Differential induction of TNF-alpha and MnSOD by endotoxin: role of reactive oxygen species and NADPH oxidase.

abstract：:Endothelin, an endothelium-derived vasoconstrictor peptide, has recently been reported to exist in airway epithelial cells. To elucidate a possible role of endothelin on epithelial functions, we studied the effects of this peptide on ciliary beat frequency (CBF) and electrical properties of canine cultured tracheal ep...

journal_title：American journal of respiratory cell and molecular biology

authors： Tamaoki J,Kanemura T,Sakai N,Isono K,Kobayashi K,Takizawa T

更新日期：1991-05-01 00:00:00

abstract：:Adenosine triphosphate (ATP) acting through epithelial nucleotide receptors exerts multiple physiologic actions on airway mucociliary clearance and caliber. However, the effect of ATP on arachidonate metabolism in the airway remains unknown. In this study, the ability of ATP to regulate eicosanoid production was studi...

journal_title：American journal of respiratory cell and molecular biology

authors： Aksoy MO,Borenstein M,Li XX,Kelsen SG

更新日期：1995-10-01 00:00:00

abstract：:The pathological hallmark lesions in idiopathic pulmonary fibrosis are the fibroblastic foci, in which fibroblasts are thought to be involved in the tissue remodeling, matrix deposition, and cross-talk with alveolar epithelium. Recent evidence indicates that some fibroblasts in fibrosis may be derived from bone marrow...

journal_title：American journal of respiratory cell and molecular biology

authors： Hashimoto N,Phan SH,Imaizumi K,Matsuo M,Nakashima H,Kawabe T,Shimokata K,Hasegawa Y

更新日期：2010-08-01 00:00:00

abstract：:Airway remodeling is strongly correlated with the progression of chronic obstructive pulmonary disease (COPD). In this study, our goal was to characterize progressive structural changes in site-specific airways, along with the temporal and spatial expression of transforming growth factor (TGF)-β in the lungs of male s...

journal_title：American journal of respiratory cell and molecular biology

authors： Hoang LL,Nguyen YP,Aspeé R,Bolton SJ,Shen YH,Wang L,Kenyon NJ,Smiley-Jewell S,Pinkerton KE

更新日期：2016-06-01 00:00:00

abstract：:The matrix glycoprotein, fibronectin, stimulates the proliferation of non-small cell lung carcinoma in vitro through α5β1 integrin receptor-mediated signals. However, the true role of fibronectin and its receptor in lung carcinogenesis in vivo remains unclear. To test this, we generated mouse Lewis lung carcinoma cell...

journal_title：American journal of respiratory cell and molecular biology

authors： Roman J,Ritzenthaler JD,Roser-Page S,Sun X,Han S

更新日期：2010-12-01 00:00:00

abstract：:To examine the effects of acid exposure with moderate acidity (pH 3.0-5.0) on bactericidal activity of airway surface liquid (ASL), ASL was collected by washing the surface of primary cultures of human tracheal epithelial cells 24 h after treatment with phosphate-buffered saline (PBS) adjusted to a pH of 3.0, 4.0, or ...

journal_title：American journal of respiratory cell and molecular biology

authors： Nakayama K,Jia YX,Hirai H,Shinkawa M,Yamaya M,Sekizawa K,Sasaki H

更新日期：2002-01-01 00:00:00

abstract：:Identification of the genetic loci underlying asthma in humans has been hampered by variability in clinical phenotype, uncontrolled environmental influences, and genetic heterogeneity. To circumvent these complications, the genetic regulation of asthma-associated phenotypes was studied in a murine model. We characteri...

journal_title：American journal of respiratory cell and molecular biology

authors： Ewart SL,Kuperman D,Schadt E,Tankersley C,Grupe A,Shubitowski DM,Peltz G,Wills-Karp M

