Thrombin and TNF-alpha/IL-1beta synergistically induce fibroblast-mediated collagen gel degradation.

abstract：:Monkey Clara cell 10 kDa protein (CC10) was purified from monkey lung lavage. This protein showed an apparent molecular weight of about 10 kDa and 5 kDa under non-reducing and reducing conditions, respectively, as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. From the amino acid sequence dat...

journal_title：American journal of respiratory cell and molecular biology

authors： Hashimoto S,Nakagawa K,Sueishi K

更新日期：1996-09-01 00:00:00

abstract：:We compared the chemical composition of salivary mucin glycopeptides from cystic fibrosis (CF) and from non-CF subjects and the adhesion of Pseudomonas aeruginosa to these different salivary glycopeptides. Three pools of CF saliva, four pools of non-CF saliva, one individual CF saliva, and one individual non-CF saliva...

journal_title：American journal of respiratory cell and molecular biology

authors： Carnoy C,Ramphal R,Scharfman A,Lo-Guidice JM,Houdret N,Klein A,Galabert C,Lamblin G,Roussel P

更新日期：1993-09-01 00:00:00

abstract：:Human tracheal gland serous (HTGS) cells are now considered one principal pulmonary target for the gene therapy of cystic fibrosis (CF). We developed a CF tracheal gland serous cell line, CF-KM4, obtained by the transformation of primary cultures of CF tracheal gland serous cells homozygous for the DeltaF508 mutation ...

journal_title：American journal of respiratory cell and molecular biology

authors： Kammouni W,Moreau B,Becq F,Saleh A,Pavirani A,Figarella C,Merten MD

更新日期：1999-04-01 00:00:00

abstract：:Zn may have an important protective role in the respiratory epithelium and Zn deficiency may enhance airway inflammation and epithelial damage. The effects of mild nutritional Zn deficiency on airway hyperresponsiveness (AHR) and airway inflammation in mice sensitized and challenged with ovalbumin (OVA) to induce an a...

journal_title：American journal of respiratory cell and molecular biology

authors： Truong-Tran AQ,Ruffin RE,Foster PS,Koskinen AM,Coyle P,Philcox JC,Rofe AM,Zalewski PD

更新日期：2002-09-01 00:00:00

abstract：:We recently described overproduction of interferon (IFN)-gamma by lung lymphocytes in mice with silicosis (11% of cells in air-control versus 19% of cells from silica-exposed mice; Davis and colleagues, Am. J. Respir. Cell Mol. Biol. 1999;20:813-824). We hypothesized that the increased IFN-gamma production might be du...

journal_title：American journal of respiratory cell and molecular biology

authors： Davis GS,Pfeiffer LM,Hemenway DR

更新日期：2000-04-01 00:00:00

abstract：:Higher numbers of eosinophil/basophil colony-forming units (Eo/B CFU) are observed in blood of atopic individuals, and can be enhanced in atopic asthmatics by allergen-inhalation challenge. It is known that mature basophils and eosinophils synthesize cytokines relevant to allergic inflammation. To investigate the pote...

journal_title：American journal of respiratory cell and molecular biology

authors： Gauvreau GM,O'Byrne PM,Moqbel R,Velazquez J,Watson RM,Howie KJ,Denburg JA

更新日期：1998-07-01 00:00:00

abstract：:The alveolar epithelium is a critical target for pulmonary viruses and can produce proinflammatory cytokines and chemokines upon viral infection. However, the molecular interactions between virus-infected alveolar epithelial cells and inflammatory cells, including polymorphonuclear leukocytes (PMNs), have not been tho...

journal_title：American journal of respiratory cell and molecular biology

authors： Rzepka JP,Haick AK,Miura TA

更新日期：2012-06-01 00:00:00

abstract：:Patients with severe acute and chronic lung diseases develop derangements in gas exchange that may result in increased levels of CO(2) (hypercapnia), the effects of which on human health are incompletely understood. It has been proposed that hypercapnia may have beneficial effects in patients with acute lung injury, a...

