Monocyte-macrophage differentiation induced by human upper airway epithelial cells.

abstract：:Tert-butylhydroquinone (TBHQ) is a monofunctional Phase II enzyme inducer, which produces reactive oxygen species. Incubation with a sublethal concentration of TBHQ increased the activities of both gamma-glutamyl transpeptidase (GGT) and gamma-glutamylcysteine synthetase (GCS), although the mechanisms are different (L...

journal_title：American journal of respiratory cell and molecular biology

authors： Liu RM,Hu H,Robison TW,Forman HJ

更新日期：1996-02-01 00:00:00

abstract：:Bacterial lung diseases are a major cause of morbidity and mortality both in immunocompromised and in immunocompetent individuals. Neutrophil accumulation, a pathological hallmark of bacterial diseases, is critical to host defense, but may also cause acute lung injury/acute respiratory distress syndrome. Toll-like rec...

journal_title：American journal of respiratory cell and molecular biology

authors： Balamayooran G,Batra S,Fessler MB,Happel KI,Jeyaseelan S

更新日期：2010-07-01 00:00:00

abstract：:Obesity affects the incidence and severity of asthma in at least two major phenotypes: an early-onset allergic (EOA) form that is complicated by obesity and a late-onset nonallergic (LONA) form that occurs only in the setting of obesity. Both groups exhibit airway hyperresponsiveness to methacholine challenge but exhi...

journal_title：American journal of respiratory cell and molecular biology

authors： Bates JH

更新日期：2016-05-01 00:00:00

abstract：:Humans and rodents exposed to an aerosol of asbestos fibers develop lung injury that can lead to a fibroproliferative response culminating in excessive scarring and impaired lung function. To define the early events that precede asbestos-induced fibrotic lung disease, rats were exposed to an aerosol of chrysotile asbe...

journal_title：American journal of respiratory cell and molecular biology

authors： Mishra A,Liu JY,Brody AR,Morris GF

更新日期：1997-04-01 00:00:00

abstract：:Silicosis is a chronic lung disease induced by the inhalation of crystalline silica. Exposure of cultured macrophages to crystalline silica leads to cell death; however, the mechanism of cell-particle interaction, the fate of particles, and the cause of death are unknown. Time-lapse imaging shows that mouse macrophage...

journal_title：American journal of respiratory cell and molecular biology

authors： Gilberti RM,Joshi GN,Knecht DA

更新日期：2008-11-01 00:00:00

abstract：:Glucose moves into airway secretions after a glucose load. Therefore people with diabetes or hyperglycemia spend a significant proportion of each day with glucose in their airways secretions. This study investigated the effects of glucose on isolated human airways and on cultured airway smooth muscle (ASM) cells. Huma...

journal_title：American journal of respiratory cell and molecular biology

authors： Cazzola M,Calzetta L,Rogliani P,Lauro D,Novelli L,Page CP,Kanabar V,Matera MG

更新日期：2012-10-01 00:00:00

abstract：:Although nitric oxide (NO) is known to inhibit vascular smooth muscle cell proliferation, the subcellular molecular mechanisms involved with the inhibitory signal transduction pathways are uncertain. We investigated the effect of exogenous NO on cell proliferation and the expression of p53, p21, and phosphorylated p42...

journal_title：American journal of respiratory cell and molecular biology

authors： Mizuno S,Kadowaki M,Demura Y,Ameshima S,Miyamori I,Ishizaki T

更新日期：2004-08-01 00:00:00

abstract：:We investigated mechanically induced cell-to-cell Ca2+ signaling in a preparation of rabbit tracheal epithelium close to its in vivo condition. We used confocal microscopy to analyze changes in intracellular free calcium concentration ([Ca2+]i) in intact ciliated tracheal mucosal explants loaded with the Ca2+-indicato...

journal_title：American journal of respiratory cell and molecular biology

authors： Felix JA,Chaban VV,Woodruff ML,Dirksen ER

更新日期：1998-05-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is a key enzyme involved in the inflammatory process that is rapidly induced in macrophages in response to LPS. Carbon monoxide (CO), a byproduct of heme oxygnease-1, can suppress proinflammatory response in various in vitro and in vivo models of inflammation. This study was undertaken to exam...

journal_title：American journal of respiratory cell and molecular biology

authors： Suh GY,Jin Y,Yi AK,Wang XM,Choi AM

更新日期：2006-08-01 00:00:00

abstract：:Fetal airway smooth muscle contracts to neural stimulation from early gestation. This study aimed to document the development of the nerves and ganglia within the bronchial tree of the fetal pig lung as the structural correlates for this function. The formation of these structures during lung development (pseudoglandu...

journal_title：American journal of respiratory cell and molecular biology

authors： Weichselbaum M,Sparrow MP

更新日期：1999-11-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) expression and PGE2 secretion from human airway smooth muscle cells (hASMCs) may contribute to β2-adrenoceptor hyporesponsiveness, a clinical feature observed in some patients with asthma. hASMCs from patients with asthma exhibit elevated expression of cytokine-responsive genes, and in some in...

