Transcriptional and epigenetic modulation of human rhinovirus-induced CXCL10 production by cigarette smoke.

abstract：:Studies in animals and in human atopic skin suggest that allergen challenge may activate acute tissue remodeling changes via transforming growth factor-beta pathways. We determined whether inhalational allergen challenge in subjects with mild asthma induces similar acute changes to the airway epithelial mesenchymal tr...

journal_title：American journal of respiratory cell and molecular biology

authors： Phipps S,Benyahia F,Ou TT,Barkans J,Robinson DS,Kay AB

更新日期：2004-12-01 00:00:00

abstract：:Fibronectin (FN) is an extracellular matrix protein that acts as a substrate for cell migration and adhesion during development. FN adheres to cells through a dimeric membrane protein, the FN receptor. Antibodies to FN and synthetic peptides that inhibit FN-receptor interaction inhibit gastrulation, block neural crest...

journal_title：American journal of respiratory cell and molecular biology

authors： Dean DC

更新日期：1989-07-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is a key enzyme involved in the inflammatory process that is rapidly induced in macrophages in response to LPS. Carbon monoxide (CO), a byproduct of heme oxygnease-1, can suppress proinflammatory response in various in vitro and in vivo models of inflammation. This study was undertaken to exam...

journal_title：American journal of respiratory cell and molecular biology

authors： Suh GY,Jin Y,Yi AK,Wang XM,Choi AM

更新日期：2006-08-01 00:00:00

abstract：:Antenatal corticosteroids enhance lung maturation. However, the importance of glucocorticoid genes on early lung development, asthma susceptibility, and treatment response remains unknown. We investigated whether glucocorticoid genes are important during lung development and their role in asthma susceptibility and tre...

journal_title：American journal of respiratory cell and molecular biology

authors： Sharma S,Kho AT,Chhabra D,Qiu W,Gaedigk R,Vyhlidal CA,Leeder JS,Barraza-Villarreal A,London SJ,Gilliland F,Raby BA,Weiss ST,Tantisira KG

更新日期：2015-05-01 00:00:00

abstract：:CTP:phosphocholine cytidylyltransferase (CT) is the rate-limiting enzyme in the biosynthesis by type II pneumocytes of phosphatidylcholine (PC), the predominant phospholipid in lung surfactant. Augmentation of endogenous CT activity might therefore result in enhanced surfactant PC production. To test this hypothesis, ...

journal_title：American journal of respiratory cell and molecular biology

authors： Li J,Marsh JJ,Spragg RG

更新日期：2002-06-01 00:00:00

abstract：:We studied the effect of the nitric oxide synthase (NOS) inhibitor asymmetric dimethyl arginine (ADMA) and the inactive enantiomer N G-methyl-D-arginine (D-NMMA) on Pseudomonas aeruginosa infection of the respiratory mucosa in nasal turbinate organ cultures. We also investigated the effect of P. aeruginosa culture fil...

journal_title：American journal of respiratory cell and molecular biology

authors： Dowling RB,Newton R,Robichaud A,Cole PJ,Barnes PJ,Wilson R

更新日期：1998-12-01 00:00:00

abstract：:We have investigated the relative efficacy of a range of natural and synthetic retinoids on the induction of alveolar regeneration in a dexamethasone-treated mouse model. The aim was to explore the roles of the different retinoic acid receptors using receptor-selective agonists and to determine whether other natural r...

journal_title：American journal of respiratory cell and molecular biology

authors： Maden M

更新日期：2006-08-01 00:00:00

abstract：:We report that S100 proteins were reduced in patients with chronic rhinosinusitis (CRS). S100A8/9, which is important in epithelial barrier function, was particularly decreased in elderly patients with CRS. Epithelial expression of S100A8/9 is partly regulated by the IL-6 trans-signaling pathway. The goal of this stud...

journal_title：American journal of respiratory cell and molecular biology

authors： Cho SH,Kim DW,Lee SH,Kolliputi N,Hong SJ,Suh L,Norton J,Hulse KE,Seshadri S,Conley DB,Kern RC,Tan BK,Peters A,Grammer LC,Schleimer RP

更新日期：2015-11-01 00:00:00

abstract：:Primary hamster tracheal surface epithelial (HTSE) cells carry mucin-like glycoproteins on the apical surface which are releasable by neutrophil elastase. In some cancer cells, mucins are localized on the cell surface and have been shown to be encoded by the MUC1 mucin gene. The objectives of the present experiments w...

journal_title：American journal of respiratory cell and molecular biology

authors： Park H,Hyun SW,Kim KC

更新日期：1996-08-01 00:00:00

abstract：:Human alveolar macrophages (HAM) express FcalphaR receptors for immunoglobulin (Ig)A which could link humoral and cellular branches of lung immunity. Here, we investigate the effects of polymeric (p-IgA) and secretory (S-IgA) IgA interaction with Fc(alpha)R on lipopolysaccharide (LPS)- and phorbol myristate acetate (P...