journal_title：American journal of respiratory cell and molecular biology

authors： Vadász I,Hubmayr RD,Nin N,Sporn PH,Sznajder JI

更新日期：2012-04-01 00:00:00

abstract：:Airway remodeling is strongly correlated with the progression of chronic obstructive pulmonary disease (COPD). In this study, our goal was to characterize progressive structural changes in site-specific airways, along with the temporal and spatial expression of transforming growth factor (TGF)-β in the lungs of male s...

journal_title：American journal of respiratory cell and molecular biology

authors： Hoang LL,Nguyen YP,Aspeé R,Bolton SJ,Shen YH,Wang L,Kenyon NJ,Smiley-Jewell S,Pinkerton KE

更新日期：2016-06-01 00:00:00

abstract：:The oleic acid (OA) model of acute lung injury in rats is characterized by a massive and rapid influx of polymorphonuclear neutrophils (PMN) within 1 h, with a peak inflammatory response at 4 h and resolution by 72 h. We hypothesized that PMN apoptosis is involved in the resolution of OA-induced acute lung injury. To ...

journal_title：American journal of respiratory cell and molecular biology

authors： Hussain N,Wu F,Zhu L,Thrall RS,Kresch MJ

更新日期：1998-12-01 00:00:00

abstract：:It had been thought that the central molecular event in the malignant transformation of a cell is the mutation of certain oncogenes-and the resultant dysregulated activation of their encoded proteins. During the past decade, however, it has become clear that alteration of the activity of the protein products of tumor ...

journal_title：American journal of respiratory cell and molecular biology

authors： Weintraub SJ

更新日期：1996-08-01 00:00:00

abstract：:Over 70% of patients with cystic fibrosis have the DeltaF508 mutation. This protein is a partially functional chloride (Cl-) channel that is prematurely degraded in the endoplasmic reticulum. Specific members of the flavonoid class of compounds have been shown to increase Cl- conductance of wild-type and DeltaF508 cys...

journal_title：American journal of respiratory cell and molecular biology

authors： Lim M,McKenzie K,Floyd AD,Kwon E,Zeitlin PL

更新日期：2004-09-01 00:00:00

abstract：:Metformin has been used as first-line treatment in patients with type 2 diabetes, and is reported to reduce cancer risk and progression by activating the liver kinase B1 (LKB1)-AMP-activated protein kinase (AMPK) pathway. Cisplatin remains the main drug for treating advanced non-small-cell lung cancer. However, drug r...

journal_title：American journal of respiratory cell and molecular biology

authors： Lin CC,Yeh HH,Huang WL,Yan JJ,Lai WW,Su WP,Chen HH,Su WC

更新日期：2013-08-01 00:00:00

abstract：:Stachybotrys chartarum is a fungal contaminant within the built environment and a respiratory health concern in the United States. The objective of this study was to characterize the mechanisms influencing pulmonary immune responses to repeatedly inhaled S. chartarum. Groups of B6C3F1/N mice repeatedly inhaled viable ...

journal_title：American journal of respiratory cell and molecular biology

authors： Croston TL,Lemons AR,Barnes MA,Goldsmith WT,Orandle MS,Nayak AP,Germolec DR,Green BJ,Beezhold DH

更新日期：2020-05-01 00:00:00

abstract：:Airway neutrophilia is a prominent feature of chronic obstructive pulmonary disease. As cigarette smoke (CS) and epidermal growth factor (EGF) both cause release of interleukin-8 (IL-8) from epithelial cells in vitro, we investigated whether autocrine ligands for the EGF receptor (EGFR) are involved in this proinflamm...

journal_title：American journal of respiratory cell and molecular biology

authors： Richter A,O'Donnell RA,Powell RM,Sanders MW,Holgate ST,Djukanović R,Davies DE

