IL-12 and IFN-gamma are required for initiating the protective Th1 response to pulmonary cryptococcosis in resistant C.B-17 mice.

abstract：:The increase of airway smooth muscle (ASM) mass in asthma results from hypertrophic and hyperplastic stimuli, and leads to an increase in cellular contractile proteins. However, little evidence correlates the relative contributions of hypertrophic and hyperplastic muscle with functional effects on airway resistance. W...

journal_title：American journal of respiratory cell and molecular biology

authors： Plant PJ,North ML,Ward A,Ward M,Khanna N,Correa J,Scott JA,Batt J

更新日期：2012-04-01 00:00:00

abstract：:Pulmonary accumulation of fibroblasts and myofibroblasts in idiopathic pulmonary fibrosis/usual interstitial pneumonia (IFP/UIP) has been linked to (1) increased migration of a circulating pool of fibrocytes, (2) cell proliferation, and (3) resistance to apoptosis. The mechanism of physiologic apoptosis of lung fibrob...

journal_title：American journal of respiratory cell and molecular biology

authors： Frankel SK,Cosgrove GP,Cha SI,Cool CD,Wynes MW,Edelman BL,Brown KK,Riches DW

更新日期：2006-03-01 00:00:00

abstract：:The pathological hallmarks of bronchopulmonary dysplasia (BPD), a chronic lung disease of premature infants, include inflammation, arrested alveolarization, and dysregulated angiogenesis. Severe BPD is often complicated by pulmonary hypertension (PH) that significantly increases morbidity and mortality. Glycogen synth...

journal_title：American journal of respiratory cell and molecular biology

authors： Hummler SC,Rong M,Chen S,Hehre D,Alapati D,Wu S

更新日期：2013-05-01 00:00:00

abstract：:Thy-1 is a glycosylphosphytidylinositol-linked cell-surface glycoprotein present on a subset of lung fibroblasts, which plays an important role in postnatal alveolarization. In the present study, we define the role of Thy-1 in pulmonary lipofibroblast differentiation and in the regulation of lipid homeostasis via pero...

journal_title：American journal of respiratory cell and molecular biology

authors： Varisco BM,Ambalavanan N,Whitsett JA,Hagood JS

更新日期：2012-06-01 00:00:00

abstract：:Antenatal corticosteroids enhance lung maturation. However, the importance of glucocorticoid genes on early lung development, asthma susceptibility, and treatment response remains unknown. We investigated whether glucocorticoid genes are important during lung development and their role in asthma susceptibility and tre...

journal_title：American journal of respiratory cell and molecular biology

authors： Sharma S,Kho AT,Chhabra D,Qiu W,Gaedigk R,Vyhlidal CA,Leeder JS,Barraza-Villarreal A,London SJ,Gilliland F,Raby BA,Weiss ST,Tantisira KG

更新日期：2015-05-01 00:00:00

abstract：:Alveolar epithelial type II cells secrete lung surfactant via exocytosis. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) are implicated in this process. Lipid rafts, the cholesterol- and sphingolipid-rich microdomains, may offer a platform for protein organization on the cell membrane. ...

journal_title：American journal of respiratory cell and molecular biology

authors： Chintagari NR,Jin N,Wang P,Narasaraju TA,Chen J,Liu L

更新日期：2006-06-01 00:00:00

abstract：:Tissue-specific transgene expression using tetracycline (tet)-regulated promoter/operator elements has been used to revolutionize our understanding of cellular and molecular processes. However, because most tet-regulated mouse strains use promoters of genes expressed in multiple tissues, to achieve exclusive expressio...

journal_title：American journal of respiratory cell and molecular biology

authors： Tata PR,Pardo-Saganta A,Prabhu M,Vinarsky V,Law BM,Fontaine BA,Tager AM,Rajagopal J

更新日期：2013-12-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF alpha) is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils, and it can promote mediator and cytokine release, adhesion molecule expression, and granulocyte migration. Therefore, we induced an IgE-mediated response in ...

