Expression of MUC1 mucin gene by hamster tracheal surface epithelial cells in primary culture.

abstract：:Successful phagolysosomal maturation is an important innate immune response to intracellular infection. However, Mycobacterium tuberculosis (Mtb) can manipulate and inhibit this host response to ensure survival within its niche cell. We investigate the role of the anti-inflammatory cytokine IL-10 on Mtb-phagosome matu...

journal_title：American journal of respiratory cell and molecular biology

authors： O'Leary S,O'Sullivan MP,Keane J

更新日期：2011-07-01 00:00:00

abstract：:Chlamydia infections are frequent causes of respiratory illness, particularly pneumonia in infants, and are linked to permanent reductions in lung function and the induction of asthma. However, the immune responses that protect against early-life infection and the mechanisms that lead to chronic lung disease are incom...

journal_title：American journal of respiratory cell and molecular biology

authors： Starkey MR,Nguyen DH,Brown AC,Essilfie AT,Kim RY,Yagita H,Horvat JC,Hansbro PM

更新日期：2016-04-01 00:00:00

abstract：:Higher numbers of eosinophil/basophil colony-forming units (Eo/B CFU) are observed in blood of atopic individuals, and can be enhanced in atopic asthmatics by allergen-inhalation challenge. It is known that mature basophils and eosinophils synthesize cytokines relevant to allergic inflammation. To investigate the pote...

journal_title：American journal of respiratory cell and molecular biology

authors： Gauvreau GM,O'Byrne PM,Moqbel R,Velazquez J,Watson RM,Howie KJ,Denburg JA

更新日期：1998-07-01 00:00:00

abstract：:Administration of supplemental oxygen remains a critical clinical intervention for survival of preterm infants with respiratory failure. However, prolonged exposure to hyperoxia can augment pulmonary damage, resulting in developmental lung diseases embodied as hyperoxia-induced acute lung injury and bronchopulmonary d...

journal_title：American journal of respiratory cell and molecular biology

authors： Sureshbabu A,Syed M,Das P,Janér C,Pryhuber G,Rahman A,Andersson S,Homer RJ,Bhandari V

更新日期：2016-11-01 00:00:00

abstract：:Histamine is an important mediator in the pathogenesis of asthma. Variation in genes along the histamine production, response, and degradation pathway may be important in predicting response to antihistamines. We hypothesize that differences exist among single-nucleotide polymorphisms (SNPs) in genes of the histamine ...

journal_title：American journal of respiratory cell and molecular biology

authors： Anvari S,Vyhlidal CA,Dai H,Jones BL

更新日期：2015-12-01 00:00:00

abstract：:Patients with systemic hypertension of various etiologies maintain their pulmonary artery pressures within normal limits. We have reported in isolated perfused rat lungs that low basal tone appears to be regulated by nitric oxide (NO)-dependent and -independent mechanisms of soluble guanylate cyclase activation, and s...

journal_title：American journal of respiratory cell and molecular biology

authors： Itani MM,Talerico MG,Pino PA,Burke-Wolin T

更新日期：1996-10-01 00:00:00

abstract：:In this study we examined the effect of oral antigen (Ag) administration on the development of experimental asthma in different mouse strains. We selected BALB/c, BP2, CBA/Ca interleukin (IL)-5 transgenic, and BALB/c T-cell receptor-delta-deficient mouse strains because they exhibit different aspects of the asthma syn...

journal_title：American journal of respiratory cell and molecular biology

authors： Russo M,Nahori MA,Lefort J,Gomes E,de Castro Keller A,Rodriguez D,Ribeiro OG,Adriouch S,Gallois V,de Faria AM,Vargaftig BB

更新日期：2001-05-01 00:00:00

abstract：:Specific changes in composition and content of lung extracellular matrix (ECM) proteoglycans (PGs) and hyaluronan (HA) have been observed during the acute response to damage in several forms of injury including infant respiratory distress syndrome (IRDS). These ECM components are thought to modulate the healing respon...

journal_title：American journal of respiratory cell and molecular biology

authors： Juul SE,Krueger RC Jr,Scofield L,Hershenson MB,Schwartz NB

更新日期：1995-12-01 00:00:00

abstract：:Glucocorticoid (GC) insensitivity represents a profound challenge in managing patients with asthma. The mutual inhibition of transcriptional activity between GC receptor (GR) and other regulators is one of the mechanisms contributing to GC resistance in asthma. We recently reported that interferon regulatory factor (I...

journal_title：American journal of respiratory cell and molecular biology

authors： Bhandare R,Damera G,Banerjee A,Flammer JR,Keslacy S,Rogatsky I,Panettieri RA,Amrani Y,Tliba O

更新日期：2010-01-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMN) release gelatinase B in response to variable stimuli. Gelatinase B degrades basement membrane components in vitro, and inhibition of matrix metalloproteinase activity blunts PMN migration through a prototype basement membrane (Matrigel) and amnionic membranes. Accordingly, it has bee...