更新日期：2002-07-01 00:00:00

abstract：:IL-27 is involved in inflammatory reactions. CXCL10 is an important chemokine contributing to airway inflammatory disease. In this study, we investigated whether IL-27 modulated the synthesis of CXCL10 in primary human lung fibroblasts (HLFs). HLFs were activated by IL-27 alone, or in combination with other cytokines....

journal_title：American journal of respiratory cell and molecular biology

authors： Dong S,Zhang X,He Y,Xu F,Li D,Xu W,Wang H,Yin Y,Cao J

更新日期：2013-04-01 00:00:00

abstract：:The present study utilized the monocrotaline (MCT) model of pulmonary hypertension in rats to examine temporal alterations in steady-state levels of basement membrane (BM) component mRNA and deposition of protein using Northern analysis and immunohistochemistry, respectively. MCT (60 mg/kg, subcutaneous) produced sust...

journal_title：American journal of respiratory cell and molecular biology

authors： Lipke DW,Arcot SS,Gillespie MN,Olson JW

更新日期：1993-10-01 00:00:00

abstract：:Tert-butylhydroquinone (TBHQ) is a monofunctional Phase II enzyme inducer, which produces reactive oxygen species. Incubation with a sublethal concentration of TBHQ increased the activities of both gamma-glutamyl transpeptidase (GGT) and gamma-glutamylcysteine synthetase (GCS), although the mechanisms are different (L...

journal_title：American journal of respiratory cell and molecular biology

authors： Liu RM,Hu H,Robison TW,Forman HJ

更新日期：1996-02-01 00:00:00

abstract：:Since the lung is repeatedly subjected to injury by pathogens and toxicants, maintenance of pulmonary homeostasis requires rapid repair of its epithelial surfaces. Ciliated bronchiolar epithelial cells, previously considered as terminally differentiated, underwent squamous cell metaplasia within hours after bronchiola...

journal_title：American journal of respiratory cell and molecular biology

authors： Park KS,Wells JM,Zorn AM,Wert SE,Laubach VE,Fernandez LG,Whitsett JA

更新日期：2006-02-01 00:00:00

abstract：:Adenosine triphosphate (ATP) acting through epithelial nucleotide receptors exerts multiple physiologic actions on airway mucociliary clearance and caliber. However, the effect of ATP on arachidonate metabolism in the airway remains unknown. In this study, the ability of ATP to regulate eicosanoid production was studi...

journal_title：American journal of respiratory cell and molecular biology

authors： Aksoy MO,Borenstein M,Li XX,Kelsen SG

更新日期：1995-10-01 00:00:00

abstract：:We examined the ability of the human surfactant protein B (SP-B) promoter to confer cell specificity of transgene expression in an adenoviral vector. Using similar replication-deficient adenoviruses (rAd), we compared lacZ reporter gene expression driven by the human SP-B promoter (rAd.SPBlacZ) with the ubiquitously e...

journal_title：American journal of respiratory cell and molecular biology

authors： Strayer MS,Guttentag SH,Ballard PL

更新日期：1998-01-01 00:00:00

abstract：:The time course and nature of the cellular response to left pneumonectomy, with or without prior adrenalectomy, were evaluated in the right lungs of male Sprague-Dawley rats using morphometric techniques. Animals were studied at days 2, 5, and 14 following pneumonectomy, intervals prior to, during the course of, and f...

journal_title：American journal of respiratory cell and molecular biology

authors： Rannels DE,Stockstill B,Mercer RR,Crapo JD

更新日期：1991-10-01 00:00:00

abstract：:Lung development is associated with a surge in surfactant phosphatidylcholine (PC) production to prepare the newborn for extrauterine breathing. This process is associated with a marked increase in the activity of the rate-regulatory surfactant enzyme, CTP:phosphocholine cytidylyltransferase (CCTalpha). To investigate...

