Multiple epithelial cell-derived factors enhance neutrophil survival. Regulation by glucocorticoids and tumor necrosis factor-alpha.

abstract：:The pathological hallmark lesions in idiopathic pulmonary fibrosis are the fibroblastic foci, in which fibroblasts are thought to be involved in the tissue remodeling, matrix deposition, and cross-talk with alveolar epithelium. Recent evidence indicates that some fibroblasts in fibrosis may be derived from bone marrow...

journal_title：American journal of respiratory cell and molecular biology

authors： Hashimoto N,Phan SH,Imaizumi K,Matsuo M,Nakashima H,Kawabe T,Shimokata K,Hasegawa Y

更新日期：2010-08-01 00:00:00

abstract：:The effects of hypoxia on the regulation of inducible nitric oxide synthase (NOS) 2 expression were examined in cultured rat pulmonary microvascular endothelial cells (EC). EC did not express NOS 2 mRNA or protein when exposed to normoxia or hypoxia unless they were pretreated with interleukin (IL)-1beta and/or tumor ...

journal_title：American journal of respiratory cell and molecular biology

authors： Zulueta JJ,Sawhney R,Kayyali U,Fogel M,Donaldson C,Huang H,Lanzillo JJ,Hassoun PM

更新日期：2002-01-01 00:00:00

abstract：:Mechanisms of protective immunity to mycobacterial infection in the lung remain poorly defined. In this study, T-cell subset expansion and cytokine expression in bronchoalveolar spaces, lung parenchyma, and mediastinal lymph nodes of mice infected intratracheally with Mycobacterium bovis-Calmette-Guerin bacillus (BCG)...

journal_title：American journal of respiratory cell and molecular biology

authors： Fulton SA,Martin TD,Redline RW,Henry Boom W

更新日期：2000-03-01 00:00:00

abstract：:Macrolides have been shown to be effective in treating diffuse panbronchiolitis (DPB), although the precise modes of action remain unclear. At sites of airway inflammation, respiratory epithelium is considered an active participant in regulating neutrophil survival. We therefore examined the effect of erythromycin, cl...

journal_title：American journal of respiratory cell and molecular biology

authors： Yamasawa H,Oshikawa K,Ohno S,Sugiyama Y

更新日期：2004-04-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) is a stress-response protein, the expression of which is transcriptionally regulated by agents that cause oxidative stress. We have previously shown that lipopolysaccharide (LPS)-induced HO-1 gene transcription in RAW 264.7 macrophage cells is mediated by a distal enhancer called SX2, located 4...

journal_title：American journal of respiratory cell and molecular biology

authors： Camhi SL,Alam J,Wiegand GW,Chin BY,Choi AM

更新日期：1998-02-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMN) contribute to epithelial injury at sites of inflammation, but their mechanisms of action are incompletely understood. PMN can injure target tissues by oxidative and nonoxidative mechanisms. Included in the nonoxidative mechanisms are defensins (DEF), small (3.5 to 4.0 kD), arginine- ...

journal_title：American journal of respiratory cell and molecular biology

authors： Nygaard SD,Ganz T,Peterson MW

更新日期：1993-02-01 00:00:00

abstract：:Na(+) absorption and Cl(-) secretion are in equilibrium to maintain an appropriate airway surface fluid volume and ensure appropriate mucociliary clearance. In cystic fibrosis, this equilibrium is disrupted by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene resulting in the absence of ...

journal_title：American journal of respiratory cell and molecular biology

authors： Caci E,Melani R,Pedemonte N,Yueksekdag G,Ravazzolo R,Rosenecker J,Galietta LJ,Zegarra-Moran O

更新日期：2009-02-01 00:00:00

abstract：:Asbestos causes asbestosis and malignancies by mechanisms that are not fully established. Alveolar epithelial cell (AEC) injury and repair are crucial determinants of the fibrogenic potential of noxious agents such as asbestos. We previously showed that mitochondrial reactive oxygen species mediate asbestos-induced AE...