journal_title：American journal of respiratory cell and molecular biology

authors： Ouadrhiri Y,Pilette C,Monteiro RC,Vaerman JP,Sibille Y

更新日期：2002-03-01 00:00:00

abstract：:The protease-antiprotease imbalance that is characteristic of most inflammatory lung disorders depends on the spatial-temporal regulation of active inhibitor and protease concentrations in lung secretions. We have studied the competition between the three main serine proteases from human neutrophil primary granules in...

journal_title：American journal of respiratory cell and molecular biology

authors： Korkmaz B,Poutrain P,Hazouard E,de Monte M,Attucci S,Gauthier FL

更新日期：2005-06-01 00:00:00

abstract：:Development of gene transfer vectors with regulated, lung-specific expression will be a useful tool for studying lung biology and developing gene therapies. In this study we constructed a series of lentiviral vectors with regulatory elements predicted to produce lung-specific transgene expression: the surfactant prote...

journal_title：American journal of respiratory cell and molecular biology

authors： Hendrickson B,Senadheera D,Mishra S,Bui KC,Wang X,Chan B,Petersen D,Pepper K,Lutzko C

更新日期：2007-10-01 00:00:00

abstract：:We have reported that von Hippel-Lindau protein (pVHL) expression is elevated in human and mouse fibrotic lungs and that overexpression of pVHL stimulates fibroblast proliferation. We sought to determine whether loss of pVHL in fibroblasts prevents injury and fibrosis in mice that are treated with bleomycin. We genera...

journal_title：American journal of respiratory cell and molecular biology

authors： Zhou Q,Chen T,Zhang W,Bozkanat M,Li Y,Xiao L,van Breemen RB,Christman JW,Sznajder JI,Zhou G

更新日期：2016-05-01 00:00:00

abstract：:Chloride (Cl(-)) movement across fetal lung epithelia is thought to be mediated by the sodium-potassium-2-Cl(-) cotransporter NKCC1. We studied the role of NKCC1 in Cl(-) and liquid secretion in late-gestation NKCC-null (-/-) and littermate control fetal mouse lung. NKCC -/- mice had decreased lung water compared with...

journal_title：American journal of respiratory cell and molecular biology

authors： Gillie DJ,Pace AJ,Coakley RJ,Koller BH,Barker PM

更新日期：2001-07-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis is a lethal parenchymal lung disease characterized by denudation of the lung epithelium, fibroblast proliferation, and collagen deposition. Cellular changes underlying disease progression involve injury to alveolar epithelial cells, epithelial to mesenchymal transition, proliferation of a...

journal_title：American journal of respiratory cell and molecular biology

authors： Shukla MN,Rose JL,Ray R,Lathrop KL,Ray A,Ray P

更新日期：2009-06-01 00:00:00

abstract：:Pneumocystis carinii causes severe pneumonia in immunocompromised patients. Recent studies indicate that P. carinii uses a Cdc2 cyclin-dependent kinase to control its proliferation. To further study the regulation of the life cycle of P. carinii, we characterized the P. carinii B-type cyclin termed Cdc13, whose bindin...

journal_title：American journal of respiratory cell and molecular biology

authors： Kottom TJ,Thomas CF Jr,Mubarak KK,Leof EB,Limper AH

更新日期：2000-06-01 00:00:00

abstract：:Lung structure undergoes rapid remodeling during late gestation as a functional respiratory unit is formed. To determine the role of collagen turnover in this process, particularly the basement membrane component, we studied the degradation of collagen in a series of fetal rats from day 18 of gestation to full term. D...

journal_title：American journal of respiratory cell and molecular biology

authors： Arden MG,Spearman MA,Adamson IY

更新日期：1993-07-01 00:00:00

abstract：:The prevalence of asthma has increased in recent years, and is characterized by airway hyperresponsiveness and inflammation. Many patients report using alternative therapies to self-treat asthma symptoms as adjuncts to short-acting and long-acting β-agonists and inhaled corticosteroids (ICS). As many as 40% of patient...

journal_title：American journal of respiratory cell and molecular biology

authors： Townsend EA,Siviski ME,Zhang Y,Xu C,Hoonjan B,Emala CW

更新日期：2013-02-01 00:00:00

abstract：:Impaired sphingolipid synthesis is linked genetically to childhood asthma and functionally to airway hyperreactivity (AHR). The objective was to investigate whether sphingolipid synthesis could be a target for asthma therapeutics. The effects of GlyH-101 and fenretinide via modulation of de novo sphingolipid synthesis...

journal_title：American journal of respiratory cell and molecular biology

authors： Heras AF,Veerappan A,Silver RB,Emala CW,Worgall TS,Perez-Zoghbi J,Worgall S

更新日期：2020-11-01 00:00:00

abstract：:Enhanced protein tyrosine phosphorylation is associated with changes in vascular permeability through formation and dissolution of adherens junctions and regulation of stress fiber formation. Inhibition of the protein tyrosine phosphorylase SH2 domain-containing protein tyrosine phosphatase 2 (SHP2) increases tyrosine...