journal_title：American journal of respiratory cell and molecular biology

authors： Casale TB,Costa JJ,Galli SJ

更新日期：1996-07-01 00:00:00

abstract：:The mammalian airways are sensitive to inhaled stimuli, and airway diseases are characterized by hypersensitivity to volatile stimuli, such as perfumes, industrial solvents, and others. However, the identity and function of the cells in the airway that can sense volatile chemicals remain uncertain, particularly in hum...

journal_title：American journal of respiratory cell and molecular biology

authors： Gu X,Karp PH,Brody SL,Pierce RA,Welsh MJ,Holtzman MJ,Ben-Shahar Y

更新日期：2014-03-01 00:00:00

abstract：:Myosin light chain kinase (MLCK; gene code, MYLK) is a multifunctional enzyme involved in isoform-specific nonmuscle (nm) and smooth muscle contraction, inflammation, and vascular permeability, processes directly relevant to asthma pathobiology. In this report, we highlight the contribution of the nm isoform (nmMLCK) ...

journal_title：American journal of respiratory cell and molecular biology

authors： Wang T,Moreno-Vinasco L,Ma SF,Zhou T,Shimizu Y,Sammani S,Epshtein Y,Watterson DM,Dudek SM,Garcia JG

更新日期：2014-06-01 00:00:00

abstract：:Hexavalent chromium (Cr[VI]) is classified by the International Agency for Research on Cancer as a group I carcinogen. Although the U.S. Occupational Safety and Health Administration was obliged to reduce the permissible exposure limit (PEL), it was reported that U.S. workers continue to be exposed to dangerously high...

journal_title：American journal of respiratory cell and molecular biology

authors： Russo P,Catassi A,Cesario A,Imperatori A,Rotolo N,Fini M,Granone P,Dominioni L

更新日期：2005-12-01 00:00:00

abstract：:Mechanical ventilation with high tidal volumes has been associated with pulmonary alveolar flooding. Understanding the mechanisms underlying cyclic stretch-induced increases in alveolar epithelial permeability may be important in designing preventive measures for acute lung injury. In this work, we assessed whether cy...

journal_title：American journal of respiratory cell and molecular biology

authors： Davidovich N,DiPaolo BC,Lawrence GG,Chhour P,Yehya N,Margulies SS

更新日期：2013-07-01 00:00:00

abstract：:Integrins are heterodimeric cell-surface glycoproteins that mediate cell-cell and cell-matrix adhesion. We previously identified cDNA encoding a novel integrin beta subunit, beta 7, from bronchoalveolar lavage fluid (BALF) leukocytes. The beta 7 subunit protein is now known to associate with at least two integrin alph...

journal_title：American journal of respiratory cell and molecular biology

authors： Erle DJ,Brown T,Christian D,Aris R

更新日期：1994-03-01 00:00:00

abstract：:Wheeze is a common symptom in infants, but not all wheezers develop asthma. Indeed, up to 50% of wheezing children outgrow their symptoms by school age. How to predict if early wheeze will become asthma is still a matter of vivid debate. In this work, we sought to assess the clinical and pathological factors that migh...

journal_title：American journal of respiratory cell and molecular biology

authors： Bonato M,Bazzan E,Snijders D,Tinè M,Biondini D,Turato G,Balestro E,Papi A,Cosio MG,Barbato A,Baraldo S,Saetta M

更新日期：2018-10-01 00:00:00

abstract：:Cytolytic lymphocytes play an important role in defense against viral and neoplastic disease. Integral to the function of these cells is the content of lysosomal granules. Recent attention has focused on a family of proteases present in the granules of natural killer (NK) cells, interleukin-2 (IL-2)-activated NK cells...

journal_title：American journal of respiratory cell and molecular biology

authors： Breite WM,Dal Nogare AR,Yarbrough WC Jr,Weissler JC

更新日期：1990-12-01 00:00:00

abstract：:IL-13 is a T-helper class 2 cytokine that induces goblet cell hyperplasia and mucus production in airway epithelial cells. Because macrolide antibiotics are known to have immunomodulatory and mucoregulatory properties, the aim of this study was to examine the effect of clarithromycin on IL-13-induced goblet cell hyper...