journal_title：American journal of respiratory cell and molecular biology

authors： Betsuyaku T,Shipley JM,Liu Z,Senior RM

更新日期：1999-06-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is characterized by excessive deposition of extracellular matrix, in particular, collagens. Two IPF therapeutics, nintedanib and pirfenidone, decelerate lung function decline, but their underlying mechanisms of action are poorly understood. In this study, we sought to analyze their ...

journal_title：American journal of respiratory cell and molecular biology

authors： Knüppel L,Ishikawa Y,Aichler M,Heinzelmann K,Hatz R,Behr J,Walch A,Bächinger HP,Eickelberg O,Staab-Weijnitz CA

更新日期：2017-07-01 00:00:00

abstract：:Profound impairment in cellular oxygen consumption, referred to as cytopathic dysoxia, is one of the pathological hallmarks in the lungs of patients with pathogen-induced acute lung injury (ALI). However, the underlying mechanism for this functional defect remains largely unexplored. In this study, we found that prima...

journal_title：American journal of respiratory cell and molecular biology

authors： Cui H,Xie N,Banerjee S,Ge J,Guo S,Liu G

更新日期：2019-02-01 00:00:00

abstract：:Pulmonary artery hypertension (PAH) is a rare and fatal disorder that involves extensive remodeling of the pulmonary arteries mediated by hyperproliferation of pulmonary artery smooth muscle cells (PASMCs). Aberrant platelet-derived growth factor (PDGF) activity can lead to hyperproliferation of PASMCs; however, littl...

journal_title：American journal of respiratory cell and molecular biology

authors： Chen J,Guo J,Cui X,Dai Y,Tang Z,Qu J,Raj JU,Hu Q,Gou D

更新日期：2018-02-01 00:00:00

abstract：:Clara cell secretory protein (CCSP), or CC10, is an inhibitor of secretory phospholipase A2 which may be produced by phagocytic cells and by a variety of other cells in the airway. Tumor necrosis factor-alpha (TNF-alpha) is capable of activating phospholipases and inducing the expression of a variety of genes in the a...

journal_title：American journal of respiratory cell and molecular biology

authors： Yao XL,Levine SJ,Cowan MJ,Logun C,Shelhamer JH

更新日期：1998-10-01 00:00:00

abstract：:Patients with severe acute and chronic lung diseases develop derangements in gas exchange that may result in increased levels of CO(2) (hypercapnia), the effects of which on human health are incompletely understood. It has been proposed that hypercapnia may have beneficial effects in patients with acute lung injury, a...

journal_title：American journal of respiratory cell and molecular biology

authors： Vadász I,Hubmayr RD,Nin N,Sporn PH,Sznajder JI

更新日期：2012-04-01 00:00:00

abstract：:Heritable pulmonary arterial hypertension (HPAH) is a serious lung vascular disease caused by heterozygous mutations in the bone morphogenetic protein (BMP) pathway genes, BMPR2 and SMAD9. One noncanonical function of BMP signaling regulates biogenesis of a subset of microRNAs. We have previously shown that this funct...

journal_title：American journal of respiratory cell and molecular biology

authors： Drake KM,Dunmore BJ,McNelly LN,Morrell NW,Aldred MA

更新日期：2013-09-01 00:00:00

abstract：:The differentiated phenotype of the alveolar type II cell is rapidly altered in vitro. To evaluate factors that might influence this process, we isolated and plated rat type II cells in serum-supplemented media to promote adherence and then maintained the cells in a simple nutrient medium in the absence (S- cells) or ...

journal_title：American journal of respiratory cell and molecular biology

authors： Paine R 3rd,Joyce-Brady M,Clement A,Brody JS

更新日期：1990-10-01 00:00:00

abstract：:Macrophage elastase (MMP12) is a key mediator of cigarette smoke (CS)-induced emphysema, yet its role in other smoking related pathologies remains unclear. The weight suppressing effects of smoking are a major hindrance to cessation efforts, and MMP12 is known to suppress the vascularization on which adipose tissue gr...

journal_title：American journal of respiratory cell and molecular biology

authors： Tsuji T,Kelly NJ,Takahashi S,Leme AS,Houghton AM,Shapiro SD

更新日期：2014-12-01 00:00:00

abstract：:Patients with acute lung injury or respiratory distress syndrome often require supplemental oxygen to maintain tissue oxygenation; however, this treatment can cause or worsen lung inflammation. CD44 is a transmembrane adhesion molecule that is present on a wide variety of cell types, including leukocytes and parenchym...

journal_title：American journal of respiratory cell and molecular biology

authors： van der Windt GJ,Schouten M,Zeerleder S,Florquin S,van der Poll T

更新日期：2011-03-01 00:00:00

abstract：:The asthmatic lung is prone to respiratory viral infections that exacerbate the symptoms of the underlying disease. Recent work has suggested that a deficient T-helper cell type 1 response in early life may lead to these aberrant antiviral responses. To study the development of long-term dysregulation of innate respon...

journal_title：American journal of respiratory cell and molecular biology

authors： Spalluto CM,Singhania A,Cellura D,Woelk CH,Sanchez-Elsner T,Staples KJ,Wilkinson TMA

