Effect of cholesterol depletion on exocytosis of alveolar type II cells.

abstract：:Stachybotrys chartarum is a fungal contaminant within the built environment and a respiratory health concern in the United States. The objective of this study was to characterize the mechanisms influencing pulmonary immune responses to repeatedly inhaled S. chartarum. Groups of B6C3F1/N mice repeatedly inhaled viable ...

journal_title：American journal of respiratory cell and molecular biology

authors： Croston TL,Lemons AR,Barnes MA,Goldsmith WT,Orandle MS,Nayak AP,Germolec DR,Green BJ,Beezhold DH

更新日期：2020-05-01 00:00:00

abstract：:Electrical field stimulation (EFS) has previously been shown to induce the release of prostaglandin (PG) E2 from ferret tracheal epithelium. We have now conducted a study to see whether this effect of EFS is due to the activation of nerves or whether it is a non-neural effect. The release of PGE2 and 6-keto-PGF1 alpha...

journal_title：American journal of respiratory cell and molecular biology

authors： Ullman A,Ciabattoni G,Svedmyr N,Skoogh BE,Löfdahl CG

更新日期：1991-03-01 00:00:00

abstract：:Glucocorticoid (GC) insensitivity represents a profound challenge in managing patients with asthma. The mutual inhibition of transcriptional activity between GC receptor (GR) and other regulators is one of the mechanisms contributing to GC resistance in asthma. We recently reported that interferon regulatory factor (I...

journal_title：American journal of respiratory cell and molecular biology

authors： Bhandare R,Damera G,Banerjee A,Flammer JR,Keslacy S,Rogatsky I,Panettieri RA,Amrani Y,Tliba O

更新日期：2010-01-01 00:00:00

abstract：:Ventilator-induced lung injury (VILI) is a severe complication of mechanical ventilation that can lead to acute respiratory distress syndrome. VILI is characterized by damage to the epithelial barrier with subsequent pulmonary edema and profound hypoxia. Available lung-protective ventilator strategies offer only a mod...

journal_title：American journal of respiratory cell and molecular biology

authors： Dolinay T,Himes BE,Shumyatcher M,Lawrence GG,Margulies SS

更新日期：2017-08-01 00:00:00

abstract：:Ozone (O3) is the principal oxidant pollutant in photochemical smog. Repeated exposures to O3 induces inflammation and mucous cell metaplasia in the nasal airways of laboratory animals. Our study was designed to determine the efficacy of a topical anti-inflammatory corticosteroid in preventing O3-induced rhinitis and ...

journal_title：American journal of respiratory cell and molecular biology

authors： Hotchkiss JA,Hilaski R,Cho H,Regan K,Spencer P,Slack K,Harkema JR

更新日期：1998-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is necessary for normal postnatal lung development and may underlie the structural lung damage that follows hyperoxic exposure. To determine the individual roles of VEGF receptors (VEGFR) 2 and 1 on postnatal lung growth, neonatal mice were treated with neutralizing antibodies...

journal_title：American journal of respiratory cell and molecular biology

authors： McGrath-Morrow SA,Cho C,Cho C,Zhen L,Hicklin DJ,Tuder RM

更新日期：2005-05-01 00:00:00

abstract：:Alveolar macrophages (AMs) play an important role in the regulation of the local immune reactivity in the lung. It was previously shown that exposure of rats to mild inescapable electrical footshock stress (20 min, 4 shocks/min, 5 s/shock, 0.8 mAmp) leads to apparent changes in the activity of AMs upon stimulation, re...

journal_title：American journal of respiratory cell and molecular biology

authors： Broug-Holub E,Persoons JH,Schornagel K,Mastbergen SC,Kraal G

更新日期：1998-11-01 00:00:00

abstract：:Organisms on our planet have evolved in an oxidizing environment that is intrinsically inimical to life, and cells have been forced to devise means of protecting themselves. One of the defenses used most widely in nature is the enzyme heme oxygenase-1 (HO-1). This enzyme performs the seemingly lackluster function of c...

journal_title：American journal of respiratory cell and molecular biology

authors： Morse D,Choi AM

更新日期：2002-07-01 00:00:00

abstract：:Neutrophil apoptosis is essential for the resolution of inflammation but is delayed by several inflammatory mediators. In such terminally differentiated cells it has been uncertain whether these agents can inhibit apoptosis through transcriptional regulation of anti-death (Bcl-X(L), Mcl-1, Bcl2A1) or BH3-only (Bim, Bi...

journal_title：American journal of respiratory cell and molecular biology

authors： Cowburn AS,Summers C,Dunmore BJ,Farahi N,Hayhoe RP,Print CG,Cook SJ,Chilvers ER

更新日期：2011-06-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha), a major product of alveolar macrophages (AM), has been implicated in many pulmonary diseases. Histamine, a mediator important in pulmonary inflammation, has been demonstrated to regulate the production of TNF-alpha by monocytes. In this study, we show that human AM and monocyte...

