether inhalational allergen challenge in subjects with mild asthma induces similar acute changes to the airway epithelial mesenchymal tr...

journal_title：American journal of respiratory cell and molecular biology

authors： Phipps S,Benyahia F,Ou TT,Barkans J,Robinson DS,Kay AB

更新日期：2004-12-01 00:00:00

abstract：:Motile cilia are essential for clearance of particulates and pathogens from airways. For effective transport, ciliary motor proteins and axonemal structures interact to generate the rhythmic, propulsive bending, but the mechanisms that produce a dynamic waveform remain incompletely understood. Biomechanical measures o...

journal_title：American journal of respiratory cell and molecular biology

authors： Oltean A,Schaffer AJ,Bayly PV,Brody SL

更新日期：2018-10-01 00:00:00

abstract：:It has long been speculated that neutrophils deploy proteases to digest subendothelial matrix as they migrate from the bloodstream. Direct evidence for the involvement of proteases in neutrophil transendothelial migration is, however, lacking. To address this issue we used transmission electron microscopy to verify th...

journal_title：American journal of respiratory cell and molecular biology

authors： Mackarel AJ,Cottell DC,Russell KJ,FitzGerald MX,O'Connor CM

更新日期：1999-06-01 00:00:00

abstract：:The prevalence of asthma has increased in recent years, and is characterized by airway hyperresponsiveness and inflammation. Many patients report using alternative therapies to self-treat asthma symptoms as adjuncts to short-acting and long-acting β-agonists and inhaled corticosteroids (ICS). As many as 40% of patient...

journal_title：American journal of respiratory cell and molecular biology

authors： Townsend EA,Siviski ME,Zhang Y,Xu C,Hoonjan B,Emala CW

更新日期：2013-02-01 00:00:00

abstract：:A number of metalloproteinases that degrade the extracellular matrix of connective tissues and two specific tissue inhibitors of metalloproteinases (TIMPs) have now been isolated, characterized, and cloned. Comparison of the enzyme sequences has allowed the delineation of domain structures, and initial studies have be...

journal_title：American journal of respiratory cell and molecular biology

authors： Murphy G,Docherty AJ

更新日期：1992-08-01 00:00:00

abstract：:Alveolar macrophages (AM) and interstitial macrophages (IM) from rat lungs were characterized with respect to morphology, phagocytosis, adhesion properties, and phenotype. AM were recovered by lung lavage and IM by treatment of the lung tissue with DNAse and collagenase. The AM were enzyme treated in the same way as t...

journal_title：American journal of respiratory cell and molecular biology

authors： Johansson A,Lundborg M,Sköld CM,Lundahl J,Tornling G,Eklund A,Camner P

更新日期：1997-05-01 00:00:00

abstract：:In surgically excised nasal polyps, most epithelial mast cells were formalin sensitive, chloroacetate esterase (CAE) negative, and chymase negative. Thus, this represents a population of mast cells not identified by staining for CAE. On the other hand, most stromal mast cells were formalin resistant and CAE positive, ...

journal_title：American journal of respiratory cell and molecular biology

authors： Kawabori S,Denburg JA,Schwartz LB,Irani AA,Wong D,Jordana G,Evans S,Dolovich J

更新日期：1992-01-01 00:00:00

abstract：:Previous studies by our group as well as others have shown that acute adenosine exposure enhances lung vascular endothelial barrier integrity and protects against increased permeability lung edema. In contrast, there is growing evidence that sustained adenosine exposure has detrimental effects on the lungs, including ...

journal_title：American journal of respiratory cell and molecular biology

authors： Lu Q,Newton J,Hsiao V,Shamirian P,Blackburn MR,Pedroza M

更新日期：2012-11-01 00:00:00

abstract：:Eosinophils are an important source of leukotriene (LT)C(4), which can be synthesized within lipid bodies-cytoplasmic organelles where eicosanoid formation may take place. Allergy-driven lipid body formation and function have never been investigated. Here, we studied the in vivo induction and role of lipid bodies with...

journal_title：American journal of respiratory cell and molecular biology

authors： Vieira-de-Abreu A,Assis EF,Gomes GS,Castro-Faria-Neto HC,Weller PF,Bandeira-Melo C,Bozza PT