更新日期：2017-10-01 00:00:00

abstract：:Pseudomonas aeruginosa colonizes the lower respiratory tracts of patients with severe bronchiectasis, including cystic fibrosis, a condition associated with increased airway mucus output. We have shown that an extract containing chloroform-soluble extracellular products of P. aeruginosa releases glycoconjugates into t...

journal_title：American journal of respiratory cell and molecular biology

authors： Somerville M,Taylor GW,Watson D,Rendell NB,Rutman A,Todd H,Davies JR,Wilson R,Cole P,Richardson PS

更新日期：1992-01-01 00:00:00

abstract：:Airway infections or irritant exposures during early postnatal periods may contribute to the onset of childhood asthma. The purpose of this study was to examine critical periods of postnatal airway development during which ozone (O(3)) exposure leads to heightened neural responses. Rats were exposed to O(3) (2 ppm) or...

journal_title：American journal of respiratory cell and molecular biology

authors： Hunter DD,Wu Z,Dey RD

更新日期：2010-12-01 00:00:00

abstract：:The mammalian alveolar epithelium is composed of alveolar type I (AT1) and alveolar type II (AT2) cells that together coordinate tissue function. We used a heterocellular culture model of AT1 and AT2 cells to determine pathways for intercellular signaling between these two phenotypes. Gap junction protein (connexin) p...

journal_title：American journal of respiratory cell and molecular biology

authors： Isakson BE,Seedorf GJ,Lubman RL,Evans WH,Boitano S

更新日期：2003-11-01 00:00:00

abstract：:In allergic airway diseases, intermediate progenitor cells (IPCs) increase in number in the surface epithelium. IPCs arise from basal cells, the origin of hallmark pathological changes, including goblet cell hyperplasia and mucus hypersecretion. Thus, targeting IPCs will benefit future treatment of allergic airway dis...

journal_title：American journal of respiratory cell and molecular biology

authors： Lee SN,Kim SJ,Yoon SA,Song JM,Ahn JS,Kim HC,Choi AMK,Yoon JH

更新日期：2020-12-02 00:00:00

abstract：:Human rhinovirus (HRV) triggers exacerbations of asthma and chronic obstructive pulmonary disease. Cigarette smoking is the primary risk factor for the development of chronic obstructive pulmonary disease, and 25% of individuals with asthma smoke. Smokers experience both longer and more severe colds. We previously sho...

journal_title：American journal of respiratory cell and molecular biology

authors： Hudy MH,Traves SL,Proud D

更新日期：2014-03-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) is a stress-response protein, the expression of which is transcriptionally regulated by agents that cause oxidative stress. We have previously shown that lipopolysaccharide (LPS)-induced HO-1 gene transcription in RAW 264.7 macrophage cells is mediated by a distal enhancer called SX2, located 4...

journal_title：American journal of respiratory cell and molecular biology

authors： Camhi SL,Alam J,Wiegand GW,Chin BY,Choi AM

更新日期：1998-02-01 00:00:00

abstract：:Rat alveolar type II pneumocytes, in situ, label with Maclura pomifera agglutinin (MPA), a plant lectin that recognizes alpha-galactosyl oligosaccharide residues of glycoproteins and glycolipids. To study the glycoproteins recognized by the lectin, MPA lectin affinity chromatography was used to isolate a novel glycopr...

journal_title：American journal of respiratory cell and molecular biology

authors： Lwebuga-Mukasa JS

更新日期：1991-06-01 00:00:00

abstract：:Pulmonary carbonic anhydrase (CA) activity plays important roles in carbon dioxide exchange, fluid secretion, and pH regulation. This study reports the use of molecular and immunologic techniques to characterize expression of the high-activity cytosolic isoenzyme CA II in rat lung tissue. Northern blot analysis of RNA...

journal_title：American journal of respiratory cell and molecular biology

authors： Fleming RE,Moxley MA,Waheed A,Crouch EC,Sly WS,Longmore WJ

更新日期：1994-05-01 00:00:00

abstract：:Adenosine triphosphate (ATP) acting through epithelial nucleotide receptors exerts multiple physiologic actions on airway mucociliary clearance and caliber. However, the effect of ATP on arachidonate metabolism in the airway remains unknown. In this study, the ability of ATP to regulate eicosanoid production was studi...

journal_title：American journal of respiratory cell and molecular biology

authors： Aksoy MO,Borenstein M,Li XX,Kelsen SG

更新日期：1995-10-01 00:00:00

abstract：:Amiodarone interferes with the endocytic pathway, inhibits proteolysis, and causes the formation of vacuoles, but uptake and intracellular distribution of the drug, origin of vacuoles, and functional consequences of amiodarone accumulation remain unclear. Our objective was to study amiodarone uptake, clarify the origi...

journal_title：American journal of respiratory cell and molecular biology

authors： Stadler K,Ha HR,Ciminale V,Spirli C,Saletti G,Schiavon M,Bruttomesso D,Bigler L,Follath F,Pettenazzo A,Baritussio A

更新日期：2008-08-01 00:00:00