journal_title：American journal of respiratory cell and molecular biology

authors： Rowe J,Finlay-Jones JJ,Nicholas TE,Bowden J,Morton S,Hart PH

更新日期：1997-08-01 00:00:00

abstract：:Gene expression for tropoelastin, the proprotein for elastin, was examined in the rat lung from 17 days of gestation (pseudoglandular stage) to adulthood by in situ hybridization using a rat-specific 35S-radiolabeled riboprobe. The tropoelastin message was present in vascular and airway smooth muscle, endothelial, sep...

journal_title：American journal of respiratory cell and molecular biology

authors： Noguchi A,Samaha H

更新日期：1991-12-01 00:00:00

abstract：:Lung elastin synthesis is normally confined to periods of development, is maximal during alveolarization, and declines to low levels in mature lung. We have previously described an elastogenic response in the adult rat lung associated with experimental granulomatous disease induced by silica instillation. Reinitiated ...

journal_title：American journal of respiratory cell and molecular biology

authors： Mariani TJ,Arikan MC,Pierce RA

更新日期：1999-08-01 00:00:00

abstract：:Neutrophil elastase (NE) is a major inflammatory mediator in cystic fibrosis (CF) that is a robust predictor of lung disease progression. NE directly causes airway injury via protease activity, and propagates persistent neutrophilic inflammation by up-regulation of neutrophil chemokine expression. Despite its key role...

journal_title：American journal of respiratory cell and molecular biology

authors： Griffin KL,Fischer BM,Kummarapurugu AB,Zheng S,Kennedy TP,Rao NV,Foster WM,Voynow JA

更新日期：2014-04-01 00:00:00

abstract：:We have investigated the relative efficacy of a range of natural and synthetic retinoids on the induction of alveolar regeneration in a dexamethasone-treated mouse model. The aim was to explore the roles of the different retinoic acid receptors using receptor-selective agonists and to determine whether other natural r...

journal_title：American journal of respiratory cell and molecular biology

authors： Maden M

更新日期：2006-08-01 00:00:00

abstract：:Preclinical models of human conditions including asthma showed the therapeutic potential of Compound A (CpdA), a dissociated glucocorticoid (GC) receptor (GRα) ligand. Whether CpdA inhibits GC resistance, a central feature of severe asthma, has not been addressed. We investigated whether CpdA modulates cytokine-induce...

journal_title：American journal of respiratory cell and molecular biology

authors： Gavrila A,Chachi L,Tliba O,Brightling C,Amrani Y

更新日期：2015-11-01 00:00:00

abstract：:Macrophages are key orchestrators of the inflammatory and repair responses in the lung, and the diversity of their function is indicated by their polarized states and distinct subpopulations and localization in the lung. Here, we characterized the pulmonary macrophage populations in the interstitial and alveolar compa...

journal_title：American journal of respiratory cell and molecular biology

authors： Johnston LK,Rims CR,Gill SE,McGuire JK,Manicone AM

更新日期：2012-10-01 00:00:00

abstract：:Na(+) absorption and Cl(-) secretion are in equilibrium to maintain an appropriate airway surface fluid volume and ensure appropriate mucociliary clearance. In cystic fibrosis, this equilibrium is disrupted by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene resulting in the absence of ...

journal_title：American journal of respiratory cell and molecular biology

authors： Caci E,Melani R,Pedemonte N,Yueksekdag G,Ravazzolo R,Rosenecker J,Galietta LJ,Zegarra-Moran O

更新日期：2009-02-01 00:00:00

abstract：:FGFs (fibroblast growth factors) are major factors associated with the pathogenesis of pulmonary fibrosis. On the one hand, nintedanib, a tyrosine kinase inhibitor targeting several growth factor receptors, including the FGF receptor (FGFR), has been approved for the treatment of idiopathic pulmonary fibrosis. On the ...

journal_title：American journal of respiratory cell and molecular biology

authors： Morizumi S,Sato S,Koyama K,Okazaki H,Chen Y,Goto H,Kagawa K,Ogawa H,Nishimura H,Kawano H,Toyoda Y,Uehara H,Nishioka Y

更新日期：2020-09-01 00:00:00

abstract：:The cytokine mRNA profiles of primary (arising from inhaled bacilli) and secondary (arising from hematogenous reseeding of the lung) granulomas from the lung lobes of bacillus Calmette-Guérin (BCG)-vaccinated and unimmunized guinea pigs challenged with virulent Mycobacterium tuberculosis by the pulmonary route were as...

journal_title：American journal of respiratory cell and molecular biology

authors： Ly LH,Russell MI,McMurray DN

更新日期：2008-04-01 00:00:00

abstract：:Recently, investigators demonstrated associations between fine particulate matter (PM)-associated metals and adverse health effects. Residual oil fly ash (ROFA), a waste product of fossil fuel combustion from boilers, is rich in the transition metals Fe, Ni, and V, and when released as a fugitive particle, is an impor...

journal_title：American journal of respiratory cell and molecular biology

authors： Farraj AK,Hazari MS,Haykal-Coates N,Lamb C,Winsett DW,Ge Y,Ledbetter AD,Carll AP,Bruno M,Ghio A,Costa DL