更新日期：2005-09-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF alpha) is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils, and it can promote mediator and cytokine release, adhesion molecule expression, and granulocyte migration. Therefore, we induced an IgE-mediated response in ...

journal_title：American journal of respiratory cell and molecular biology

authors： Casale TB,Costa JJ,Galli SJ

更新日期：1996-07-01 00:00:00

abstract：:To investigate mechanisms regulating intra-alveolar coagulation, we studied monolayers of the A549 human lung epithelial cell line. The surface of A549 cells delayed the onset of prothrombin-to-thrombin conversion and prevented total prothrombin consumption in normal plasma compared to plastic cell-free wells. Similar...

journal_title：American journal of respiratory cell and molecular biology

authors： Berry L,Andrew M,Post M,Ofosu F,O'Brodovich H

更新日期：1991-04-01 00:00:00

abstract：:Alveolar type (AT)I and ATII cells are central to maintaining normal alveolar fluid homeostasis. When disrupted, they contribute to the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome. Research on ATII cells has been limited by the inability to propagate primary cells in vitro to study ...

journal_title：American journal of respiratory cell and molecular biology

authors： Bove PF,Dang H,Cheluvaraju C,Jones LC,Liu X,O'Neal WK,Randell SH,Schlegel R,Boucher RC

更新日期：2014-04-01 00:00:00

abstract：:Tumor necrosis factor (TNF) is an inflammatory cytokine produced by many cell types which may contribute to the pathophysiology of a variety of lung diseases. In this study we have used Ro 45-2081 (a soluble receptor composed of the human p55 TNF receptor and human heavy-chain immunoglobulin G) to explore the role of ...

journal_title：American journal of respiratory cell and molecular biology

authors： Gater PR,Wasserman MA,Paciorek PM,Renzetti LM

更新日期：1996-05-01 00:00:00

abstract：:The etiology of acute lung injury is complex and associated with numerous, chemically diverse precipitating factors. During acute lung injury in mice, one key event is epithelial cell injury that leads to reduced surfactant biosynthesis. We have previously reported that transgenic mice that express transforming growth...

journal_title：American journal of respiratory cell and molecular biology

authors： Bein K,Wesselkamper SC,Liu X,Dietsch M,Majumder N,Concel VJ,Medvedovic M,Sartor MA,Henning LN,Venditto C,Borchers MT,Barchowsky A,Weaver TE,Tichelaar JW,Prows DR,Korfhagen TR,Hardie WD,Bachurski CJ,Leikauf GD

更新日期：2009-08-01 00:00:00

abstract：:Endotoxin (lipopolysaccharide [LPS]) is known to induce the production of tumor necrosis factor (TNF)-alpha and the induction of manganese superoxide dismutase (MnSOD). We have recently demonstrated that induction of TNF-alpha and MnSOD by LPS is mediated through different signal transduction pathways. In the current ...

journal_title：American journal of respiratory cell and molecular biology

authors： White JE,Tsan MF

更新日期：2001-02-01 00:00:00

abstract：:Hypervascularity is known as an important element of airway remodeling in bronchial asthma. However, it remains obscure how allergic inflammation relates to angiogenesis in the lung. In this study, we examined the in vitro effects of inflammatory cytokines on endothelial cell functions, particularly angiogenesis. Huma...

journal_title：American journal of respiratory cell and molecular biology

authors： Matsuda A,Fukuda S,Matsumoto K,Saito H

更新日期：2008-02-01 00:00:00

abstract：:Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease negatively impacts quality of life and survival. Cigarette smoking (CS) is the major risk factor for chronic obstructive pulmonary disease and skeletal muscle dysfunction; however, how CS affects skeletal muscle function remains enigmat...

journal_title：American journal of respiratory cell and molecular biology

authors： Chan SMH,Cerni C,Passey S,Seow HJ,Bernardo I,van der Poel C,Dobric A,Brassington K,Selemidis S,Bozinovski S,Vlahos R