journal_title：American journal of respiratory cell and molecular biology

authors： Tanabe T,Kanoh S,Tsushima K,Yamazaki Y,Kubo K,Rubin BK

更新日期：2011-11-01 00:00:00

abstract：:PS-341 is a highly selective and potent proteasome inhibitor that is cytotoxic to various types of cancer. However, no objective response was seen in a clinical trial with PS-341 as a single agent in non-small cell lung cancer. Its antitumor activity is limited by the simultaneously activated antiapoptosis pathway. Re...

journal_title：American journal of respiratory cell and molecular biology

authors： Lee KH,Jang AH,Yoo CG

更新日期：2015-09-01 00:00:00

abstract：:Asthma is characterized by appearance of eosinophils in the airway. Eosinophils purified from the airway 48 h after segmental antigen challenge are described as exhibiting greater adhesion to albumin-coated surfaces via an unidentified beta2 integrin and increased expression of alphaMbeta2 (CD11b/18) compared with pur...

journal_title：American journal of respiratory cell and molecular biology

authors： Barthel SR,Jarjour NN,Mosher DF,Johansson MW

更新日期：2006-09-01 00:00:00

abstract：:Chronic hypoxia induces proliferation of human pulmonary artery smooth muscle cells (hPASMCs), leading to remodeling and pulmonary hypertension, but the mechanism remains unclear. The present study tested the roles of mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) and mitochondrial membrane potential (Delt...

journal_title：American journal of respiratory cell and molecular biology

authors： Hu HL,Zhang ZX,Chen CS,Cai C,Zhao JP,Wang X

更新日期：2010-06-01 00:00:00

abstract：:Cytochrome P4501A1 (CYP1A1) metabolizes polycyclic aromatic hydrocarbons in cigarette smoke to DNA-binding reactive intermediates associated with carcinogenesis. Epidemiologic studies indicate that the majority of coal miners are smokers but have a lower risk of lung cancer than other smokers. We hypothesized that coa...

journal_title：American journal of respiratory cell and molecular biology

authors： Ghanem MM,Porter D,Battelli LA,Vallyathan V,Kashon ML,Ma JY,Barger MW,Nath J,Castranova V,Hubbs AF

更新日期：2004-08-01 00:00:00

abstract：:Combustion-generated radicals interact to form polynuclear aromatic hydrocarbons (PAHs), including carcinogens. PAHs aggregate into 20- to 50-nm particles, which extend into branched-chain structures (soots). Incomplete combustion yields black soot particles and black smoke. Many PAHs, including those in soots, fluore...

journal_title：American journal of respiratory cell and molecular biology

authors： Murphy G Jr,Rouse RL,Polk WW,Henk WG,Barker SA,Boudreaux MJ,Floyd ZE,Penn AL

更新日期：2008-05-01 00:00:00

abstract：:Excessive growth of pulmonary arterial (PA) smooth muscle cells (SMCs) is a major component of PA hypertension (PAH). The calcium-activated neutral cysteine proteases calpains 1 and 2, expressed by PASMCs, contribute to PH but are tightly controlled by a single specific inhibitor, calpastatin. Our objective was to inv...

journal_title：American journal of respiratory cell and molecular biology

authors： Wan F,Letavernier E,Abid S,Houssaini A,Czibik G,Marcos E,Rideau D,Parpaleix A,Lipskaia L,Amsellem V,Gellen B,Sawaki D,Derumeaux G,Dubois-Randé JL,Delcroix M,Quarck R,Baud L,Adnot S

更新日期：2016-09-01 00:00:00

abstract：:Smoking cigarettes is the major risk factor for chronic obstructive pulmonary disease (COPD). COPD is a condition associated with chronic pulmonary inflammation, characterized by macrophage activation, neutrophil recruitment, and cell injury. Many substances contained in cigarette smoke, including reactive oxygen spec...