journal_title：American journal of respiratory cell and molecular biology

authors： Comer BS,Camoretti-Mercado B,Kogut PC,Halayko AJ,Solway J,Gerthoffer WT

更新日期：2015-04-01 00:00:00

abstract：:Substantial challenges remain in our understanding of fibrotic lung diseases. Nowhere is this more true than in the elucidation and verification of the pathogenetic basis upon which they develop. Scientific progress, most recently in the field of experimental therapy, has relied closely on interpreting data derived fr...

journal_title：American journal of respiratory cell and molecular biology

authors： Chua F,Gauldie J,Laurent GJ

更新日期：2005-07-01 00:00:00

abstract：:Elevated concentrations of CO2 (hypercapnia) lead to alveolar epithelial dysfunction by promoting Na,K-ATPase endocytosis. In the present report, we investigated whether the CO2/HCO3(-) activated soluble adenylyl cyclase (sAC) regulates this process. We found that hypercapnia increased the production of cyclic adenosi...

journal_title：American journal of respiratory cell and molecular biology

authors： Lecuona E,Sun H,Chen J,Trejo HE,Baker MA,Sznajder JI

更新日期：2013-05-01 00:00:00

abstract：:We investigated the effects of hypoxia (< 2.5% O2) on rat manganese superoxide dismutase (MnSOD) gene promoter-luciferase reporter constructs in transiently transfected lung epithelial cells (A549, L2, and E1A-T2) and fibroblasts (R9Ab). We cloned MnSOD promoter-luciferase reporter constructs (numbers refer to length ...

journal_title：American journal of respiratory cell and molecular biology

authors： Ohman T,Parish G,Jackson RM

更新日期：1999-07-01 00:00:00

abstract：:Idiopathic pneumonia syndrome (IPS) is a significant clinical problem encountered among patients treated with bone marrow transplantation (BMT). IPS is identified as an inflammatory lung disease characterized by diffuse interstitial pneumonitis and alveolitis leading to interstitial fibrosis in the absence of an ident...

journal_title：American journal of respiratory cell and molecular biology

authors： Shankar G,Scott Bryson J,Darrell Jennings C,Kaplan AM,Cohen DA

更新日期：1999-06-01 00:00:00

abstract：:Recent evidence suggests that the surface fluid secreted by human airway epithelial cells contains antimicrobial activity. The identification of the factor(s) responsible for the antibacterial activity in airway surface fluid may bring new insights into lung defense mechanisms and the pathogenesis of disease. Defensin...

journal_title：American journal of respiratory cell and molecular biology

authors： McCray PB Jr,Bentley L

更新日期：1997-03-01 00:00:00

abstract：:Fibroblasts are the major mesenchymal cells present within the interstitium of the lung and are a major source of vascular endothelial growth factor (VEGF), which modulates the maintenance of pulmonary microvasculature. Prostaglandin E(2) (PGE(2)) acts on a set of E-prostanoid (EP) receptors that activate multiple sig...

journal_title：American journal of respiratory cell and molecular biology

authors： Nakanishi M,Sato T,Li Y,Nelson AJ,Farid M,Michalski J,Kanaji N,Wang X,Basma H,Patil A,Goraya J,Liu X,Togo S,L Toews M,Holz O,Muller KC,Magnussen H,Rennard SI

更新日期：2012-02-01 00:00:00

abstract：:Genome-wide association studies (GWAS) have identified multiple associations with emphysema apicobasal distribution (EABD), but the biological functions of these variants are unknown. To characterize the functions of EABD-associated variants, we integrated GWAS results with 1) expression quantitative trait loci (eQTL)...

journal_title：American journal of respiratory cell and molecular biology

authors： Boueiz A,Pham B,Chase R,Lamb A,Lee S,Naing ZZC,Cho MH,Parker MM,Sakornsakolpat P,Hersh CP,Crapo JD,Stergachis AB,Tal-Singer R,DeMeo DL,Silverman EK,Zhou X,Castaldi PJ,COPDGene investigators, by Core Units:, ECLIPSE Inve

更新日期：2019-04-01 00:00:00

abstract：:The asthmatic lung is prone to respiratory viral infections that exacerbate the symptoms of the underlying disease. Recent work has suggested that a deficient T-helper cell type 1 response in early life may lead to these aberrant antiviral responses. To study the development of long-term dysregulation of innate respon...

journal_title：American journal of respiratory cell and molecular biology

authors： Spalluto CM,Singhania A,Cellura D,Woelk CH,Sanchez-Elsner T,Staples KJ,Wilkinson TMA

更新日期：2017-10-01 00:00:00

abstract：:Interleukin (IL)-9 has recently been shown to play an important role in allergic disease because its expression is strongly associated with the degree of airway responsiveness and the asthmatic-like phenotype. IL-9 is a pleiotropic cytokine that is active on many cell types involved in the allergic immune response. Mu...