更新日期：2000-10-01 00:00:00

abstract：:Alveolar type II cells produce pulmonary surfactant and serve as the stem cell of the alveolar epithelium by proliferating and transforming into type I cells. The study of the differentiated function and proliferative capacity of type II cells in response to injury in vivo has been hindered by the complexity of the sy...

journal_title：American journal of respiratory cell and molecular biology

authors： Kinnard WV,Tuder R,Papst P,Fisher JH

更新日期：1994-10-01 00:00:00

abstract：:Persistent polyclonal lymphocytosis has been described in a group of female patients who all have the HLA-DR7 antigen in common and who are all heavy cigarette smokers. Immunoglobulin heavy chain gene rearrangement was analyzed by hybridization with specific immunoglobulin heavy chain genes to restriction enzyme-diges...

journal_title：American journal of respiratory cell and molecular biology

authors： Chan MA,Benedict SH,Carstairs KC,Francombe WH,Gelfand EW

更新日期：1990-06-01 00:00:00

abstract：:Inhaled nitric oxide (NO) is an important new therapeutic agent used to treat pulmonary arterial hypertension in a variety of disease states. However, the effects of NO on cells in the lung are uncertain. Previously, we have shown that NO gas depresses neutrophil oxidative cell function and increases neutrophil cell d...

journal_title：American journal of respiratory cell and molecular biology

authors： Fortenberry JD,Owens ML,Brown MR,Atkinson D,Brown LA

更新日期：1998-03-01 00:00:00

abstract：:Multiple cytokines play a role in the orchestration of inflammation in inflammatory airway diseases, such as chronic obstructive pulmonary disease, through the recruitment, activation and survival of inflammatory cells. Lymphokines secreted from T cells regulate the pattern of inflammation, whereas proinflammatory cyt...

journal_title：American journal of respiratory cell and molecular biology

authors： Barnes PJ

更新日期：2009-12-01 00:00:00

abstract：:Cigarette smoke-induced apoptosis and necrosis contribute to the pathogenesis of chronic obstructive pulmonary disease. The induction of heme oxygenase-1 provides cytoprotection against oxidative stress, and may protect in smoking-related disease. Since mitochondria regulate cellular death, we examined the functional ...

journal_title：American journal of respiratory cell and molecular biology

authors： Slebos DJ,Ryter SW,van der Toorn M,Liu F,Guo F,Baty CJ,Karlsson JM,Watkins SC,Kim HP,Wang X,Lee JS,Postma DS,Kauffman HF,Choi AM

更新日期：2007-04-01 00:00:00

abstract：:Airway epithelial cell defenses to viral infections are often compromised in disease or injury. Danger molecules, including ATP, are released during infection and contribute to nucleotide receptor-dependent inflammatory responses, largely through P2X(7). Although respiratory epithelium has been shown to express a vari...

journal_title：American journal of respiratory cell and molecular biology

authors： Shi L,Manthei DM,Guadarrama AG,Lenertz LY,Denlinger LC

更新日期：2012-09-01 00:00:00

abstract：:Alveolar macrophages (AM) and interstitial macrophages (IM) from rat lungs were characterized with respect to morphology, phagocytosis, adhesion properties, and phenotype. AM were recovered by lung lavage and IM by treatment of the lung tissue with DNAse and collagenase. The AM were enzyme treated in the same way as t...

journal_title：American journal of respiratory cell and molecular biology

authors： Johansson A,Lundborg M,Sköld CM,Lundahl J,Tornling G,Eklund A,Camner P

更新日期：1997-05-01 00:00:00

abstract：:Interleukin-13 (IL-13) is one of the central mediators for development of airway hyperresponsiveness in asthma. However, its effect on bronchial smooth muscle (BSM) is not well known. Recent studies revealed an involvement of RhoA/Rho-kinase in BSM contraction, and this pathway has now been proposed as a new target fo...

