Wound repair of human surface respiratory epithelium.

abstract：:Protein kinase C (PKC) is known to regulate ryanodine receptor (RyR)-mediated local Ca(2+) signaling (Ca(2+) spark) in airway and vascular smooth muscle cells (SMCs), but its specific molecular mechanisms and functions still remain elusive. In this study, we reveal that, in airway SMCs, specific PKCepsilon peptide inh...

journal_title：American journal of respiratory cell and molecular biology

authors： Liu QH,Zheng YM,Korde AS,Li XQ,Ma J,Takeshima H,Wang YX

更新日期：2009-06-01 00:00:00

abstract：:Surfactant protein (SP)-D, a 43-kD multifunctional collagen-like lectin, is synthesized and secreted by the airway epithelium. SP-D knockout (SP-D [-/-]) mice exhibit an increase in the number and size of airway macrophages, peribronchiolar inflammation, increases in metalloproteinase activity, and development of emph...

journal_title：American journal of respiratory cell and molecular biology

authors： Atochina EN,Beers MF,Hawgood S,Poulain F,Davis C,Fusaro T,Gow AJ

更新日期：2004-03-01 00:00:00

abstract：:Human rhinovirus (HRV) triggers exacerbations of asthma and chronic obstructive pulmonary disease. Cigarette smoking is the primary risk factor for the development of chronic obstructive pulmonary disease, and 25% of individuals with asthma smoke. Smokers experience both longer and more severe colds. We previously sho...

journal_title：American journal of respiratory cell and molecular biology

authors： Hudy MH,Traves SL,Proud D

更新日期：2014-03-01 00:00:00

abstract：:A subset of workers in swine confinement facilities develops chronic respiratory disease. An aqueous extract of dust from these facilities (hogbarn dust extract [HDE]) induces IL-6 and IL-8 release and several other responses in isolated airway epithelial cells. The cell membrane receptors by which HDE initiates these...

journal_title：American journal of respiratory cell and molecular biology

authors： Dodmane PR,Schulte NA,Heires AJ,Band H,Romberger DJ,Toews ML

更新日期：2011-10-01 00:00:00

abstract：:Modification of tyrosine residues and formation of 3-nitrotyrosine is one of the most commonly identified effects of reactive nitrogen species on proteins. In this study we evaluated the presence and localization of tyrosine nitration in various ventilatory and limb muscles. We also assessed the contribution of the ne...

journal_title：American journal of respiratory cell and molecular biology

authors： Barreiro E,Comtois AS,Gea J,Laubach VE,Hussain SN

更新日期：2002-04-01 00:00:00

abstract：:The mammalian airways are sensitive to inhaled stimuli, and airway diseases are characterized by hypersensitivity to volatile stimuli, such as perfumes, industrial solvents, and others. However, the identity and function of the cells in the airway that can sense volatile chemicals remain uncertain, particularly in hum...

journal_title：American journal of respiratory cell and molecular biology

authors： Gu X,Karp PH,Brody SL,Pierce RA,Welsh MJ,Holtzman MJ,Ben-Shahar Y

更新日期：2014-03-01 00:00:00

abstract：:Stimulated migration of eosinophils out of the bloodstream and into the lung is key in the development of tissue eosinophilia and inflammation in asthma. Platelet-activating factor (PAF) has been implicated as an important inflammatory mediator in asthma pathogenesis in part because of its chemotactic capacity. We the...

journal_title：American journal of respiratory cell and molecular biology

authors： Casale TB,Erger RA,Little MM

更新日期：1993-01-01 00:00:00

abstract：:Recent studies have indicated that, during the development of pulmonary hypertension (PH), there is a switch from oxidative phosphorylation to glycolysis in the pulmonary endothelium. However, the mechanisms underlying this phenomenon have not been elucidated. Endothelin (ET)-1, an endothelial-derived vasoconstrictor ...

journal_title：American journal of respiratory cell and molecular biology

authors： Sun X,Kumar S,Sharma S,Aggarwal S,Lu Q,Gross C,Rafikova O,Lee SG,Dasarathy S,Hou Y,Meadows ML,Han W,Su Y,Fineman JR,Black SM

更新日期：2014-06-01 00:00:00

abstract：:Mutations in the p53 gene have been implicated to play an important role in the development of various human cancers. To evaluate the importance of p53 in lung cancer, a transgenic mouse model was established by utilizing the Clara cell secretory protein (CCSP) promoter to target the expression of a dominant-negative ...

journal_title：American journal of respiratory cell and molecular biology

authors： Tchou-Wong KM,Jiang Y,Yee H,LaRosa J,Lee TC,Pellicer A,Jagirdar J,Gordon T,Goldberg JD,Rom WN

更新日期：2002-08-01 00:00:00

abstract：:Idiopathic pneumonia syndrome (IPS) is a significant clinical problem encountered among patients treated with bone marrow transplantation (BMT). IPS is identified as an inflammatory lung disease characterized by diffuse interstitial pneumonitis and alveolitis leading to interstitial fibrosis in the absence of an ident...