更新日期：2020-02-01 00:00:00

abstract：:Redox imbalance has been implicated in the pathogenesis of many acute and chronic lung diseases. The b-Zip transcription factor Nrf2 acts via an antioxidant/electrophilic response element to regulate antioxidants and maintain cellular redox homeostasis. Our previous studies have shown that Nrf2-deficient mice (Nrf2(-/...

journal_title：American journal of respiratory cell and molecular biology

authors： Reddy NM,Kleeberger SR,Cho HY,Yamamoto M,Kensler TW,Biswal S,Reddy SP

更新日期：2007-07-01 00:00:00

abstract：:We examined the potential of several epithelial-derived factors to enhance neutrophil activation and survival. Neutrophils incubated in the presence of supernatants from nasal-derived primary epithelial cultures had significantly increased survival compared with neutrophils cultured in media alone. Of the cytokines re...

journal_title：American journal of respiratory cell and molecular biology

authors： Daffern PJ,Jagels MA,Hugli TE

更新日期：1999-08-01 00:00:00

abstract：:Degradation of preexisting and newly synthesized extracellular matrix is thought to play an important role in tissue remodeling. The current study evaluated whether thrombin and TNF-alpha/IL-1beta could collaboratively induce collagen degradation by human fetal lung fibroblasts (HFL-1) and adult bronchial fibroblasts ...

journal_title：American journal of respiratory cell and molecular biology

authors： Fang Q,Liu X,Al-Mugotir M,Kobayashi T,Abe S,Kohyama T,Rennard SI

更新日期：2006-12-01 00:00:00

abstract：:Interstitial lung disease is a devastating disease in humans that can be further complicated by the development of secondary pulmonary hypertension. Accumulating evidence indicates that the oxidant superoxide can contribute to the pathogenesis of both interstitial lung disease and pulmonary hypertension. We used a mod...

journal_title：American journal of respiratory cell and molecular biology

authors： Van Rheen Z,Fattman C,Domarski S,Majka S,Klemm D,Stenmark KR,Nozik-Grayck E

更新日期：2011-04-01 00:00:00

abstract：:Approximately 3 billion people-half the worldwide population-are exposed to extremely high concentrations of household air pollution due to the burning of biomass fuels on inefficient cookstoves, accounting for 4 million annual deaths globally. Yet, our understanding of the pulmonary responses to household air polluti...

journal_title：American journal of respiratory cell and molecular biology

authors： Sussan TE,Ingole V,Kim JH,McCormick S,Negherbon J,Fallica J,Akulian J,Yarmus L,Feller-Kopman D,Wills-Karp M,Horton MR,Breysse PN,Agrawal A,Juvekar S,Salvi S,Biswal S

更新日期：2014-03-01 00:00:00

abstract：:Pulmonary accumulation of fibroblasts and myofibroblasts in idiopathic pulmonary fibrosis/usual interstitial pneumonia (IFP/UIP) has been linked to (1) increased migration of a circulating pool of fibrocytes, (2) cell proliferation, and (3) resistance to apoptosis. The mechanism of physiologic apoptosis of lung fibrob...

journal_title：American journal of respiratory cell and molecular biology

authors： Frankel SK,Cosgrove GP,Cha SI,Cool CD,Wynes MW,Edelman BL,Brown KK,Riches DW

更新日期：2006-03-01 00:00:00

abstract：:The growth factors that operate while the lung remodels in hyperoxia are not known. At the lung periphery, high oxygen levels cause cell hypertrophy and hyperplasia, and this results in a thickening of the alveolar-capillary membrane and the walls of its associated microvessels. The present study examines gene express...

journal_title：American journal of respiratory cell and molecular biology

authors： Powell PP,Wang CC,Jones R

更新日期：1992-09-01 00:00:00

abstract：:The biologic activity of substance P has been demonstrated to be limited both in in vivo and in vitro by a membrane-bound protease, neutral endopeptidase (EC 3.4.24.11). The interaction of substance P with its receptor on guinea pig lung tissues was studied in the presence of an inhibitor of neutral endopeptidase unde...

journal_title：American journal of respiratory cell and molecular biology

authors： Coats SR,Gerard NP

更新日期：1989-10-01 00:00:00