journal_title：American journal of respiratory cell and molecular biology

authors： McCoy DM,Fisher K,Robichaud J,Ryan AJ,Mallampalli RK

更新日期：2006-09-01 00:00:00

abstract：:Emphasis has recently been placed on the roles of chemotactic cytokines called chemokines to explain the accumulation of inflammatory cells in the lung that may precede or accompany pulmonary fibrosis in interstitial lung diseases. We hypothesized that RANTES, a member of the C-C chemokines, is one such chemokine. Bro...

journal_title：American journal of respiratory cell and molecular biology

authors： Kodama N,Yamaguchi E,Hizawa N,Furuya K,Kojima J,Oguri M,Takahashi T,Kawakami Y

更新日期：1998-04-01 00:00:00

abstract：:Morphologic changes are reported to occur in rat lung vasculature after 3 days of hypoxia. We have previously shown that immunoreactivity for the vasodilator calcitonin gene-related peptide (CGRP) is increased in pulmonary endocrine cells by 7 days of hypoxia. Because these cells may be among the earliest mediators of...

journal_title：American journal of respiratory cell and molecular biology

authors： Roncalli M,Springall DR,Maggioni M,Moradoghli-Haftvani A,Winter RJ,Zhao L,Coggi G,Polak JM

更新日期：1993-11-01 00:00:00

abstract：:The lung is richly supplied with peptidergic nerves that store and secrete substance P (SP), vasoactive intestinal peptide (VIP), and other neuropeptides known to potently modulate leukocyte function in vitro and airway inflammation in vivo. To investigate and characterize neuromodulation of immune responses compartme...

journal_title：American journal of respiratory cell and molecular biology

authors： Kaltreider HB,Ichikawa S,Byrd PK,Ingram DA,Kishiyama JL,Sreedharan SP,Warnock ML,Beck JM,Goetzl EJ

更新日期：1997-02-01 00:00:00

abstract：:Clara cell secretory protein (CCSP), or CC10, is an inhibitor of secretory phospholipase A2 which may be produced by phagocytic cells and by a variety of other cells in the airway. Tumor necrosis factor-alpha (TNF-alpha) is capable of activating phospholipases and inducing the expression of a variety of genes in the a...

journal_title：American journal of respiratory cell and molecular biology

authors： Yao XL,Levine SJ,Cowan MJ,Logun C,Shelhamer JH

更新日期：1998-10-01 00:00:00

abstract：:Ground-level ozone (O3) is a ubiquitous environmental air pollutant that is a potent inducer of airway inflammation and has been linked with respiratory and cardiovascular morbidity and mortality. Some studies using transformed or immortalized cells have attributed O3-mediated expression of inflammatory cytokines with...

journal_title：American journal of respiratory cell and molecular biology

authors： McCullough SD,Duncan KE,Swanton SM,Dailey LA,Diaz-Sanchez D,Devlin RB

更新日期：2014-09-01 00:00:00

abstract：:Specific changes in composition and content of lung extracellular matrix (ECM) proteoglycans (PGs) and hyaluronan (HA) have been observed during the acute response to damage in several forms of injury including infant respiratory distress syndrome (IRDS). These ECM components are thought to modulate the healing respon...

journal_title：American journal of respiratory cell and molecular biology

authors： Juul SE,Krueger RC Jr,Scofield L,Hershenson MB,Schwartz NB

更新日期：1995-12-01 00:00:00

abstract：:β(2)-Adrenoceptor (β2AR) agonists are the most effective class of bronchodilators and a mainstay of asthma management. The first potent β2AR agonist discovered and widely used in reversing the airway constriction associated with asthma exacerbation was the endogenous activator of the β2AR, epinephrine. In this study, ...

journal_title：American journal of respiratory cell and molecular biology

authors： Thanawala VJ,Forkuo GS,Al-Sawalha N,Azzegagh Z,Nguyen LP,Eriksen JL,Tuvim MJ,Lowder TW,Dickey BF,Knoll BJ,Walker JK,Bond RA

更新日期：2013-02-01 00:00:00