journal_title：American journal of respiratory cell and molecular biology

authors： Shankar G,Scott Bryson J,Darrell Jennings C,Kaplan AM,Cohen DA

更新日期：1999-06-01 00:00:00

abstract：:Although neutrophil migration from the systemic circulation involves the beta2- (or CD18) integrin family, the existence of an alternative, CD18-independent route of neutrophil extravasation to tissues has been demonstrated in animal models. The molecular interactions involved in this alternative migratory route have ...

journal_title：American journal of respiratory cell and molecular biology

authors： Mackarel AJ,Russell KJ,Brady CS,FitzGerald MX,O'Connor CM

更新日期：2000-08-01 00:00:00

abstract：:A murine model was used to assess the role of cytokines in initiating protective T-cell-mediated immunity in the lung. A pulmonary infection was initiated by intratracheal inoculation of Cryptococcus neoformans (Cne). Previously, we had established that Cne lung clearance was mouse-strain-specific: C.B-17 mice were re...

journal_title：American journal of respiratory cell and molecular biology

authors： Hoag KA,Lipscomb MF,Izzo AA,Street NE

更新日期：1997-12-01 00:00:00

abstract：:The role of pro-inflammatory cytokines in an animal model of allergic lung disease was examined by use of an interleukin-1 receptor antagonist (IL-1ra) and a specific bioassay for tumor necrosis factor (TNF). Ovalbumin-sensitized guinea pigs exhibit a marked bronchial hyperreactivity (assessed by airway responsiveness...

journal_title：American journal of respiratory cell and molecular biology

authors： Watson ML,Smith D,Bourne AD,Thompson RC,Westwick J

更新日期：1993-04-01 00:00:00

abstract：:We have previously characterized dog mastocytoma cells propagated in nude mice. We have established two of these lines (C1 and C2) in continuous culture. Freshly disaggregated mastocytoma cells were cultured in Dulbecco's modified Eagle's medium (DME)-H16 mixed with 50% Ham's F12 and supplemented with histidine and 5%...

journal_title：American journal of respiratory cell and molecular biology

authors： DeVinney R,Gold WM

更新日期：1990-11-01 00:00:00

abstract：:Transformation-related protein 63-expressing (p63(+)) basal cells are confined to the trachea in the mouse lung. However, after influenza virus infection or bleomycin treatment, patches of p63(+) cells were observed in the damaged lung parenchyma. To address whether the newly induced p63(+) cells are derived from the ...

journal_title：American journal of respiratory cell and molecular biology

authors： Zheng D,Yin L,Chen J

更新日期：2014-03-01 00:00:00

abstract：:Lung development is associated with a surge in surfactant phosphatidylcholine (PC) production to prepare the newborn for extrauterine breathing. This process is associated with a marked increase in the activity of the rate-regulatory surfactant enzyme, CTP:phosphocholine cytidylyltransferase (CCTalpha). To investigate...

journal_title：American journal of respiratory cell and molecular biology

authors： McCoy DM,Fisher K,Robichaud J,Ryan AJ,Mallampalli RK

更新日期：2006-09-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR) γ is critical for alveolar macrophage (AM) function. Chronic alcohol abuse causes AM phagocytic dysfunction and susceptibility to respiratory infections by stimulating nicotinamide adenine dinucleotide oxidases (Nox), transforming growth factor-β1, and oxidative stress...

journal_title：American journal of respiratory cell and molecular biology

authors： Yeligar SM,Mehta AJ,Harris FL,Brown LA,Hart CM

更新日期：2016-07-01 00:00:00

abstract：:Inhaled nitric oxide (NO) is an important new therapeutic agent used to treat pulmonary arterial hypertension in a variety of disease states. However, the effects of NO on cells in the lung are uncertain. Previously, we have shown that NO gas depresses neutrophil oxidative cell function and increases neutrophil cell d...

journal_title：American journal of respiratory cell and molecular biology

authors： Fortenberry JD,Owens ML,Brown MR,Atkinson D,Brown LA

更新日期：1998-03-01 00:00:00

abstract：:While elastin degradation is a hallmark of pulmonary emphysema, it is likely that elastin synthesis also occurs. However, the supramolecular structure and function of the newly synthesized elastin are abnormal. Very little is known about the regulation of elastin synthesis during the development of emphysema when prom...

journal_title：American journal of respiratory cell and molecular biology

authors： McGowan SE,McNamer R

更新日期：1990-10-01 00:00:00

abstract：:The increase of airway smooth muscle (ASM) mass in asthma results from hypertrophic and hyperplastic stimuli, and leads to an increase in cellular contractile proteins. However, little evidence correlates the relative contributions of hypertrophic and hyperplastic muscle with functional effects on airway resistance. W...

journal_title：American journal of respiratory cell and molecular biology

authors： Plant PJ,North ML,Ward A,Ward M,Khanna N,Correa J,Scott JA,Batt J

更新日期：2012-04-01 00:00:00

abstract：:Enhanced protein tyrosine phosphorylation is associated with changes in vascular permeability through formation and dissolution of adherens junctions and regulation of stress fiber formation. Inhibition of the protein tyrosine phosphorylase SH2 domain-containing protein tyrosine phosphatase 2 (SHP2) increases tyrosine...