更新日期：2011-02-01 00:00:00

abstract：:5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is a metabolite of arachidonic acid formed by the oxidation of 5-hydroxy-6,8,11, 14-eicosatetraenoic acid by a highly specific dehydrogenase. 5-oxo-ETE is a chemoattractant for both neutrophils and eosinophils. Although it is not as effective as leukotriene B4 (LTB4) a...

journal_title：American journal of respiratory cell and molecular biology

authors： Powell WS,Gravel S,Halwani F

更新日期：1999-01-01 00:00:00

abstract：:We have previously reported that medium conditioned by hypoxic pulmonary artery endothelial cells (ECCM) contains a factor of small molecular weight that inhibits the growth of pulmonary artery smooth muscle cells (SMC). We postulated that this factor might be a breakdown product of ATP and, therefore, measured the le...

journal_title：American journal of respiratory cell and molecular biology

authors： Hassoun PM,Shedd AL,Lanzillo JJ,Thappa V,Landman MJ,Fanburg BL

更新日期：1992-06-01 00:00:00

abstract：:We examined the contribution of the leukocyte function-associated antigen (LFA-1) in a murine model of lung inflammation determined by exposure to the thermophilic actinomycete Faeni rectivirgula. The exposure generated a large influx of cells in the bronchoalveolar space and in the lung parenchyma, as seen from enhan...

journal_title：American journal of respiratory cell and molecular biology

authors： Denis M,Bisson D

更新日期：1994-05-01 00:00:00

abstract：:The vascular endothelium plays an important role in the regulation of inflammatory responses after trauma and hemorrhage. Interactions of neutrophils with endothelial cells (ECs) contribute to the activation of specific EC responses involved in innate immunity. We have previously reported that oxidants derived from th...

journal_title：American journal of respiratory cell and molecular biology

authors： Xiang M,Yin L,Li Y,Xiao G,Vodovotz Y,Billiar TR,Wilson MA,Fan J

更新日期：2011-03-01 00:00:00

abstract：:The protease-antiprotease imbalance that is characteristic of most inflammatory lung disorders depends on the spatial-temporal regulation of active inhibitor and protease concentrations in lung secretions. We have studied the competition between the three main serine proteases from human neutrophil primary granules in...

journal_title：American journal of respiratory cell and molecular biology

authors： Korkmaz B,Poutrain P,Hazouard E,de Monte M,Attucci S,Gauthier FL

更新日期：2005-06-01 00:00:00

abstract：:In addition to inhibiting proliferation and causing enlargement of bovine pulmonary artery endothelial cells in culture, porcine platelet transforming growth factor-beta 1 (TGF-beta 1) (2 ng/ml) lowered glutathione (GSH) of these cells by 48% after 96 h in culture when GSH levels were normalized for cell counts. This ...

journal_title：American journal of respiratory cell and molecular biology

authors： White AC,Das SK,Fanburg BL

更新日期：1992-04-01 00:00:00

abstract：:In allergic airway diseases, intermediate progenitor cells (IPCs) increase in number in the surface epithelium. IPCs arise from basal cells, the origin of hallmark pathological changes, including goblet cell hyperplasia and mucus hypersecretion. Thus, targeting IPCs will benefit future treatment of allergic airway dis...

journal_title：American journal of respiratory cell and molecular biology

authors： Lee SN,Kim SJ,Yoon SA,Song JM,Ahn JS,Kim HC,Choi AMK,Yoon JH

更新日期：2020-12-02 00:00:00

abstract：:The transcription factor (TF) Foxp2 has been shown to partially repress surfactant protein C (SP-C) transcription, presumably through interaction of an independent repressor domain with a conserved Foxp2 consensus site in the SP-C promoter. We explored the role of interactions between Foxp2 and the homeodomain TF Nkx2...

journal_title：American journal of respiratory cell and molecular biology

authors： Zhou B,Zhong Q,Minoo P,Li C,Ann DK,Frenkel B,Morrisey EE,Crandall ED,Borok Z

更新日期：2008-06-01 00:00:00

abstract：:We have developed a method to harvest and culture Clara cells isolated from guinea pig lungs. Their identity was confirmed by the presence of CC16kD protein specific for these cells; we studied their capacity to generate endothelin 1 (ET-1). Using monoclonal antibody and immunofluorescence techniques, ET-1 was localiz...

journal_title：American journal of respiratory cell and molecular biology

authors： Laporte J,D'Orléans-Juste P,Sirois P

更新日期：1996-04-01 00:00:00

abstract：:Serum contains a number of polypeptide growth factors, hormones, and soluble matrix components and may influence the state of differentiation of epithelial cells in general and of alveolar epithelial cells (AEC) in particular. To evaluate the influence of sera on the transition from the type II toward the type I cell ...

journal_title：American journal of respiratory cell and molecular biology

authors： Borok Z,Hami A,Danto SI,Zabski SM,Crandall ED

更新日期：1995-01-01 00:00:00