journal_title：American journal of respiratory cell and molecular biology

authors： Chichger H,Braza J,Duong H,Harrington EO

更新日期：2015-06-01 00:00:00

abstract：:Cystic fibrosis (CF) is characterized by a dramatic neutrophil recruitment and repeated Pseudomonas infections in the lungs. To evaluate cytokine releasibility by airway epithelial cells in the context of CF, we studied primary nasal epithelial cells isolated from the upper airways and continuous epithelial cell lines...

journal_title：American journal of respiratory cell and molecular biology

authors： Bédard M,McClure CD,Schiller NL,Francoeur C,Cantin A,Denis M

更新日期：1993-10-01 00:00:00

abstract：:Alveolar type (AT)I and ATII cells are central to maintaining normal alveolar fluid homeostasis. When disrupted, they contribute to the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome. Research on ATII cells has been limited by the inability to propagate primary cells in vitro to study ...

journal_title：American journal of respiratory cell and molecular biology

authors： Bove PF,Dang H,Cheluvaraju C,Jones LC,Liu X,O'Neal WK,Randell SH,Schlegel R,Boucher RC

更新日期：2014-04-01 00:00:00

abstract：:Macrolides have been shown to be effective in treating diffuse panbronchiolitis (DPB), although the precise modes of action remain unclear. At sites of airway inflammation, respiratory epithelium is considered an active participant in regulating neutrophil survival. We therefore examined the effect of erythromycin, cl...

journal_title：American journal of respiratory cell and molecular biology

authors： Yamasawa H,Oshikawa K,Ohno S,Sugiyama Y

更新日期：2004-04-01 00:00:00

abstract：:Airway epithelial cells produce a number of chemokines, including eotaxins. Among the three known eotaxins, T helper (Th) type 2 cytokines have been observed to induce the expression of eotaxin-3 mRNA. This study investigated the effect of interferon (IFN)-gamma, a Th1 cytokine, on Th2 cytokine-induced eotaxin-3 produ...

journal_title：American journal of respiratory cell and molecular biology

authors： Yamamoto S,Kobayashi I,Tsuji K,Nishi N,Muro E,Miyazaki M,Zaitsu M,Inada S,Ichimaru T,Hamasaki Y

更新日期：2004-10-01 00:00:00

abstract：:Severe deterioration of surfactant function is noted under conditions of plasma protein leakage into the alveolar space; moreover, fibrinogen has previously been reported to possess strong surfactant inhibitory capacity. Dissolution of alveolar deposits of fibrinogen and fibrin (e.g., hyaline membranes) requires enzym...

journal_title：American journal of respiratory cell and molecular biology

authors： Seeger W,Grube C,Günther A

更新日期：1993-09-01 00:00:00

abstract：:Adenosine concentrations are elevated in the lungs of patients with asthma and chronic obstructive pulmonary disease, where it balances between tissue repair and excessive airway remodeling. We previously demonstrated that the activation of the adenosine A2A receptor promotes epithelial wound closure. However, the mec...

journal_title：American journal of respiratory cell and molecular biology

authors： Allen-Gipson DS,Zimmerman MC,Zhang H,Castellanos G,O'Malley JK,Alvarez-Ramirez H,Kharbanda K,Sisson JH,Wyatt TA

更新日期：2013-05-01 00:00:00

abstract：:Substantial challenges remain in our understanding of fibrotic lung diseases. Nowhere is this more true than in the elucidation and verification of the pathogenetic basis upon which they develop. Scientific progress, most recently in the field of experimental therapy, has relied closely on interpreting data derived fr...

journal_title：American journal of respiratory cell and molecular biology

authors： Chua F,Gauldie J,Laurent GJ

更新日期：2005-07-01 00:00:00

abstract：:Cyclic adenosine monophosphate (cAMP) was the original "second messenger" to be discovered. Its formation is promoted by adenylyl cyclase activation after ligation of G protein-coupled receptors by ligands including hormones, autocoids, prostaglandins, and pharmacologic agents. Increases in intracellular cAMP generall...

journal_title：American journal of respiratory cell and molecular biology

authors： Serezani CH,Ballinger MN,Aronoff DM,Peters-Golden M

更新日期：2008-08-01 00:00:00

abstract：:Pulmonary carbonic anhydrase (CA) activity plays important roles in carbon dioxide exchange, fluid secretion, and pH regulation. This study reports the use of molecular and immunologic techniques to characterize expression of the high-activity cytosolic isoenzyme CA II in rat lung tissue. Northern blot analysis of RNA...

journal_title：American journal of respiratory cell and molecular biology

authors： Fleming RE,Moxley MA,Waheed A,Crouch EC,Sly WS,Longmore WJ

更新日期：1994-05-01 00:00:00

abstract：:We have tested the murine macrophagic cell line RAW 264.7 for its ability to undergo activation after exposure to silica particles in vitro. When exposed to silica under controlled conditions (each cell having access to about 10 silica particles), RAW 264.7 cells were able to phagocytose the particles. Concomitantly, ...

journal_title：American journal of respiratory cell and molecular biology

authors： Claudio E,Segade F,Wróbel K,Ramos S,Lazo PS

更新日期：1995-11-01 00:00:00