journal_title：American journal of respiratory cell and molecular biology

authors： Cheresh P,Morales-Nebreda L,Kim SJ,Yeldandi A,Williams DB,Cheng Y,Mutlu GM,Budinger GR,Ridge K,Schumacker PT,Bohr VA,Kamp DW

更新日期：2015-01-01 00:00:00

abstract：:Ground-level ozone (O3) is a ubiquitous environmental air pollutant that is a potent inducer of airway inflammation and has been linked with respiratory and cardiovascular morbidity and mortality. Some studies using transformed or immortalized cells have attributed O3-mediated expression of inflammatory cytokines with...

journal_title：American journal of respiratory cell and molecular biology

authors： McCullough SD,Duncan KE,Swanton SM,Dailey LA,Diaz-Sanchez D,Devlin RB

更新日期：2014-09-01 00:00:00

abstract：:The complement system plays a critical role in immune responses against pathogens. However, its identity and regulation in the lung are not fully understood. This study aimed to explore the role of tripartite motif protein (TRIM) 72 in regulating complement receptor (CR) of the Ig superfamily (CRIg) in alveolar macrop...

journal_title：American journal of respiratory cell and molecular biology

authors： Nagre N,Cong X,Terrazas C,Pepper I,Schreiber JM,Fu H,Sill JM,Christman JW,Satoskar AR,Zhao X

更新日期：2018-06-01 00:00:00

abstract：:Hexavalent chromium (Cr[VI]) is classified by the International Agency for Research on Cancer as a group I carcinogen. Although the U.S. Occupational Safety and Health Administration was obliged to reduce the permissible exposure limit (PEL), it was reported that U.S. workers continue to be exposed to dangerously high...

journal_title：American journal of respiratory cell and molecular biology

authors： Russo P,Catassi A,Cesario A,Imperatori A,Rotolo N,Fini M,Granone P,Dominioni L

更新日期：2005-12-01 00:00:00

abstract：:We have previously shown that long-term treatment of airway smooth muscle (ASM) cells with a combination of TNF-alpha and IFN-gamma impaired steroid anti-inflammatory action through the up-regulation of glucocorticoid receptor beta isoform (GRbeta) (Mol Pharmacol 2006;69:588-596). We here found that steroid actions co...

journal_title：American journal of respiratory cell and molecular biology

authors： Tliba O,Damera G,Banerjee A,Gu S,Baidouri H,Keslacy S,Amrani Y

更新日期：2008-04-01 00:00:00

abstract：:Mutations in the p53 gene have been implicated to play an important role in the development of various human cancers. To evaluate the importance of p53 in lung cancer, a transgenic mouse model was established by utilizing the Clara cell secretory protein (CCSP) promoter to target the expression of a dominant-negative ...

journal_title：American journal of respiratory cell and molecular biology

authors： Tchou-Wong KM,Jiang Y,Yee H,LaRosa J,Lee TC,Pellicer A,Jagirdar J,Gordon T,Goldberg JD,Rom WN

更新日期：2002-08-01 00:00:00

abstract：:Interleukin (IL)-4 and (IL)-13 induce immunoglobulin (Ig)E synthesis via activation of the transcription factor signal transducer and activator of transcription (Stat)6. The present study describes the identification and characterization of antisense oligonucleotides to Stat6 as an approach to interrupt IL-4 and IL-13...

journal_title：American journal of respiratory cell and molecular biology

authors： Hill S,Herlaar E,Le Cardinal A,van Heeke G,Nicklin P

更新日期：1999-12-01 00:00:00

abstract：:Although nitric oxide (NO) is known to inhibit vascular smooth muscle cell proliferation, the subcellular molecular mechanisms involved with the inhibitory signal transduction pathways are uncertain. We investigated the effect of exogenous NO on cell proliferation and the expression of p53, p21, and phosphorylated p42...

