Abstract:
:Persistent polyclonal lymphocytosis has been described in a group of female patients who all have the HLA-DR7 antigen in common and who are all heavy cigarette smokers. Immunoglobulin heavy chain gene rearrangement was analyzed by hybridization with specific immunoglobulin heavy chain genes to restriction enzyme-digested genomic DNA samples. The results in two of these patients showed that the lymphocytosis was associated with an expanded subpopulation of B-lineage cells represented by the presence of an unusual immunoglobulin gene rearrangement pattern. Expansion of this subpopulation of B cells appeared to be linked to cigarette smoking since the intensity of the cell population harboring the rearranged gene was much stronger in patients who were smoking heavily compared with the same patients who were temporarily not smoking.
journal_name
Am J Respir Cell Mol Biolauthors
Chan MA,Benedict SH,Carstairs KC,Francombe WH,Gelfand EWdoi
10.1165/ajrcmb/2.6.549subject
Has Abstractpub_date
1990-06-01 00:00:00pages
549-52issue
6eissn
1044-1549issn
1535-4989journal_volume
2pub_type
杂志文章abstract::Using a rat model of acute lung inflammation induced by intratracheal instillation of lipopolysaccharide (LPS), we investigated the kinetics of mRNA expression and the potential cellular sources of tumor necrosis factor-alpha (TNF-alpha), macrophage inflammatory protein-2 (MIP-2), interleukin (IL)-1 beta, IL-6, RANTES...
journal_title:American journal of respiratory cell and molecular biology
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pub_type: 杂志文章,评审
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journal_title:American journal of respiratory cell and molecular biology
pub_type: 杂志文章,评审
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journal_title:American journal of respiratory cell and molecular biology
pub_type: 杂志文章
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更新日期:1996-09-01 00:00:00