Aging enhances susceptibility to cigarette smoke-induced inflammation through bronchiolar chemokines.

abstract：:The asthmatic lung is prone to respiratory viral infections that exacerbate the symptoms of the underlying disease. Recent work has suggested that a deficient T-helper cell type 1 response in early life may lead to these aberrant antiviral responses. To study the development of long-term dysregulation of innate respon...

journal_title：American journal of respiratory cell and molecular biology

authors： Spalluto CM,Singhania A,Cellura D,Woelk CH,Sanchez-Elsner T,Staples KJ,Wilkinson TMA

更新日期：2017-10-01 00:00:00

abstract：:The pathological hallmark lesions in idiopathic pulmonary fibrosis are the fibroblastic foci, in which fibroblasts are thought to be involved in the tissue remodeling, matrix deposition, and cross-talk with alveolar epithelium. Recent evidence indicates that some fibroblasts in fibrosis may be derived from bone marrow...

journal_title：American journal of respiratory cell and molecular biology

authors： Hashimoto N,Phan SH,Imaizumi K,Matsuo M,Nakashima H,Kawabe T,Shimokata K,Hasegawa Y

更新日期：2010-08-01 00:00:00

abstract：:Transplantation of mesenchymal stem cells (MSCs) holds great promise in the repair of cigarette smoke (CS)-induced lung damage in chronic obstructive pulmonary disease (COPD). Because CS leads to mitochondrial dysfunction, we aimed to investigate the potential benefit of mitochondrial transfer from human-induced pluri...

journal_title：American journal of respiratory cell and molecular biology

authors： Li X,Zhang Y,Yeung SC,Liang Y,Liang X,Ding Y,Ip MS,Tse HF,Mak JC,Lian Q

更新日期：2014-09-01 00:00:00

abstract：:In addition to inhibiting proliferation and causing enlargement of bovine pulmonary artery endothelial cells in culture, porcine platelet transforming growth factor-beta 1 (TGF-beta 1) (2 ng/ml) lowered glutathione (GSH) of these cells by 48% after 96 h in culture when GSH levels were normalized for cell counts. This ...

journal_title：American journal of respiratory cell and molecular biology

authors： White AC,Das SK,Fanburg BL

更新日期：1992-04-01 00:00:00

abstract：:Heritable pulmonary arterial hypertension (HPAH) is a serious lung vascular disease caused by heterozygous mutations in the bone morphogenetic protein (BMP) pathway genes, BMPR2 and SMAD9. One noncanonical function of BMP signaling regulates biogenesis of a subset of microRNAs. We have previously shown that this funct...

journal_title：American journal of respiratory cell and molecular biology

authors： Drake KM,Dunmore BJ,McNelly LN,Morrell NW,Aldred MA

更新日期：2013-09-01 00:00:00

abstract：:Electrical field stimulation (EFS) has previously been shown to induce the release of prostaglandin (PG) E2 from ferret tracheal epithelium. We have now conducted a study to see whether this effect of EFS is due to the activation of nerves or whether it is a non-neural effect. The release of PGE2 and 6-keto-PGF1 alpha...

journal_title：American journal of respiratory cell and molecular biology

authors： Ullman A,Ciabattoni G,Svedmyr N,Skoogh BE,Löfdahl CG

更新日期：1991-03-01 00:00:00

abstract：:Surface airway epithelium is frequently injured by noxious inhaled agents, epithelial wound repair may be an important process by which the epithelial barrier integrity is maintained. To evaluate the role of surface airway cells in the wound repair process, we developed an in vitro wounding model of human nasal epithe...

journal_title：American journal of respiratory cell and molecular biology

authors： Zahm JM,Chevillard M,Puchelle E

更新日期：1991-09-01 00:00:00

abstract：:Cigarette smoking is a major risk factor for chronic obstructive pulmonary disease (COPD). Recent reports of increased matrix metalloproteinase-2 (MMP-2) in lungs of patients with emphysema support the paradigm of proteinase/antiproteinase imbalance in the pathogenesis of COPD. We sought to define the signaling pathwa...