journal_title：American journal of respiratory cell and molecular biology

authors： Mizuno S,Kadowaki M,Demura Y,Ameshima S,Miyamori I,Ishizaki T

更新日期：2004-08-01 00:00:00

abstract：:Chronic lung diseases (CLDs), such as chronic obstructive pulmonary disease, interstitial lung disease, and lung cancer, are among the leading causes of morbidity globally and impose major health and financial burdens on patients and society. Effective treatments are scarce, and relevant human model systems to effecti...

journal_title：American journal of respiratory cell and molecular biology

authors： Alsafadi HN,Uhl FE,Pineda RH,Bailey KE,Rojas M,Wagner DE,Königshoff M

更新日期：2020-06-01 00:00:00

abstract：:Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are major causes of acute respiratory failure with high rates of morbidity and mortality. Although surfactant protein (SP)-D plays a critical role in pulmonary innate immunity and several clinical studies suggest that this protein...

journal_title：American journal of respiratory cell and molecular biology

authors： King BA,Kingma PS

更新日期：2011-05-01 00:00:00

abstract：:In addition to inhibiting proliferation and causing enlargement of bovine pulmonary artery endothelial cells in culture, porcine platelet transforming growth factor-beta 1 (TGF-beta 1) (2 ng/ml) lowered glutathione (GSH) of these cells by 48% after 96 h in culture when GSH levels were normalized for cell counts. This ...

journal_title：American journal of respiratory cell and molecular biology

authors： White AC,Das SK,Fanburg BL

更新日期：1992-04-01 00:00:00

abstract：:Mucus obstruction is a key feature of many inflammatory airway diseases. Neutrophil extracellular traps (NETs) are released upon neutrophil stimulation and consist of extracellular chromatin networks studded with cytotoxic proteins. When released in the airways, these NETs can become part of the airway mucus. We hypot...

journal_title：American journal of respiratory cell and molecular biology

authors： Linssen RS,Chai G,Ma J,Kummarapurugu AB,van Woensel JBM,Bem RA,Kaler L,Duncan GA,Zhou L,Rubin BK,Xu Q

更新日期：2021-01-01 00:00:00

abstract：:The cytokine mRNA profiles of primary (arising from inhaled bacilli) and secondary (arising from hematogenous reseeding of the lung) granulomas from the lung lobes of bacillus Calmette-Guérin (BCG)-vaccinated and unimmunized guinea pigs challenged with virulent Mycobacterium tuberculosis by the pulmonary route were as...

journal_title：American journal of respiratory cell and molecular biology

authors： Ly LH,Russell MI,McMurray DN

更新日期：2008-04-01 00:00:00

abstract：:We have investigated the relative efficacy of a range of natural and synthetic retinoids on the induction of alveolar regeneration in a dexamethasone-treated mouse model. The aim was to explore the roles of the different retinoic acid receptors using receptor-selective agonists and to determine whether other natural r...

journal_title：American journal of respiratory cell and molecular biology

authors： Maden M

更新日期：2006-08-01 00:00:00

abstract：:Asthma arises from the complex interplay of inflammatory pathways in diverse cell types and tissues. We sought to undertake a comprehensive transcriptomic assessment of the epithelium and airway T cells that remain understudied in asthma and investigate interactions between multiple cells and tissues. Epithelial brush...

journal_title：American journal of respiratory cell and molecular biology

authors： Singhania A,Wallington JC,Smith CG,Horowitz D,Staples KJ,Howarth PH,Gadola SD,Djukanović R,Woelk CH,Hinks TSC

更新日期：2018-02-01 00:00:00

abstract：:Two isoforms of the human glucocorticoid receptor (hGR) have been described, hGRalpha and hGRbeta. We analyzed the expression and regulation of both hGR isoforms in human respiratory epithelial cells (BEAS-2B, A549, and primary nasal epithelial cells). In BEAS-2B cells, the expression of hGRalpha messenger RNA (mRNA) ...

journal_title：American journal of respiratory cell and molecular biology

authors： Pujols L,Mullol J,Pérez M,Roca-Ferrer J,Juan M,Xaubet A,Cidlowski JA,Picado C