journal_title：American journal of respiratory cell and molecular biology

authors： Louahed J,Toda M,Jen J,Hamid Q,Renauld JC,Levitt RC,Nicolaides NC

更新日期：2000-06-01 00:00:00

abstract：:Lung injury is a frequent consequence of oxygen (O2) therapy administered to newborns and adults with respiratory distress. Acute exposure to hyperoxia results in a well-described pathophysiologic response in the lungs. Because inflammation is an important component of pulmonary O2 toxicity, we have an interest in ide...

journal_title：American journal of respiratory cell and molecular biology

authors： Piedboeuf B,Gamache M,Frenette J,Horowitz S,Baldwin HS,Petrov P

更新日期：1998-10-01 00:00:00

abstract：:Persistent polyclonal lymphocytosis has been described in a group of female patients who all have the HLA-DR7 antigen in common and who are all heavy cigarette smokers. Immunoglobulin heavy chain gene rearrangement was analyzed by hybridization with specific immunoglobulin heavy chain genes to restriction enzyme-diges...

journal_title：American journal of respiratory cell and molecular biology

authors： Chan MA,Benedict SH,Carstairs KC,Francombe WH,Gelfand EW

更新日期：1990-06-01 00:00:00

abstract：:Gene therapy requires the presence of a robust and yet small promoter to drive high-level expression of desired proteins. In comparative analysis, we investigated the promoter strength of the CTP:phosphocholine cytidylyltransferase promoter (CCT alpha) with other commonly used promoters, which were all cloned into a s...

journal_title：American journal of respiratory cell and molecular biology

authors： Zhou J,You Y,Zabner J,Ryan AJ,Mallampalli RK

更新日期：2004-01-01 00:00:00

abstract：:T1alpha is a protein of unknown function that is expressed at the plasma membrane in epithelia involved in fluid transport, including type I alveolar epithelial cells, choroid plexus, and ciliary epithelium. The purpose of this study was to test the hypothesis that T1alpha functions as a water channel or a regulator o...

journal_title：American journal of respiratory cell and molecular biology

authors： Ma T,Yang B,Matthay MA,Verkman AS

更新日期：1998-07-01 00:00:00

abstract：:Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease negatively impacts quality of life and survival. Cigarette smoking (CS) is the major risk factor for chronic obstructive pulmonary disease and skeletal muscle dysfunction; however, how CS affects skeletal muscle function remains enigmat...

journal_title：American journal of respiratory cell and molecular biology

authors： Chan SMH,Cerni C,Passey S,Seow HJ,Bernardo I,van der Poel C,Dobric A,Brassington K,Selemidis S,Bozinovski S,Vlahos R

更新日期：2020-02-01 00:00:00

abstract：:The effects of hypoxia on the regulation of inducible nitric oxide synthase (NOS) 2 expression were examined in cultured rat pulmonary microvascular endothelial cells (EC). EC did not express NOS 2 mRNA or protein when exposed to normoxia or hypoxia unless they were pretreated with interleukin (IL)-1beta and/or tumor ...

journal_title：American journal of respiratory cell and molecular biology

authors： Zulueta JJ,Sawhney R,Kayyali U,Fogel M,Donaldson C,Huang H,Lanzillo JJ,Hassoun PM

更新日期：2002-01-01 00:00:00

abstract：:Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are major causes of acute respiratory failure with high rates of morbidity and mortality. Although surfactant protein (SP)-D plays a critical role in pulmonary innate immunity and several clinical studies suggest that this protein...

journal_title：American journal of respiratory cell and molecular biology

authors： King BA,Kingma PS

更新日期：2011-05-01 00:00:00

abstract：:Redox imbalance has been implicated in the pathogenesis of many acute and chronic lung diseases. The b-Zip transcription factor Nrf2 acts via an antioxidant/electrophilic response element to regulate antioxidants and maintain cellular redox homeostasis. Our previous studies have shown that Nrf2-deficient mice (Nrf2(-/...

journal_title：American journal of respiratory cell and molecular biology

authors： Reddy NM,Kleeberger SR,Cho HY,Yamamoto M,Kensler TW,Biswal S,Reddy SP

更新日期：2007-07-01 00:00:00

abstract：:Studies in animals and in human atopic skin suggest that allergen challenge may activate acute tissue remodeling changes via transforming growth factor-beta pathways. We determined whether inhalational allergen challenge in subjects with mild asthma induces similar acute changes to the airway epithelial mesenchymal tr...

journal_title：American journal of respiratory cell and molecular biology

authors： Phipps S,Benyahia F,Ou TT,Barkans J,Robinson DS,Kay AB

更新日期：2004-12-01 00:00:00

abstract：:Species in the genus Pneumocystis can cause severe pneumonia in immune-compromised hosts. The identification of specific targets present in Pneumocystis species, but lacking in mammalian hosts, is paramount to developing new means to treat this infection. One such potential protein is Rtt109, which is a type of histon...

journal_title：American journal of respiratory cell and molecular biology

authors： Kottom TJ,Han J,Zhang Z,Limper AH

更新日期：2011-06-01 00:00:00