journal_title：American journal of respiratory cell and molecular biology

authors： Ning W,Dong Y,Sun J,Li C,Matthay MA,Feghali-Bostwick CA,Choi AM

更新日期：2007-04-01 00:00:00

abstract：:The investigation of novel targets for the treatment of cystic fibrosis (CF) lung inflammation is a major priority, considering that no effective therapy is available for this purpose. Consistent with the evidence that the sphingolipid (SL) ceramide regulates airway inflammation and infection in mice and patients with...

journal_title：American journal of respiratory cell and molecular biology

authors： Dechecchi MC,Nicolis E,Mazzi P,Cioffi F,Bezzerri V,Lampronti I,Huang S,Wiszniewski L,Gambari R,Scupoli MT,Berton G,Cabrini G

更新日期：2011-10-01 00:00:00

abstract：:Primary ciliary dyskinesia (PCD) is a genetically heterogeneous chronic destructive airway disease. PCD is traditionally diagnosed by nasal nitric oxide measurement, analysis of ciliary beating, transmission electron microscopy (TEM), and/or genetic testing. In most genetic PCD variants, laterality defects can occur. ...

journal_title：American journal of respiratory cell and molecular biology

authors： Cindrić S,Dougherty GW,Olbrich H,Hjeij R,Loges NT,Amirav I,Philipsen MC,Marthin JK,Nielsen KG,Sutharsan S,Raidt J,Werner C,Pennekamp P,Dworniczak B,Omran H

更新日期：2020-03-01 00:00:00

abstract：:Bleomycin-induced lung disease is characterized by cell injury followed by fibroblast proliferation. Cells respond to injury by synthesizing a family of heat shock proteins. These proteins are critical to cell survival, and those of the 70,000 MW group (hsp 70) are essential for cell division and proliferation. To eva...

journal_title：American journal of respiratory cell and molecular biology

authors： Moseley PL,York SJ,York J

更新日期：1989-08-01 00:00:00

abstract：:Chronic hypoxia induces proliferation of human pulmonary artery smooth muscle cells (hPASMCs), leading to remodeling and pulmonary hypertension, but the mechanism remains unclear. The present study tested the roles of mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) and mitochondrial membrane potential (Delt...

journal_title：American journal of respiratory cell and molecular biology

authors： Hu HL,Zhang ZX,Chen CS,Cai C,Zhao JP,Wang X

更新日期：2010-06-01 00:00:00

abstract：:Although mast cell secretion has been intensively studied because of its pivotal role in allergic reactions and its advantages as a physiologic model, the molecular composition of the secretory machine is virtually unknown. In view of the guanine-nucleotide dependency of mast cell exocytosis and the participation of R...

journal_title：American journal of respiratory cell and molecular biology

authors： Tuvim MJ,Adachi R,Chocano JF,Moore RH,Lampert RM,Zera E,Romero E,Knoll BJ,Dickey BF

更新日期：1999-01-01 00:00:00

abstract：:Human rhinovirus (HRV) infections are associated with exacerbations of lower-airway diseases. HRV-induced production of proinflammatory chemokines, such as CXCL10, from infected airway epithelial cells may play a role in the pathogenesis of exacerbations. We have previously shown that the MAP/ERK kinase (MEK) pathway ...

journal_title：American journal of respiratory cell and molecular biology

authors： Zaheer RS,Proud D

更新日期：2010-10-01 00:00:00

abstract：:Endothelin (ET)-1 causes long-lasting vasoconstriction and vascular remodeling by interacting with specific G-protein-coupled receptors in pulmonary artery smooth muscle cells (PASMCs), and thus plays an important role in the pathophysiology of pulmonary arterial hypertension. The two-pore domain K(+) channel, TASK-1,...