更新日期：2001-01-01 00:00:00

abstract：:T lymphocytes and alveolar macrophages accumulating in the lower respiratory tract of patients with pulmonary sarcoidosis are known to be activated to produce several cytokines, presumably leading to granuloma formation within the lung. We hypothesized that these cells produce colony-stimulating factors (CSFs), which ...

journal_title：American journal of respiratory cell and molecular biology

authors： Itoh A,Yamaguchi E,Kuzumaki N,Okazaki N,Furuya K,Abe S,Kawakami Y

更新日期：1990-09-01 00:00:00

abstract：:The double-stranded RNA (dsRNA)-activated serine/threonine kinase R (PKR) is well characterized as an essential component of the innate antiviral response. Recently, PKR has been implicated in Toll-like receptor (TLR) signal transduction in response to bacterial cell wall components. Its contribution to pulmonary immu...

journal_title：American journal of respiratory cell and molecular biology

authors： Cabanski M,Steinmüller M,Marsh LM,Surdziel E,Seeger W,Lohmeyer J

更新日期：2008-01-01 00:00:00

abstract：:MyD88 is an adapter protein required for the induction of proinflammatory cytokines by most Toll-like receptors (TLR), and Pseudomonas aeruginosa expresses ligands for multiple TLRs. MyD88(-/-) (KO) mice are highly susceptible to aerosolized P. aeruginosa, failing to elicit an early inflammatory response and permittin...

journal_title：American journal of respiratory cell and molecular biology

authors： Hajjar AM,Harowicz H,Liggitt HD,Fink PJ,Wilson CB,Skerrett SJ

更新日期：2005-11-01 00:00:00

abstract：:We compared the chemical composition of salivary mucin glycopeptides from cystic fibrosis (CF) and from non-CF subjects and the adhesion of Pseudomonas aeruginosa to these different salivary glycopeptides. Three pools of CF saliva, four pools of non-CF saliva, one individual CF saliva, and one individual non-CF saliva...

journal_title：American journal of respiratory cell and molecular biology

authors： Carnoy C,Ramphal R,Scharfman A,Lo-Guidice JM,Houdret N,Klein A,Galabert C,Lamblin G,Roussel P

更新日期：1993-09-01 00:00:00

abstract：:The present study investigated mechanisms underlying apical and basolateral P2Y(1)-mediated Cl(-) secretion in human airway epithelial cells. Apical and basolateral ATP induced short-circuit currents (I(sc)) with different properties via P2Y(1) receptors. The former comprised an immediate rise followed by a slow atten...

journal_title：American journal of respiratory cell and molecular biology

authors： Son M,Ito Y,Sato S,Ishikawa T,Kondo M,Nakayama S,Shimokata K,Kume H

更新日期：2004-03-01 00:00:00

abstract：:Cigarette smoking and aging are major risk factors for chronic obstructive pulmonary disease. An unsolved question is whether elderly lungs are particularly vulnerable to cigarette smoke (CS) exposure. In this study, we used a mouse model to test the hypothesis that aging increases the susceptibility to CS-induced pul...

journal_title：American journal of respiratory cell and molecular biology

authors： Moriyama C,Betsuyaku T,Ito Y,Hamamura I,Hata J,Takahashi H,Nasuhara Y,Nishimura M

更新日期：2010-03-01 00:00:00

abstract：:Ozone (O3) is the principal oxidant pollutant in photochemical smog. Repeated exposures to O3 induces inflammation and mucous cell metaplasia in the nasal airways of laboratory animals. Our study was designed to determine the efficacy of a topical anti-inflammatory corticosteroid in preventing O3-induced rhinitis and ...

journal_title：American journal of respiratory cell and molecular biology

authors： Hotchkiss JA,Hilaski R,Cho H,Regan K,Spencer P,Slack K,Harkema JR

更新日期：1998-01-01 00:00:00