journal_title：American journal of respiratory cell and molecular biology

authors： Facchinetti F,Amadei F,Geppetti P,Tarantini F,Di Serio C,Dragotto A,Gigli PM,Catinella S,Civelli M,Patacchini R

更新日期：2007-11-01 00:00:00

abstract：:Bombesin-like peptides within neuroepithelial cells elicit proliferation of normal and malignant airway epithelial cells. It is not clear that these peptides also elicit epithelial cell migration, a necessary component of airway repair after injury. We studied the effects of the bombesin analogues, gastrin releasing p...

journal_title：American journal of respiratory cell and molecular biology

authors： Kim JS,McKinnis VS,White SR

更新日期：1997-03-01 00:00:00

abstract：:Airway surface fluids are mainly secreted from submucosal glands, and play important roles in the defense of airways via the up-regulation of mucociliary transport, resulting in an exclusion of many microbes or foreign substances. Although there are many articles concerning the importance of Toll-like receptors (TLRs)...

journal_title：American journal of respiratory cell and molecular biology

authors： Murakami K,Tamada T,Nara M,Muramatsu S,Kikuchi T,Kanehira M,Maruyama Y,Ebina M,Nukiwa T

更新日期：2011-11-01 00:00:00

abstract：:Opiate-like peptides can regulate many cellular functions. We now map [D-Ala(2)]deltorphin I (DADTI)-like immunoreactivity (DADTI-LI) in developing mouse lung and analyze potential functional roles. Most DADTI-LI-positive cells were alveolar cells negative for prosurfactant protein (proSP)-C immunoreactivity. Peak num...

journal_title：American journal of respiratory cell and molecular biology

authors： Sunday ME,Haley KJ,Emanuel RL,Torday JS,Asokananthan N,Sikorski KA,Tooyama I,Kimura H,Renda T,Erspamer V

更新日期：2001-10-01 00:00:00

abstract：:The investigation of novel targets for the treatment of cystic fibrosis (CF) lung inflammation is a major priority, considering that no effective therapy is available for this purpose. Consistent with the evidence that the sphingolipid (SL) ceramide regulates airway inflammation and infection in mice and patients with...

journal_title：American journal of respiratory cell and molecular biology

authors： Dechecchi MC,Nicolis E,Mazzi P,Cioffi F,Bezzerri V,Lampronti I,Huang S,Wiszniewski L,Gambari R,Scupoli MT,Berton G,Cabrini G

更新日期：2011-10-01 00:00:00

abstract：:Bitter taste receptor (TAS2R) agonists dilate airways by receptor-dependent smooth muscle relaxation. Besides their coupling to relaxation, we have found that human airway smooth muscle (HASM) cell TAS2Rs activate (phosphorylate) extracellular signal-related kinase 1/2 (ERK1/2), but the cellular effects are not known....

journal_title：American journal of respiratory cell and molecular biology

authors： Kim D,Cho S,Castaño MA,Panettieri RA,Woo JA,Liggett SB

更新日期：2019-05-01 00:00:00

abstract：:LL-37 is a human cationic host defense peptide that is present in the specific granules of neutrophils, produced by epithelial cells from a variety of tissues, and is upregulated during inflammation, infection, and injury. It has been proposed to have a variety of antimicrobial functions, including both direct antimic...

journal_title：American journal of respiratory cell and molecular biology

authors： Lau YE,Bowdish DM,Cosseau C,Hancock RE,Davidson DJ

更新日期：2006-04-01 00:00:00

abstract：:The primary function of neutrophils in host defense is to contain and eradicate invading microbial pathogens. This is achieved through a series of swift and highly coordinated responses culminating in ingestion (phagocytosis) and killing of invading microbes. While these tasks are usually performed without injury to h...

journal_title：American journal of respiratory cell and molecular biology

authors： Zemans RL,Colgan SP,Downey GP

更新日期：2009-05-01 00:00:00