journal_title：American journal of respiratory cell and molecular biology

authors： Chichger H,Braza J,Duong H,Harrington EO

更新日期：2015-06-01 00:00:00

abstract：:Airway allergen exposure induces inflammation among individuals with atopy that is characterized by altered airway gene expression, elevated levels of T helper type 2 cytokines, mucus hypersecretion, and airflow obstruction. To identify the genetic determinants of the airway allergen response, we employed a systems ge...

journal_title：American journal of respiratory cell and molecular biology

authors： Kelada SN,Carpenter DE,Aylor DL,Chines P,Rutledge H,Chesler EJ,Churchill GA,Pardo-Manuel de Villena F,Schwartz DA,Collins FS

更新日期：2014-09-01 00:00:00

abstract：:Adenosine triphosphate (ATP) acting through epithelial nucleotide receptors exerts multiple physiologic actions on airway mucociliary clearance and caliber. However, the effect of ATP on arachidonate metabolism in the airway remains unknown. In this study, the ability of ATP to regulate eicosanoid production was studi...

journal_title：American journal of respiratory cell and molecular biology

authors： Aksoy MO,Borenstein M,Li XX,Kelsen SG

更新日期：1995-10-01 00:00:00

abstract：:Muc1 is a heterodimeric mucin that is expressed on the apical surface of airway epithelial cells as well as hematopoietic cells. Both in vivo and in vitro studies revealed that Muc1 suppresses inflammatory responses induced by Pseudomonas aeruginosa (PA). In this study, we sought to determine, using intact animals (C5...

journal_title：American journal of respiratory cell and molecular biology

authors： Choi S,Park YS,Koga T,Treloar A,Kim KC

更新日期：2011-02-01 00:00:00

abstract：:Patients with severe acute and chronic lung diseases develop derangements in gas exchange that may result in increased levels of CO(2) (hypercapnia), the effects of which on human health are incompletely understood. It has been proposed that hypercapnia may have beneficial effects in patients with acute lung injury, a...

journal_title：American journal of respiratory cell and molecular biology

authors： Vadász I,Hubmayr RD,Nin N,Sporn PH,Sznajder JI

更新日期：2012-04-01 00:00:00

abstract：:Hyperplasia and cell migration of smooth muscle are features of both airway and pulmonary vascular diseases. The precise cellular and molecular mechanisms that regulate smooth muscle migration in the lungs remain unknown. In this study, we examined the effect of cAMP-mobilizing agents and steroids on smooth muscle cel...

journal_title：American journal of respiratory cell and molecular biology

authors： Goncharova EA,Billington CK,Irani C,Vorotnikov AV,Tkachuk VA,Penn RB,Krymskaya VP,Panettieri RA Jr

更新日期：2003-07-01 00:00:00

abstract：:Multiple cytokines play a role in the orchestration of inflammation in inflammatory airway diseases, such as chronic obstructive pulmonary disease, through the recruitment, activation and survival of inflammatory cells. Lymphokines secreted from T cells regulate the pattern of inflammation, whereas proinflammatory cyt...

journal_title：American journal of respiratory cell and molecular biology

authors： Barnes PJ

更新日期：2009-12-01 00:00:00

abstract：:Impaired sphingolipid synthesis is linked genetically to childhood asthma and functionally to airway hyperreactivity (AHR). The objective was to investigate whether sphingolipid synthesis could be a target for asthma therapeutics. The effects of GlyH-101 and fenretinide via modulation of de novo sphingolipid synthesis...

journal_title：American journal of respiratory cell and molecular biology

authors： Heras AF,Veerappan A,Silver RB,Emala CW,Worgall TS,Perez-Zoghbi J,Worgall S

更新日期：2020-11-01 00:00:00

abstract：:Neutrophil-associated inflammation during Pseudomonas aeruginosa lung infection is a determinant of morbidity in cystic fibrosis (CF). Neutrophil apoptosis is a key factor in inflammation resolution and is controlled by cytosolic proliferating cell nuclear antigen (PCNA). p21/Waf1, a cyclin-dependent kinase inhibitor,...

journal_title：American journal of respiratory cell and molecular biology

authors： Martin C,Ohayon D,Alkan M,Mocek J,Pederzoli-Ribeil M,Candalh C,Thevenot G,Millet A,Tamassia N,Cassatella MA,Thieblemont N,Burgel PR,Witko-Sarsat V

更新日期：2016-05-01 00:00:00

abstract：:Chloride (Cl(-)) movement across fetal lung epithelia is thought to be mediated by the sodium-potassium-2-Cl(-) cotransporter NKCC1. We studied the role of NKCC1 in Cl(-) and liquid secretion in late-gestation NKCC-null (-/-) and littermate control fetal mouse lung. NKCC -/- mice had decreased lung water compared with...

journal_title：American journal of respiratory cell and molecular biology

authors： Gillie DJ,Pace AJ,Coakley RJ,Koller BH,Barker PM

更新日期：2001-07-01 00:00:00