journal_title：American journal of respiratory cell and molecular biology

authors： Chiba Y,Nakazawa S,Todoroki M,Shinozaki K,Sakai H,Misawa M

更新日期：2009-02-01 00:00:00

abstract：:Tissue factor pathway inhibitor (TFPI) is the primary inhibitor of the extrinsic coagulation cascade, and its expression is reported to be relatively stable. Various pathophysiologic agents have been shown to influence TFPI activity by regulating its expression or by modifying the protein. It is not clear how TFPI act...

journal_title：American journal of respiratory cell and molecular biology

authors： Jeffers A,Owens S,Koenig K,Quaid B,Pendurthi UR,Rao VM,Idell S,Tucker TA

更新日期：2015-06-01 00:00:00

abstract：:Vitamin A deficiency strongly predicts the risk of developing tuberculosis (TB) in individuals exposed to Mycobacterium tuberculosis (Mtb). The burden of antibiotic-resistant TB is increasing globally; therefore, there is an urgent need to develop host-directed adjunctive therapies to treat TB. Alveolar macrophages, t...

journal_title：American journal of respiratory cell and molecular biology

authors： Coleman MM,Basdeo SA,Coleman AM,Cheallaigh CN,Peral de Castro C,McLaughlin AM,Dunne PJ,Harris J,Keane J

更新日期：2018-11-01 00:00:00

abstract：:Lung endothelial cell apoptosis and injury occur throughout all stages of acute lung injury/acute respiratory distress syndrome and impact disease progression. Caspases 1, 4, and 5 are essential for completion of the apoptotic program known as pyroptosis that also involves proinflammatory cytokines. Because gasdermin ...

journal_title：American journal of respiratory cell and molecular biology

authors： Mitra S,Exline M,Habyarimana F,Gavrilin MA,Baker PJ,Masters SL,Wewers MD,Sarkar A

更新日期：2018-07-01 00:00:00

abstract：:Extracellular signal-regulated kinases (ERKs) phosphorylate and regulate cytoskeletal components of contractile cells and have been implicated in integrin-mediated adhesion. In this study, we examined the contributions of adherence, cell flattening, and cytoskeletal reorganization to adhesion-induced ERK activation in...

journal_title：American journal of respiratory cell and molecular biology

authors： Heuertz RM,Hamann KJ,Hershenson MB,Leff AR

更新日期：1997-10-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/APO-2L) is a member of the tumor necrosis factor family that induces apoptosis in a variety of transformed cell lines and in normal human hepatocytes and brain cells. Soluble TRAIL at high concentrations was found to induce apoptotic death in normal human ...

journal_title：American journal of respiratory cell and molecular biology

authors： Yurovsky VV

更新日期：2003-02-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a potent peptide growth factor specific for vascular endothelial cells, which promotes neovascularization and increases vascular permeability in vivo. Enhanced microvascular permeability and edema are common characteristics of inflammatory and neoplastic disorders. Two proi...

journal_title：American journal of respiratory cell and molecular biology

authors： Nauck M,Roth M,Tamm M,Eickelberg O,Wieland H,Stulz P,Perruchoud AP

更新日期：1997-04-01 00:00:00

abstract：:Increased susceptibility to infections, including tuberculosis (TB), is a major cause of morbidity and mortality in patients with diabetes. Despite the clinical importance of this problem, little is known about how diabetes impairs protective immunity. We modeled this phenomenon by infecting acute (< or = 1 mo) or chr...

journal_title：American journal of respiratory cell and molecular biology

authors： Martens GW,Arikan MC,Lee J,Ren F,Greiner D,Kornfeld H

更新日期：2007-11-01 00:00:00

abstract：:Although several studies have demonstrated that the pulmonary collectins surfactant protein (SP)-A and SP-D contribute to innate immunity by enhancing pathogen phagocytosis, the role of SP-A and SP-D in regulating production of free radicals and cytokines is controversial. We hypothesized that the state and mechanism ...