journal_title：American journal of respiratory cell and molecular biology

authors： Tang B,Li Y,Nagaraj C,Morty RE,Gabor S,Stacher E,Voswinckel R,Weissmann N,Leithner K,Olschewski H,Olschewski A

更新日期：2009-10-01 00:00:00

abstract：:The dynamics and mechanisms of extracellular release of hydrogen peroxide (H2O2) from bovine pulmonary artery endothelial cells (EC) subjected to anoxia, hypoxia, and hypoxia followed by reoxygenation were examined using various inhibitors of enzymatic systems in intact cells and by direct measurement of H2O2 producti...

journal_title：American journal of respiratory cell and molecular biology

authors： Zulueta JJ,Yu FS,Hertig IA,Thannickal VJ,Hassoun PM

更新日期：1995-01-01 00:00:00

abstract：:In this study, we have used the rat model of hyperoxia to examine the molecular responses to oxidative stress in lung. We show that in addition to the antioxidant enzyme manganese superoxide dismutase, expression of a variety of stress-responsive genes including heme oxygenase-1, c-fos, c-jun, CAAT-enhancer binding pr...

journal_title：American journal of respiratory cell and molecular biology

authors： Choi AM,Sylvester S,Otterbein L,Holbrook NJ

更新日期：1995-07-01 00:00:00

abstract：:Prenatal nicotine exposure impairs normal lung development and leads to diminished pulmonary function after birth. Previous work from our laboratory has demonstrated that nicotine alters lung development by affecting a nonneuronal cholinergic autocrine loop that is expressed in lung. Bronchial epithelial cells (BECs) ...

journal_title：American journal of respiratory cell and molecular biology

authors： Fu XW,Lindstrom J,Spindel ER

更新日期：2009-07-01 00:00:00

abstract：:Stimulated migration of eosinophils out of the bloodstream and into the lung is key in the development of tissue eosinophilia and inflammation in asthma. Platelet-activating factor (PAF) has been implicated as an important inflammatory mediator in asthma pathogenesis in part because of its chemotactic capacity. We the...

journal_title：American journal of respiratory cell and molecular biology

authors： Casale TB,Erger RA,Little MM

更新日期：1993-01-01 00:00:00

abstract：:Motile cilia are essential for clearance of particulates and pathogens from airways. For effective transport, ciliary motor proteins and axonemal structures interact to generate the rhythmic, propulsive bending, but the mechanisms that produce a dynamic waveform remain incompletely understood. Biomechanical measures o...

journal_title：American journal of respiratory cell and molecular biology

authors： Oltean A,Schaffer AJ,Bayly PV,Brody SL

更新日期：2018-10-01 00:00:00

abstract：:German cockroach extract synergistically regulates tumor necrosis factor-alpha (TNF-alpha)-induced interleukin (IL)-8 expression in human airway epithelial cells. The IL-8 promoter contains nuclear factor (NF)-kappaB, activating protein (AP)-1, and NF for IL-6 (NF-IL6) transcription factor binding regions. Because coc...

journal_title：American journal of respiratory cell and molecular biology

authors： Page K,Hughes VS,Odoms KK,Dunsmore KE,Hershenson MB

更新日期：2005-03-01 00:00:00

abstract：:Acute lung injury (ALI) is characterized by pulmonary inflammation and edema. Innate immune cells (e.g., neutrophils and macrophages) are major contributors to inflammation in ALI. Less is known regarding the role of T cells. We examined the effects of rapamycin on inflammation in a LPS-induced murine model of ALI. Ra...

journal_title：American journal of respiratory cell and molecular biology

authors： Nakajima T,Lin KW,Li J,McGee HS,Kwan JM,Perkins DL,Finn PW

更新日期：2014-08-01 00:00:00

abstract：:We examined the mechanisms underlying tachyphylaxis to beta-adrenergic receptor agonists (beta-agonists) in tracheal smooth muscle. Simultaneous measurements of isometric tension and intracellular Ca2+ concentration ([Ca2+]i) using fura-2-loaded guinea pig tracheas showed that the inhibitory effects of isoproterenol (...