journal_title：American journal of respiratory cell and molecular biology

authors： Stamme C,Walsh E,Wright JR

更新日期：2000-12-01 00:00:00

abstract：:Type 2 alveolar epithelial cells (AEC2) are regarded as the progenitor population of the alveolus responsible for injury repair and homeostatic maintenance. Depletion of this population is hypothesized to underlie various lung pathologies. Current models of lung injury rely on either uncontrolled, nonspecific destruct...

journal_title：American journal of respiratory cell and molecular biology

authors： Garcia O,Hiatt MJ,Lundin A,Lee J,Reddy R,Navarro S,Kikuchi A,Driscoll B

更新日期：2016-03-01 00:00:00

abstract：:Metformin has been used as first-line treatment in patients with type 2 diabetes, and is reported to reduce cancer risk and progression by activating the liver kinase B1 (LKB1)-AMP-activated protein kinase (AMPK) pathway. Cisplatin remains the main drug for treating advanced non-small-cell lung cancer. However, drug r...

journal_title：American journal of respiratory cell and molecular biology

authors： Lin CC,Yeh HH,Huang WL,Yan JJ,Lai WW,Su WP,Chen HH,Su WC

更新日期：2013-08-01 00:00:00

abstract：:The role of guanine nucleotide-binding proteins in the induction of prostacyclin synthesis by stimulated endothelial cells is incompletely understood. We report that sodium fluoride (NaF), a potent activator of cellular guanine nucleotide-binding proteins, affected time- and concentration-dependent generation of prost...

journal_title：American journal of respiratory cell and molecular biology

authors： Garcia JG,Dominguez J,English D

更新日期：1991-08-01 00:00:00

abstract：:Recent studies have indicated that, during the development of pulmonary hypertension (PH), there is a switch from oxidative phosphorylation to glycolysis in the pulmonary endothelium. However, the mechanisms underlying this phenomenon have not been elucidated. Endothelin (ET)-1, an endothelial-derived vasoconstrictor ...

journal_title：American journal of respiratory cell and molecular biology

authors： Sun X,Kumar S,Sharma S,Aggarwal S,Lu Q,Gross C,Rafikova O,Lee SG,Dasarathy S,Hou Y,Meadows ML,Han W,Su Y,Fineman JR,Black SM

更新日期：2014-06-01 00:00:00

abstract：:The purpose of this study was to elucidate the effects of aging on diaphragmatic mitochondrial function. Diaphragm mitochondria were prepared from specific pathogen-free rats aged 7 wk (n = 7), 35 wk (n = 7), and 55 wk (n = 7). The activities of various portions of the mitochondrial electron transport chain, i.e., com...

journal_title：American journal of respiratory cell and molecular biology

authors： Torii K,Sugiyama S,Takagi K,Satake T,Ozawa T

更新日期：1992-01-01 00:00:00

abstract：:Acute lung injury (ALI) is a devastating disease with an overall mortality rate of 30 to 40%. The coagulation/fibrinolysis system is implicated in the pathogenesis of ALI. Thrombin-activatable fibronolysis inhibitor (TAFI) is an important component of the fibrinolysis system. Recent studies have shown that the active ...

journal_title：American journal of respiratory cell and molecular biology

authors： Naito M,Taguchi O,Kobayashi T,Takagi T,D'Alessandro-Gabazza CN,Matsushima Y,Boveda-Ruiz D,Gil-Bernabe P,Matsumoto T,Chelakkot-Govindalayathil AL,Toda M,Yasukawa A,Hataji O,Morser J,Takei Y,Gabazza EC

更新日期：2013-10-01 00:00:00

abstract：:A number of metalloproteinases that degrade the extracellular matrix of connective tissues and two specific tissue inhibitors of metalloproteinases (TIMPs) have now been isolated, characterized, and cloned. Comparison of the enzyme sequences has allowed the delineation of domain structures, and initial studies have be...

journal_title：American journal of respiratory cell and molecular biology

authors： Murphy G,Docherty AJ

更新日期：1992-08-01 00:00:00