journal_title：American journal of respiratory cell and molecular biology

authors： Kume H,Ishikawa T,Oguma T,Ito S,Shimokata K,Kotlikoff MI

更新日期：2003-09-01 00:00:00

abstract：:Nitric oxide (NO) is produced in lung epithelial cells by nitric oxide synthases (NOSs), which can enhance inflammation and edema formation. The inducible NOS (iNOS, type II NOS) has been shown to be increased in lung disorders such as asthma. Therapy for asthma includes antiinflammatory agents such as corticosteroids...

journal_title：American journal of respiratory cell and molecular biology

authors： Robbins RA,Jinkins PA,Bryan TW,Prado SC,Milligan SA

更新日期：1998-06-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) is a cytokine implicated in wound healing and in the pathogenesis of pulmonary fibrosis. TGF-beta stimulates myofibroblast differentiation characterized by expression of contractile smooth muscle (SM)-specific proteins such as SM-alpha-actin. In the present study, we examined...

journal_title：American journal of respiratory cell and molecular biology

authors： Sandbo N,Kregel S,Taurin S,Bhorade S,Dulin NO

更新日期：2009-09-01 00:00:00

abstract：:To assess the temporal and spatial expression of the matrix-associated proteoglycan, biglycan, in a model of chronic hyperoxia-induced lung injury, changes in mRNA and protein were examined using Northern blot analyses and immunohistochemistry. Newborn rats were exposed to 85% or 100% oxygen for 6 and 4 wk, respective...

journal_title：American journal of respiratory cell and molecular biology

authors： Veness-Meehan KA,Rhodes DN,Stiles AD

更新日期：1994-11-01 00:00:00

abstract：:In this study, we investigated the effect of the novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (AHPN/CD437) on the growth of human lung carcinoma cell lines. AHPN inhibits the proliferation of all cell lines tested, irrespective of the lung tumor type, in a concentration- and time-de...

journal_title：American journal of respiratory cell and molecular biology

authors： Adachi H,Preston G,Harvat B,Dawson MI,Jetten AM

更新日期：1998-03-01 00:00:00

abstract：:We have determined eicosanoid production from endogenous arachidonic acid by neonatal lamb lungs stimulated with calcium ionophore A23187 during normoxia and hypoxia. Lungs of lambs 19 to 25 d of age were isolated and perfused with cell-free Krebs' bicarbonate buffer at a flow rate of 15 to 20 ml/kg/min. After 30 min ...

journal_title：American journal of respiratory cell and molecular biology

authors： Ibe BO,Isenberg WB,Raj JU

更新日期：1991-04-01 00:00:00

abstract：:Tissue factor pathway inhibitor (TFPI) is the primary inhibitor of the extrinsic coagulation cascade, and its expression is reported to be relatively stable. Various pathophysiologic agents have been shown to influence TFPI activity by regulating its expression or by modifying the protein. It is not clear how TFPI act...

journal_title：American journal of respiratory cell and molecular biology

authors： Jeffers A,Owens S,Koenig K,Quaid B,Pendurthi UR,Rao VM,Idell S,Tucker TA

更新日期：2015-06-01 00:00:00

abstract：:Extracellular signal-regulated kinases (ERKs) phosphorylate and regulate cytoskeletal components of contractile cells and have been implicated in integrin-mediated adhesion. In this study, we examined the contributions of adherence, cell flattening, and cytoskeletal reorganization to adhesion-induced ERK activation in...

journal_title：American journal of respiratory cell and molecular biology

authors： Heuertz RM,Hamann KJ,Hershenson MB,Leff AR

更新日期：1997-10-01 00:00:00